{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:22:46Z","timestamp":1789690966453,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National High Technology Research and Development Program of China","award":["2007AA092001-10"],"award-info":[{"award-number":["2007AA092001-10"]}]},{"name":"Shanghai Science and Technology Development Funds","award":["11dz1204706"],"award-info":[{"award-number":["11dz1204706"]}]},{"name":"the National Science & Technology Pillar Program of China","award":["2013BAK12B00"],"award-info":[{"award-number":["2013BAK12B00"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Scientific Foundation of China","doi-asserted-by":"crossref","award":["41206076"],"award-info":[{"award-number":["41206076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Scientific Foundation of Shandong Province","award":["ZR2011BQ011"],"award-info":[{"award-number":["ZR2011BQ011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.chemosphere.2014.05.006","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T13:16:39Z","timestamp":1401282999000},"page":"560-567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Detection, occurrence and monthly variations of typical lipophilic marine toxins associated with diarrhetic shellfish poisoning in the coastal seawater of Qingdao City, China"],"prefix":"10.1016","volume":"111","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2014.05.006_b0005","first-page":"1","article-title":"Marine biotoxins in shellfish \u2013 okadaic acid and analogues","volume":"589","author":"Alexander","year":"2008","journal-title":"EFSA J."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0010","first-page":"1","article-title":"Marine biotoxins in shellfish\u2014yessotoxin group","volume":"907","author":"Alexander","year":"2008","journal-title":"EFSA J."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0015","first-page":"1","article-title":"Marine biotoxins in shellfish \u2013 pectenotoxin group","volume":"1109","author":"Alexander","year":"2009","journal-title":"EFSA J."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0020","unstructured":"Alves-de-Souza, C., Varela, D., Contreras, C., La Iglesia, P.D., Fern\u00e1ndez, P., Hipp, B., Hern\u00e1ndez, C., Riob\u00f3, P., Reguera, B., Franco, J.M., Diog\u00e8ne, J., Garc\u00eda, C., Lagos, N., 2013. Seasonal variability of Dinophysis spp. and Protoceratium reticulatum associated to lipophilic shellfish toxins in a strongly stratified Chilean fjord. Deep-Sea Res. II <http:\/\/dx.doi.org\/10.1016\/j.dsr2.2013.01.014i>."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0041-0101(01)00192-1","article-title":"Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice","volume":"40","author":"Aune","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chemosphere.2012.03.030","article-title":"Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography\u2013tandem mass spectrometry (HPLC\u2013MS\/MS)","volume":"88","author":"Berset","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0035","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.chemosphere.2010.08.011","article-title":"Analysis of llicit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography\u2013electrospray tandem mass spectrometry (HPLC\u2013MS\/MS)","volume":"81","author":"Berset","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chemosphere.2013.10.007","article-title":"Investigation of cannabis biomarkers and transformation products in waters by liquid chromatography coupled to time of flight and triple quadrupole mass spectrometry","volume":"99","author":"Boix","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0045","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1021\/es2011385","article-title":"Tailored microarray platform for the detection of marine toxins","volume":"45","author":"Bovee","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0050","unstructured":"Commission Decision (2002\/657\/EC) of 12 August 2002 Implementing Council Directive 96\/23\/EC concerning the performance of analytical methods and the interpretation of results. Official Journal of the European Communities L221, Brussels, Belgium, pp. 8\u201336."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/enrs.2000.4103","article-title":"Ecological analysis of digestive cancer mortality related to contamination by diarrhetic shellfish poisoning toxins along the coasts of France","volume":"84","author":"Cordier","year":"2000","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0060","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.1111\/j.1742-4658.2008.06714.x","article-title":"Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin","volume":"275","author":"Espi\u00f1a","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0065","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.chemosphere.2009.07.027","article-title":"Expression of the genes siamois, engrailed-2, bmp4 and myf5 during Xenopus development in presence of the marine toxins okadaic acid and palytoxin","volume":"77","author":"Franchini","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0065-230X(08)60958-6","article-title":"Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds","volume":"61","author":"Fujiki","year":"1993","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0075","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.hal.2008.10.007","article-title":"Comparative accumulation and composition of lipophilic marine biotoxins in passive samplers and in mussels (M. edulis) on the West Coast of Ireland","volume":"8","author":"Fux","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0080","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00216-009-2790-0","article-title":"Solid phase extraction for removal of matrix effects in lipophilic marine toxin analysis by liquid chromatography\u2013tandem mass spectrometry","volume":"394","author":"Gerssen","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0085","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.chroma.2008.12.099","article-title":"Liquid chromatography\u2013tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions","volume":"1216","author":"Gerssen","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0090","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/toxins2040878","article-title":"Marine toxins: chemistry, toxicity, occurrence and detection, with special reference to the Dutch situation","volume":"2","author":"Gerssen","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0095","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.aca.2010.11.036","article-title":"Screening of lipophilic marine toxins in shellfish and algae: Development of a library using liquid chromatography coupled to orbitrap mass spectrometry","volume":"685","author":"Gerssen","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0100","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1016\/j.chroma.2010.08.070","volume":"1217","author":"G\u00f3mez","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.chroma.2013.04.028","article-title":"Multi-residue analytical method for the determination of endocrine disruptors and related compounds in river and waste water using dual column liquid chromatography switching system coupled to mass spectrometry","volume":"1295","author":"Gorga","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0110","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00216-009-3444-y","article-title":"Requirements for screening and confirmatory methods for the detection and quantification of marine biotoxins in end-product and official control","volume":"397","author":"Hess","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.hal.2011.10.008","article-title":"Brevetoxin persistence in sediments and seagrass epiphytes of east Florida coastal waters","volume":"13","author":"Hitchcock","year":"2012","journal-title":"Harmful algae"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0120","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4319\/lom.2010.8.0645","article-title":"Application of solid phase adsorption toxin tracking (SPATT) for field detection of the hydrophilic phycotoxins domoic acid and saxitoxin in coastal California","volume":"8","author":"Lane","year":"2010","journal-title":"Limnol. Oceanogr.-Meth."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0125","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00003877","article-title":"Determination of diarrhetic shellfish toxins in various dinoflagellate species","volume":"1","author":"Lee","year":"1989","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0130","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3390\/md8041263","article-title":"Investigation of pectenotoxin profiles in the Yellow sea (China) using a passive sampling technique","volume":"8","author":"Li","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0135","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.chemosphere.2011.07.071","article-title":"Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra high performance liquid chromatography (UHPLC)\u2013tandem mass spectrometry (MS\/MS)","volume":"85","author":"L\u00f3pez-Serna","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0140","series-title":"Population Dynamics and Toxin Production of Dinophysis species in the coastal waters of Qingdao","author":"Luo","year":"2011"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.copbio.2010.01.013","article-title":"In situ passive solid-phase adsorption of micro-algal biotoxins as a monitoring tool","volume":"21","author":"MacKenzie","year":"2010","journal-title":"Curr. Opin. Biotech."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0150","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.toxicon.2004.08.020","article-title":"Solid phase adsorption toxin tracking (SPATT): a new monitoring tool that simulates the biotoxin contamination of filter feeding bivalves","volume":"44","author":"MacKenzie","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mehy.2007.03.041","article-title":"Shellfish consumption: a major risk factor for colorectal cancer","volume":"70","author":"Manerio","year":"2008","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0160","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.chemosphere.2008.07.089","article-title":"Determination of brevetoxin in recent marine sediments","volume":"73","author":"Mendoza","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2003.10.003","article-title":"Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities","volume":"43","author":"Miles","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0170","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1016\/S0040-4039(01)81076-5","article-title":"Isolation and structure of yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning","volume":"28","author":"Murata","year":"1987","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0175","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1021\/es300189h","article-title":"Toxin-producing Ostreopsis cf. ovata are likely to bloom undetected along coastal areas","volume":"46","author":"Pfannkuchen","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3354\/meps07179","article-title":"Growth, behaviour and cell toxin quota of Dinophysis acuta during a daily cycle","volume":"353","author":"Pizarro","year":"2008","journal-title":"Mar. Ecol. Progr. Ser."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0185","series-title":"Manual on Harmful Marine Microalgae","first-page":"95","article-title":"Methods for diarrhetic shellfish poisons","author":"Quiliam","year":"1995"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0190","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1016\/j.chroma.2008.09.041","article-title":"Multi-residue analytical method for the determination of emerging pollutants in water by solid-phase extraction and liquid chromatography\u2013tandem mass spectrometry","volume":"1216","author":"Rodil","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0195","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.toxicon.2009.01.010","article-title":"A convenient and cost-effective method for monitoring marine algal toxins with passive samplers","volume":"53","author":"Rundberget","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0200","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1073\/pnas.85.6.1768","article-title":"Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter","volume":"85","author":"Suganuma","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0205","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.marenvres.2007.03.005","article-title":"Occurrence and seasonal variations of algal toxins in water, phytoplankton and shellfish from North Stradbroke Island, Queensland","volume":"64","author":"Takahashi","year":"2007","journal-title":"Australia. Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0210","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1016\/j.chroma.2009.03.062","article-title":"Sensitive method for the determination of lipophilic marine biotoxins in extracts of mussels and processed shellfish by high-performance liquid chromatography-tandem mass spectrometry based on enrichment by solid-phase extraction","volume":"1216","author":"These","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0215","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00216-010-4383-3","volume":"399","author":"These","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0220","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0041-0101(02)00095-8","article-title":"First confirmation of human diarrhoeic poisonings by okadaic acid esters after ingestion of razor clams (Solen marginatus) and green crabs (Carcinus maenas) in Aveiro lagoon, Portugal and detection of okadaic acid esters in phytoplankton","volume":"40","author":"Vale","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0225","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.chemosphere.2012.09.012","article-title":"Detection of yessotoxin by three different methods in Mytilus alloprovincialis of Adriatic Sea, Italy","volume":"90","author":"Visciano","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0230","doi-asserted-by":"crossref","first-page":"6616","DOI":"10.1016\/j.chroma.2010.03.054","article-title":"A validated analytical method for the determination of perfluorinated compounds in surface-, sea- and sewagewater using liquid chromatography coupled to time-of-flight mass spectrometry","volume":"1217","author":"Wille","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0235","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1134\/S1063074013020090","article-title":"The seasonal dynamics of potentially toxic and harmful phytoplankton species in Novorossiysk Bay (Black Sea)","volume":"39","author":"Yasakova","year":"2013","journal-title":"Russ. J. Mar. Biol."},{"key":"10.1016\/j.chemosphere.2014.05.006_b0240","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2331\/suisan.44.1249","article-title":"Occurrence of a new type of shellfish poisoning in the Tohoku district","volume":"44","author":"Yasumoto","year":"1978","journal-title":"Bull. Jpn. Soc. Sci. Fish"},{"key":"10.1016\/j.chemosphere.2014.05.006_b0245","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0040-4020(01)96469-5","article-title":"Diarrhetic shellfish toxins","volume":"41","author":"Yasumoto","year":"1985","journal-title":"Tetrahedron"},{"issue":"2520\u20132525","key":"10.1016\/j.chemosphere.2014.05.006_b0250","first-page":"563","article-title":"Detection, occurrence and fate of 22 psychiatric pharmaceuticals in psychiatric hospital and municipal wastewater treatment plants in Beijing, China","volume":"90","author":"Yuan","year":"2012","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653514006080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653514006080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T16:27:18Z","timestamp":1538584038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653514006080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":50,"alternative-id":["S0045653514006080"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2014.05.006","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection, occurrence and monthly variations of typical lipophilic marine toxins associated with diarrhetic shellfish poisoning in the coastal seawater of Qingdao City, China","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2014.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}