{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:27:55Z","timestamp":1793064475659,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.chemosphere.2019.125227","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T10:58:08Z","timestamp":1572605888000},"page":"125227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Formation and interdependence of disinfection byproducts during chlorination of natural organic matter in a conventional drinking water treatment plant"],"prefix":"10.1016","volume":"242","author":[{"given":"Xiaoxiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-6804","authenticated-orcid":false,"given":"Yaoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2019.125227_bib1","first-page":"388","article-title":"National primary drinking water regulations: stage 2 disinfectants and disinfection byproducts rule: final rule","volume":"71","year":"2006","journal-title":"Fed. Regist."},{"key":"10.1016\/j.chemosphere.2019.125227_bib2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.watres.2017.12.031","article-title":"Relationships between DBP concentrations and differential UV absorbance in full-scale conditions","volume":"131","author":"Beauchamp","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.watres.2016.07.065","article-title":"Generation of dissolved organic matter and byproducts from activated sludge during contact with sodium hypochlorite and its implications to on-line chemical cleaning in MBR","volume":"104","author":"Cai","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cej.2017.04.099","article-title":"Fate of dissolved organic matter and byproducts generated from on-line chemical cleaning with sodium hypochlorite in MBR","volume":"323","author":"Cai","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.chemosphere.2019.125227_bib5","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1021\/es034354c","article-title":"Fluorescence excitation- emission matrix regional integration to quantify spectra for dissolved organic matter","volume":"37","author":"Chen","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0043-1354(01)00187-7","article-title":"Chlorination of natural organic matter: kinetics of chlorination and of THM formation","volume":"36","author":"Gallard","year":"2002","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.watres.2019.02.004","article-title":"Effect of UV wavelength on humic acid degradation and disinfection by-product formation during the UV\/chlorine process","volume":"154","author":"Gao","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2016.11.148","article-title":"Carbonaceous and nitrogenous disinfection by-product formation from algal organic matter","volume":"170","author":"Goslan","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2019.125227_bib11","doi-asserted-by":"crossref","first-page":"10552","DOI":"10.1021\/acs.est.8b02054","article-title":"Evaluating the comparative toxicity of DBP mixtures from different disinfection scenarios: a new approach by combining freeze-drying or rotoevaporation with a marine polychaete bioassay","volume":"52","author":"Han","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jhazmat.2015.04.070","article-title":"Trihalomethanes (THMs) precursor fractions removal by coagulation and adsorption for bio-treated municipal wastewater: molecular weight, hydrophobicity\/hydrophily and fluorescence","volume":"297","author":"Han","year":"2015","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.chemosphere.2019.125227_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.chemosphere.2017.08.172","article-title":"Occurrence of nitrogenous and carbonaceous disinfection byproducts in drinking water distributed in Shenzhen, China","volume":"188","author":"Huang","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2019.125227_bib14","doi-asserted-by":"crossref","first-page":"13749","DOI":"10.1021\/es506358x","article-title":"Occurrence and comparative toxicity of haloacetaldehyde disinfection byproducts in drinking water","volume":"49","author":"Jeong","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib15","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1021\/acs.est.6b06161","article-title":"Removal of intermediate aromatic halogenated DBPs by activated carbon adsorption: a new approach to controlling halogenated DBPs in chlorinated drinking water","volume":"51","author":"Jiang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib16","series-title":"Disinfection By-Products in Drinking Water, ACS Symposium Series","first-page":"2","article-title":"Recent advances in disinfection by-product formation, occurrence, control, Health effects, and regulations","author":"Karanfil","year":"2008"},{"key":"10.1016\/j.chemosphere.2019.125227_bib17","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/es060353j","article-title":"Occurrence of a new generation of disinfection byproducts","volume":"40","author":"Krasner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.watres.2014.04.006","article-title":"To add or not to add: the use of quenching agents for the analysis of disinfection by-products in water samples","volume":"59","author":"Kristiana","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib19","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/acs.est.7b05440","article-title":"Drinking water disinfection byproducts (DBPs) and human Health effects: multidisciplinary challenges and opportunities","volume":"52","author":"Li","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.watres.2018.11.059","article-title":"Phototransformation of halophenolic disinfection byproducts in receiving seawater: kinetics, products, and toxicity","volume":"150","author":"Liu","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.scitotenv.2018.05.369","article-title":"Use of fluorescence excitation\u2013emission matrices coupled with parallel factor analysis to monitor C- and N-DBPs formation in drinking water recovered from cyanobacteria-laden sludge dewatering","volume":"640\u2013641","author":"Ma","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2019.125227_bib22","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.chemosphere.2016.05.088","article-title":"Characterization of haloacetaldehyde and trihalomethane formation potentials during drinking water treatment","volume":"159","author":"Mao","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2019.125227_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.chemosphere.2018.11.100","article-title":"Formation, distribution, and speciation of DBPs (THMs, HAAs, ClO2\u2212, and ClO3\u2212) during treatment of different source water with chlorine and chlorine dioxide","volume":"218","author":"Padhi","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2019.125227_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.watres.2018.02.052","article-title":"Neural networks for dimensionality reduction of fluorescence spectra and prediction of drinking water disinfection by-products","volume":"136","author":"Peleato","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib25","first-page":"36","article-title":"Comparative mammalian cell toxicity of N-DBPs and C-DBPs","volume":"vol. 995","author":"Plewa","year":"2008"},{"key":"10.1016\/j.chemosphere.2019.125227_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2166\/wst.2011.006","article-title":"Quantifying the formation of nitrogen-containing disinfection by-products in chlorinated water using absorbance and fluorescence indexes","volume":"63","author":"Roccaro","year":"2011","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2166\/aqua.2013.043","article-title":"Relationships between trihalomethanes, haloacetic acids, and haloacetonitriles formed by the chlorination of raw, treated, and fractionated surface waters","volume":"63","author":"Roccaro","year":"2014","journal-title":"J.\u00a0Water Supply Res. Technol. - Aqua"},{"key":"10.1016\/j.chemosphere.2019.125227_bib28","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1021\/es5062006","article-title":"The relationship between MX [3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone], routinely monitored trihalomethanes, and other characteristics in drinking water in a long-term survey","volume":"49","author":"Smith","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1039\/C5EW00285K","article-title":"Prediction of disinfection by-product formation in drinking water via fluorescence spectroscopy","volume":"2","author":"Trueman","year":"2016","journal-title":"Environ. Sci. Water Res. Technol."},{"issue":"585","key":"10.1016\/j.chemosphere.2019.125227_bib30","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.scitotenv.2017.01.184","article-title":"Fluorescence spectroscopy and parallel factor analysis as a dissolved organic monitoring tool to assess treatment performance in drinking water trains","volume":"584","author":"Vera","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2019.125227_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2018.05.280","article-title":"Using fluorescence-parallel factor analysis for assessing disinfection by-product formation and natural organic matter removal efficiency in secondary treated synthetic drinking waters","volume":"640\u2013641","author":"Watson","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2019.125227_bib32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.scitotenv.2019.07.071","article-title":"A\u00a0comparison study of sand filtration and ultrafiltration in drinking water treatment: removal of organic foulants and disinfection by-product formation","volume":"691","author":"Xu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2019.125227_bib33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cej.2018.09.070","article-title":"Origami system for efficient solar driven distillation in emergency water supply","volume":"356","author":"Xu","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.chemosphere.2019.125227_bib34","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.watres.2006.12.004","article-title":"Factors affecting formation of haloacetonitriles, haloketones, chloropicrin and cyanogen halides during chloramination","volume":"41","author":"Yang","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.coesh.2018.12.006","article-title":"Current methods for analyzing drinking water disinfection byproducts","volume":"7","author":"Yang","year":"2019","journal-title":"Curr. Opin. Environ. Sci. Health"},{"key":"10.1016\/j.chemosphere.2019.125227_bib36","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.watres.2019.04.033","article-title":"Application of (LC\/)MS\/MS precursor ion scan for evaluating the occurrence, formation and control of polar halogenated DBPs in disinfected waters: a review","volume":"158","author":"Yang","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2019.125227_bib37","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1021\/acs.est.5b02772","article-title":"Kinetic analysis of haloacetonitrile stability in drinking waters","volume":"49","author":"Yu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2019.125227_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.chemosphere.2018.06.018","article-title":"Removal of precursors of typical nitrogenous disinfection byproducts in ozonation integrated with biological activated carbon (O3\/BAC)","volume":"209","author":"Zheng","year":"2018","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653519324671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653519324671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:03:13Z","timestamp":1758625393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653519324671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":36,"alternative-id":["S0045653519324671"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.125227","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formation and interdependence of disinfection byproducts during chlorination of natural organic matter in a conventional drinking water treatment plant","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.125227","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"125227"}}