{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:16:13Z","timestamp":1788232573077,"version":"build-2803163510"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":613,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.chemosphere.2020.126947","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T05:54:32Z","timestamp":1588226072000},"page":"126947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["First evidence of transcriptional modulation by chlorothalonil in mussels Perna perna"],"prefix":"10.1016","volume":"255","author":[{"given":"Amanda da Silveira","family":"Guerreiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhonatas Sirino","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Dias","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Zomer","family":"Sandrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2020.126947_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2017.12.004","article-title":"Induction of oxidative stress by chlorothalonil in the estuarine polychaete Laeonereis acuta","volume":"196","author":"Barreto","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.marpolbul.2013.06.004","article-title":"Factors contributing to heavy metal accumulation in sediments and in the intertidal mussel Perna perna in the Gulf of Annaba (Algeria)","volume":"74","author":"Belabed","year":"2013","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2020.126947_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.scitotenv.2006.01.028","article-title":"Comparative toxicity of alternative antifouling biocides on embryos and larvae of marine invertebrates","volume":"367","author":"Bellas","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2020.126947_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.gene.2003.12.027","article-title":"Response of the Pacific oyster Crassostrea gigas to hydrocarbon contamination under experimental conditions","volume":"329","author":"Boutet","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.chemosphere.2020.126947_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0378-1119(01)00724-7","article-title":"An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8- tetrachlorodibenzo-p-dioxin and b-naphthoflavone binding","volume":"278","author":"Butler","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.chemosphere.2020.126947_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cbpb.2016.02.006","article-title":"Molecular evidence for the existence of an aryl hydrocarbon receptor pathway in scallops Chlamys farreri","volume":"196\u2013197","author":"Cai","year":"2016","journal-title":"Comp Biochem Physiol B"},{"key":"10.1016\/j.chemosphere.2020.126947_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2007.06.002","article-title":"Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas","volume":"276","author":"Canesi","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.aquatox.2007.11.010","article-title":"Toxic effects of new antifouling compounds on tunicate haemocytes I. Sea-Nine 211\u2122 and chlorothalonil","volume":"86","author":"Cima","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib9","series-title":"Ecology of Marine Bivalves: an Ecosystem Approach","first-page":"254p","author":"Dame","year":"1996"},{"key":"10.1016\/j.chemosphere.2020.126947_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0166-445X(85)90045-1","article-title":"The toxicology and metabolism of chlorothalonil in fish. III. Metabolism, enzymatics and detoxification in Salmo spp. and Galaxias spp","volume":"7","author":"Davies","year":"1985","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.marenvres.2013.06.005","article-title":"Differential ABCB and ABCC gene expression and efflux activities in gills and hemocytes of Mytilus galloprovincialis and their involvement in cadmium response","volume":"93","author":"Della-Torre","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2020.126947_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01055550","article-title":"The toxicity of chlorothalonil to aquatic fauna and the impact of its operational use on a pond ecosystem","volume":"21","author":"Ernst","year":"1991","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.scitotenv.2016.09.055","article-title":"Multi-tool assessment of trace metals in mangroves combining sediment and clam sampling, DGT passive samplers and caged mussels","volume":"574","author":"Estrada","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2020.126947_bib14","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s10646-012-0938-8","article-title":"Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure","volume":"21","author":"Fang","year":"2012","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2020.126947_bib15","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.scitotenv.2010.02.047","article-title":"Comparative toxicity of single and combined mixtures of selected pollutants among larval stages of the native freshwater mussels (Unio elongatulus) and the invasive zebra mussel (Dreissena polymorpha)","volume":"408","author":"Faria","year":"2010","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.chemosphere.2020.126947_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0006-2952(91)90692-X","article-title":"Glutathione S-transferase-mediated chlorothalonil metabolism in liver and gill subcellular fractions of channel catfish","volume":"42","author":"Gallagher","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib17","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1046\/j.1432-1033.2002.03254.x","article-title":"Characterization of an omega- class glutathione S-transferase from Schistosoma mansoni with glutaredoxin-like dehydroascorbate reductase and thiol transferase activities","volume":"269","author":"Girardini","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.chemosphere.2020.126947_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00398031","article-title":"The mussel watch concept","volume":"7","author":"Goldberg","year":"1986","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.chemosphere.2020.126947_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0048-9697(99)00488-X","article-title":"Beyond the Mussel Watch - new directions for monitoring marine pollution","volume":"247","author":"Goldberg","year":"2000","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2020.126947_bib20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.aquatox.2017.06.012","article-title":"Antifouling biocides: impairment of bivalve immune system by chlorothalonil","volume":"189","author":"Guerreiro","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib21","doi-asserted-by":"crossref","first-page":"110119","DOI":"10.1016\/j.ecoenv.2019.110119","article-title":"Effects of chlorothalonil on the antioxidant defense system of mussels Perna perna","volume":"190","author":"Guerreiro","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2020.126947_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0009-2797(02)00070-4","article-title":"Aryl hydrocarbon receptors: diversity and evolution","volume":"141","author":"Hahn","year":"2002","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.chemosphere.2020.126947_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214236","article-title":"Chlorothalonil induces oxidative stress and reduces enzymatic activities of Na+\/K+-ATPase and acetylcholinesterase in gill tissues of marine bivalves","volume":"14","author":"Haque","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.chemosphere.2020.126947_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione transferases","volume":"45","author":"Hayes","year":"2005","journal-title":"Annu.\u00a0Rev.\u00a0Pharmacol. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ecoenv.2018.11.021","article-title":"Xenobiotic biotransformation, oxidative stress and obesogenic molecular biomarker responses in Tilapia guineensis from Eleyele Lake, Nigeria","volume":"169","author":"Ibor","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"36","key":"10.1016\/j.chemosphere.2020.126947_bib26","doi-asserted-by":"crossref","first-page":"22934","DOI":"10.1074\/jbc.272.36.22934","article-title":"Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities","volume":"272","author":"Jakobsson","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2020.126947_bib27","first-page":"358","article-title":"Molecular cloning, phylogenetic analysis and expression of a MAPEG superfamily gene from the pufferfish Takifugu obscurus","volume":"149","author":"Kim","year":"2009","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.chemosphere.2020.126947_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1042\/BJ20041578","article-title":"A\u00a0new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major","volume":"388","author":"Konishi","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.chemosphere.2020.126947_bib29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00128-010-0145-3","article-title":"Study on the new antifouling compounds in Korean coasts","volume":"85","author":"Lee","year":"2010","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib30","first-page":"279","article-title":"Molecular cloning and sequence analysis and the response of a aryl hydrocarbon receptor homologue gene in the clam Ruditapes philippinarum exposed to benzo(a)pyrene","volume":"152","author":"Liu","year":"2010","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.chemosphere.2020.126947_bib31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.chemosphere.2020.126947_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1095-6433(98)10008-9","article-title":"The fate of organic xenobiotics in aquatic ecosystems: quantitative and qualitative differences in biotransformation by invertebrates and fish","volume":"120","author":"Livingstone","year":"1998","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.chemosphere.2020.126947_bib33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0025-326X(01)00060-1","article-title":"Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms","volume":"42","author":"Livingstone","year":"2001","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2020.126947_bib34","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.aquatox.2011.09.003","article-title":"Biochemical biomarkers and hydrocarbons concentrations in the mangrove oyster Crassostrea brasiliana following exposure to diesel fuel water-accommodated fraction","volume":"105","author":"L\u00fcchmann","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib35","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.aquatox.2014.04.021","article-title":"A\u00a0light in the darkness: new biotransformation genes, antioxidant parameters and tissue-specific responses in oysters exposed to phenanthrene","volume":"152","author":"L\u00fcchmann","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib36","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1471-2164-12-234","article-title":"Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring","volume":"12","author":"Milan","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.chemosphere.2020.126947_bib37","series-title":"An\u00e1lise do transcritoma do mexilh\u00e3o marrom (Perna perna) sob contamina\u00e7\u00e3o por antraceno. Disserta\u00e7\u00e3o (mestrado)","author":"Monteiro","year":"2017"},{"issue":"12","key":"10.1016\/j.chemosphere.2020.126947_bib38","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2020.126947_bib39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.chemosphere.2015.04.034","article-title":"Biochemical responses in mussels Perna perna exposed to diesel B5","volume":"134","author":"Nogueira","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.126947_bib40","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.sbi.2005.10.005","article-title":"Glutathione transferases: new functions","volume":"15","author":"Oakley","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib41","series-title":"Bioindicators and Biomo- Nitors","first-page":"577","article-title":"Molluscs as bioindicators, article","author":"Oehlmann","year":"2003"},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2020.126947_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mrrev.2007.11.006","article-title":"Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults","volume":"659","author":"Osburn","year":"2008","journal-title":"Mutat. Res-Rev. Mutat."},{"key":"10.1016\/j.chemosphere.2020.126947_bib43","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s10646-011-0709-y","article-title":"Effects of pesticide compounds (chlorothalonil and mancozeb) and benzo[a]pyrene mixture on aryl hydrocarbon receptor, p53 and ubiquitin gene expression levels in haemocytes of soft-shell clams (Mya arenaria)","volume":"20","author":"Pariseau","year":"2011","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2020.126947_bib44","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.fsi.2009.07.008","article-title":"Molecular cloning, characterization, and the response of manganese superoxide dismutase from the Antarctic bivalve Laternula elliptica to PCB exposure","volume":"27","author":"Park","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib45","first-page":"528","article-title":"Glutathione S-transferase as a biomarker in the Antarctic bivalve Laternula elliptica after exposure to the polychlorinated biphenyl mixture Aroclor 1254","volume":"150","author":"Park","year":"2009","journal-title":"Comp. Biochem. Physiol., C"},{"issue":"12","key":"10.1016\/j.chemosphere.2020.126947_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168978","article-title":"Effects of antifouling biocides on molecular and biochemical defense system in the gill of the pacific oyster Crassostrea gigas","volume":"11","author":"Park","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.chemosphere.2020.126947_bib47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.aquatox.2018.08.018","article-title":"Adverse effects of two pharmaceuticals acetaminophen and oxytetracycline on life cycle parameters, oxidative stress, and defensome system in the marine rotifer Brachionus rotundiformis","volume":"204","author":"Park","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib48","series-title":"Casarett & Doull\u2019s Essentials of Toxicology","first-page":"133","article-title":"Biotransformation of xenobiotics, article","volume":"vol. 2e","author":"Parkinson","year":"2001"},{"key":"10.1016\/j.chemosphere.2020.126947_bib49","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ecoenv.2016.04.003","article-title":"Upregulation of biotransformation genes in gills of oyster Crassostrea brasiliana exposed in situ to urban effluents, Florian\u00f3polis Bay, Southern Brazil","volume":"131","author":"Pessatti","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2020.126947_bib50","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.aquatox.2016.05.025","article-title":"Exposure to phenanthrene and depuration: changes on gene transcription, enzymatic activity and lipid peroxidation in gill of scallops Nodipecten nodosus","volume":"177","author":"Piazza","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.marenvres.2013.07.006","article-title":"Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms","volume":"93","author":"Regoli","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2020.126947_bib52","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aquatox.2011.06.014","article-title":"Molecular and biochemical biomarkers in environmental monitoring: a comparison of biotransformation and antioxidant defense systems in multiple tissues","volume":"105S","author":"Regoli","year":"2011","journal-title":"Aquat. Toxicol."},{"issue":"5","key":"10.1016\/j.chemosphere.2020.126947_bib53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02987576","article-title":"Survey for the occurrence of antifouling paint booster biocides in the aquatic environment of Greece","volume":"9","author":"Sakkas","year":"2002","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.chemosphere.2020.126947_bib54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1515\/aep-2017-0010","article-title":"Effects of three pesticides on superoxide dismutase and glutathione-S-transferase activities and reproduction of Daphnia magna","volume":"43","author":"Song","year":"2017","journal-title":"Arch. Environ. Protect."},{"key":"10.1016\/j.chemosphere.2020.126947_bib55","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ecoenv.2016.10.014","article-title":"Effects of the herbicide Roundup on the polychaeta Laeonereis acuta: cholinesterases and oxidative stress","volume":"135","author":"Tarouco","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2020.126947_bib56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.aquatox.2013.09.031","article-title":"An investigation of endocrine disrupting effects and toxic mechanisms modulated by benzo[a]pyrene in female scallop Chlamys farreri","volume":"144\u2013145","author":"Tian","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib57","first-page":"22","article-title":"Zinc causes acute impairment of glutathione metabolism followed by coordinated antioxidant defenses amplification in gills of brown mussels Perna perna","volume":"159","author":"Trevisan","year":"2014","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.chemosphere.2020.126947_bib58","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aquatox.2016.01.008","article-title":"Gills as a glutathione-dependent metabolic barrier in Pacific oysters Crassostrea gigas: absorption, metabolism and excretion of a model electrophile","volume":"173","author":"Trevisan","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib59","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","article-title":"Fish bioaccumulation and biomarkers in environmental risk assessment: a review","volume":"13","author":"van der Oost","year":"2003","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0044-8486(91)90120-V","article-title":"Mussels as biological indicators of pollution","volume":"94","author":"Viarengo","year":"1991","journal-title":"Aquaculture"},{"key":"10.1016\/j.chemosphere.2020.126947_bib61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/(SICI)1099-0739(199903)13:3<135::AID-AOC831>3.0.CO;2-G","article-title":"Alternative antifouling biocides","volume":"13","author":"Voulvoulis","year":"1999","journal-title":"Appl. Organomet. Chem."},{"issue":"11","key":"10.1016\/j.chemosphere.2020.126947_bib62","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0025-326X(00)00034-5","article-title":"Occurrence of four biocides utilized in antifouling paints, as alternatives to organotin compounds, in waters and sediments of a commercial estuary in the UK","volume":"40","author":"Voulvoulis","year":"2000","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2020.126947_bib63","first-page":"558","article-title":"Novel omega glutathione S-transferases in disk abalone: characterization and protective roles against environmental stress","volume":"150","author":"Wan","year":"2009","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.chemosphere.2020.126947_bib64","first-page":"325","article-title":"The role of Nrf2-Keap1 signaling pathway in the antioxidant defense response induced by PAHs in the calm Ruditapes philippinarum","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib65","first-page":"82","article-title":"Response of glutathione S-transferase (GST) genes to cadmium exposure in the marine pollution indicator worm","volume":"154","author":"Won","year":"2011","journal-title":"Perinereis nuntia. Comp. Biochem. Physiol. Part C"},{"key":"10.1016\/j.chemosphere.2020.126947_bib66","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.aquatox.2016.12.016","article-title":"Transcriptional changes in oysters Crassostrea brasiliana exposed to phenanthrene at different salinities","volume":"183","author":"Zacchi","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.126947_bib67","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.marenvres.2009.10.013","article-title":"Identification of CYP genes in Mytilus (mussel) and Crassostrea (oyster) species: first approach to the full complement of cytochrome P450 genes in bivalves","volume":"69","author":"Zanette","year":"2010","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.chemosphere.2020.126947_bib68","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.aquatox.2012.11.017","article-title":"Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis","volume":"128\u2013 129","author":"Zanette","year":"2013","journal-title":"Aquat. Toxicol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520311401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520311401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:13:46Z","timestamp":1758626026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520311401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":68,"alternative-id":["S0045653520311401"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126947","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First evidence of transcriptional modulation by chlorothalonil in mussels Perna perna","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126947","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"126947"}}