{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:59:43Z","timestamp":1768071583031,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.chemosphere.2013.12.068","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T11:15:21Z","timestamp":1390475721000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["The neurological effects of prenatal and postnatal mercury\/methylmercury exposure on three-year-old children in Taiwan"],"prefix":"10.1016","volume":"100","author":[{"given":"Hsing-Cheng","family":"Hsi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuen-Bin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Hsuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Chu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2013.12.068_b0005","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1016\/j.scitotenv.2011.04.047","article-title":"Mercury (Hg) burden in children: the impact of dental amalgam","volume":"409","author":"Al-Saleh","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.reprotox.2007.03.003","article-title":"Concentrations of xenobiotic chemicals in the maternal\u2013fetal unit","volume":"23","author":"Barr","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ijheh.2007.09.015","article-title":"Mercury in breast milk \u2013 a health hazard for infants in gold mining areas?","volume":"211","author":"Bose-O\u2019Reilly","year":"2008","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.chemosphere.2005.11.059","article-title":"Analysis of the health risk of exposure to breast milk mercury in infants in Taiwan","volume":"64","author":"Chien","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0025","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00005072-197811000-00001","article-title":"Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero","volume":"37","author":"Choi","year":"1978","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1289\/ehp.877559","article-title":"Metal toxicity in the central nervous system","volume":"75","author":"Clarkson","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0035","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0040","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1542\/peds.2011-0523","article-title":"Chemical-management policy: prioritizing children\u2019s health","volume":"127","author":"COEH","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0045","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1023\/B:RIAN.0000005917.52151.e6","article-title":"Influence of prenatal mercury exposure upon scholastic and psychological test performance: benchmark analysis of a New Zealand cohort","volume":"18","author":"Crump","year":"1998","journal-title":"Risk Anal."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0050","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/archpediatrics.2012.199","article-title":"Nutrient supplementation and neurodevelopment: timing is the key","volume":"166","author":"Cusick","year":"2012","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0055","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2003.06.008","article-title":"The nail and hair in forensic science","volume":"50","author":"Daniel","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0060","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/jama.280.8.701","article-title":"Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study","volume":"280","author":"Davidson","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.envint.2006.08.002","article-title":"Fetal methylmercury exposure as measured by cord blood mercury concentrations in a mother-infant cohort in Hong Kong","volume":"33","author":"Fok","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0070","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.envres.2009.10.005","article-title":"Hair mercury levels, fish consumption, and cognitive development in preschool children from Granada","volume":"110","author":"Freire","year":"2010","journal-title":"Spain. Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0075","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.envres.2007.05.015","article-title":"Prenatal exposure to mercury and neurobehavioral development of neonates in Zhoushan City","volume":"105","author":"Gao","year":"2007","journal-title":"China. Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0080","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.reprotox.2007.03.002","article-title":"Methylmercury toxicity and functional programming","volume":"23","author":"Grandjean","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0085","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/oxfordjournals.aje.a010002","article-title":"Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years","volume":"150","author":"Grandjean","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0090","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(07)60277-3","article-title":"Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study","volume":"369","author":"Hibbeln","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0095","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.envint.2007.06.001","article-title":"Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life: Krakow epidemiologic study","volume":"33","author":"Jedrychowski","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.scitotenv.2008.04.010","article-title":"Hair mercury concentrations of children and mothers in Korea: implication for exposure and evaluation","volume":"402","author":"Kim","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0105","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1289\/ehp.1104431","article-title":"Early-life cadmium exposure and child development in 5-year-old girls and boys: a cohort study in rural bangladesh","volume":"120","author":"Kippler","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0110","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archpsyc.65.5.578","article-title":"Breastfeeding and child cognitive development: new evidence from a large randomized trial","volume":"65","author":"Kramer","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0115","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/adc.2003.048819","article-title":"Biomarkers in paediatric research and practice","volume":"90","author":"Lanphear","year":"2005","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijheh.2006.08.001","article-title":"Maternal mercury exposure and neuro-motor development in breastfed infants from Porto Velho (Amazon)","volume":"210","author":"Marques","year":"2007","journal-title":"Brazil. Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0125","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1289\/ehp.7046","article-title":"Hair mercury levels in U.S. children and women of childbearing age: reference range data from NHANES 1999\u20132000","volume":"112","author":"McDowell","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/enrs.2000.4085","article-title":"Secondary analysis from the Seychelles child development study: the child behavior checklist","volume":"84","author":"Myers","year":"2000","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0135","series-title":"Toxicological Effects of Methylmercury","author":"NRC","year":"2000"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0140","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1289\/ehp.8041","article-title":"Maternal fish consumption, hair mercury, and infant cognition in a U.S","volume":"113","author":"Oken","year":"2005","journal-title":"Cohort. Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0145","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/aje\/kwn034","article-title":"Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort","volume":"167","author":"Oken","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuro.2009.10.008","article-title":"The relation of environmental contaminants exposure to behavioral indicators in Inuit preschoolers in Arctic Quebec","volume":"31","author":"Plusquellec","year":"2010","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpeds.2011.06.035","article-title":"Breastfeeding is associated with improved child cognitive development: a population-based cohort study","volume":"160","author":"Quigley","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0160","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1542\/peds.113.S3.1076","article-title":"Environmental causes of central nervous system maldevelopment","volume":"113","author":"Rodier","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0048-9697(00)00531-3","article-title":"Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part II. A study of the inhabitants of northern Sweden","volume":"262","author":"Rodushkin","year":"2000","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0170","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ntt.2005.12.009","article-title":"Motor function following developmental exposure to PCBS and\/or MEHG","volume":"28","author":"Roegge","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0175","series-title":"Chapter 23: Placental Transfer and Pharmacokinetics of Developmental Neurotoxicant","author":"Slikker","year":"1994"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0180","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuro.2008.06.002","article-title":"Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles child development nutrition study","volume":"29","author":"Strain","year":"2008","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0185","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.envres.2009.04.006","article-title":"Neuropsychological function in school-age children with low mercury exposures","volume":"109","author":"Surkan","year":"2009","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0190","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.envres.2010.07.001","article-title":"Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development","volume":"110","author":"Suzuki","year":"2010","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0195","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1289\/ehp.10471","article-title":"Effects of prenatal exposure to coal-burning pollutants on children\u2019s development in China","volume":"116","author":"Tang","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0200","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1037\/0003-066X.56.1.5","article-title":"Developmental science and the media. Early brain development","volume":"56","author":"Thompson","year":"2001","journal-title":"Am. Psychol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0205","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.envint.2010.05.017","article-title":"Mercury hair concentrations and dietary exposure among Inuit preschool children in Nunavut","volume":"37","author":"Tian","year":"2011","journal-title":"Canada. Environ. Int."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0210","unstructured":"U.S. EPA, 1997. Mercury study report to congress, vol. I: executive summary. U.S. Environmental Protection Agency, Washington, D.C."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0215","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0041-008X(85)90392-8","article-title":"The effects of methyl mercury binding to microtubules","volume":"80","author":"Vogel","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0220","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(07)60076-2","article-title":"Child development: risk factors for adverse outcomes in developing countries","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0225","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(11)60555-2","article-title":"Inequality in early childhood: risk and protective factors for early child development","volume":"378","author":"Walker","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0230","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jhazmat.2012.12.060","article-title":"In vitro estimation of exposure of Hong Kong residents to mercury and methylmercury via consumption of market fishes","volume":"248\u2013249","author":"Wang","year":"2013","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0235","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1289\/ehp.6964","article-title":"Water arsenic exposure and children\u2019s intellectual function in Araihazar, Bangladesh","volume":"112","author":"Wasserman","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0240","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10995-007-0230-3","article-title":"The effects of prenatal use of folic acid and other dietary supplements on early child development","volume":"12","author":"Wehby","year":"2008","journal-title":"Matern. Child Health J."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0245","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-3016.2010.01161.x","article-title":"Duration of breast feeding and language ability in middle childhood","volume":"25","author":"Whitehouse","year":"2011","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.chemosphere.2013.12.068_b0250","series-title":"Environmental Health Criteria 101: Methylmercury","author":"WHO","year":"1990"},{"key":"10.1016\/j.chemosphere.2013.12.068_b0255","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3200\/AEOH.59.8.400-409","article-title":"Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community","volume":"59","author":"Wickre","year":"2004","journal-title":"Arch. Environ. Health"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653514000058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653514000058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T09:36:27Z","timestamp":1648114587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653514000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":51,"alternative-id":["S0045653514000058"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2013.12.068","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The neurological effects of prenatal and postnatal mercury\/methylmercury exposure on three-year-old children in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2013.12.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}