{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:31:46Z","timestamp":1790339506191,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011223","name":"State Key Laboratory of Freshwater Ecology and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011223","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.chemosphere.2020.126536","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T17:08:49Z","timestamp":1584464929000},"page":"126536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Titanium dioxide nanoparticles enhanced thyroid endocrine disruption of pentachlorophenol rather than neurobehavioral defects in zebrafish larvae"],"prefix":"10.1016","volume":"249","author":[{"given":"Lei","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2020.126536_bib57","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1073\/pnas.0307674100","article-title":"Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory","volume":"101","author":"Alessia","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.chemosphere.2020.126536_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.envres.2015.12.003","article-title":"Combined effects of n-TiO2 and 2,3,7,8-TCDD in Mytilus galloprovincialis digestive gland: a transcriptomic and immunohistochemical study","volume":"145","author":"Banni","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2020.126536_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1089\/thy.1998.8.827","article-title":"Effects of environmental synthetic chemicals on thyroid function","volume":"8","author":"Brucker-Davis","year":"1998","journal-title":"Thyroid"},{"key":"10.1016\/j.chemosphere.2020.126536_bib4","first-page":"2891","article-title":"Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications","volume":"38","author":"Chen","year":"2007","journal-title":"ChemInform"},{"key":"10.1016\/j.chemosphere.2020.126536_bib5","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/etc.1958","article-title":"Acute exposure to DE-71: effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae","volume":"31","author":"Chen","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2020.126536_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aquatox.2012.01.008","article-title":"Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae","volume":"110\u2013111","author":"Chen","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib7","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1039\/C8EN00174J","article-title":"Adverse reproductive performance in zebrafish with increased bioconcentration of microcystin-LR in the presence of titanium dioxide nanoparticles","volume":"5","author":"Cheng","year":"2018","journal-title":"Environ. Sci. Nano."},{"key":"10.1016\/j.chemosphere.2020.126536_bib8","first-page":"47","article-title":"Characterization of myelination in the developing zebrafish","volume":"39","author":"Christian","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.chemosphere.2020.126536_bib56","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1021\/es8032549","article-title":"Estimates of upper bounds and trends in nano-TiO2 production as a basis for exposure assessment","volume":"43","author":"Christine Ogilvie","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.chemosphere.2020.126536_bib9","first-page":"17","article-title":"Estimates of PCP-Na consumption in districts and provinces in China by the Top-down calculation method","volume":"30","author":"Da","year":"2008","journal-title":"Environ. Pollut. Control"},{"issue":"2","key":"10.1016\/j.chemosphere.2020.126536_bib10","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1021\/acs.est.5b05024","article-title":"Enhanced bioconcentration of Bisphenol A in the presence of nano-TiO2 can lead to adverse reproductive outcomes in zebrafish","volume":"50","author":"Fang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib11","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jhazmat.2014.10.039","article-title":"Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae","volume":"283","author":"Fang","year":"2015","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.chemosphere.2020.126536_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.aquatox.2007.07.009","article-title":"Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects","volume":"84","author":"Federici","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tiv.2019.03.024","article-title":"Cytotoxic activity of pentachlorophenol and its active metabolites in SH-SY5Y neuroblastoma cells","volume":"58","author":"Fraser","year":"2019","journal-title":"Toxicol. In. Vitro"},{"key":"10.1016\/j.chemosphere.2020.126536_bib14","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.chemosphere.2007.10.018","article-title":"Levels and spatial distribution of chlorophenols-2,4-Dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol in surface water of China","volume":"71","author":"Gao","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.126536_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1098-1136(19990201)25:3<247::AID-GLIA5>3.0.CO;2-2","article-title":"Cerebellar astrocytes treated by thyroid hormone modulate neuronal proliferation","volume":"25","author":"Gomes","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.chemosphere.2020.126536_bib16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.aquatox.2013.08.005","article-title":"Thyroid endocrine system disruption by pentachlorophenol: an in\u00a0vitro and in\u00a0vivo assay","volume":"142\u2013143","author":"Guo","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.chemosphere.2015.12.080","article-title":"Waterborne exposure to Bisphenol F causes thyroid endocrine disruption in zebrafish larvae","volume":"147","author":"Huang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.126536_bib55","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Jason","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2020.126536_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.taap.2012.04.029","article-title":"Use of TSH beta:EGFP transgenic zebrafish as a rapid in\u00a0vivo model for assessing thyroid-disrupting chemicals","volume":"262","author":"Ji","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12020-008-9086-6","article-title":"Developmental exposure to pentachlorophenol affects the expression of thyroid hormone receptor \u03b21 and synapsin I in brain, resulting in thyroid function vulnerability in rats","volume":"33","author":"Kawaguchi","year":"2008","journal-title":"Endocrine"},{"key":"10.1016\/j.chemosphere.2020.126536_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/B978-0-12-381320-6.00022-9","article-title":"Using the zebrafish photomotor response for psychotropic drug screening","volume":"105","author":"Kokel","year":"2011","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib21","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.envint.2009.07.006","article-title":"Bioaccumulation and biotransformation of brominated and chlorinated contaminants and their metabolites in ringed seals (Pusa hispida) and polar bears (Ursus maritimus) from East Greenland","volume":"35","author":"Letcher","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2020.126536_bib22","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/etc.1858","article-title":"Phototoxicity of TiO2 nanoparticles under solar radiation to two aquatic species: Daphnia magna and Japanese medaka","volume":"31","author":"Ma","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2020.126536_bib23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.bcp.2009.11.006","article-title":"Endocrine disruptors and thyroid hormone physiology","volume":"79","author":"Mary-Line","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2014.09.009","article-title":"Transcriptional changes induced by in\u00a0vivo exposure to pentachlorophenol (PCP) in Chironomus riparius (Diptera) aquatic larvae","volume":"157","author":"Morales","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib25","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1021\/es7029637","article-title":"Exposure modeling of engineered nanoparticles in the environment","volume":"42","author":"Mueller","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0048-9697(99)00281-8","article-title":"PCP in the freshwater and marine environment of the European Union","volume":"236","author":"Muir","year":"1999","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2020.126536_bib27","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.scitotenv.2018.04.180","article-title":"Environmental mixtures of nanomaterials and chemicals: the Trojan-horse phenomenon and its relevance for ecotoxicity","volume":"635","author":"Naasz","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2020.126536_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/bs.vh.2017.05.005","article-title":"Thyroid hormone in the CNS: contribution of neuron-glia interaction","volume":"106","author":"Noda","year":"2018","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.chemosphere.2020.126536_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1383-5718(99)00222-3","article-title":"Detection of micronuclei in haemocytes of zebra mussel and great ramshorn snail exposed to pentachlorophenol","volume":"465","author":"Pavlica","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.chemosphere.2020.126536_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ecoenv.2017.12.059","article-title":"Developmental neurotoxicity of Microcystis aeruginosa in the early life stages of zebrafish","volume":"151","author":"Qian","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2020.126536_bib32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/17435390.2015.1084058","article-title":"Effects of nano-TiO2 on perfluorooctanesulfonate bioaccumulation in fishes living in different water layers: implications for enhanced risk of perfluorooctanesulfonate","volume":"10","author":"Qiang","year":"2015","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.chemosphere.2020.126536_bib33","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.envpol.2017.10.101","article-title":"Enhanced bio-concentration of tris(1,3-dichloro-2-propyl) phosphate in the presence of nano-TiO2 can lead to adverse reproductive outcomes in zebrafish","volume":"233","author":"Ren","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2020.126536_bib36","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1289\/ehp.0901015","article-title":"Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age","volume":"117","author":"Roze","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.126536_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ymeth.2007.09.006","article-title":"Real-time PCR quantification of precursor and mature microRNA","volume":"44","author":"Schmittgen","year":"2008","journal-title":"Methods"},{"key":"10.1016\/j.chemosphere.2020.126536_bib38","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1080\/10934520903263231","article-title":"Aggregation and toxicity of titanium dioxide nanoparticles in aquatic environment-a review","volume":"44","author":"Sharma","year":"2009","journal-title":"J.\u00a0Environ. Sci. Heal A."},{"key":"10.1016\/j.chemosphere.2020.126536_bib39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/geno.1998.5468","article-title":"Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique","volume":"53","author":"Tine","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.chemosphere.2020.126536_bib40","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.128.7.1175","article-title":"GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration","volume":"128","author":"Udvadia","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2020.126536_bib41","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1210\/en.2008-0457","article-title":"Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish","volume":"150","author":"Walpita","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2020.126536_bib42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/17435390.2013.875232","article-title":"Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae","volume":"8","author":"Wang","year":"2014","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.chemosphere.2020.126536_bib43","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1021\/acs.est.5b00558","article-title":"Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib44","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.envpol.2017.08.038","article-title":"Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring","volume":"231","author":"Wu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2020.126536_bib45","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1021\/acs.est.9b00218","article-title":"Emerging polar phenolic disinfection byproducts are high-affinity human transthyretin disruptors: an in\u00a0vitro and in silico study","volume":"53","author":"Yang","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib54","article-title":"The endocrine-disrupting potential of four chlorophenols by in\u00a0vitro and in silico assay","author":"Yu","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.126536_bib46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/etc.2408","article-title":"Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish","volume":"33","author":"Yu","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2020.126536_bib47","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s001289910003","article-title":"Analysis of pentachlorophenol from water, sediments, and fish bile of Dongting Lake in China","volume":"64","author":"Zheng","year":"2000","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib48","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1021\/es1043563","article-title":"Global trends and diversity in pentachlorophenol levels in the environment and in humans: a meta-analysis","volume":"45","author":"Zheng","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.126536_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.envint.2011.04.014","article-title":"Systematic review of pentachlorophenol occurrence in the environment and in humans in China: not a negligible health risk due to the re-emergence of schistosomiasis","volume":"42","author":"Zheng","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2020.126536_bib51","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.chemosphere.2018.01.080","article-title":"Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae","volume":"197","author":"Zhu","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.126536_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10408440601123446","article-title":"General background on the hypothalamic-pituitary-thyroid (HPT) axis","volume":"37","author":"Zoeller","year":"2007","journal-title":"Crit. Rev. Toxicol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520307293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520307293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:14:31Z","timestamp":1758626071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520307293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":51,"alternative-id":["S0045653520307293"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126536","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Titanium dioxide nanoparticles enhanced thyroid endocrine disruption of pentachlorophenol rather than neurobehavioral defects in zebrafish larvae","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126536"}}