{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:29:31Z","timestamp":1769016571979,"version":"3.49.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1D1A1A02060346"],"award-info":[{"award-number":["NRF-2015R1D1A1A02060346"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1A02042604"],"award-info":[{"award-number":["NRF-2018R1D1A1A02042604"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B070455309"],"award-info":[{"award-number":["NRF-2018R1D1A1B070455309"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National R&D Program for Cancer Control"},{"DOI":"10.13039\/501100003625","name":"Ministry of Health & Welfare, Republic of Korea","doi-asserted-by":"publisher","award":["HA17C0035"],"award-info":[{"award-number":["HA17C0035"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","award":["T38662"],"award-info":[{"award-number":["T38662"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.chemosphere.2019.04.061","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T12:14:55Z","timestamp":1554984895000},"page":"551-560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["3D light-sheet assay assessing novel valproate-associated cardiotoxicity and folic acid relief in zebrafish embryogenesis"],"prefix":"10.1016","volume":"227","author":[{"given":"Seoyoung","family":"Ki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juneyong","family":"Eum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Raslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kil-Nam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Joon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-1468","authenticated-orcid":false,"given":"Yun","family":"Kee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2019.04.061_bib1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/13880209.2017.1299768","article-title":"Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model","volume":"55","author":"Ahmad","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.scitotenv.2018.06.124","article-title":"Assessment of river sediment toxicity: combining empirical zebrafish embryotoxicity testing with in silico toxicity characterization","volume":"643","author":"Babic","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib3","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1136\/bmj.g5159","article-title":"Use of antiepileptic drugs during pregnancy and risk of spontaneous abortion and stillbirth: population based cohort study","volume":"349","author":"Bech","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0272-0590(88)90112-1","article-title":"Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats","volume":"11","author":"Binkerd","year":"1988","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib5","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1289\/ehp.1104477","article-title":"Pharmaceuticals and personal care products in the environment: what are the big questions?","volume":"120","author":"Boxall","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/bdrb.20223","article-title":"Development of a zebrafish embryo teratogenicity assay and quantitative prediction model","volume":"89","author":"Brannen","year":"2010","journal-title":"Birth Defects Res. B. Dev. Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib7","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.1226850","article-title":"Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations","volume":"339","author":"Brodin","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib8","article-title":"Setting up a simple light sheet microscope for in toto imaging of C. elegans development","volume":"87","author":"Chardes","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib9","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-3016.2010.01160.x","article-title":"Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis","volume":"25","author":"Cleves","year":"2011","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.reprotox.2011.11.111","article-title":"Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos","volume":"33","author":"Cowden","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yrtph.2008.10.006","article-title":"Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment","volume":"53","author":"Cunningham","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L","article-title":"Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation","volume":"62","author":"Czeizel","year":"1996","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/2042098611411358","article-title":"Primary prevention of neural-tube defects and some other congenital abnormalities by folic acid and multivitamins: history, missed opportunity and tasks","volume":"2","author":"Czeizel","year":"2011","journal-title":"Ther. Adv. Drug Saf."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000330776","article-title":"Prevention of neural-tube defects with periconceptional folic acid, methylfolate, or multivitamins?","volume":"58","author":"Czeizel","year":"2011","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib16","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.3390\/nu5114760","article-title":"Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects","volume":"5","author":"Czeizel","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib17","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1242\/dev.030924","article-title":"Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart","volume":"136","author":"de Pater","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib18","first-page":"59","article-title":"Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children","volume":"21","author":"Ebadifar","year":"2016","journal-title":"J.\u00a0Res. Med. Sci."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib19","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.3390\/ijms17111925","article-title":"3D visualization of developmental toxicity of 2,4,6-trinitrotoluene in zebrafish embryogenesis using light-sheet microscopy","volume":"17","author":"Eum","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.pharmtox.42.083001.110955","article-title":"Molecular basis of environmentally induced birth defects","volume":"42","author":"Finnell","year":"2002","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00002018-200629010-00001","article-title":"Valproic acid in epilepsy : pregnancy-related issues","volume":"29","author":"Genton","year":"2006","journal-title":"Drug Saf."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib22","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1017\/S0007114515003013","article-title":"Folic acid supplements and risk for oral clefts in the newborn: a population-based study","volume":"114","author":"Gildestad","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00213-006-0317-3","article-title":"Sodium- and magnesium-valproate in\u00a0vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex","volume":"185","author":"Gobbi","year":"2006","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib24","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1242\/dev.088351","article-title":"Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function","volume":"140","author":"Guner-Ataman","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib25","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1096\/fj.04-3425fje","article-title":"Association of valproate-induced teratogenesis with histone deacetylase inhibition in\u00a0vivo","volume":"19","author":"Gurvich","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib26","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1242\/dev.061473","article-title":"Zebrafish cardiac development requires a conserved secondary heart field","volume":"138","author":"Hami","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.5698\/1535-7511-16.3.156","article-title":"Intrauterine death in pregnancy: some reassurance, yet some caution","volume":"16","author":"Harden","year":"2016","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib28","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200011303432204","article-title":"Folic acid antagonists during pregnancy and the risk of birth defects","volume":"343","author":"Hernandez-Diaz","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/dvdy.10356","article-title":"Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish","volume":"228","author":"Huang","year":"2003","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib30","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1364\/OL.32.002608","article-title":"Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM)","volume":"32","author":"Huisken","year":"2007","journal-title":"Opt. Lett."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/dev.126136","article-title":"The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field","volume":"143","author":"Jahangiri","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib32","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.1523\/JNEUROSCI.2002-07.2007","article-title":"Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling","volume":"27","author":"Jessberger","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1162493","article-title":"Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy","volume":"322","author":"Keller","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib34","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1101\/pdb.prot065839","article-title":"Digital scanned laser light-sheet fluorescence microscopy (DSLM) of zebrafish and Drosophila embryonic development","volume":"2011","author":"Keller","year":"2011","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1534-5807(01)00040-5","article-title":"The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm","volume":"1","author":"Kelly","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3171\/jns.2001.95.5.0778","article-title":"Craniosynostosis and fetal exposure to sodium valproate","volume":"95","author":"Lajeunie","year":"2001","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ydbio.2011.03.028","article-title":"Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish","volume":"354","author":"Lazic","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib39","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1182\/blood-2009-06-227777","article-title":"Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos","volume":"114","author":"Li","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187996","article-title":"Maternal folic acid supplementation and dietary folate intake and congenital heart defects","volume":"12","author":"Mao","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/neuro.01.1.1.006.2007","article-title":"The intense world syndrome--an alternative hypothesis for autism","volume":"1","author":"Markram","year":"2007","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib42","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1474-4422(12)70323-X","article-title":"Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study","volume":"12","author":"Meador","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib43","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0140-6736(68)91781-9","article-title":"Anticonvulsant drugs and congenital abnormalities","volume":"2","author":"Meadow","year":"1968","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1520-6866(1996)16:2<97::AID-TCM4>3.0.CO;2-A","article-title":"Teratogenic effects of sodium valproate in mice and rats at midgestation and at term","volume":"16","author":"Menegola","year":"1996","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib45","doi-asserted-by":"crossref","first-page":"016027","DOI":"10.1117\/1.3324890","article-title":"Scanning light-sheet microscopy in the whole mouse brain with HiLo background rejection","volume":"15","author":"Mertz","year":"2010","journal-title":"J.\u00a0Biomed. Opt."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/dbio.2001.0409","article-title":"The outflow tract of the heart is recruited from a novel heart-forming field","volume":"238","author":"Mjaatvedt","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib47","first-page":"53","article-title":"Occurrence and fate of human pharmaceuticals in the environment","volume":"202","author":"Monteiro","year":"2010","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib48","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.reprotox.2006.03.014","article-title":"Neuroteratogens in man: an overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy","volume":"22","author":"Ornoy","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/14767058.2010.501120","article-title":"Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly","volume":"24","author":"Ozkan","year":"2011","journal-title":"J.\u00a0Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib50","doi-asserted-by":"crossref","first-page":"975","DOI":"10.14348\/molcells.2015.0160","article-title":"3D light-sheet fluorescence microscopy of cranial neurons and vasculature during zebrafish embryogenesis","volume":"38","author":"Park","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/JCP.0000000000000813","article-title":"Mood-stabilizing anticonvulsants, spina bifida, and folate supplementation: commentary","volume":"38","author":"Patel","year":"2018","journal-title":"J.\u00a0Clin. Psychopharmacol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib52","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s13311-016-0464-0","article-title":"Use of antiepileptic drugs during pregnancy: evolving concepts","volume":"13","author":"Pennell","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ydbio.2010.08.036","article-title":"Cranial vasculature in zebrafish forms by angioblast cluster-derived angiogenesis","volume":"348","author":"Proulx","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib54","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1084\/jem.20081588","article-title":"Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models","volume":"205","author":"Qing","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib55","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1471-4159.2004.02406.x","article-title":"Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction","volume":"89","author":"Ren","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib56","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2144\/000113087","article-title":"Thin-sheet laser imaging microscopy for optical sectioning of thick tissues","volume":"46","author":"Santi","year":"2009","journal-title":"Biotechniques"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib57","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/dvdy.24015","article-title":"Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid","volume":"242","author":"Sarmah","year":"2013","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib58","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.reprotox.2009.05.004","article-title":"Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo","volume":"28","author":"Selderslaghs","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2009.10.033","article-title":"Valproate for the treatment of acute bipolar depression: systematic review and meta-analysis","volume":"122","author":"Smith","year":"2010","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib60","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/tera.1420480206","article-title":"Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect","volume":"48","author":"Sonoda","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/35047564","article-title":"Zebrafish genetics and vertebrate heart formation","volume":"2","author":"Stainier","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib62","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1242\/dev.123.1.285","article-title":"Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo","volume":"123","author":"Stainier","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib63","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tiv.2012.07.010","article-title":"Assessment of developmental delay in the zebrafish embryo teratogenicity assay","volume":"27","author":"Teixido","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib64","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/pd.1098","article-title":"Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure","volume":"25","author":"ten Berg","year":"2005","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib65","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1242\/jcs.084285","article-title":"Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium","volume":"124","author":"Terbach","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib67","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nmeth.2062","article-title":"Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy","volume":"9","author":"Tomer","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib68","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1474-4422(12)70103-5","article-title":"Teratogenic effects of antiepileptic drugs","volume":"11","author":"Tomson","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib69","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1212\/WNL.0000000000001840","article-title":"Antiepileptic drugs and intrauterine death: a prospective observational study from EURAP","volume":"85","author":"Tomson","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib70","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nmeth.1652","article-title":"Deep and fast live imaging with two-photon scanned light-sheet microscopy","volume":"8","author":"Truong","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib71","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-0404.2005.00458.x","article-title":"Maternal valproate dosage and foetal malformations","volume":"112","author":"Vajda","year":"2005","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib72","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.128.16.3179","article-title":"Conotruncal myocardium arises from a secondary heart field","volume":"128","author":"Waldo","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib73","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.gde.2011.09.009","article-title":"Light sheet microscopy for real-time developmental biology","volume":"21","author":"Weber","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib74","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/oxfordjournals.aje.a010070","article-title":"Multivitamin supplementation and risk of birth defects","volume":"150","author":"Werler","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/dbio.1999.9406","article-title":"Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish","volume":"214","author":"Yelon","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12012-015-9316-0","article-title":"The phosphorylation state of GSK3beta serine 9 correlated to the development of valproic acid-associated fetal cardiac teratogenicity, fetal VPA syndrome, rescued by folic acid administration","volume":"16","author":"Yu","year":"2016","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pbb.2009.08.001","article-title":"Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease","volume":"94","author":"Zadori","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.chemosphere.2019.04.061_bib78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nature10094","article-title":"Latent TGF-beta binding protein 3 identifies a second heart field in zebrafish","volume":"474","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2019.04.061_bib79","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/jhg.2017.91","article-title":"The pharmacogenomics of valproic acid","volume":"62","author":"Zhu","year":"2017","journal-title":"J.\u00a0Hum. Genet."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653519307088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653519307088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:13:05Z","timestamp":1758622385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653519307088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":79,"alternative-id":["S0045653519307088"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.04.061","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D light-sheet assay assessing novel valproate-associated cardiotoxicity and folic acid relief in zebrafish embryogenesis","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.04.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}