{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:21:46Z","timestamp":1778088106655,"version":"3.51.4"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.chemosphere.2019.125400","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T20:26:32Z","timestamp":1574713592000},"page":"125400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in Wistar rats"],"prefix":"10.1016","volume":"244","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1362-769X","authenticated-orcid":false,"given":"Helen Tais da","family":"Rosa-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Castro","family":"Panzenhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vict\u00f3ria","family":"Schmidtt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexsander","family":"Alves Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Espitia-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"de Oliveira Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moara","family":"Mingori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 F.","family":"Torres-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Eduardo","family":"Schnorr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolla Rissi Silva","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo Pomp\u00e9u","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Farina","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Cl\u00e1udio Fonseca","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2019.125400_bib1","first-page":"121","volume":"vol. 105","author":"Aebi","year":"1984"},{"issue":"3","key":"10.1016\/j.chemosphere.2019.125400_bib112","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pbb.2010.05.022","article-title":"Systemic administration of GMP induces anxiolytic-like behavior in rats","volume":"96","author":"Almeida","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.chemosphere.2019.125400_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1590\/S0001-37652000000400004","article-title":"Cytogenetic damage related to low levels of methyl mercury contamination in the Brazilian Amazon","volume":"72","author":"Amorim","year":"2000","journal-title":"An Acad. Bras Ci\u00eancias"},{"key":"10.1016\/j.chemosphere.2019.125400_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/0006-8993(83)91246-5","article-title":"Decrease of brain zinc in experimental hepatic encephalopathy","author":"Baraldi","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib116","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.envres.2015.10.006","article-title":"Country-specific estimates of the incidence of intellectual disability associated with prenatal exposure to methylmercury","volume":"147","author":"Bellinger","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004671","article-title":"Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism","volume":"4","author":"Berger","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2019.125400_bib5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/em.2850220310","article-title":"Comparative studies on cytotoxic and genotoxic effects of two organic mercury compounds in lymphocytes and gastric mucosa cells of sprague-dawley rats","volume":"22","author":"Betti","year":"1993","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.chemosphere.2019.125400_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jtemb.2013.09.008","article-title":"Behavioral effects of developmental methylmercury drinking water exposure in rodents","volume":"28","author":"Bisen-Hersh","year":"2014","journal-title":"J.\u00a0Trace Elem. Med. Biol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2019.05.022","article-title":"Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy","author":"Braissant","year":"2019","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib113","article-title":"Reduced glutathione and glutathione disulfide","volume":"108","author":"Browne","year":"1998","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.chemosphere.2019.125400_bib8","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1074\/jbc.M710133200","article-title":"Inhibition of the human thioredoxin system: a molecular mechanism of mercury toxicity","volume":"283","author":"Carvalho","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2019.125400_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0361-9230(01)00458-0","article-title":"Neurotoxicity and molecular effects of methylmercury","volume":"55","author":"Castoldi","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.chemosphere.2019.125400_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yrtph.2008.03.005","article-title":"Neurodevelopmental toxicity of methylmercury: laboratory animal data and their contribution to human risk assessment","volume":"51","author":"Castoldi","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s13256-017-1462-5","article-title":"Diabetes mellitus in a patient with glycogen storage disease type Ia: a case report","volume":"11","author":"Cohn","year":"2017","journal-title":"J.\u00a0Med. Case Rep."},{"key":"10.1016\/j.chemosphere.2019.125400_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mutage\/geu079","article-title":"The comet assay: a heavenly method!","volume":"30","author":"Collins","year":"2015","journal-title":"Mutagenesis"},{"key":"10.1016\/j.chemosphere.2019.125400_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.envint.2006.08.005","article-title":"Methylmercury genotoxicity: a novel effect in human cell lines of the central nervous system","volume":"33","author":"Crespo-L\u00f3pez","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2019.125400_bib14","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1172\/JCI31669","article-title":"Hypoglycemia, functional brain failure, and brain death","volume":"117","author":"Cryer","year":"2007","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.chemosphere.2019.125400_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jceh.2019.02.003","article-title":"Brain edema in chronic hepatic encephalopathy","author":"Cudalbu","year":"2019","journal-title":"J.\u00a0Clin. Exp. Hepatol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib16","doi-asserted-by":"crossref","first-page":"21749","DOI":"10.1074\/jbc.M312267200","article-title":"Protein disulfide bond formation in the cytoplasm during oxidative stress","volume":"279","author":"Cumming","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2019.125400_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-017-0218-4","article-title":"Regional and temporal trends in blood mercury concentrations and fish consumption in women of child bearing Age in the United States using NHANES data from 1999-2010","volume":"16","author":"Cusack","year":"2017","journal-title":"Environ. Health: A Glob. Access Sci. Source"},{"key":"10.1016\/j.chemosphere.2019.125400_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cortex.2015.05.017","article-title":"Cognitive deficits at age 22 years associated with prenatal exposure to methylmercury","volume":"74","author":"Debes","year":"2016","journal-title":"Cortex"},{"key":"10.1016\/j.chemosphere.2019.125400_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0076-6879(90)86135-I","article-title":"[43] Malondialdehyde determination as index of lipid Peroxidation","volume":"186","author":"Draper","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib20","first-page":"421","volume":"vol. 186","author":"Draper","year":"1990"},{"key":"10.1016\/j.chemosphere.2019.125400_bib21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.chemosphere.2019.125400_bib22","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/sj.jcbfm.9600303","article-title":"Activation of the Akt\/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats","volume":"26","author":"Endo","year":"2006","journal-title":"J.\u00a0Cereb. Blood Flow Metab.: Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.chemosphere.2019.125400_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0009-9236(01)79918-3","article-title":"Heavy metals in traditional Chinese medicines: a systematic review","volume":"70","author":"Ernst","year":"2001","journal-title":"Clin. Pharmacol. Therapeut."},{"key":"10.1016\/j.chemosphere.2019.125400_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuro.2018.10.004","article-title":"Neurobehavioral and oxidative stress alterations following methylmercury and retinyl palmEspitia-P\u00e9rez P, Albino SM, Espitia-P\u00e9rez L, Brango H, da Rosa H, Kleber Silveira A, et\u00a0al. Neurobehavioral and oxidative stress alterations following methylmercury a","volume":"69","author":"Espitia-P\u00e9rez","year":"2018","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.chemosphere.2019.125400_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ecoenv.2018.06.093","article-title":"Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: metabolic and redox parameters in dams and their offspring","volume":"162","author":"Espitia-P\u00e9rez","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2019.125400_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jtemb.2014.10.009","article-title":"Mercury levels assessment in hair of riverside inhabitants of the Tapaj\u00f3s River, Par\u00e1 State, Amazon, Brazil: fish consumption as a possible route of exposure","volume":"30","author":"Faial","year":"2015","journal-title":"J.\u00a0Trace Elem. Med. Biol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.taap.2011.05.001","article-title":"Oxidative stress in MeHg-induced neurotoxicity","volume":"256","author":"Farina","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.05.012","article-title":"Perinatal exposure to low-dose methylmercury induces dysfunction of motor coordination with decreases in synaptophysin expression in the cerebellar granule cells of rats","volume":"1464","author":"Fujimura","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib29","article-title":"Systemic inflammation changes the site of RAGE expression from endothelial cells to neurons in different brain areas","author":"Gasparotto","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib30","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/aps.2011.202","article-title":"Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways","volume":"33","author":"Gelain","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.chemosphere.2019.125400_bib31","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2019.125400_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00204-008-0353-3","article-title":"Low levels of methylmercury induce DNA damage in rats: protective effects of selenium","volume":"83","author":"Grotto","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ecoenv.2010.10.012","article-title":"Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury","volume":"74","author":"Grotto","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2019.125400_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105832","article-title":"Dysbalance of astrocyte calcium under hyperammonemic conditions","volume":"9","author":"Haack","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2019.125400_bib35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life","volume":"141","author":"Halliwell","year":"2006","journal-title":"Plant Physiol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-3806(98)00039-X","article-title":"Effects of gestational methylmercury exposure on immunoreactivity of specific isoforms of PKC and enzyme activity during post-natal development of the rat brain","volume":"109","author":"Haykal-Coates","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib37","first-page":"1","article-title":"Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling","volume":"92","author":"Heimfarth","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.toxlet.2017.12.006","article-title":"Delayed neurochemical effects of prenatal exposure to MeHg in the cerebellum of developing rats","volume":"284","author":"Heimfarth","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2019.125400_bib39","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s11064-016-1966-1","article-title":"Multifactorial effects on different types of brain cells contribute to ammonia toxicity","volume":"42","author":"Hertz","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ceb.2015.02.004","article-title":"Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system","volume":"32","author":"Hol","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1590\/1678-4685-GMB-2015-0157","article-title":"Protective effects of acerola juice on genotoxicity induced by iron in\u00a0vivo","volume":"39","author":"Horta","year":"2016","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib42","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/s6070756","article-title":"Aspartate aminotransferase (AST\/GOT) and alanine aminotransferase (ALT\/GPT) detection techniques","volume":"6","author":"Huang","year":"2006","journal-title":"Sensors"},{"key":"10.1016\/j.chemosphere.2019.125400_bib43","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1615\/JEnvironPatholToxicolOncol.2014010291","article-title":"Reversal of methylmercury-induced oxidative stress, lipid peroxidation, and DNA damage by the treatment of N-acetyl cysteine: a protective approach","volume":"33","author":"Joshi","year":"2014","journal-title":"J.\u00a0Environ. Pathol. Toxicol. Oncol.: Off. Organ Int. Soc. Environ. Toxicol. Canc."},{"key":"10.1016\/j.chemosphere.2019.125400_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02034946","article-title":"Chronic effects of methylmercury on the urinary excretion of catecholamines and their responses to hypoglycemic stress","volume":"65","author":"Kabuto","year":"1991","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib45","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.sab.2005.03.006","article-title":"Determination of inorganic and total mercury by vapor generation atomic absorption spectrometry using different temperatures of the measurement cell","volume":"60","author":"Kaercher","year":"2005","journal-title":"Spectrochim. Acta B At. Spectrosc."},{"key":"10.1016\/j.chemosphere.2019.125400_bib46","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1242\/jcs.114.16.2903","article-title":"PKB\/Akt: a key mediator of cell proliferation, survival and insulin responses?","volume":"114","author":"Lawlor","year":"2001","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib47","volume":"vol. 22","author":"Lehnherr","year":"2014"},{"key":"10.1016\/j.chemosphere.2019.125400_bib48","first-page":"464","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"vol. 186","author":"Levine","year":"1990"},{"key":"10.1016\/j.chemosphere.2019.125400_bib49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","article-title":"Carbonyl assays for determination of oxidatively modified proteins","volume":"233","author":"Levine","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib50","article-title":"Protein assay","author":"Lowry","year":"1951","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2019.125400_bib51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejmech.2015.10.018","article-title":"Pivotal role of glycogen synthase kinase-3: a therapeutic target for Alzheimer\u2019s disease","volume":"107","author":"Maqbool","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.chemosphere.2019.125400_bib115","article-title":"Determination of the estrous cycle phases of rats: Some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib52","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jpeds.2004.02.033","article-title":"Brain damage in glycogen storage disease type I","volume":"144","author":"Melis","year":"2004","journal-title":"J.\u00a0Pediatr."},{"issue":"81","key":"10.1016\/j.chemosphere.2019.125400_bib111","article-title":"Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging","volume":"6","author":"M\u00e9nard","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib53","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2019.125400_bib54","first-page":"79","volume":"vol. 71","author":"Mizoguchi","year":"2002"},{"key":"10.1016\/j.chemosphere.2019.125400_bib55","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2131\/jts.33.537","article-title":"Effects of reduced food intake on toxicity study parameters in rats","volume":"33","author":"Moriyama","year":"2008","journal-title":"J.\u00a0Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.envres.2014.07.019","article-title":"Total and methyl mercury in whole blood measured for the first time in the U.S. population: NHANES 2011-2012","volume":"134","author":"Mortensen","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib57","series-title":"Toxic E Ects of Mercury","author":"Nabi","year":"2014"},{"key":"10.1016\/j.chemosphere.2019.125400_bib58","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.neuro.2006.05.007","article-title":"Brain and blood mercury and selenium after chronic and developmental exposure to methylmercury","volume":"27","author":"Newland","year":"2006","journal-title":"Neurotoxicology (Little Rock)"},{"key":"10.1016\/j.chemosphere.2019.125400_bib59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/toxsci\/50.1.106","article-title":"Blood and brain mercury levels after chronic gestational exposure to methylmercury in rats","volume":"50","author":"Newland","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib60","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ntt.2003.12.004","article-title":"Gestational exposure to methylmercury retards choice in transition in aging rats","volume":"26","author":"Newland","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib61","series-title":"Guide for the Care and Use of Laboratory Animals","author":"NRC","year":"2011"},{"key":"10.1016\/j.chemosphere.2019.125400_bib62","series-title":"Test No. 474: Mammalian Erythrocyte Micronucleus Test","author":"OECD","year":"2014"},{"key":"10.1016\/j.chemosphere.2019.125400_bib114","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.jes.7500599","article-title":"Daily mercury intake in fish-eating populations in the Brazilian Amazon","volume":"18","author":"Passos","year":"2007","journal-title":"J.\u00a0Expo. Sci. Environ. Epidemiol."},{"issue":"1","key":"10.1016\/j.chemosphere.2019.125400_bib110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijdevneu.2006.11.002","article-title":"Behavioral alterations induced by HgCl2 depend on the postnatal period of exposure","volume":"25","author":"Peixoto","year":"2007","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.toxlet.2003.08.006","article-title":"Effects of zinc and cadmium on HgCl2-\u03b4-ALA-D inhibition and Hg levels in tissues of suckling rats","volume":"146","author":"Peixoto","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2019.125400_bib64","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1039\/C3MT00337J","article-title":"Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response","volume":"6","author":"Pieper","year":"2014","journal-title":"Metall: Integr. Biometal Sci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13060582","article-title":"Serum concentrations of selected heavy metals in patients with alcoholic liver cirrhosis from the lublin region in eastern Poland","volume":"13","author":"Prystupa","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.chemosphere.2019.125400_bib66","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2337\/db09-1495","article-title":"Recurrent moderate hypoglycemia ameliorates brain damage and cognitive dysfunction induced by severe hypoglycemia","volume":"59","author":"Puente","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.chemosphere.2019.125400_bib67","first-page":"25","volume":"vol. 9","author":"Rajasekaran","year":"2000"},{"key":"10.1016\/j.chemosphere.2019.125400_bib68","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0890-6238(01)00183-6","article-title":"Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice","volume":"15","author":"Rao","year":"2001","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib69","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/ijms18040725","article-title":"Methylmercury induced neurotoxicity and the influence of selenium in the brains of adult zebrafish (Danio rerio)","volume":"18","author":"Rasinger","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib70","series-title":"Environmental Mercury and its Toxic Effects","first-page":"74","author":"Rice","year":"2014"},{"key":"10.1016\/j.chemosphere.2019.125400_bib71","first-page":"288","article-title":"Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS)","volume":"12","author":"Ristow","year":"2014","journal-title":"Dose-Response\u00a0: A Publication of International Hormesis Society"},{"key":"10.1016\/j.chemosphere.2019.125400_bib72","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ntt.2005.10.001","article-title":"Purkinje cell and cerebellar effects following developmental exposure to PCBs and\/or MeHg","volume":"28","author":"Roegge","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib73","first-page":"1074","article-title":"NIH public access","volume":"25","author":"Roegge","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib74","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/toxsci\/kfg252","article-title":"Motor impairment in rats exposed to PCBs and methylmercury during early development","volume":"77","author":"Roegge","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib75","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuro.2016.07.009","article-title":"Sex- and structure-specific differences in antioxidant responses to methylmercury during early development","volume":"56","author":"Ruszkiewicz","year":"2016","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.chemosphere.2019.125400_bib76","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envres.2018.06.038","article-title":"Brain methylmercury uptake in fetal, neonate, weanling, and adult rats","volume":"167","author":"Sakamoto","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib77","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0041-008X(75)90233-1","article-title":"Time-dependent tissue\/organ uptake and distribution of 203Hg in mice exposed to multiple sublethal doses of methyl mercury","volume":"32","author":"Salvaterra","year":"1975","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib78","doi-asserted-by":"crossref","first-page":"39505","DOI":"10.1074\/jbc.M506096200","article-title":"Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex","volume":"280","author":"Sarbassov","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2019.125400_bib79","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11011-008-9125-2","article-title":"RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia","volume":"24","author":"Schliess","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.chemosphere.2019.125400_bib80","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/mnfr.201400637","article-title":"Chronic retinyl palmitate supplementation to middle-aged Wistar rats disrupts the brain redox homeostasis and induces changes in emotional behavior","volume":"59","author":"Schnorr","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib81","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/j.fct.2011.07.010","article-title":"The effects of vitamin A supplementation to rats during gestation and lactation upon redox parameters: increased oxidative stress and redox modulation in mothers and their offspring","volume":"49","author":"Schnorr","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib82","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.3390\/nu6125572","article-title":"Supplementation of adult rats with moderate amounts of\u00a0??-carotene modulates the redox status in plasma without exerting pro-oxidant effects in the brain: a safer alternative to food fortification with vitamin A?","volume":"6","author":"Schnorr","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.chemosphere.2019.125400_bib83","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0584-8547(03)00015-6","article-title":"Determination of inorganic mercury and total mercury in biological and environmental samples by flow injection-cold vapor-atomic absorption spectrometry using sodium borohydride as the sole reducing agent","volume":"58","author":"Segade","year":"2003","journal-title":"Spectrochim. Acta B At. Spectrosc."},{"key":"10.1016\/j.chemosphere.2019.125400_bib84","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s12035-013-8571-y","article-title":"Glycogen synthase kinase 3 beta (GSK3beta) at the tip of neuronal development and regeneration","volume":"49","author":"Seira","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib85","first-page":"161","article-title":"Protection against mercury-induced renal damage in Swiss albino mice by","volume":"19","author":"Sharma","year":"2005","journal-title":"Ocimum sanctum"},{"key":"10.1016\/j.chemosphere.2019.125400_bib86","doi-asserted-by":"crossref","DOI":"10.2174\/1875318301306010001","article-title":"DNA damage and oxidative stress in patients with chronic obstructive pulmonary disease","volume":"6","author":"da Silva","year":"2013","journal-title":"Open Biomark. J."},{"key":"10.1016\/j.chemosphere.2019.125400_bib87","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-2613.2012.00825.x","article-title":"Oral exposure to methylmercury modifies the prostatic microenvironment in adult rats","volume":"93","author":"Da Silva","year":"2012","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib88","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A\u00a0simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.chemosphere.2019.125400_bib89","article-title":"Stress, protein (Mis)folding, and signaling: the redox connection","volume":"2004","author":"Sitia","year":"2004","journal-title":"Sci. Signal."},{"key":"10.1016\/j.chemosphere.2019.125400_bib90","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0300-483X(77)90076-2","article-title":"Disturbances of perinatal carbohydrate metabolism in rats exposed to methylmercury in utero","volume":"8","author":"Snell","year":"1977","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2019.125400_bib91","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/jcbfm.2008.80","article-title":"The role of Akt signaling in oxidative stress mediates NF-kappaB activation in mild transient focal cerebral ischemia","volume":"28","author":"Song","year":"2008","journal-title":"J.\u00a0Cereb. Blood Flow Metab.: Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.chemosphere.2019.125400_bib92","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ntt.2010.11.003","article-title":"A\u00a0longitudinal analysis of prenatal exposure to methylmercury and fatty acids in the Seychelles","volume":"33","author":"Stokes-Riner","year":"2011","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib93","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.taap.2007.10.010","article-title":"Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain","volume":"227","author":"Stringari","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib94","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnmol.2014.00028","article-title":"mTOR signaling and its roles in normal and abnormal brain development","volume":"7","author":"Takei","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.chemosphere.2019.125400_bib95","first-page":"133","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Exp. Suppl."},{"key":"10.1016\/j.chemosphere.2019.125400_bib96","doi-asserted-by":"crossref","first-page":"19773","DOI":"10.1074\/jbc.M113.457622","article-title":"Enhanced phosphatidylinositol 3-kinase (PI3K)\/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress","volume":"288","author":"Uranga","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2019.125400_bib97","volume":"vol. 2","author":"USEPA","year":"2000"},{"key":"10.1016\/j.chemosphere.2019.125400_bib98","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/jn\/115.11.1418","article-title":"Effects of undernutrition during suckling on footshock escape behavior and on related neurochemical parameters in rats","volume":"115","author":"Vendite","year":"1985","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.chemosphere.2019.125400_bib99","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ntt.2004.08.003","article-title":"Hippocampal antioxidant system in neonates from methylmercury-intoxicated rats","volume":"26","author":"Vicente","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","article-title":"Glutathione peroxidase","volume":"77","author":"Wendel","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chemosphere.2019.125400_bib101","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1172\/JCI79895","article-title":"Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis","volume":"126","author":"Winnick","year":"2016","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.chemosphere.2019.125400_bib102","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0891-5849(99)00051-9","article-title":"Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide","volume":"27","author":"Winterbourn","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2019.125400_bib103","series-title":"Mercury in Health Care","author":"World Health Organization","year":"2005"},{"key":"10.1016\/j.chemosphere.2019.125400_bib104","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2015.05.008","article-title":"Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways","volume":"97","author":"Xu","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.chemosphere.2019.125400_bib105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.febslet.2013.11.021","article-title":"Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects","volume":"588","author":"Xu","year":"2014","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"key":"10.1016\/j.chemosphere.2019.125400_bib106","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s12864-016-2864-2","article-title":"Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism","volume":"17","author":"Yadetie","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.chemosphere.2019.125400_bib107","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1242\/dev.137075","article-title":"Proliferation, survival and metabolism: the role of PI3K\/AKT\/mTOR signalling in pluripotency and cell fate determination","volume":"143","author":"Yu","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2019.125400_bib108","first-page":"591","article-title":"The modulatory role of dopamine in anxiety-like behavior","volume":"18","author":"Zarrindast","year":"2015","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.chemosphere.2019.125400_bib109","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/jcb.24607","article-title":"Activation of the PI3K\/Akt pathway by oxidative stress mediates high glucose-induced increase of adipogenic differentiation in primary rat osteoblasts","volume":"114","author":"Zhang","year":"2013","journal-title":"J.\u00a0Cell. Biochem."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653519326402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653519326402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:49:40Z","timestamp":1758624580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653519326402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":116,"alternative-id":["S0045653519326402"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.125400","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2019.125400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"125400"}}