{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:44:44Z","timestamp":1786963484273,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["31172376 and 31372497"],"award-info":[{"award-number":["31172376 and 31372497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation for Young Scientists of Shanxi Province","award":["2012021027-5"],"award-info":[{"award-number":["2012021027-5"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.chemosphere.2015.04.012","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T02:19:03Z","timestamp":1431656343000},"page":"297-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Fluoride exposure changed the structure and the expressions of reproductive related genes in the hypothalamus\u2013pituitary\u2013testicular axis of male mice"],"prefix":"10.1016","volume":"135","author":[{"given":"Haijun","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jundong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2015.04.012_b0005","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1152\/physrev.2001.81.2.871","article-title":"Biology of oligodendrocyte and myelin in the mammalian central nervous system","volume":"81","author":"Baumann","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0010","doi-asserted-by":"crossref","first-page":"e25585","DOI":"10.1371\/journal.pone.0025585","article-title":"Action mechanism of inhibin alpha-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice","volume":"6","author":"Cai","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0015","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1073\/pnas.1317838111","article-title":"Germ-line activation of the luteinizing hormone receptor directly drives spermiogenesis in a nonmammalian vertebrate","volume":"111","author":"Chauvign\u00e9","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2014.00001","article-title":"Role of estrogen receptors and g protein-coupled estrogen receptor in regulation of hypothalamus\u2013pituitary\u2013testis axis and spermatogenesis","volume":"5","author":"Chimento","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0025","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0022034510384626","article-title":"Fluoride\u2019s effects on the formation of teeth and bones, and the influence of genetics","volume":"90","author":"Everett","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0030","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/0748233708089041","article-title":"The toxic effects of sodium fluoride on the reproductive system of male rats","volume":"23","author":"Gupta","year":"2007","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12011-014-9889-7","article-title":"Effects of chronic fluoride exposure on object recognition memory and mRNA expression of SNARE complex in hippocampus of male mice","volume":"158","author":"Han","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0040","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2605.2004.00502.x","article-title":"Hormonal regulation of spermatogenesis","volume":"27","author":"Holdcraft","year":"2004","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cbpb.2013.11.002","article-title":"Kisspeptin regulates the hypothalamus\u2013pituitary\u2013gonad axis gene expression during sexual maturation in the cinnamon clownfish, Amphiprion melanopus","volume":"168","author":"Kim","year":"2014","journal-title":"Comp. Biochem. Physiol. B. Biochem. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0050","first-page":"164","article-title":"Ultrastructural studies of spermiogenesis in rabbit exposed to chronic fluoride toxicity","volume":"39","author":"Kumar","year":"1993","journal-title":"Int. J. Fertil. Menopausal Stud."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00204-013-1099-0","article-title":"In vivo influence of sodium fluoride on sperm chemotaxis in male mice","volume":"88","author":"Lu","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0060","first-page":"733","article-title":"Experimental research on endocrine disturbing effect of fluorin on hypothalamus\u2013hypophysis\u2013testis axis in male rats","volume":"37","author":"Ma","year":"2008","journal-title":"J. Hyg. Res."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/B978-0-12-385961-7.00014-7","article-title":"Feedback regulation by inhibins A and B of the pituitary secretion of follicle-stimulating hormone","volume":"85","author":"Makanji","year":"2011","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0070","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1095\/biolreprod.102.004424","article-title":"Immunolocalization of inhibin and activin \u03b1 and \u03b2B subunits and expression of corresponding messenger RNAs in the human adult testis","volume":"68","author":"Marchetti","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0075","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1152\/physiol.00032.2011","article-title":"Social regulation of gene expression in the hypothalamic\u2013pituitary\u2013gonadal axis","volume":"26","author":"Maruska","year":"2011","journal-title":"Physiology"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1073\/pnas.85.1.247","article-title":"Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions","volume":"85","author":"Meunier","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0085","first-page":"276","article-title":"Effects of fluoride and lead on locomotor behavior and expression of nissl body in brain of adult rats","volume":"41","author":"Niu","year":"2008","journal-title":"Fluoride"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0090","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0013-9351(03)00059-8","article-title":"Fluoride-induced disruption of reproductive hormones in men","volume":"93","author":"Ortiz-P\u00e9rez","year":"2003","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0095","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.toxlet.2013.09.005","article-title":"A brief review on experimental fluorosis","volume":"223","author":"Perumal","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0100","first-page":"68","article-title":"Acute toxicity of fluoride to mice","volume":"20","author":"Pillai","year":"1987","journal-title":"Fluoride"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10534-005-0336-2","article-title":"Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats","volume":"18","author":"Pushpalatha","year":"2005","journal-title":"Biometals"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0110","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00114-007-0224-4","article-title":"Suppression of male reproduction in rats after exposure to sodium fluoride during early stages of development","volume":"94","author":"Reddy","year":"2007","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0115","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0120","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1074\/jbc.M409616200","article-title":"Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors","volume":"280","author":"Selva","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0125","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0278-6915(97)88938-7","article-title":"Testing the potential of sodium fluoride to affect spermatogenesis in the rat","volume":"35","author":"Sprando","year":"1997","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0130","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00204-011-0672-7","article-title":"Fluoride-induced apoptosis and gene expression profiling in mice sperm in vivo","volume":"85","author":"Sun","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0135","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1098\/rstb.2009.0258","article-title":"Non-classical actions of testosterone and spermatogenesis","volume":"365","author":"Walker","year":"2010","journal-title":"Philos. Trans. R. Soc. London B. Biol. Sci."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/rep.1.00358","article-title":"FSH and testosterone signaling in Sertoli cells","volume":"130","author":"Walker","year":"2005","journal-title":"Reproduction"},{"key":"10.1016\/j.chemosphere.2015.04.012_b0145","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.fct.2012.02.098","article-title":"Influence of royal jelly on the reproductive function of puberty male rats","volume":"50","author":"Yang","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.taap.2013.04.033","article-title":"Fluoride-elicited developmental testicular toxicity in rats: roles of endoplasmic reticulum stress and inflammatory response","volume":"271","author":"Zhang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0155","first-page":"1","article-title":"Environmental fluoride exposure and reproductive hormones in male living in endemic fluorosis villages in China","volume":"9","author":"Zhou","year":"2012","journal-title":"Life Sci. J."},{"key":"10.1016\/j.chemosphere.2015.04.012_b0160","first-page":"241","article-title":"Influence of water fluoride exposure on sex hormone binding globulin and testosterone in adult male","volume":"42","author":"Zhou","year":"2013","journal-title":"J. Hyg. Res."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565351500332X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565351500332X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T03:55:38Z","timestamp":1566705338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004565351500332X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":32,"alternative-id":["S004565351500332X"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2015.04.012","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoride exposure changed the structure and the expressions of reproductive related genes in the hypothalamus\u2013pituitary\u2013testicular axis of male mice","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2015.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}