{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:58:35Z","timestamp":1791950315733,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.chemosphere.2009.08.041","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T11:03:30Z","timestamp":1253099010000},"page":"902-906","source":"Crossref","is-referenced-by-count":51,"title":["Mixture toxicity assessment of cadmium and benzo[a]pyrene in the sea worm Hediste diversicolor"],"prefix":"10.1016","volume":"77","author":[{"given":"M.","family":"Banni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Bouraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Clerandeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Narbonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Boussetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2009.08.041_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ecoenv.2008.07.017","article-title":"Mixture toxicity assessment of wood preservative pesticides in the freshwater amphipod Gammarus pulex (L.)","volume":"72","author":"Adam","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0166-445X(99)00082-X","article-title":"Enzymatic biomarker measurement and study of DNA adduct formation in benzo[a]pyrene-contaminated mussels, Mytilus galloprovincialis","volume":"49","author":"Akcha","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.freeradbiomed.2005.04.017","article-title":"Oxidative stress during the chronic phase of stroke","volume":"39","author":"Alexandrova","year":"2005","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.aquatox.2007.03.001","article-title":"The effects of copper and benzo[a]pyrene on retinoids and reproduction in zebrafish","volume":"82","author":"Alsop","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib5","series-title":"Potentials of Living Resources","first-page":"459","article-title":"Cytochrome P450 and other biotransformation activity in aquatic organisms: potential biomarkers to environmental pollution","author":"Arun","year":"2003"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/13547500500107497","article-title":"Monitoring pollution in Tunisian coasts: application of a classification scale based on biochemical markers","volume":"10","author":"Banni","year":"2005","journal-title":"Biomarkers"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/13547500701217061","article-title":"Assessment of heavy metal contamination using real time PCR analysis of mussel metallothionein mt10 and mt20 expression: a validation along the Tunisian coasts","volume":"12","author":"Banni","year":"2007","journal-title":"Biomarkers"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2006.01.013","article-title":"Toxicity of binary mixtures of metals and pyrethroid insecticides to Daphnia magna Straus. Implications for multi-substance risks assessment","volume":"78","author":"Barata","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.aquatox.2007.08.009","article-title":"Oxidative and modulatory effects of trace metals on metabolism of polycyclic aromatic hydrocarbons in the Antarctic fish Trematomus bernacchii","volume":"85","author":"Benedetti","year":"2007","journal-title":"Aquat Toxicol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Annu. Appl. Biol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib11","article-title":"Monitoring pollution in Tunisian coasts using a scale of classification based on biochemical markers in worms Nereis (Hediste) diversicolor","author":"Bouraoui","year":"2009","journal-title":"Environ. Monit. Assess"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib13","doi-asserted-by":"crossref","unstructured":"Buege, J.A., Aust, S.D., 1978. Microsomal lipid peroxidation. In: Packer, L. (Ed.), Meth. Enzymol. 52, 302\u2013310.","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0166-445X(01)00217-X","article-title":"Metabolism of pyrene by the polychaetes Nereis diversicolor and Arenicola marina","volume":"58","author":"Christensen","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib15","series-title":"CRC Handbook of Methods in Oxygen Radical Research","first-page":"283","article-title":"Catalase activity","author":"Claiborne","year":"1985"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.envpol.2006.12.022","article-title":"Biomonitoring in a clean and a multi-contaminated estuary based on biomarkers and chemical analyses in the endobenthic worm Nereis diversicolor","volume":"148","author":"Durou","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.chemosphere.2009.08.041_bib18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ecoenv.2008.07.003","article-title":"Antioxidant responses in different body regions of the polychaeta Laeonereis acuta (Nereididae) exposed to copper","volume":"72","author":"Ferreira-Cravo","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0043-1354(91)90023-J","article-title":"Semi-automated colorimetric and enzymatic assays for aquatic organisms using microplate readers","volume":"25","author":"Galgani","year":"1991","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib20","first-page":"398","article-title":"Application of a biomarker battery for the evaluation of the sublethal effects of pollutants in the earthworm Eisenia Andrei","volume":"146","author":"Gastaldi","year":"2007","journal-title":"Comp. Biochem. Physiol Part C"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib21","first-page":"287","article-title":"Use of the fish enzyme system in monitoring water quality: Effects of mercury on tissue enzymes","volume":"97C","author":"Gill","year":"1990","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0887-2333(03)00093-6","article-title":"Comparative effects of cadmium, copper, paraquat and benzo[a]pyrene on the actin cytoskeleton and production of reactive oxygen species (ROS) in mussel haemocytes","volume":"17","author":"Gomez-Mendikute","year":"2003","journal-title":"Toxicol. Invitro."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0025-326X(89)90438-4","article-title":"Mapping the ecological impact of heavy metals on the estuarine polychaete Nereis diversicolor using inherited metal tolerance","volume":"5","author":"Grant","year":"1989","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1021\/es981309+","article-title":"Geochemical influences on assimilation of sediment-bound metals in clams and mussels","volume":"34","author":"Griscom","year":"2000","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0048-9697(99)00485-4","article-title":"In vitro and in vivo inhibition of Daphnia magna acetylcholinesterase by surfactant agents: possible implications for contamination biomonitoring","volume":"247","author":"Guilhermino","year":"2000","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib26","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases, the first step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib27","series-title":"Principles and Methods of Toxicology","author":"Hayes","year":"1982"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10695-006-0041-2","article-title":"Effects of malathion and cadmium on acetylcholinesterase activity and metallothionein levels in the fish Seriola dumerilli","volume":"32","author":"Jebali","year":"2006","journal-title":"Fish. Physiol. Bioch."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib29","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1897\/07-187.1","article-title":"Application of statistical experimental design and multivariate data analysis for evaluation of mixtures using cytochrome P4501A induction","volume":"27","author":"Jensen","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib30","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.marpolbul.2004.07.010","article-title":"Polycyclic aromatic hydrocarbon contamination and recovery characteristics in some organisms after the Nakhodka oil spill","volume":"49","author":"Koyama","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib31","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1073\/pnas.090091397","article-title":"A biological function for cadmium in marine diatoms","volume":"97","author":"Lane","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib32","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1126\/science.287.5451.282","article-title":"Influence of dietary uptake and reactive sulfides on metal bioavailability from aquatic sediments","volume":"287","author":"Lee","year":"2000","journal-title":"Science."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib33","unstructured":"Michel, X., Narbonne, J.F., Mora, P., Daub\u00e8ze, M., Ribera, D., Lafaurie, M., Budzinski, H., Garrigues, P., 1998. Indicateurs biog\u00e9ochimiques de pollution des \u00e9cosyst\u00e8mes c\u00f4tiers: exp\u00e9rience du groupe interface chimie-biologie des \u00e9cosyst\u00e8mes marins (GICBEM). In: Lagadic, L., Caquet, T., Amiard, J.C., Ramade, F. (Eds.), Utilisation de biomarqueurs pour la surveillance de la qualit\u00e9 de l\u2019environnement. Lavoisier Tec et Doc, Paris, New York, Londres, 9\u201330."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib34","series-title":"Fundamental of Aquatic Toxicology Methods and Applications","first-page":"416","article-title":"Polycyclic Aromatic Hydrocarbon","author":"Neff","year":"1985"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib35","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/303468a0","article-title":"Fifty years of benzo[a]pyrene","volume":"303","author":"Phillips","year":"1981","journal-title":"Nature."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1439-0485.1997.tb00431.x","article-title":"Nereis diversicolor: an unreliable biomonitor of metal contamination in the R\u00eda de Bilbao (Spain)","volume":"18","author":"Saiz-Salinas","year":"1997","journal-title":"Mar. Ecol;"},{"key":"10.1016\/j.chemosphere.2009.08.041_bib37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ecoenv.2007.03.004","article-title":"Antioxidant responses in the nereidid Laeonereis acuta (Annelida, Polychaeta) after cadmium exposure","volume":"70","author":"Sandrini","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ecoenv.2003.08.009","article-title":"A review of lysosomal membrane stability measured by neutral red retention: is it a workable earthworm biomarker?","volume":"54","author":"Svendsen","year":"2004","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2009.08.041_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0300-483X(03)00305-6","article-title":"Molecular and cellular mechanisms of cadmium carcinogenesis","volume":"192","author":"Waisberg","year":"2003","journal-title":"Toxicology"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565350901011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565350901011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T20:30:06Z","timestamp":1633897806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004565350901011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S004565350901011X"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2009.08.041","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}