{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:24:27Z","timestamp":1787955867039,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013140","name":"Jiangsu National Synergistic Innovation Center for Advanced Materials","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013140","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.chemosphere.2020.127177","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T23:30:36Z","timestamp":1590363036000},"page":"127177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Gender-differentiated metabolic abnormalities of adult zebrafish with zinc pyrithione (ZPT) -induced hepatotoxicity"],"prefix":"10.1016","volume":"257","author":[{"given":"Ye","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanrong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunbao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chimeng","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2020.127177_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1467-2494.2003.00183.x","article-title":"A\u00a0double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity","volume":"25","author":"Bailey","year":"2003","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.chemosphere.2020.127177_bib2","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1021\/ic50174a002","article-title":"Structural characterization of bis (N-oxopyridine-2-thionato) zinc (II)","volume":"16","author":"Barnett","year":"1977","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.chemosphere.2020.127177_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.chroma.2006.07.068","article-title":"Improved method for the determination of zinc pyrithione in environmental water samples incorporating on-line extraction and preconcentration coupled with liquid chromatography atmospheric pressure chemical ionisation mass spectrometry","volume":"1132","author":"Bones","year":"2006","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2020.127177_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/ics.12501","article-title":"Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo","volume":"40","author":"Collins","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.chemosphere.2020.127177_bib5","series-title":"Analysis, Fate and Toxicity of Zinc-And Copper Pyrithione in the Marine Environment","author":"Dahll\u00f6f","year":"2005"},{"key":"10.1016\/j.chemosphere.2020.127177_bib6","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/sj.ejcn.1601479","article-title":"Zinc and immune function","volume":"56","author":"Dardenne","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.chemosphere.2020.127177_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10661-007-0041-4","article-title":"Monitoring pollution in Esmoriz-Paramos lagoon, Portugal: liver histological and biochemical effects in Liza saliens","volume":"145","author":"Fernandes","year":"2008","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.chemosphere.2020.127177_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"CMAJ (Can. Med. Assoc. J.) : Canadian Medical Association journal\u00a0= journal de l\u2019Association medicale canadienne"},{"key":"10.1016\/j.chemosphere.2020.127177_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ajic.2004.07.012","article-title":"Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects","volume":"33","author":"Guthery","year":"2005","journal-title":"Am. J. Infect. Contr."},{"key":"10.1016\/j.chemosphere.2020.127177_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.etap.2013.12.017","article-title":"Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): association with P-glycoprotein expression and location within tissues","volume":"37","author":"Hu","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.127177_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/tox.20403","article-title":"Difference in the sensitivity to chemical compounds between female and male neonates of Daphnia magna","volume":"23","author":"Ikuno","year":"2008","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.127177_bib12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.chemosphere.2019.03.140","article-title":"The effects of hexaconazole and epoxiconazole enantiomers on metabolic profile following exposure to zebrafish (Danio rerio) as well as the histopathological changes","volume":"226","author":"Jia","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.127177_bib13","doi-asserted-by":"crossref","first-page":"44327","DOI":"10.1074\/jbc.M205634200","article-title":"Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen","volume":"277","author":"Korichneva","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2020.127177_bib14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/JVI.01543-08","article-title":"Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections","volume":"83","author":"Krenn","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chemosphere.2020.127177_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s12885-019-5453-3","article-title":"Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?","volume":"19","author":"Lai","year":"2019","journal-title":"BMC Canc."},{"key":"10.1016\/j.chemosphere.2020.127177_bib16","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10534-011-9441-6","article-title":"Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis","volume":"24","author":"Lamore","year":"2011","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"key":"10.1016\/j.chemosphere.2020.127177_bib17","doi-asserted-by":"crossref","first-page":"122056","DOI":"10.1016\/j.jhazmat.2020.122056","article-title":"Targeted toxicometabolomics of endosulfan sulfate in adult zebrafish (Danio rerio) using GC-MS\/MS in multiple reaction monitoring mode","volume":"389","author":"Lee","year":"2020","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.chemosphere.2020.127177_bib18","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2020.127177_bib19","article-title":"Metabolomic characterizations of liver injury caused by acute arsenic toxicity in zebrafish","volume":"11","author":"Li","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.chemosphere.2020.127177_bib20","doi-asserted-by":"crossref","first-page":"41280","DOI":"10.1038\/srep41280","article-title":"Males develop faster and more severe hepatocellular carcinoma than females in kras(V12) transgenic zebrafish","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2020.127177_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2019.02.014","article-title":"Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats","volume":"418","author":"Luo","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2020.127177_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2019.02.014","article-title":"Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats","volume":"418","author":"Luo","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2020.127177_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10495-005-0811-9","article-title":"Zinc pyrithione induces apoptosis and increases expression of Bim","volume":"10","author":"Mann","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.chemosphere.2020.127177_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquatox.2010.12.015","article-title":"Novel antifouling agent-zinc pyrithione: stress induction and genotoxicity to the marine mussel Mytilus galloprovincialis","volume":"102","author":"Marcheselli","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.127177_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.chemosphere.2017.08.149","article-title":"Assessing biological effects of fluoxetine in developing zebrafish embryos using gas chromatography-mass spectrometry based metabolomics","volume":"188","author":"Mishra","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.127177_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ecoenv.2018.06.026","article-title":"Apoptosis in HepG2 cells induced by zinc pyrithione via mitochondrial dysfunction pathway: involvement of zinc accumulation and oxidative stress","volume":"161","author":"Mo","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2020.127177_bib27","doi-asserted-by":"crossref","first-page":"13551","DOI":"10.1007\/s11356-019-04810-1","article-title":"Study of the effects of zinc pyrithione in biochemical parameters of the Polychaeta Hediste diversicolor: evidences of neurotoxicity at ecologically relevant concentrations","volume":"26","author":"Nunes","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2020.127177_bib28","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1007\/s10646-015-1525-6","article-title":"Ecotoxicological effect of zinc pyrithione in the freshwater fish Gambusia holbrooki","volume":"24","author":"Nunes","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2020.127177_bib29","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1007\/s10646-015-1525-6","article-title":"Ecotoxicological effect of zinc pyrithione in the freshwater fish Gambusia holbrooki","volume":"24","author":"Nunes","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2020.127177_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1042\/bj1060699","article-title":"The \u2019neurotoxicity\u2019 of L-2,4-diaminobutyric acid","volume":"106","author":"O\u2019Neal","year":"1968","journal-title":"Biochem. J."},{"key":"10.1016\/j.chemosphere.2020.127177_bib31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000066452","article-title":"A\u00a0multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis","volume":"15","author":"Pierard-Franchimont","year":"2002","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"10.1016\/j.chemosphere.2020.127177_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10695-016-0262-y","article-title":"Toxicity and accumulation of zinc pyrithione in the liver and kidneys of Carassius auratus gibelio: association with P-glycoprotein expression","volume":"43","author":"Ren","year":"2017","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.chemosphere.2020.127177_bib33","article-title":"The zinc-metallothionein redox system reduces oxidative stress in","volume":"10","author":"Rodr\u00edguez-Men\u00e9ndez","year":"2018","journal-title":"Retinal Pigment Epithelial Cells"},{"key":"10.1016\/j.chemosphere.2020.127177_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10534-010-9302-8","article-title":"Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes","volume":"23","author":"Rudolf","year":"2010","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.chemosphere.2020.127177_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2133.2011.10573.x","article-title":"New insights on dandruff\/seborrhoeic dermatitis: the role of the scalp follicular infundibulum in effective treatment strategies","volume":"165","author":"Schwartz","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.chemosphere.2020.127177_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1566524043479211","article-title":"Rethinking the excitotoxic ionic milieu: the emerging role of Zn 2+ in ischemic neuronal injury","volume":"4","author":"Sensi","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.chemosphere.2020.127177_bib37","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1073\/pnas.1031598100","article-title":"Modulation of mitochondrial function by endogenous Zn2+ pools","volume":"100","author":"Sensi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.chemosphere.2020.127177_bib38","doi-asserted-by":"crossref","first-page":"D768","DOI":"10.1093\/nar\/gkm956","article-title":"The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes","volume":"36","author":"Sprague","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chemosphere.2020.127177_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1872-034X.2009.00611.x","article-title":"Sex difference in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"40","author":"Tomiya","year":"2010","journal-title":"Hepatol. Res. : the official journal of the Japan Society of Hepatology"},{"key":"10.1016\/j.chemosphere.2020.127177_bib40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/08927010500044351","article-title":"Pyrithiones as antifoulants: environmental fate and loss of toxicity","volume":"21","author":"Turley","year":"2005","journal-title":"Biofouling"},{"key":"10.1016\/j.chemosphere.2020.127177_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.porgcoat.2003.06.001","article-title":"Antifouling technology\u2014past, present and future steps towards efficient and environmentally friendly antifouling coatings","volume":"50","author":"Yebra","year":"2004","journal-title":"Prog. Org. Coating"},{"key":"10.1016\/j.chemosphere.2020.127177_bib42","article-title":"Estrogenic activity of zinc pyrithione: an in\u00a0vivo and in\u00a0vitro study","volume":"32","author":"Yoon","year":"2017"},{"key":"10.1016\/j.chemosphere.2020.127177_bib43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.chemosphere.2018.04.010","article-title":"Acute toxic responses of embryo-larval zebrafish to zinc pyrithione (ZPT) reveal embryological and developmental toxicity","volume":"205","author":"Zhao","year":"2018","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520313709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520313709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:16:39Z","timestamp":1758626199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520313709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":43,"alternative-id":["S0045653520313709"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127177","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gender-differentiated metabolic abnormalities of adult zebrafish with zinc pyrithione (ZPT) -induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127177","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127177"}}