{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:16:47Z","timestamp":1792430207250,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.chemosphere.2009.11.051","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T05:45:47Z","timestamp":1262756747000},"page":"822-829","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Subcellular compartmentalization of cadmium, nickel, and lead in Gammarus fossarum: Comparison of methods"],"prefix":"10.1016","volume":"78","author":[{"given":"Alain","family":"Geffard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Sartelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Garric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Biagianti-Risbourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Delahaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Geffard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2009.11.051_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.aquatox.2005.08.015","article-title":"Metallothioneins in aquatic invertebrates: their use as biomarkers","volume":"76","author":"Amiard","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib2","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00244-003-0135-0","article-title":"Accumulation and soluble binding of cadmium, copper, and zinc in the Polychaete Hediste diversicolor from coastal sites from different trace metal bioavailabilities","volume":"45","author":"Berthet","year":"2003","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.aquatox.2004.11.025","article-title":"Sub-cellular partitioning of metals (Cd,Cu,Zn) in the gills of a freshwater bivalve, Pyganodon grandis: role of calcium concretions in metal sequestration","volume":"7","author":"Bonneris","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1095-6433(02)00239-8","article-title":"Some methodological aspects of metallothionein evaluation","volume":"134A","author":"Bragigand","year":"2003","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib5","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.fct.2004.07.011","article-title":"Estimates of trace metal bioavailability to humans ingesting contaminated oysters","volume":"42","author":"Bragigand","year":"2004","journal-title":"Food. Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.scitotenv.2004.07.004","article-title":"Subcellular and body distributions of 17 trace elements in the variegated scallop Chlamys varia from the French coast of the Bay of Biscay","volume":"337","author":"Bustamante","year":"2006","journal-title":"Sci. Tot. Environ."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aquatox.2004.11.023","article-title":"Cadmuim-handling strategies in two chronically exposed indigenous freshwater organisms \u2013 the yellow perch (Perca flavescens) and the floater mollusk (Pyganodon grandis)","volume":"72","author":"Campbell","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3354\/meps286155","article-title":"Influence of subcellular metal compartmentalization in different prey on the transfer of metals to a predatory gastropod","volume":"286","author":"Cheung","year":"2005","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib9","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1897\/07-423.1","article-title":"Uses of subcellular metal distribution in prey to predict metal bioaccumulation","volume":"27","author":"Cheung","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.scitotenv.2003.09.035","article-title":"Assessment of two-compartment models as predictive tools for the bioaccumulation of trace metals in the amphipod Gammarus oceanicus Segestrale, 1947 from Grunnfjord (Northern Norway)","volume":"323","author":"Clason","year":"2004","journal-title":"Sci. Tot. Environ."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib11","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.chemosphere.2009.09.042","article-title":"Effects of metals on feeding rate and digestives enzymes in Gammarus fossarum: an in situ experiment","volume":"77","author":"Dedourge-Geffard","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2009.11.051_bib12","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1021\/es800378j","article-title":"The internal distribution of nickel and thallium in two freshwater invertebrates and its relevance to trophic transfer","volume":"42","author":"Dumas","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.aquatox.2007.12.002","article-title":"Physiological and behavioural responses of Gammarus pulex (Crustacean amphipoda) exposed to cadmium","volume":"86","author":"Felten","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib14","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.watres.2006.02.035","article-title":"The discriminatory power of two biomonitors of trace metal bioavailabilities in freshwater streams","volume":"40","author":"Fialkowski","year":"2006","journal-title":"Wat. Res."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/iroh.200390014","article-title":"Biomonitoring survey of trace metal pollution in streams of catchment draining a zinc and lead mining area of upper silesia, Poland using the amphipod Gammarus fossarum","volume":"88","author":"Fialkowski","year":"2003","journal-title":"Inter Rev. Hydrobiol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib16","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1002\/etc.5620190820","article-title":"Toward a mechanistic understanding of contaminant induced changes in detritus processing in streams: direct and indirect effects on detritivore feeding","volume":"19","author":"Forrow","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib17","first-page":"286","article-title":"Importance of metallothioneins in the cadmium detoxification process in Daphnia magna","volume":"144C","author":"Fraysse","year":"2006","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00016850","article-title":"The effect of brown trout (Salmo trutta L.) on stream invertebrate drift, with special reference to Gammarus pulex L","volume":"294","author":"Friberg","year":"1994","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.chemosphere.2009.11.051_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3354\/meps233131","article-title":"Relationships between metal bioaccumulation and metallothionein levels in larvae of Mytilus galloprovincialis exposed to contaminated estuarine sediment elutriate","volume":"233","author":"Geffard","year":"2002","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/13547500110091292","article-title":"Use of metallothionein in gills from oysters (Crassostrea gigas) as a biomarker: seasonal and intersite fluctuations","volume":"7","author":"Geffard","year":"2002","journal-title":"Biomarkers"},{"key":"10.1016\/j.chemosphere.2009.11.051_bib21","first-page":"631","article-title":"Influence of biotic and abiotic factors on metallothionein level in Gammarus pulex","volume":"145C","author":"Geffard","year":"2007","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00244-006-0046-y","article-title":"Bioaccumulation of metals in sediment elutriates and their effects on growth, condition index and metallothionein contents in oyster larvae","volume":"53","author":"Geffard","year":"2007","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1017\/S0025315404009683h","article-title":"Comparative study of metal handling strategies in bivalves Mytilus edulis and Crassostrea gigas: a multidisciplinary approach","volume":"84","author":"Geffard","year":"2004","journal-title":"J. Mar. Biol. Ass. UK"},{"key":"10.1016\/j.chemosphere.2009.11.051_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.aquatox.2005.12.001","article-title":"Sub-cellular partitioning of cadmium, copper, nickel and zinc in indigenous yellow perch (Perca flavescens) sampled along a polymetallic gradient","volume":"77","author":"Gigu\u00e8re","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib25","series-title":"Metal Metabolism in Aquatic Environments","first-page":"219","article-title":"Metal handling strategies in molluscs","author":"Langston","year":"1998"},{"key":"10.1016\/j.chemosphere.2009.11.051_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00244-009-9298-7","article-title":"Influence of the route of exposure on the accumulation and subcellular distribution of nickel and thallium in juvenile fathead minnows (Pimephales promelas)","volume":"57","author":"Lapointe","year":"2009","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1127\/archiv-hydrobiol\/149\/2000\/87","article-title":"Factors influencing the importance of Gammarus spp. (Crustacea: Amphipoda) in riverine salmonid diets","volume":"149","author":"MacNeil","year":"2000","journal-title":"Archiv. Hydrobiol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jemt.10040","article-title":"Cellular and subcellular distribution of metals in molluscs","volume":"56","author":"Marigomez","year":"2002","journal-title":"Micro. Res. Tech."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.aquatox.2006.05.008","article-title":"Linking changes in subcellular cadmium distribution to growth and mortality rates in transplanted freshwater bivalves","volume":"79","author":"Perceval","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.aquatox.2004.06.009","article-title":"Metal-induced stress in bivalves living along a gradient of Cd contamination: relating sub-cellular metal distribution to population-level responses","volume":"69","author":"Perceval","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib31","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ecoenv.2008.04.009","article-title":"Assessing the risk of metal mixtures in contaminated sediments on Chironomus riparius based on cytosolic accumulation","volume":"71","author":"P\u00e9ry","year":"2008","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0269-7491(02)00238-5","article-title":"Trace metal concentrations in aquatic invertebrates: why and so what?","volume":"120","author":"Rainbow","year":"2002","journal-title":"Environ. Poll."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3354\/meps308091","article-title":"Trophic transfer of trace metals: subcellular compartmentalization in a polychaete and assimilation by a decapods crustacean","volume":"308","author":"Rainbow","year":"2006","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.envpol.2006.10.031","article-title":"Subcellular distribution of Cd in the aquatic oligochaete Tubifex tubifex, implications for trophic availability and toxicity","volume":"148","author":"Redeker","year":"2007","journal-title":"Environ. Poll."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib35","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/0025-326X(94)90360-3","article-title":"Accumulation and subcellular distribution of metals (Cu,Fe,Mn,Pb and Zn) in the Mediterranean mussel Mytilus galloprovincialis during a field transplant experiment","volume":"28","author":"Regoli","year":"1994","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3354\/meps272215","article-title":"Importance of metal-binding proteins in the partitioning of Cd and Zn as trophically available metal (TAM) in the brine shrimp Artemia franciscana","volume":"272","author":"Seebaugh","year":"2004","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.marenvres.2004.07.003","article-title":"Bioenhancement of cadmium transfer along a multi-level chain","volume":"59","author":"Seebaugh","year":"2005","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquatox.2009.04.010","article-title":"Assimilation and subcellular partitioning of elements by grass shrimp collected along an impact gradient","volume":"93","author":"Seebaugh","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.marenvres.2003.08.001","article-title":"The relative importance of water and diet for uptake and subcellular distribution of cadmium in the deposit-feeding polychaete Capitella sp.I","volume":"57","author":"Selck","year":"2004","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jez.1402360204","article-title":"Calcium from extracellular concretions in the gills of freshwater unionid mussels is mobilized during reproduction","volume":"236","author":"Silverman","year":"1985","journal-title":"J. Exp. Zoo."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib41","first-page":"355","article-title":"Mechanisms of heavy metal cation homeostasis in marine invertebrates","volume":"104C","author":"Viarengo","year":"1993","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib42","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1021\/es040354g","article-title":"Internal metal sequestration and its ecotoxicological relevance. A review","volume":"38","author":"Vijver","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3354\/meps257125","article-title":"Subcellular compartmentalization of Cd and Zn in two bivalves. II. Significance of trophically available metal (TAM)","volume":"257","author":"Wallace","year":"2003","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3354\/meps249183","article-title":"Subcellular compartmentalization of Cd and Zn in two bivalves. I. Significance of metal-sensitive fractions (MSF) and biologically detoxified metal (BDM)","volume":"249","author":"Wallace","year":"2003","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib45","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1139\/f99-003","article-title":"Changes in subcellular metal partitioning in the gills freshwater bivalves (Pyganodon grandis) living along an environmental cadmium gradient","volume":"56","author":"Wang","year":"1999","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib46","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2427.1979.tb01508.x","article-title":"Life-history and production of the amphipod Gammarus pulex in a dorset chalk stream","volume":"9","author":"Welton","year":"1979","journal-title":"Freshwater Biol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00214147","article-title":"The importance of food and waters as sources of zinc during exposure of Gammarus pulex (Amphipoda)","volume":"26","author":"Xu","year":"1994","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2009.11.051_bib48","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tox.2007.04.010","article-title":"Cholinesterase activity in Gammarus pulex (Crustacea: Amphipoda): characterization and effects of chlorpyrifos","volume":"236","author":"Xuereb","year":"2007","journal-title":"Toxicology"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565350901409X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565350901409X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:07:28Z","timestamp":1758618448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004565350901409X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S004565350901409X"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2009.11.051","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subcellular compartmentalization of cadmium, nickel, and lead in Gammarus fossarum: Comparison of methods","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2009.11.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}