{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:13:17Z","timestamp":1769897597295,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.chemosphere.2013.05.064","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T14:47:08Z","timestamp":1371912428000},"page":"978-985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Simulation of a Hazardous and Noxious Substances (HNS) spill in the marine environment: Lethal and sublethal effects of acrylonitrile to the European seabass"],"prefix":"10.1016","volume":"93","author":[{"given":"T.","family":"Neuparth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Capela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rey-Salgueiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Reis-Henriques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2013.05.064_b0005","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.chemosphere.2011.10.059","article-title":"Challenges in assessing the toxic effects of polycyclic aromatic hydrocarbons to marine organisms: a case study on the acute toxicity of pyrene to the European seabass (Dicentrarchus labrax L.)","volume":"86","author":"Almeida","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2013.05.064_b0010","unstructured":"Analytical BioChemistry Laboratories, 1980. Early Life Stage Toxicity of Acrylonitrile to Fathead Minnow (Pimephales promelas) in a Flow-through System. Report Submitted to Monsanto Chemical Company, St. Louis, Missouri. 23 pp. (Early Life Stage Final Report #25673, December 16, 1980; Project #AB-80-542)."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/faat.1997.2295","article-title":"Dose dependence of covalent binding of acrylonitrile to tissue protein and globin in rat","volume":"36","author":"Benz","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0020","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ecoenv.2004.06.009","article-title":"In vitro and in vivo comparisons of fish-specific CYP1A induction relative potency factors for selected polycyclic aromatic hydrocarbons","volume":"59","author":"Billiard","year":"2004","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0166-445X(95)00014-U","article-title":"Octopus pallidus cytochrome P-450: characterisation and induction studies with \u03b2-naphthoflavone and Aroclor 1254","volume":"33","author":"Cheah","year":"1995","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0030","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.yrtph.2008.09.004","article-title":"Acrylonitrile and cancer: a review of the epidemiology","volume":"52","author":"Cole","year":"2008","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.envres.2010.09.011","article-title":"Assessment of the genotoxic potential of contaminated estuarine sediments in fish peripheral blood: laboratory versus in situ studies","volume":"111","author":"Costa","year":"2011","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0045","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10565-008-9072-z","article-title":"Comet assay: a reliable tool for the assessment of DNA damage in different models","volume":"25","author":"Dhawan","year":"2009","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0050","unstructured":"EPA \u2013 Environmental Protection Agency, 1994. Method 8316 Acrylamide, Acrylonitrile and Acrolein by High Performance Liquid Chromatography, Revision 0."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.toxlet.2007.05.001","article-title":"Toxicity and oxidative stress of acrylonitrile in rat primary glial cells: preventive effects of N-acetylcysteine","volume":"171","author":"Esmat","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0060","unstructured":"EU RAR \u2013 European Union Risk Assessment Report, 2004. Acrylonitrile, CAS No. 107-13-1, vol. 32. European Chemicals Bureau, European Commission Joint Research Centre."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.marenvres.2007.01.001","article-title":"The effect of long-term depuration on levels of oxidative stress biomarkers in mullets (Mugil cephalus) chronically exposed to contaminants","volume":"64","author":"Ferreira","year":"2007","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0070","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.chemosphere.2008.07.070","article-title":"Organochlorine bioaccumulation and biomarkers levels in culture and wild white seabream (Diplodus sargus)","volume":"73","author":"Ferreira","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2013.05.064_b0075","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ecoenv.2010.01.019","article-title":"Assessment of contaminants and biomarkers of exposure in wild and farmed seabass","volume":"73","author":"Ferreira","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0080","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0009-2614(96)00668-9","article-title":"A combined theoretical and experimental study of the electrochemically induced chemisorption of acrylonitrile on nickel, copper, and zinc","volume":"258","author":"Fredriksson","year":"1996","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1099-1263(199801\/02)18:1<25::AID-JAT466>3.0.CO;2-V","article-title":"Relative neurotoxicological properties of five unsaturated aliphatic nitriles in rats","volume":"18","author":"Gagnaire","year":"1998","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0090","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0892-0362(91)90056-3","article-title":"Assessment of the acute acrylonitrile-induced neurotoxicity in rats","volume":"13","author":"Ghanayem","year":"1991","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0040","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tox.2009.11.001","article-title":"Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats","volume":"267","author":"Guangwei","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2013.05.064_b0095","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases \u2013 first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0100","unstructured":"Hawkins, W.E., Walker, W.W., Overstreet, R.M., Lytle, J.S., Lytle, T.F., 1991. Development of Carcinogenesis Bioassay Models: Response of Small Fish Species to Various Classes of Carcinogens. US Gulf Coast Research Laboratory. Ocean Springs, Mississippi. Prepared for the U.S. Army Medical Research and Development Command. Contract No. DAMD17-88-C-8050."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0105","unstructured":"HASREP, 2005. Response to Harmful Substances Spilt at Sea. Report on Task 1: Monitoring of the Flow of Chemicals Transported by Sea in Bulk. Prepared by The Alliance of Maritime Regional Influences in Europe (AMRIE)."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0110","unstructured":"IARC \u2013 International Agency for Research on Cancer, 1999. Acrylonitrile. In: IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans, vol. 71(Part 1), pp. 43\u2013108."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0115","unstructured":"IMO \u2013 International Maritime Organization, 2010. Are HNS spills more dangerous than oil spills? A White Paper for the Interspill 2009 Conference and the Fourth IMO R&D Forum, May 2009, Marseille, France."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0120","unstructured":"ITOPF \u2013 The International Tanker Owners Pollution Federation Limited, 2010. About HNS. <http:\/\/www.itopf.com\/marine-spills\/about-hns\/>."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0125","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/toxsci\/46.2.333","article-title":"Induction of oxidative stress in rat brain by acrylonitrile (ACN)","volume":"46","author":"Jiang","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0130","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-4274(02)00073-5","article-title":"Comparative chronic toxicity and carcinogenicity of acrylonitrile by drinking water and oral intubation to Spartan Sprague\u2013Dawley rats","volume":"132","author":"Johanssen","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0135","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1021\/es60152a601","article-title":"Priority pollutants. I. A perspective view","volume":"13","author":"Keith","year":"1979","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0140","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.marpolbul.2010.03.015","article-title":"Accidental spills at sea \u2013 risk, impact, mitigation and the need for co-ordinated post-incident monitoring","volume":"60","author":"Kirby","year":"2010","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.yrtph.2005.06.007","article-title":"Cancer dose\u2013response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity","volume":"43","author":"Kirman","year":"2005","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0150","unstructured":"Mamaca, E., Girin, M., Le Floch, S., Zir, R., 2009. Review of chemical spills at sea and lessons learnt. A Technical Appendix to the INTERSPILL 2009 Conference White Paper \u201cAre HNS Spills More Dangerous than Oil Spills?\u201d CEDRE."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0155","unstructured":"NTP \u2013 National Toxicology Program (US) Technical Report 506, 2001. Toxicology and Carcinogenesis Studies of Acrylonitrile (CAS No. 107-13-1) in B6C3F1 Mice (Gavage Studies)."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0160","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1021\/tx010002c","article-title":"Covalent binding of acrylonitrile to specific rat liver glutathione S-transferases in vivo","volume":"14","author":"Nerland","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.marpolbul.2010.09.016","article-title":"Hazardous and noxious substances (HNS) in the marine environment: prioritizing HNS that pose major risk in a European context","volume":"62","author":"Neuparth","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0170","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.marpolbul.2012.03.016","article-title":"Review of oil and HNS accidental spills in Europe: identifying major environmental monitoring gaps and drawing priorities","volume":"64","author":"Neuparth","year":"2012","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0175","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/toxsci\/kfp133","article-title":"Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague\u2013Dawley rats","volume":"111","author":"Pu","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2298\/ABS1001097R","article-title":"Superoxide dismutase and catalase activities in the liver and muscle of barbel (Barbus barbus) and its intestinal parasite (Pomphoryinchus laevis) from the Danube river, Serbia","volume":"62","author":"Radovanovi\u0107","year":"2010","journal-title":"Arch. Biol. Sci."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0185","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.chemosphere.2010.07.065","article-title":"Validating a multi-biomarker approach with the shanny Lipophrys pholis to monitor oil spills in European marine ecosystems","volume":"81","author":"Santos","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2013.05.064_b0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0195","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/tx990040k","article-title":"Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice","volume":"12","author":"Sumner","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0200","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1023\/A:1005906214267","article-title":"Study on fish and amphibian embryo-larva toxicity test","volume":"55","author":"Tong","year":"1999","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0205","doi-asserted-by":"crossref","first-page":"35523","DOI":"10.1074\/jbc.M111548200","article-title":"Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe","volume":"277","author":"Veal","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0210","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/jat.1535","article-title":"Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell","volume":"30","author":"Watcharasit","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0215","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s002040050523","article-title":"Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile","volume":"72","author":"Whysner","year":"1998","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0220","unstructured":"World Health Organization, 2002. Concise International Chemical Assessment Document 39: Acrylonitrile. Geneva, 2002."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0225","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0166-445X(91)90033-6","article-title":"Prooxidant and antioxidant mechanisms in aquatic organisms","volume":"19","author":"Winston","year":"1991","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1383-5718(03)00055-X","article-title":"Exposure to acrylonitrile induced DNA strand breakage and sex chromosome aneuploidy in human spermatozoa","volume":"537","author":"Xu","year":"2003","journal-title":"Mut. Res."},{"key":"10.1016\/j.chemosphere.2013.05.064_b0235","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/toxsci\/67.2.247","article-title":"Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile","volume":"67","author":"Zhang","year":"2002","journal-title":"Toxicol. Sci."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653513008102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653513008102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T02:30:30Z","timestamp":1645842630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653513008102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0045653513008102"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2013.05.064","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simulation of a Hazardous and Noxious Substances (HNS) spill in the marine environment: Lethal and sublethal effects of acrylonitrile to the European seabass","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2013.05.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}