{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:10:33Z","timestamp":1775686233796,"version":"3.50.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MAR-EST\/3399\/2012"],"award-info":[{"award-number":["PTDC\/MAR-EST\/3399\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCOMP-01-0124-FEDER-029435"],"award-info":[{"award-number":["FCOMP-01-0124-FEDER-029435"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["IF\/00335(2015)"],"award-info":[{"award-number":["IF\/00335(2015)"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["UID\/AMB\/50017"],"award-info":[{"award-number":["UID\/AMB\/50017"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["SFRH\/BD\/97624\/2013"],"award-info":[{"award-number":["SFRH\/BD\/97624\/2013"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["UID\/QUI\/50006\/2013"],"award-info":[{"award-number":["UID\/QUI\/50006\/2013"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["BI\/UI88\/6881\/2014"],"award-info":[{"award-number":["BI\/UI88\/6881\/2014"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013239","name":"Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007638"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007638"]}],"id":[{"id":"10.13039\/100013239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.chemosphere.2018.12.090","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T09:25:45Z","timestamp":1544693145000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Genotoxicity of gold nanoparticles in the gilthead seabream (Sparus aurata) after single exposure and combined with the pharmaceutical gemfibrozil"],"prefix":"10.1016","volume":"220","author":[{"given":"A.","family":"Barreto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.G.","family":"Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-4783","authenticated-orcid":false,"given":"E.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-3198","authenticated-orcid":false,"given":"A.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pa\u00edga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.H.M.L.M.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Delerue-Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-7243","authenticated-orcid":false,"given":"T.","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.V.M.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hylland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-9623","authenticated-orcid":false,"given":"S.","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2018.12.090_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cbpb.2015.11.009","article-title":"Exposure to gemfibrozil and atorvastatin affects cholesterol metabolism and steroid production in zebrafish (Danio rerio)","volume":"199","author":"Al-Habsi","year":"2016","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib2","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11051-010-9911-8","article-title":"'Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?","volume":"12","author":"Alkilany","year":"2010","journal-title":"J.\u00a0Nanoparticle Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/17435390902788086","article-title":"'CeO2 nanoparticles induce DNA damage towards human dermal fibroblasts in\u00a0vitro","volume":"3","author":"Auffan","year":"2009","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1383-5718(00)00033-4","article-title":"Induction of micronuclei and other nuclear abnormalities in European minnow Phoxinus phoxinus and mollie Poecilia latipinna: an assessment of the fish micronucleus test","volume":"467","author":"Ayllon","year":"2000","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib5","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.biomaterials.2009.11.079","article-title":"Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats","volume":"31","author":"Balasubramanian","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib69","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.chemosphere.2018.09.175","article-title":"Effects and bioaccumulation of gold nanoparticles in the gilthead seabream (Sparus aurata) \u2013 Single and combined exposures with gemfibrozil","volume":"215","author":"Barreto","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mrgentox.2017.05.011","article-title":"Genotoxicity of gemfibrozil in the gilthead seabream (Sparus aurata)","volume":"821","author":"Barreto","year":"2017","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11051-015-3302-0","article-title":"Behavior of colloidal gold nanoparticles in different ionic strength media","volume":"17","author":"Barreto","year":"2015","journal-title":"J.\u00a0Nanoparticle Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/carcin\/bgl177","article-title":"An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans","volume":"28","author":"Bonassi","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib9","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.nano.2015.12.384","article-title":"Ligand-lipid and ligand-core affinity control the interaction of gold nanoparticles with artificial lipid bilayers and cell membranes","volume":"12","author":"Broda","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mrfmmm.2014.05.009","article-title":"Acute and chronic administration of gold nanoparticles cause DNA damage in the cerebral cortex of adult rats","volume":"766\u2013767","author":"Cardoso","year":"2014","journal-title":"Mutat. Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib11","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1007\/s11356-014-2537-0","article-title":"'Frequency of micronuclei and of other nuclear abnormalities in erythrocytes of the grey mullet from the Mondego, Douro and Ave estuaries\u2014Portugal","volume":"21","author":"Carrola","year":"2014","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib12","series-title":"Genotoxicity and DNA Repair: a Practical Approach","article-title":"Analysis of nanoparticle-induced DNA damage by the comet assay","author":"Catal\u00e1n","year":"2014"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jhazmat.2013.11.031","article-title":"Differential cytotoxic effects of gold nanoparticles in different mammalian cell lines","volume":"264","author":"Chueh","year":"2014","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/MB:26:3:249","article-title":"The comet assay for DNA damage and repair","volume":"26","author":"Collins","year":"2004","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jes.2017.04.034","article-title":"Genotoxicity of gold nanoparticles functionalized with indolicidin towards Saccharomyces cerevisiae","volume":"66","author":"de Alteriis","year":"2017","journal-title":"J.\u00a0Environ. Sci."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mrgentox.2004.02.006","article-title":"Comet assay using mullet (Mugil sp.) and sea catfish (Netuma sp.) erythrocytes for the detection of genotoxic pollutants in aquatic environment","volume":"560","author":"de Andrade","year":"2004","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/17435390.2014.889238","article-title":"Impact of gold nanoparticles on zebrafish exposed to a spiked sediment","volume":"9","author":"Dedeh","year":"2015","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11051-015-3023-4","article-title":"Cyto- and genotoxicity assessment of Gold nanoparticles obtained by laser ablation in A549 lung adenocarcinoma cells","volume":"17","author":"Di Bucchianico","year":"2015","journal-title":"J.\u00a0Nanoparticle Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2015.02.015","article-title":"Effects of charge and surface ligand properties of nanoparticles on oxidative stress and gene expression within the gut of Daphnia magna","volume":"162","author":"Dominguez","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/etc.1725","article-title":"Occurrence, fate, and persistence of gemfibrozil in water and soil","volume":"31","author":"Fang","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.aquatox.2009.09.016","article-title":"Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes","volume":"96","author":"Farkas","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s10535-017-0751-6","article-title":"The effects of silver ions and silver nanoparticles on cell division and expression of cdc2 gene in Allium cepa root tips","volume":"62","author":"Fouad","year":"2017","journal-title":"Biol. Plant."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib23","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/jat.2865","article-title":"Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells","volume":"33","author":"Fraga","year":"2013","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.envpol.2012.11.014","article-title":"Behaviour of Au-citrate nanoparticles in seawater and accumulation in bivalves at environmentally relevant concentrations","volume":"174","author":"Garc\u00eda-Negrete","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib25","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0572","article-title":"Sources, impacts and trends of pharmaceuticals in the marine and coastal environment","volume":"369","author":"Gaw","year":"2014","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3109\/17435390.2011.562328","article-title":"Impact of dietary gold nanoparticles in zebrafish at very low contamination pressure: the role of size, concentration and exposure time","volume":"6","author":"Geffroy","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mrgentox.2003.07.010","article-title":"Detection of oxidative DNA damage in isolated marine bivalve hemocytes using the comet assay and formamidopyrimidine glycosylase (Fpg)","volume":"542","author":"Gielazyn","year":"2003","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1021\/bc049951i","article-title":"Toxicity of gold nanoparticles functionalized with cationic and anionic side chains","volume":"15","author":"Goodman","year":"2004","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib29","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1166\/jnn.2012.6430","article-title":"In\u00a0vitro safety toxicology data for evaluation of gold nanoparticles-chronic cytotoxicity, genotoxicity and uptake","volume":"12","author":"Guglielmo","year":"2012","journal-title":"J.\u00a0Nanosci. Nanotechnol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.radphyschem.2014.07.006","article-title":"The synthesis of gold nanoparticles by a citrate-radiolytical method","volume":"106","author":"Han\u017ei\u0107","year":"2015","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ecoenv.2014.02.015","article-title":"The role of vitamins A, C, E and selenium as antioxidants against genotoxicity and cytotoxicity of cadmium, copper, lead and zinc on erythrocytes of Nile tilapia, Oreochromis niloticus","volume":"104","author":"Harabawy","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib32","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1007\/s11356-015-5683-0","article-title":"Surface capping and size-dependent toxicity of gold nanoparticles on different trophic levels","volume":"23","author":"Iswarya","year":"2016","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00216-010-3977-0","article-title":"The comet assay in nanotoxicology research","volume":"398","author":"Karlsson","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib34","first-page":"1","article-title":"Nanoparticles: properties, applications and toxicities","volume":"5","author":"Khan","year":"2017","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cis.2013.06.003","article-title":"Gold nanoparticles: a paradigm shift in biomedical applications","volume":"199\u2013200","author":"Khan","year":"2013","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1383-5742(03)00017-6","article-title":"Use of the single cell gel electrophoresis\/comet assay for detecting DNA damage in aquatic (marine and freshwater) animals","volume":"544","author":"Lee","year":"2003","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib37","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1039\/c0cc00935k","article-title":"Core-shell Au@(TiO2, SiO2) nanoparticles with tunable morphology","volume":"46","author":"Lekeufack","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-6-440","article-title":"Facile synthesis of concentrated gold nanoparticles with low size-distribution in water: temperature and pH controls","volume":"6","author":"Li","year":"2011","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib39","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1016\/j.biomaterials.2011.04.023","article-title":"Genomic instability of gold nanoparticle treated human lung fibroblast cells","volume":"32","author":"Li","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib40","article-title":"Effects of internalized gold nanoparticles with respect to cytotoxicity and invasion activity in lung cancer cells","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib41","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.marpolbul.2016.02.064","article-title":"Effects of emerging contaminants on neurotransmission and biotransformation in marine organisms \u2014 an in\u00a0vitro approach","volume":"106","author":"Luis","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib42","doi-asserted-by":"crossref","first-page":"505606","DOI":"10.1088\/0957-4484\/20\/50\/505606","article-title":"Minute synthesis of extremely stable gold nanoparticles","volume":"20","author":"Min","year":"2009","journal-title":"Nanotechnology"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib43","series-title":"NCL Method PCC-8, Determination of Gold in Rat Tissue with Inductively Coupled Plasma Mass Spectrometry","author":"NIST","year":"2010"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib44","series-title":"Test No. 203: Fish, Acute Toxicity Test","author":"OECD","year":"1992"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mrgentox.2010.08.003","article-title":"Evaluation of oxidative DNA lesions in plasma and nuclear abnormalities in erythrocytes of wild fish (Liza aurata) as an integrated approach to genotoxicity assessment","volume":"703","author":"Oliveira","year":"2010","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib46","first-page":"746","article-title":"Induction of micronuclei and nuclear abnormalities in the erythrocytes of Anguilla anguilla L. exposed either to cyclophosphamide or to bleached kraft pulp mill effluent","volume":"5","author":"Pacheco","year":"1996","journal-title":"Fresenius Environ. Bull."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10661-005-5308-z","article-title":"Biotransformation and genotoxic biomarkers in mullet species (LIZA SP.) from a contaminated coastal lagoon (ria de aveiro, Portugal)","volume":"107","author":"Pacheco","year":"2005","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.toxlet.2012.09.025","article-title":"Cyto and genotoxicity of gold nanoparticles in human hepatocellular carcinoma and peripheral blood mononuclear cells","volume":"215","author":"Paino","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.envpol.2012.03.051","article-title":"Size dependent bioaccumulation and ecotoxicity of gold nanoparticles in an endobenthic invertebrate: the Tellinid clam Scrobicularia plana","volume":"168","author":"Pan","year":"2012","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2010.12.013","article-title":"The fibrate drug gemfibrozil disrupts lipoprotein metabolism in rainbow trout","volume":"251","author":"Prindiville","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib51","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF03216589","article-title":"Impacts of gold nanoparticle exposure on two freshwater species: a phytoplanktonic alga (Scenedesmus subspicatus) and a benthic bivalve (Corbicula fluminea)","volume":"41","author":"Renault","year":"2008","journal-title":"Gold Bull."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib52","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1021\/es0522635","article-title":"Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques","volume":"40","author":"Rothen-Rutishauser","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib53","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1039\/c0nr00478b","article-title":"Surface charge of gold nanoparticles mediates mechanism of toxicity","volume":"3","author":"Schaeublin","year":"2011","journal-title":"Nanoscale"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib54","series-title":"Nanoparticles: from Theory to Application","author":"Schmid","year":"2010"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib55","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A\u00a0simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib56","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mrgentox.2016.01.003","article-title":"Analysis of nuclear abnormalities in erythrocytes of rainbow trout (Oncorhynchus mykiss) treated with Cu and Zn and after 4-, 8-, and 12-day depuration (post-treatment recovery)","volume":"797","author":"Stankevi\u010di\u016bt\u0117","year":"2016","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib57","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.marenvres.2008.02.044","article-title":"Gold nanoparticles and oxidative stress in Mytilus edulis","volume":"66","author":"Tedesco","year":"2008","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib58","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.aquatox.2010.03.001","article-title":"Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis","volume":"100","author":"Tedesco","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.aquatox.2016.05.015","article-title":"Assessment of gold nanoparticle effects in a marine teleost (Sparus aurata) using molecular and biochemical biomarkers","volume":"177","author":"Teles","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib60","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.scitotenv.2017.01.153","article-title":"Linking cortisol response with gene expression in fish exposed to gold nanoparticles","volume":"584\u2013585","author":"Teles","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0027-5107(00)00019-1","article-title":"Hydroperoxide-induced DNA damage and mutations","volume":"450","author":"Termini","year":"2000","journal-title":"Mutat. Res. Fund Mol. Mech. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib62","series-title":"Integration of Genotoxic and Population Genetic Endpoints in Biomonitoring and Risk Assessment","author":"Theodorakis","year":"2001"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib63","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.chroma.2008.09.008","article-title":"Considerations for environmental fate and ecotoxicity testing to support environmental risk assessments for engineered nanoparticles","volume":"1216","author":"Tiede","year":"2009","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A\u00a0study of the nucleation and growth processes in the synthesis of colloidal gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss. Faraday Soc."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib65","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1002\/etc.2004","article-title":"Contaminants of emerging concern in municipal wastewater effluents and marine receiving water","volume":"31","author":"Vidal-Dorsch","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib66","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0027-5107(97)00256-X","article-title":"Altered gene expression and genetic damage in North American fish populations","volume":"399","author":"Wirgin","year":"1998","journal-title":"Mutat. Res. Fund Mol. Mech. Mutagen"},{"key":"10.1016\/j.chemosphere.2018.12.090_bib67","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/jbm.a.35944","article-title":"The effect of particle size on the genotoxicity of gold nanoparticles","volume":"105","author":"Xia","year":"2017","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.chemosphere.2018.12.090_bib68","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3184\/095422914X14144332205573","article-title":"Toxicity, bioaccumulation and biomagnification of silver nanoparticles in green algae (Chlorella sp.), water flea (Moina macrocopa), blood worm (Chironomus spp.) and silver barb (Barbonymus gonionotus)","volume":"26","author":"Yoo-Iam","year":"2014","journal-title":"Chem. Speciat. Bioavailab."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653518324123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653518324123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:58:47Z","timestamp":1758621527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653518324123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":69,"alternative-id":["S0045653518324123"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2018.12.090","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotoxicity of gold nanoparticles in the gilthead seabream (Sparus aurata) after single exposure and combined with the pharmaceutical gemfibrozil","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2018.12.090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}