{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:02:29Z","timestamp":1784606549012,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201963, 31302158, 31101869 and 31201965"],"award-info":[{"award-number":["31201963, 31302158, 31101869 and 31201965"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["2012-079"],"award-info":[{"award-number":["2012-079"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Shanxi Province Science and Technology Bureau Program","award":["2011021030-1"],"award-info":[{"award-number":["2011021030-1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.chemosphere.2014.12.090","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T06:00:30Z","timestamp":1422856830000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Effects of fluoride on the ultrastructure and expression of Type I collagen in rat hard tissue"],"prefix":"10.1016","volume":"128","author":[{"given":"Xiaoyan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jundong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.chemosphere.2014.12.090_b0005","first-page":"227","article-title":"Bone fluoride in proximal femur fractures","volume":"34","author":"Bohatyrewicz","year":"2001","journal-title":"Fluoride"},{"issue":"8","key":"10.1016\/j.chemosphere.2014.12.090_b0010","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.chemosphere.2013.01.037","article-title":"Effects of fluoride on liver apoptosis and Bcl-2, Bax protein expression in freshwater teleost, Cyprinus carpio","volume":"91","author":"Cao","year":"2013","journal-title":"Chemosphere"},{"issue":"10","key":"10.1016\/j.chemosphere.2014.12.090_b0015","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrd916","article-title":"Discoveries, drugs and skeletal disorders","volume":"1","author":"Goltzman","year":"2002","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0020","first-page":"149","article-title":"Effects of excessive fluoride ingestion on collagen protein and expression of type I collagen gene in skeletal muscles of rats","volume":"46","author":"Gupta","year":"2013","journal-title":"Fluoride"},{"issue":"1","key":"10.1016\/j.chemosphere.2014.12.090_b0025","first-page":"19","article-title":"Decreased expression of type I collagen (COL1A1) and dentin phosphoprotein (DPP) in teeth of fluorosed sheep","volume":"43","author":"Han","year":"2010","journal-title":"Fluoride"},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0030","first-page":"192","article-title":"Effects of protein versus calcium supplementation on bone metabolism and development in fluoride-exposed offspring rats fed protein-and calcium-deficient diets","volume":"41","author":"He","year":"2008","journal-title":"Fluoride"},{"key":"10.1016\/j.chemosphere.2014.12.090_b0035","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12011-013-9770-0","article-title":"Flouride promotes viability and differentiation of osteoblast-like saos-2 cells via BMP\/smads signaling pathway","volume":"155","author":"Huo","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"issue":"3\u20134","key":"10.1016\/j.chemosphere.2014.12.090_b0040","first-page":"279","article-title":"Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease","volume":"10","author":"Krishnamachari","year":"1986","journal-title":"Prog. Food Nutr. Sci."},{"issue":"1","key":"10.1016\/j.chemosphere.2014.12.090_b0045","first-page":"13","article-title":"Quantification of rib COL1A2 gene expression in healthy and fluorosed Inner Mongolia cashmere goats","volume":"40","author":"Li","year":"2007","journal-title":"Fluoride"},{"key":"10.1016\/j.chemosphere.2014.12.090_b0050","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.chemosphere.2013.11.032","article-title":"Effects of fluoride on bacterial growth and its gene\/protein expression","volume":"100","author":"Ma","year":"2013","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0055","first-page":"145","article-title":"In vivo and in vitro study on the effect of excessive fluoride on type I collagen of rats","volume":"31","author":"Miu","year":"2002","journal-title":"Wei Sheng Yan Jiu"},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00418-004-0697-6","article-title":"Expression of collagen type I and type II in consecutive stages of human osteoarthritis","volume":"122","author":"Nicolai","year":"2004","journal-title":"Histochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.chemosphere.2014.12.090_b0065","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/tox.21784","article-title":"Fluoride decreased osteoclastic bone resorption through the inhibition of NFATc1 gene expression","volume":"29","author":"Pei","year":"2012","journal-title":"Environ. Toxicol."},{"issue":"9","key":"10.1016\/j.chemosphere.2014.12.090_b0070","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A New mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.chemosphere.2014.12.090_b0075","first-page":"75","article-title":"Effects of excessive fluoride on metabolism of collagen protein in cartilage matrix","volume":"11","author":"Pu","year":"1996","journal-title":"Chin. J. Control. Endem. Dis."},{"key":"10.1016\/j.chemosphere.2014.12.090_b0080","first-page":"18252","article-title":"Studies on the comparative effect of sodium fluoride on collagen content in various rat organs","volume":"10","author":"Siddiqi","year":"2011","journal-title":"Afr. J. Biotechnol."},{"issue":"4","key":"10.1016\/j.chemosphere.2014.12.090_b0085","first-page":"177","article-title":"Certain facets of F\u2212 action on collagen protein in osseous and nonosseous tissues","volume":"13","author":"Susheela","year":"1982","journal-title":"Fluoride"},{"issue":"2","key":"10.1016\/j.chemosphere.2014.12.090_b0090","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/0748233711428641","article-title":"Evaluation of total oxidative status and total antioxidant capacity in patients with endemic fluorosis","volume":"29","author":"Varol","year":"2013","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.chemosphere.2014.12.090_b0095","first-page":"217","article-title":"Effects of fluoride on lipid per oxidation, DNA damage and apoptosis in human embryo hepatocytes","volume":"17","author":"Wang","year":"2004","journal-title":"Biomed. Environ. Sci."},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0100","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/tox.20421","article-title":"Effects of dietary protein and calcium on thymus apoptosis induced by fluoride in female rats (Wistar rats)","volume":"24","author":"Wang","year":"2009","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2014.12.090_b0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0748233709102720","article-title":"Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level","volume":"25","author":"Wang","year":"2009","journal-title":"Toxicol. Ind. Health."},{"key":"10.1016\/j.chemosphere.2014.12.090_b0110","first-page":"51","article-title":"Effect of high fluoride and low protein on tooth matrix development in goats","volume":"35","author":"Wang","year":"2002","journal-title":"Fluoride"},{"issue":"1","key":"10.1016\/j.chemosphere.2014.12.090_b0115","first-page":"45","article-title":"Effects of aluminium and fluoride on the expression of type I collagen in the teeth of guinea pigs","volume":"43","author":"Wang","year":"2010","journal-title":"Fluoride"},{"issue":"4","key":"10.1016\/j.chemosphere.2014.12.090_b0120","first-page":"204","article-title":"Effects of excessive fluoride on the expression of type I collagen mRNA and fiber characteristics in rat bone","volume":"20","author":"Xu","year":"2003","journal-title":"J. Environ. Health"},{"key":"10.1016\/j.chemosphere.2014.12.090_b0125","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00204-008-0365-z","article-title":"Effects of sodium fluoride treatment in vitro on cell proliferation, apoptosis and caspase-3 and caspase-9 mRNA expression by neonatal rat osteoblasts","volume":"83","author":"Yan","year":"2009","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0130","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxlet.2010.11.005","article-title":"Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts","volume":"200","author":"Yan","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.chemosphere.2014.12.090_b0135","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bbrc.2011.06.094","article-title":"Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells","volume":"410","author":"Yang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0140","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12011-013-9633-8","article-title":"Effect of fluoride and low versus high levels of dietary calcium on mRNA expression of osteoprotegerin and osteoprotegerin ligand in the bone of rats","volume":"152","author":"Yu","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2014.12.090_b0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12011-013-9632-9","article-title":"Myeloperoxidase activity and its corresponding mRNA expression as well as gene polymorphism in the population living in the coal-burning endemic fluorosis area in Guizhou of China","volume":"152","author":"Zhang","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.chemosphere.2014.12.090_b0150","first-page":"230","article-title":"Effect of fluoride on proliferation, differentiation, and apoptosis of cultured caprine (goat) osteoblasts","volume":"38","author":"Zhong","year":"2005","journal-title":"Fluoride"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653515000351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653515000351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T17:53:42Z","timestamp":1537898022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653515000351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":30,"alternative-id":["S0045653515000351"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2014.12.090","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of fluoride on the ultrastructure and expression of Type I collagen in rat hard tissue","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2014.12.090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}