{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:10:13Z","timestamp":1790061013201,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["CZ.1.05\/2.1.00\/01.0024"],"award-info":[{"award-number":["CZ.1.05\/2.1.00\/01.0024"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LO1205"],"award-info":[{"award-number":["LO1205"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["211-2013-1320"],"award-info":[{"award-number":["211-2013-1320"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.chemosphere.2015.12.051","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T16:23:43Z","timestamp":1451492623000},"page":"723-730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Fate of three anti-influenza drugs during ozonation of wastewater effluents \u2013 degradation and formation of transformation products"],"prefix":"10.1016","volume":"150","author":[{"given":"Ganna","family":"Fedorova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Grabic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Nyhlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef D.","family":"J\u00e4rhult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2015.12.051_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jhazmat.2005.03.004","article-title":"Antibiotic removal from wastewaters: the ozonation of amoxicillin","volume":"122","author":"Andreozzi","year":"2005","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib2","doi-asserted-by":"crossref","first-page":"12873","DOI":"10.1021\/es303203c","article-title":"Synchronous dynamics of observed and predicted values of anti-influenza drugs in environmental waters during a seasonal influenza outbreak","volume":"46","author":"Azuma","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jhazmat.2007.05.034","article-title":"Sulfamethoxazole abatement by means of ozonation","volume":"150","author":"Dantas","year":"2008","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib4","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1021\/es101061w","article-title":"Transformation of beta-lactam antibacterial agents during aqueous ozonation: reaction pathways and quantitative bioassay of biologically-active oxidation products","volume":"44","author":"Dodd","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib30","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/rcm.6628","article-title":"Comparison of the quantitative performance of Q Exactive high resolution mass spectrometer with that of triple quadrupole MS\/MS for the analysis of illicit drugs in wastewater","volume":"27","author":"Fedorova","year":"2013","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib5","doi-asserted-by":"crossref","first-page":"e986","DOI":"10.1371\/journal.pone.0000986","article-title":"Antiviral oseltamivir is not removed or degraded in Normal sewage water Treatment: Implications for development of resistance by influenza a virus","volume":"2","author":"Fick","year":"2007","journal-title":"Plos One"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chemosphere.2010.07.023","article-title":"Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants","volume":"81","author":"Ghosh","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib7","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1128\/AEM.04034-14","article-title":"Oseltamivir-resistant influenza a (H1N1) virus strain with an H274Y mutation in neuraminidase persists without drug pressure in infected mallards","volume":"81","author":"Gillman","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib8","doi-asserted-by":"crossref","first-page":"e71230","DOI":"10.1371\/journal.pone.0071230","article-title":"Resistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivir","volume":"8","author":"Gillman","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib9","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1021\/es1032629","article-title":"Photofate of oseltamivir (Tamiflu) and oseltamivir carboxylate under natural and simulated solar irradiation: kinetics, identification of the transformation products, and environmental occurrence","volume":"45","author":"Goncalves","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib10","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3390\/v2081510","article-title":"Combination chemotherapy for influenza","volume":"2","author":"Govorkova","year":"2010","journal-title":"Viruses-Basel"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s13238-010-0008-z","article-title":"The emergence of pandemic influenza viruses","volume":"1","author":"Guan","year":"2010","journal-title":"Protein Cell"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib12","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/es048396s","article-title":"Oxidation of pharmaceuticals during ozonation of municipal wastewater effluents: a pilot study","volume":"39","author":"Huber","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib13","article-title":"Oseltamivir (Tamiflu\u00a9) in the environment, resistance development in influenza A viruses of dabbling ducks and the risk of transmission of an oseltamivir-resistant virus to humans - a review","volume":"2","author":"J\u00e4rhult","year":"2012","journal-title":"Infect. Ecol. Epidemiol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib14","doi-asserted-by":"crossref","first-page":"e24742","DOI":"10.1371\/journal.pone.0024742","article-title":"Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A\/H1N1 virus in mallards","volume":"6","author":"J\u00e4rhult","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpba.2012.02.011","article-title":"The development and application of a system for simultaneously determining anti-infectives and nasal decongestants using on-line solid-phase extraction and liquid chromatography-tandem mass spectrometry","volume":"66","author":"Khan","year":"2012","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.trac.2008.08.014","article-title":"Applications of mass spectrometry to identifying pharmaceutical transformation products in water treatment","volume":"27","author":"Kosjek","year":"2008","journal-title":"Trac-Trend Anal. Chem."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2015.03.066","article-title":"Online solid phase extraction liquid chromatography using bonded zwitterionic stationary phases and tandem mass spectrometry for rapid environmental trace analysis of highly polar Hydrophilic compounds-application for the antiviral drug zanamivir","volume":"141","author":"Lindberg","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib18","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1021\/es5017894","article-title":"Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks","volume":"48","author":"Malchi","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.virol.2009.03.026","article-title":"The origin and global emergence of adamantane resistant A\/H3N2 influenza viruses","volume":"388","author":"Nelson","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1122438","article-title":"Global patterns of influenza a virus in wild birds","volume":"312","author":"Olsen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib21","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3201\/eid1510.090844","article-title":"Maximizing the value of drug stockpiles for pandemic influenza","volume":"15","author":"Po","year":"2009","journal-title":"Emerg. Inf. Dis."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhazmat.2009.12.023","article-title":"Oxidation products of sulfamethoxazole in ozonated secondary effluent","volume":"177","author":"Rodayan","year":"2010","journal-title":"J.\u00a0Hazard. Mater."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib23","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.watres.2009.07.004","article-title":"Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation","volume":"44","author":"Rosal","year":"2010","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006064","article-title":"Detection of the antiviral drug oseltamivir in aquatic environments","volume":"4","author":"S\u00f6derstr\u00f6m","year":"2009","journal-title":"Plos One"},{"key":"10.1016\/j.chemosphere.2015.12.051_bib25","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/j.watres.2010.01.023","article-title":"Comparative toxicity assessment of ozone and activated carbon treated sewage effluents using an in\u00a0vivo test battery","volume":"44","author":"Stalter","year":"2010","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2965\/jwet.2010.363","article-title":"Detection of antiviral drugs oseltamivir phosphate and oseltamivir carboxylate in Neya River, Osaka Japan","volume":"8","author":"Takanami","year":"2010","journal-title":"J.\u00a0Water Environ. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2965\/jwet.2012.57","article-title":"Antiviral drugs zanamivir and oseltamivir found in wastewater and surface water in Osaka Japan","volume":"10","author":"Takanami","year":"2012","journal-title":"J.\u00a0Water Environ. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib28","doi-asserted-by":"crossref","first-page":"11286","DOI":"10.1021\/es502868k","article-title":"Treated wastewater irrigation: uptake of pharmaceutical and personal care products by common vegetables under field conditions","volume":"48","author":"Wu","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/01919510701878387","article-title":"Impact of operating conditions on decomposition of antibiotics during ozonation: a review","volume":"30","author":"Yargeau","year":"2008","journal-title":"Ozone-Sci. Eng."},{"key":"10.1016\/j.chemosphere.2015.12.051_bib29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jhazmat.2013.10.008","article-title":"Evaluation of the phototransformation of the antiviral zanamivir in surface waters through identification of transformation products","volume":"265","author":"Zonja","year":"2014","journal-title":"J.\u00a0Hazard. Mater."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653515305051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653515305051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:25:49Z","timestamp":1758619549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653515305051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":31,"alternative-id":["S0045653515305051"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2015.12.051","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fate of three anti-influenza drugs during ozonation of wastewater effluents \u2013 degradation and formation of transformation products","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2015.12.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}