{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:26:26Z","timestamp":1790540786726,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.chemosphere.2014.07.085","type":"journal-article","created":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T15:45:16Z","timestamp":1408808716000},"page":"316-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Degradation pathways of lamotrigine under advanced treatment by direct UV photolysis, hydroxyl radicals, and ozone"],"prefix":"10.1016","volume":"117","author":[{"given":"Olya S.","family":"Keen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imma","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Michael Thurman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl G.","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.chemosphere.2014.07.085_b0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/es990724e","article-title":"Degradation kinetics of atrazine and its degradation products with ozone and OH radicals: a predictive tool for drinking water treatment","volume":"34","author":"Acero","year":"2000","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.chemosphere.2014.07.085_b0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/09593332208618273","article-title":"Partial oxidation by ozone to remove recalcitrance from wastewaters \u2013 a review","volume":"22","author":"Alvares","year":"2001","journal-title":"Environ. Technol."},{"issue":"4","key":"10.1016\/j.chemosphere.2014.07.085_b0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/(SICI)1097-4660(199804)71:4<345::AID-JCTB869>3.0.CO;2-C","article-title":"Aqueous degradation of atrazine and some of its main by-products with ozone\/hydrogen peroxide","volume":"71","author":"Beltr\u00e1n","year":"1998","journal-title":"J. Chem. Technol. Biotechnol."},{"issue":"3","key":"10.1016\/j.chemosphere.2014.07.085_b0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhazmat.2005.03.012","article-title":"Occurrence and fate of pharmaceutically active compounds in the environment, a case study: H\u00f6je River in Sweden","volume":"122","author":"Bendz","year":"2005","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1061\/(ASCE)0733-9372(2003)129:3(209)","article-title":"Standardization of methods for fluence (UV dose) determination in bench-scale UV experiments","author":"Bolton","year":"2003","journal-title":"ASCE J. Environ. Eng."},{"issue":"12","key":"10.1016\/j.chemosphere.2014.07.085_b0030","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/ps.405","article-title":"Phototransformation of metoxuron 3-(3-chloro-4-methoxyphenyl)-1,1-dimethylurea in aqueous solution","volume":"57","author":"Boulkamh","year":"2001","journal-title":"Pest Manage. Sci."},{"issue":"18","key":"10.1016\/j.chemosphere.2014.07.085_b0035","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1016\/j.watres.2009.07.031","article-title":"Ozone oxidation of pharmaceuticals, endocrine disruptors and pesticides during drinking water treatment","volume":"43","author":"Bros\u00e9us","year":"2009","journal-title":"Water Res."},{"issue":"8","key":"10.1016\/j.chemosphere.2014.07.085_b0040","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0045-6535(82)90099-6","article-title":"Photo-dechlorination of PCBs \u2013 current status","volume":"11","author":"Bunce","year":"1982","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2014.07.085_b0045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1063\/1.555805","article-title":"Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (OH\/O\u2212) in aqueous solution","volume":"17","author":"Buxton","year":"1988","journal-title":"J. Phys. Chem. Ref. Data"},{"issue":"1\u20133","key":"10.1016\/j.chemosphere.2014.07.085_b0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jhazmat.2005.10.039","article-title":"Photo-degradation of chlorophenols in the aqueous solution","volume":"134","author":"Czaplicka","year":"2006","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.chemosphere.2014.07.085_b0055","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1061\/(ASCE)EE.1943-7870.0000377","article-title":"Ozonation of propranolol: transformation, biodegradability, and toxicity assessment","volume":"137","author":"Dantas","year":"2011","journal-title":"J. Environ. Eng."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0060","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","article-title":"Pharmaceuticals and personal care products in the environment: agents of subtle change","volume":"107","author":"Daughton","year":"1999","journal-title":"Environ. Health Perspectives Suppl."},{"issue":"6","key":"10.1016\/j.chemosphere.2014.07.085_b0065","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1021\/es051369x","article-title":"Oxidation of antibacterial molecules by aqueous ozone: moiety-specific reaction kinetics and application to ozone-based wastewater treatment","volume":"40","author":"Dodd","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.chemosphere.2014.07.085_b0070","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1021\/es8025424","article-title":"Oxidation of antibacterial compounds by ozone and hydroxyl radical: elimination of biological activity during aqueous ozonation processes","volume":"43","author":"Dodd","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.chemosphere.2014.07.085_b0075","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1021\/ac1014645","article-title":"Identification of a new antidepressant and its glucuronide metabolite in water samples using liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"82","author":"Ferrer","year":"2010","journal-title":"Anal. Chem."},{"issue":"12","key":"10.1016\/j.chemosphere.2014.07.085_b0080","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1002\/etc.345","article-title":"Chronic exposure to fluoxetine (Prozac) causes developmental delays in Rana pipiens larvae","volume":"29","author":"Foster","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.chemosphere.2014.07.085_b0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0045-6535(97)00354-8","article-title":"Occurrence, fate and effects of pharmaceutical substances in the environment \u2013 a review","volume":"36","author":"Halling-S\u00f8rensen","year":"1998","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.chemosphere.2014.07.085_b0090","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0043-1354(83)90099-4","article-title":"Rate constants of reactions of ozone with organic and inorganic compounds in water \u2013 II: dissociating organic compounds","volume":"17","author":"Hoign\u00e9","year":"1983","journal-title":"Water Res."},{"issue":"5","key":"10.1016\/j.chemosphere.2014.07.085_b0095","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1021\/es025896h","article-title":"Oxidation of pharmaceuticals during ozonation and advanced oxidation processes","volume":"37","author":"Huber","year":"2003","journal-title":"Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.chemosphere.2014.07.085_b0100","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1016\/j.watres.2012.09.026","article-title":"Reaction kinetics of selected micropollutants in ozonation and advanced oxidation processes","volume":"46","author":"Jin","year":"2012","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.chemosphere.2014.07.085_b0105","doi-asserted-by":"crossref","first-page":"6222","DOI":"10.1021\/es300897u","article-title":"Enhanced biodegradation of carbamazepine after UV\/H2O2 advanced oxidation","volume":"46","author":"Keen","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0110","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1021\/ac00090a020","article-title":"H2O2 determination by the I3\u2212 method and by KMnO4 titration","volume":"66","author":"Klassen","year":"1994","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.chemosphere.2014.07.085_b0115","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","article-title":"Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. Streams, 1999\u20132000: a national reconnaissance","volume":"36","author":"Kolpin","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0120","unstructured":"Levy, R.H., 2002. Antiepileptic Drugs, Lippincott Williams & Wilkins."},{"issue":"12","key":"10.1016\/j.chemosphere.2014.07.085_b0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2166\/wst.2007.423","article-title":"UV\/H2O2 degradation of endocrine-disrupting chemicals in water evaluated via toxicity assays","volume":"55","author":"Linden","year":"2007","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0130","unstructured":"Lyman, W.J., 1985. In: Neely, W.B., Blau, G.E. (Eds.), CRC Press, Boca Raton, FL, p. 31."},{"issue":"19","key":"10.1016\/j.chemosphere.2014.07.085_b0135","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/es050261e","article-title":"Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant","volume":"39","author":"Miao","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0140","unstructured":"Mosby\u2019s GenRx, 2001. Lamotrigine, pp. III-1415."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0145","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1111\/j.1528-1157.1993.tb05922.x","article-title":"Advances in the pharmacotherapy of epilepsy","volume":"34","author":"Ramsay","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.chemosphere.2014.07.085_b0150","doi-asserted-by":"crossref","unstructured":"Schwarzenbach, R.P., Gschwend, P.M., Imboden, D.M., 2005. Environmental Organic Chemistry. John Wiley & Sons Inc., pp. 611\u2013654.","DOI":"10.1002\/0471649643.ch15"},{"issue":"4","key":"10.1016\/j.chemosphere.2014.07.085_b0155","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00027-003-0674-5","article-title":"Nitrate photosensitized degradation of atrazine during UV water treatment","volume":"65","author":"Sharpless","year":"2003","journal-title":"Aquat. Sci."},{"issue":"14","key":"10.1016\/j.chemosphere.2014.07.085_b0160","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1021\/es0602602","article-title":"Relative rate constants of contaminant candidate list pesticides with hydroxyl radicals","volume":"40","author":"Shemer","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"1\u20133","key":"10.1016\/j.chemosphere.2014.07.085_b0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.scitotenv.2004.03.015","article-title":"Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-watertreatment plant","volume":"329","author":"Stackelberg","year":"2004","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.chemosphere.2014.07.085_b0170","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0045-6535(93)90359-D","article-title":"A quantitative structure-activity relationship for the direct photohydrolysis of meta-substituted halobenzene derivatives in water","volume":"26","author":"Stegeman","year":"1993","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.chemosphere.2014.07.085_b0175","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/S0043-1354(02)00570-5","article-title":"Ozonation: a tool for removal of pharmaceuticals, contrast media and musk fragrances from wastewater?","volume":"37","author":"Ternes","year":"2003","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.chemosphere.2014.07.085_b0180","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0043-1354(02)00457-8","article-title":"Ozonation of drinking water: Part I. Oxidation kinetics and product formation","volume":"37","author":"von Gunten","year":"2003","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.chemosphere.2014.07.085_b0185","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1021\/jf00047a046","article-title":"Comparative study on the quantum yields of direct photolysis of organophosphorus pesticides in aqueous solution","volume":"42","author":"Wan","year":"1994","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.chemosphere.2014.07.085_b0190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0920-1211(92)90049-Y","article-title":"Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11-epoxide","volume":"11","author":"Warner","year":"1992","journal-title":"Epilepsy Res."},{"issue":"9","key":"10.1016\/j.chemosphere.2014.07.085_b0195","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.watres.2012.03.036","article-title":"Review of photochemical reaction constants of organic micropollutants required for UV advanced oxidation processes in water","volume":"46","author":"Wols","year":"2012","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.chemosphere.2014.07.085_b0200","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0043-1354(01)00352-9","article-title":"Oxidation kinetics of phenolic and indolic compounds by ozone: applications to synthetic and real swine manure slurry","volume":"36","author":"Wu","year":"2002","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2014.07.085_b0205","doi-asserted-by":"crossref","unstructured":"Young, R.B., Chefetz, B., Liu, A., Desyaterik, Y., Borch, T., 2014. Direct photodegradation of lamotrigine (an antiepileptic) in simulated sunlight \u2013 pH influenced rates and products. Environ. Sci.: Processes Impacts.","DOI":"10.1039\/C3EM00581J"},{"issue":"6","key":"10.1016\/j.chemosphere.2014.07.085_b0210","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0043-1354(99)00338-3","article-title":"Oxidative treatment of pharmaceuticals in water","volume":"34","author":"Zwiener","year":"2000","journal-title":"Water Res."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653514009485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653514009485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T03:22:46Z","timestamp":1565752966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653514009485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":42,"alternative-id":["S0045653514009485"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2014.07.085","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degradation pathways of lamotrigine under advanced treatment by direct UV photolysis, hydroxyl radicals, and ozone","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2014.07.085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}