{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:01:52Z","timestamp":1787504512139,"version":"build-2736575974"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31320103915"],"award-info":[{"award-number":["31320103915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2013CB945204"],"award-info":[{"award-number":["2013CB945204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.chemosphere.2016.05.071","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T05:50:34Z","timestamp":1464760234000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT\/AMPK pathway in mouse epididymis"],"prefix":"10.1016","volume":"158","author":[{"given":"Yin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan Z.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2016.05.071_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.aquatox.2012.12.026","article-title":"Changes in morphometry and association between whole-body fatty acids and steroid hormone profiles in relation to bioaccumulation patterns in salmon larvae exposed to perfluorooctane sulfonic or perfluorooctane carboxylic acids","volume":"130\u2013131","author":"Arukwe","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1203\/PDR.0b013e3181a9eafb","article-title":"Oxygen toxicity and reactive oxygen species: the devil is in the details","volume":"66","author":"Auten","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbalip.2006.03.014","article-title":"Oxidative stress and arachidonic acid mobilization","volume":"1761","author":"Balboa","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1126\/science.1833819","article-title":"A\u00a0retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region","volume":"254","author":"Bellacosa","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00441-012-1381-0","article-title":"Region-specific gene expression in the epididymis","volume":"349","author":"Belleannee","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10555-011-9299-7","article-title":"Polyunsaturated fatty acid metabolism in prostate cancer","volume":"30","author":"Berquin","year":"2011","journal-title":"Cancer metastasis Rev."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib7","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1194\/jlr.M600136-JLR200","article-title":"Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI","volume":"47","author":"Brundert","year":"2006","journal-title":"J.\u00a0lipid Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(87)80292-2","article-title":"A\u00a0common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis","volume":"223","author":"Carling","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0003-9861(74)90058-7","article-title":"Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation","volume":"164","author":"Carlson","year":"1974","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00404-013-2801-4","article-title":"Influence of reactive oxygen species on human sperm functions and fertilizing capacity including therapeutical approaches","volume":"288","author":"Chen","year":"2013","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib11","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1242\/bio.201411288","article-title":"Differences in the fatty-acid composition of rodent spermatozoa are associated to levels of sperm competition","volume":"4","author":"delBarco-Trillo","year":"2015","journal-title":"Biol. Open"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/1062936032000169688","article-title":"Predicting the biodegradation products of perfluorinated chemicals using CATABOL","volume":"15","author":"Dimitrov","year":"2004","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1042\/bj20031320","article-title":"Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone","volume":"378","author":"Dolinsky","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1472-6882-13-64","article-title":"Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway","volume":"13","author":"Dong","year":"2013","journal-title":"BMC Complementary Altern. Med."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.reprotox.2010.05.010","article-title":"Effects of PFNA exposure on expression of junction-associated molecules and secretory function in rat Sertoli cells","volume":"30","author":"Feng","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.toxlet.2009.07.020","article-title":"Perfluorononanoic acid induces apoptosis involving the Fas death receptor signaling pathway in rat testis","volume":"190","author":"Feng","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jez.1402290317","article-title":"Evidence suggesting the importance of fatty acids and the fatty acid moieties of sperm membrane phospholipids in the acrosome reaction of guinea pig spermatozoa","volume":"229","author":"Fleming","year":"1984","journal-title":"J.\u00a0Exp. Zool."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0092-8674(95)90534-0","article-title":"The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase","volume":"81","author":"Franke","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1001\/archpediatrics.2010.163","article-title":"Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project","volume":"164","author":"Frisbee","year":"2010","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1194\/jlr.M200356-JLR200","article-title":"Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes","volume":"44","author":"Funari","year":"2003","journal-title":"J.\u00a0lipid Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1439-0531.2010.01609.x","article-title":"Membrane lipids of the stallion spermatozoon in relation to sperm quality and susceptibility to lipid peroxidation","volume":"46","author":"Garcia","year":"2011","journal-title":"Reprod. Domest. Anim.Zuchthyg."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib23","article-title":"Electroacupuncture attenuates hepatic lipid accumulation via AMP-activated protein kinase (AMPK) activation in obese rats","author":"Gong","year":"2015","journal-title":"Acupunct. Med. J. Br. Med. Acupunct. Soc."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib24","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1101\/gad.889901","article-title":"Inhibition of early apoptotic events by Akt\/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase","volume":"15","author":"Gottlob","year":"2001","journal-title":"Genes & Dev."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib25","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1021\/es001489z","article-title":"Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices","volume":"35","author":"Hansen","year":"2001","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/aja.2010.76","article-title":"Leukocytes and oxidative stress: dilemma for sperm function and male fertility","volume":"13","author":"Henkel","year":"2011","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1152\/physrev.00047.2006","article-title":"Life and death: metabolic rate, membrane composition, and life span of animals","volume":"87","author":"Hulbert","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.prostaglandins.2009.05.003","article-title":"Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis","volume":"89","author":"Ichimura","year":"2009","journal-title":"Prostagl. Other Lipid Mediat."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib30","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"Jager","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbrc.2009.07.130","article-title":"A\u00a0role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids","volume":"388","author":"Kohan","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02537038","article-title":"Thermal acclimation and dietary lipids alter the composition, but not fluidity, of trout sperm plasma membrane","volume":"30","author":"Labbe","year":"1995","journal-title":"Lipids"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib33","first-page":"385","article-title":"Potential role of Akt signaling in chronic kidney disease. Nephrology, dialysis, transplantation","volume":"30","author":"Lan","year":"2015","journal-title":"Off. Publ. Eur. Dial. Transpl. Assoc. Eur. Ren. Assoc."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1113\/expphysiol.1983.sp002714","article-title":"Effect of dietary linoleic and linolenic acids on testicular development in the rat","volume":"68","author":"Leat","year":"1983","journal-title":"Q.\u00a0J. Exp. Physiol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib35","doi-asserted-by":"crossref","first-page":"e0142041","DOI":"10.1371\/journal.pone.0142041","article-title":"The herbal medicine KBH-1 inhibits fat accumulation in 3T3-L1 adipocytes and reduces high fat diet-induced obesity through regulation of the AMPK pathway","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib36","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.chemosphere.2004.11.078","article-title":"Synthesis of environmentally relevant fluorinated surfactants\u2013a review","volume":"58","author":"Lehmler","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib37","doi-asserted-by":"crossref","first-page":"9439","DOI":"10.3748\/wjg.v19.i48.9439","article-title":"Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly","volume":"19","author":"Liu","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib38","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1161\/STROKEAHA.110.589895","article-title":"Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function","volume":"41","author":"Loh","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib39","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00204-015-1492-y","article-title":"Perfluorooctanoic acid disrupts the blood-testis barrier and activates the TNFalpha\/p38 MAPK signaling pathway in\u00a0vivo and in\u00a0vitro","volume":"90","author":"Lu","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1742-4658.2010.07972.x","article-title":"Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells","volume":"278","author":"Mantzaris","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib41","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1194\/jlr.R016675","article-title":"Early steps in steroidogenesis: intracellular cholesterol trafficking","volume":"52","author":"Miller","year":"2011","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1254\/jphs.09R09FM","article-title":"New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract","volume":"112","author":"Miyauchi","year":"2010","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2012.06.019","article-title":"AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity","volume":"366","author":"O\u2019Neill","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-005-4816-z","article-title":"Studies of the FABP family: a retrospective","volume":"277","author":"Ono","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib45","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.3390\/ijms16023831","article-title":"Fatty acid signaling: the new function of intracellular lipases","volume":"16","author":"Papackova","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/10408391003721727","article-title":"Perfluorinated compounds in food: a global perspective","volume":"51","author":"Pico","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/es0512475","article-title":"Sources, fate and transport of perfluorocarboxylates","volume":"40","author":"Prevedouros","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib48","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.bbalip.2011.09.007","article-title":"Liver triacylglycerol lipases","volume":"1821","author":"Quiroga","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib49","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1530\/REP-06-00294","article-title":"Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis","volume":"133","author":"Saether","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/aja.2010.64","article-title":"Epididymis cholesterol homeostasis and sperm fertilizing ability","volume":"13","author":"Saez","year":"2011","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib51","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2337\/db14-0582","article-title":"Regulation of AMPK activation by CD36 links fatty acid uptake to beta-oxidation","volume":"64","author":"Samovski","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib52","doi-asserted-by":"crossref","first-page":"e24066","DOI":"10.1371\/journal.pone.0024066","article-title":"Fatty acid and peptide profiles in plasma membrane and membrane rafts of PUFA supplemented RAW264.7 macrophages","volume":"6","author":"Schumann","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib53","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00204-014-1391-7","article-title":"Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein","volume":"90","author":"Sheng","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib54","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1124\/mol.109.058479","article-title":"Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway","volume":"76","author":"Shin","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib55","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/mol.108.051128","article-title":"Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners","volume":"75","author":"Shin","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-005-0753-8","article-title":"Functional consequences of oxidative membrane damage","volume":"205","author":"Stark","year":"2005","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib57","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/aje\/kwp279","article-title":"Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant","volume":"170","author":"Steenland","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib58","doi-asserted-by":"crossref","first-page":"32679","DOI":"10.1074\/jbc.R110.135210","article-title":"Tissue-specific functions in the fatty acid-binding protein family","volume":"285","author":"Storch","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib59","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1080\/10428190310001639470","article-title":"Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells","volume":"45","author":"Thomas","year":"2004","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-0033-1345269","article-title":"Optimal diagnosis and medical treatment of male infertility","volume":"31","author":"Trussell","year":"2013","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib62","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/pr500641b","article-title":"Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice","volume":"14","author":"Wang","year":"2015","journal-title":"J.\u00a0Proteom. Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib63","doi-asserted-by":"crossref","first-page":"9274","DOI":"10.1021\/es300906q","article-title":"Association of perfluorooctanoic acid with HDL cholesterol and circulating miR-26b and miR-199-3p in workers of a fluorochemical plant and nearby residents","volume":"46","author":"Wang","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib64","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.chemosphere.2009.01.033","article-title":"8-2 fluorotelomer alcohol aerobic soil biodegradation: pathways, metabolites, and metabolite yields","volume":"75","author":"Wang","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib65","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1530\/rep.1.01049","article-title":"Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm","volume":"131","author":"Waterhouse","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib66","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bbalip.2008.10.010","article-title":"Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis","volume":"1791","author":"Wendel","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemosphere.2016.05.071_bib67","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jsbmb.2011.03.011","article-title":"Endocrine disrupting properties of perfluorooctanoic acid","volume":"127","author":"White","year":"2011","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib68","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00204-014-1322-7","article-title":"Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days","volume":"89","author":"Yan","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.toxlet.2013.10.017","article-title":"Circulating microRNA profiles altered in mice after 28 d exposure to perfluorooctanoic acid","volume":"224","author":"Yan","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib70","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1262\/jrd.11-015","article-title":"Fertilization studies and assisted fertilization in mammals: their development and future","volume":"58","author":"Yanagimachi","year":"2012","journal-title":"J.\u00a0Reprod. Dev."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib71","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/aps.2014.147","article-title":"Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob\/ob mice","volume":"36","author":"Zeng","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib72","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1021\/pr500228d","article-title":"Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery","volume":"13","author":"Zhang","year":"2014","journal-title":"J.\u00a0Proteom. Res."},{"key":"10.1016\/j.chemosphere.2016.05.071_bib73","doi-asserted-by":"crossref","first-page":"463815","DOI":"10.1155\/2014\/463815","article-title":"The attenuation of Moutan Cortex on oxidative stress for renal injury in AGEs-induced mesangial cell dysfunction and streptozotocin-induced diabetic nephropathy rats","volume":"2014","author":"Zhang","year":"2014","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653516307184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653516307184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T18:25:26Z","timestamp":1589653526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653516307184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":73,"alternative-id":["S0045653516307184"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2016.05.071","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT\/AMPK pathway in mouse epididymis","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2016.05.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}