{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:25:51Z","timestamp":1790814351658,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["470298\/2014-6"],"award-info":[{"award-number":["470298\/2014-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.chemosphere.2018.10.035","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T02:31:40Z","timestamp":1538965900000},"page":"365-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Molluscicidal activity of polyhexamethylene biguanide hydrochloride on the early-life stages and adults of the Biomphalaria glabrata (Say, 1818)"],"prefix":"10.1016","volume":"216","author":[{"given":"Amanda","family":"de Oliveira Melo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Braz dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Damacena","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Lopes","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Clecildo Barreto","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2018.10.035_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2014.06.005","article-title":"Toxic effects of Microgramma vacciniifolia rhizome lectin on Artemia salina, human cells, and the schistosomiasis vector Biomphalaria glabrata","volume":"138","author":"Albuquerque","year":"2014","journal-title":"Acta Trop."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib2","series-title":"Vigil\u00e2ncia e Controle de Moluscos de Import\u00e2ncia Epidemiol\u00f3gica","author":"Brasil Minist\u00e9rio da Sa\u00fade","year":"2008"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib3","first-page":"19","volume":"vol. 10","author":"Brasil Minist\u00e9rio da Sa\u00fade","year":"2010"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib4","series-title":"The Social Context of Schistosomiasis and its Control: an Introduction and Annotated Bibliography","author":"Bruun","year":"2008"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2017.02.114","article-title":"Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in\u00a0vitro and in zebrafish eleuthero-embryos","volume":"586","author":"Christen","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s40249-016-0153-6","article-title":"Critical analysis of molluscicide application in schistosomiasis control programs in Brazil","volume":"5","author":"Coelho","year":"2016","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib7","series-title":"A\u00a0Municipal Level Approach to the Management of Schistosomiasis Control in Peri-peri","volume":"vol. 34","author":"Coura-Filho","year":"1992"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2015.01.036","article-title":"Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: a review of research progress over the last decade","volume":"46","author":"Coustau","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2014.12.013","article-title":"New insights into the amphibious life of Biomphalaria glabrata and susceptibility of its egg masses to fungal infection","author":"Duarte","year":"2015","journal-title":"J.\u00a0Invertebr. Pathol."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib10","article-title":"Development and validation of guidelines for mollusc reproductive toxicity test","author":"Ducrot","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actatropica.2014.09.018","article-title":"Spotlight on the in\u00a0vitro effect of artemisinin-naphthoquine phosphate on Schistosoma mansoni and its snail host Biomphalaria alexandrina","volume":"14","author":"El-Beshbishi","year":"2015","journal-title":"Acta Tropica"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004041","article-title":"Pathogen- and host-directed antileishmanial effects mediated by polyhexanide (PHMB)","volume":"9","author":"Firdessa","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib12","article-title":"Polyheksanid - sikkerhet og effekt som antiseptikum","volume":"136","author":"Fjeld","year":"2016","journal-title":"Tidsskrift for Den Norske Laegeforening"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-015-0766-9","article-title":"The roles of water, sanitation and hygiene in reducing schistosomiasis: a review","volume":"8","author":"Grimes","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2009.12.001","article-title":"Identification of protein components of egg masses indicates parental investment in immunoprotection of offspring by Biomphalaria glabrata (Gastropoda, Mollusca)","author":"Hathaway","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002865","article-title":"The Global Burden of Disease study 2010: interpretation and implications for the neglected tropical diseases","volume":"8","author":"Hotez","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib18","doi-asserted-by":"crossref","DOI":"10.1159\/000318237","article-title":"Polihexanide: a safe and highly effective biocide","volume":"23","author":"Kaehn","year":"2010","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003657","article-title":"Historical perspective: snail control to prevent schistosomiasis","volume":"9","author":"King","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dkq212","article-title":"Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate","volume":"65","author":"Koburger","year":"2010","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib21","doi-asserted-by":"crossref","DOI":"10.1590\/S0074-02762010000400012","article-title":"Acute schistosomiasis mansoni: revisited and reconsidered","volume":"105","author":"Lambertucci","year":"2010","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111102","article-title":"Usnic acid potassium salt: an alternative for the control of Biomphalaria glabrata (Say, 1818)","volume":"9","author":"Martins","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib23","article-title":"Polyhexamethylene biguanide hydrochloride: features and applications","volume":"4","author":"Mashat","year":"2016","journal-title":"Br. J. Environ. Sci."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00436-011-2712-x","article-title":"Molluscicidal activity of some marine substances against the snail Biomphalaria glabrata (Mollusca, Planorbidae)","volume":"110","author":"Miyasato","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib25","series-title":"Molluscicidal Activity of Synadenium Carinatum Boiss. (Euphorbiaceae) Latex against Biomphalaria Glabrata and Asolation of Aajor Aompound","author":"Moreira","year":"2010"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib27","series-title":"Test No. 243: Lymnaea stagnalis Reproduction Test, OECD Guidelines for the Testing of Chemicals, Section 2","author":"OECD","year":"2016"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2010.06.038","article-title":"Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos","volume":"81","author":"Oliveira-Filho","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib30","doi-asserted-by":"crossref","DOI":"10.1590\/S1413-95962002000400010","article-title":"Aspectos histop\u00e1tol\u00f3gicos de Biophalaria glabrata Say, 1817 hospedeiro intermedi\u00e1rio de Schistosoma mansoni, submetida a Niclosamida","author":"Pile","year":"2002","journal-title":"Braz. J. Vet. Res. Anim. Sci."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib31","series-title":"R: a Language and Environmental for Statistical Computing","author":"R Core Team","year":"2016"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib32","series-title":"Ovicidal Effect of Piperaceae Species on Biomphalaria glabrata, Schistosoma Mansoni Host","first-page":"55","author":"Rapado","year":"2013"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002251","article-title":"Schistosomiasis control using piplartine against Biomphalaria glabrata at different developmental stages","volume":"7","author":"Rapado","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2009.02.008","article-title":"Activities of naphthoquinones against Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae), vector of dengue and Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni","author":"Ribeiro","year":"2009","journal-title":"Acta Trop."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib36","series-title":"Aspectos imunol\u00f3gicos do sistema enzim\u00e1tico fenoloxidase de Schistosoma mansoni","author":"Ribeiro-Paes","year":"1994"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2015.03.041","article-title":"Assessment of toxicity of Moringa ole\u00edfera \ufb02ower extract to Biomphalaria glabrata, Schistosoma mansoni and Artemia salina","author":"Rocha-Filho","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2009.07.062","article-title":"Toxicity of some glucose\/mannose-binding lectins to Biomphalaria glabrata and Artemia salina","volume":"101","author":"Santos","year":"2010","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib39","first-page":"276","article-title":"Account of two new genera, and several new species, of fresh water and land shells","volume":"1","author":"Say","year":"1818","journal-title":"J.\u00a0Acad. Nat. Sci. Phila."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.actatropica.2013.12.007","article-title":"Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models","volume":"132","author":"Scholte","year":"2014","journal-title":"Acta Trop."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2017.09.019","article-title":"Laboratory assessment of divaricatic acid against Biomphalaria glabrata and Schistosoma mansoni cercariae","volume":"178","author":"Silva","year":"2018","journal-title":"Acta Trop."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004794","article-title":"Global assessment of schistosomiasis control over the past century shows targeting the snail intermediate host works best","volume":"10","author":"Sokolow","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2014.09.005","article-title":"Developmental toxicity, acute toxicity and mutagenicity testing in freshwater snails Biomphalaria glabrata (Mollusca: Gastropoda) exposed to chromium and water samples","volume":"110","author":"Tallarico","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib45","series-title":"Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms","first-page":"1","author":"United States Environmental Protection Agency","year":"2002"},{"issue":"6","key":"10.1016\/j.chemosphere.2018.10.035_bib46","article-title":"Reports of the scientific working group on plant molluscicides","volume":"61","author":"WHO. World Health Organization","year":"1983","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.chemosphere.2018.10.035_bib47","series-title":"The Control of Schistosomiasis, Technical Report Series","author":"WHO. World Health Organization","year":"1993"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib48","series-title":"WHO Speci\ufb01cations and Evaluations for Public Health Pesticides. World Health Organization","article-title":"World health organization. Niclosamide (2(, 5-dichloro-4(nitrosalicylanilide)","author":"WHO. World Health Organization","year":"2002"},{"key":"10.1016\/j.chemosphere.2018.10.035_bib49","series-title":"Schistosomiasis: Progress Report 2001 - 2011, Strategic Plan 2012 - 2020","author":"World Health Organization","year":"2013"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653518318897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653518318897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T21:50:08Z","timestamp":1544133008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653518318897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":44,"alternative-id":["S0045653518318897"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2018.10.035","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molluscicidal activity of polyhexamethylene biguanide hydrochloride on the early-life stages and adults of the Biomphalaria glabrata (Say, 1818)","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2018.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}