{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:23:52Z","timestamp":1768559032542,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.chemosphere.2020.127278","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T17:29:25Z","timestamp":1591205365000},"page":"127278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Has the formation of disinfection by-products been overestimated? Membrane leakage from syringe filter heads serves as unexpected precursors"],"prefix":"10.1016","volume":"258","author":[{"given":"Tian","family":"Ou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunke","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaogang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhai","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.chemosphere.2020.127278_bib1","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1021\/es0496468","article-title":"Size exclusion chromatography to characterize DOC removal in drinking water treatment","volume":"39","author":"Allpike","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.127278_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.seppur.2013.01.013","article-title":"Hybrid ozonation-ceramic membrane filtration of surface waters: the effect of water characteristics on permeate flux and the removal of DBP precursors, dicloxacillin and ceftazidime","volume":"107","author":"Alpatova","year":"2013","journal-title":"Separ. Purif. Technol."},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2020.127278_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.memsci.2008.11.044","article-title":"Removal of disinfection by-product precursors by UF and NF membranes in low-SUVA waters","volume":"328","author":"Ates","year":"2009","journal-title":"J.\u00a0Membr. Sci."},{"issue":"15","key":"10.1016\/j.chemosphere.2020.127278_bib4","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1016\/j.watres.2011.05.034","article-title":"Occurrence and control of nitrogenous disinfection by-products in drinking water \u2013 a review","volume":"45","author":"Bond","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2020.127278_bib5","doi-asserted-by":"crossref","first-page":"125321","DOI":"10.1016\/j.chemosphere.2019.125321","article-title":"Characterizing property and treatability of dissolved effluent organic matter using size exclusion chromatography with an array of absorbance, fluorescence, organic nitrogen and organic carbon detectors","volume":"243","author":"Cai","year":"2020","journal-title":"Chemosphere"},{"issue":"15","key":"10.1016\/j.chemosphere.2020.127278_bib6","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1021\/es0205582","article-title":"Hydrogen abstraction and decomposition of bromopicrin and other trihalogenated disinfection byproducts by GC\/MS","volume":"36","author":"Chen","year":"2002","journal-title":"Environ. Sci. Technol."},{"issue":"24","key":"10.1016\/j.chemosphere.2020.127278_bib7","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1021\/es034354c","article-title":"Fluorescence excitation - emission matrix regional integration to quantify spectra for dissolved organic matter","volume":"37","author":"Chen","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.127278_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jhazmat.2016.12.058","article-title":"Production of trihalornethanes, haloacetaldehydes and haloacetonitriles during chlorination of microcystin-LR and impacts of pre-oxidation on their formation","volume":"327","author":"Chu","year":"2017","journal-title":"J.\u00a0Hazard Mater."},{"issue":"11","key":"10.1016\/j.chemosphere.2020.127278_bib9","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/es00069a014","article-title":"Destruction of chlorination byproducts with sulfite","volume":"23","author":"Croue","year":"1989","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.chemosphere.2020.127278_bib10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.watres.2007.07.049","article-title":"Removal of natural organic matter and THM formation potential by ultra- and nanofiltration of surface water","volume":"42","author":"de la Rubia","year":"2008","journal-title":"Water Res."},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2020.127278_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.watres.2007.07.025","article-title":"Reactions of chlorine with inorganic and organic compounds during water treatment - kinetics and mechanisms: a critical review","volume":"42","author":"Deborde","year":"2008","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2020.127278_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.teac.2017.04.001","article-title":"Recent advances in the analysis of nitrogenous disinfection by-products","author":"Ding","year":"2017","journal-title":"Trends Environ. Anal. Chem."},{"key":"10.1016\/j.chemosphere.2020.127278_bib13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.cej.2018.06.002","article-title":"Contribution of amide-based coagulant polyacrylamide as precursors of haloacetamides and other disinfection by-products","volume":"350","author":"Ding","year":"2018","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.chemosphere.2020.127278_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.watres.2019.05.024","article-title":"Disinfection byproduct formation during drinking water treatment and distribution: a review of unintended effects of engineering agents and materials","volume":"160","author":"Ding","year":"2019","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.chemosphere.2020.127278_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/acs.estlett.5b00015","article-title":"N-nitrosodimethylamine (NDMA) precursors leach from nanofiltration membranes","volume":"2","author":"Ersan","year":"2015","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.chemosphere.2020.127278_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.watres.2016.08.065","article-title":"The control of N-nitrosodimethylamine, halonitromethane, and trihalomethane precursors by nanofiltration","volume":"105","author":"Ersan","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2020.127278_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cej.2019.01.143","article-title":"Formation of CX3R-type disinfection by-products during the chlorination of protein: the effect of enzymolysis","volume":"363","author":"Fang","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"5","key":"10.1016\/j.chemosphere.2020.127278_bib18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2166\/aqua.2013.017","article-title":"Disinfection by-product occurrence in selected European waters","volume":"63","author":"Goslan","year":"2013","journal-title":"J.\u00a0Water Supply Res. Technol. - Aqua"},{"issue":"2","key":"10.1016\/j.chemosphere.2020.127278_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.watres.2010.09.023","article-title":"Characterisation of aquatic humic and non-humic matter with size-exclusion chromatography - organic carbon detection - organic nitrogen detection (LC-OCD-OND)","volume":"45","author":"Huber","year":"2011","journal-title":"Water Res."},{"issue":"23","key":"10.1016\/j.chemosphere.2020.127278_bib20","doi-asserted-by":"crossref","first-page":"13749","DOI":"10.1021\/es506358x","article-title":"Occurrence and comparative toxicity of haloacetaldehyde disinfection byproducts in drinking water","volume":"49","author":"Jeong","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"14","key":"10.1016\/j.chemosphere.2020.127278_bib21","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1016\/j.watres.2007.04.025","article-title":"Influence of dissolved organic matter on estrone removal by NF membranes and the role of their structures","volume":"41","author":"Jin","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2020.127278_bib22","series-title":"Drinking Water: Occurrence, Formation, Health Effects, and Control","first-page":"2","article-title":"Disinfection by-products","author":"Karanfil","year":"2008"},{"issue":"6","key":"10.1016\/j.chemosphere.2020.127278_bib23","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.chemosphere.2008.03.062","article-title":"Formation of halogenated acetaldehydes, and occurrence in Canadian drinking water","volume":"72","author":"Koudjonou","year":"2008","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.chemosphere.2020.127278_bib24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.chemosphere.2005.10.063","article-title":"Halogenated acetaldehydes: analysis, stability and fate in drinking water","volume":"64","author":"Koudjonou","year":"2006","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.chemosphere.2020.127278_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/j.1551-8833.1989.tb03258.x","article-title":"The occurrence of disinfection by-products in US drinking water","volume":"81","author":"Krasner","year":"1989","journal-title":"Journal - AWWA"},{"issue":"23","key":"10.1016\/j.chemosphere.2020.127278_bib26","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/es060353j","article-title":"Occurrence of a new generation of disinfection byproducts","volume":"40","author":"Krasner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.127278_bib27","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.watres.2014.04.006","article-title":"To add or not to add: the use of quenching agents for the analysis of disinfection by-products in water samples","volume":"59","author":"Kristiana","year":"2014","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.chemosphere.2020.127278_bib28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1021\/es048818y","article-title":"Dissolved organic nitrogen measurement using dialysis pretreatment","volume":"39","author":"Lee","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.127278_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.chemosphere.2016.05.018","article-title":"Toward better understanding of chloral hydrate stability in water: kinetics, pathways, and influencing factors","volume":"157","author":"Ma","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.127278_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.watres.2015.09.003","article-title":"Removal of disinfection by-product precursors by coagulation and an innovative suspended ion exchange process","volume":"87","author":"Metcalfe","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2020.127278_bib31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.watres.2014.02.050","article-title":"Chemical cleaning\/disinfection and ageing of organic UF membranes: a review","volume":"56","author":"Regula","year":"2014","journal-title":"Water Res."},{"issue":"10","key":"10.1016\/j.chemosphere.2020.127278_bib32","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0165-9936(03)01003-3","article-title":"Disinfection by-products and other emerging contaminants in drinking water","volume":"22","author":"Richardson","year":"2003","journal-title":"TrAC Trends Anal. Chem. (Reference Ed.)"},{"key":"10.1016\/j.chemosphere.2020.127278_bib33","series-title":"Encyclopedia of Environmental Health","first-page":"110","author":"Richardson","year":"2011"},{"issue":"1","key":"10.1016\/j.chemosphere.2020.127278_bib34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/acs.analchem.9b05269","article-title":"Water analysis: emerging contaminants and current issues","volume":"92","author":"Richardson","year":"2020","journal-title":"Anal. Chem."},{"issue":"1\u20133","key":"10.1016\/j.chemosphere.2020.127278_bib35","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res."},{"issue":"2","key":"10.1016\/j.chemosphere.2020.127278_bib36","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.watres.2012.11.014","article-title":"The roles of tertiary amine structure, background organic matter and chloramine species on NDMA formation","volume":"47","author":"Selbes","year":"2013","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.chemosphere.2020.127278_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/es203312s","article-title":"Halonitroalkanes, halonitriles, haloamides, and N-nitrosamines: a critical review of nitrogenous disinfection byproduct formation pathways","volume":"46","author":"Shah","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.127278_bib38","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cej.2017.02.071","article-title":"Impact of metal ions, metal oxides, and nanoparticles on the formation of disinfection byproducts during chlorination","volume":"317","author":"Sharma","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.chemosphere.2020.127278_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jwpe.2014.04.003","article-title":"Fouling and cleaning of ultrafiltration membranes: a review","volume":"1","author":"Shi","year":"2014","journal-title":"J.\u00a0Water Process. Eng."},{"issue":"2","key":"10.1016\/j.chemosphere.2020.127278_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2166\/aqua.2020.122","article-title":"Assessment of Cau River water quality assessment using a combination of water quality and pollution indices","volume":"69","author":"Son","year":"2020","journal-title":"J.\u00a0Water Supply Res Technol. Aqua."},{"issue":"1","key":"10.1016\/j.chemosphere.2020.127278_bib40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cis.2010.10.007","article-title":"Colloidal interactions and fouling of NF and RO membranes: a review","volume":"164","author":"Tang","year":"2011","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.chemosphere.2020.127278_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.desal.2012.06.024","article-title":"Fulvic acid removal performance and control of disinfection by-product formation potential in coagulation\u2013ultrafiltration process","volume":"302","author":"Wang","year":"2012","journal-title":"Desalination"},{"key":"10.1016\/j.chemosphere.2020.127278_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scitotenv.2018.05.280","article-title":"Using fluorescence-parallel factor analysis for assessing disinfection by-product formation and natural organic matter removal efficiency in secondary treated synthetic drinking waters","volume":"640","author":"Watson","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2020.127278_bib43","first-page":"167","article-title":"The fluorescence of organic natural products","author":"Wolfbeis","year":"1985","journal-title":"Molecular Luminescence Spectroscopy. Part I: Methods and Applications"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.chemosphere.2020.127278_bib44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1289\/ehp.02110s175","article-title":"Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products","volume":"110","author":"Woo","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.127278_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.memsci.2015.03.058","article-title":"Chlorination of polyvinyl pyrrolidone-polysulfone membranes: organic compound release, byproduct formation, and changes in membrane properties","volume":"489","author":"Xie","year":"2015","journal-title":"J.\u00a0Membr. Sci."},{"issue":"11","key":"10.1016\/j.chemosphere.2020.127278_bib46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/j.1551-8833.2002.tb10235.x","article-title":"Acidic methanol methylation for HAA analysis: limitations and possible solutions","volume":"94","author":"Xie","year":"2002","journal-title":"J.\u00a0Am. Water Works Assoc."},{"issue":"18","key":"10.1016\/j.chemosphere.2020.127278_bib47","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1021\/acs.est.5b02772","article-title":"Kinetic analysis of haloacetonitrile stability in drinking waters","volume":"49","author":"Yu","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.chemosphere.2020.127278_bib48","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1021\/acs.est.6b04218","article-title":"formation and occurrence of N-Chloro-2,2-dichloroacetamide, a previously overlooked nitrogenous disinfection byproduct in chlorinated drinking waters","volume":"51","author":"Yu","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.chemosphere.2020.127278_bib49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2166\/aqua.2013.107","article-title":"Genotoxicity of disinfection by-products (DBPs) upon chlorination of nine different freshwater algal species at variable reaction time","volume":"63","author":"Zhang","year":"2013","journal-title":"J.\u00a0Water Supply Res. Technol. - Aqua"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520314715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520314715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:22:26Z","timestamp":1758626546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520314715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":50,"alternative-id":["S0045653520314715"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127278","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Has the formation of disinfection by-products been overestimated? Membrane leakage from syringe filter heads serves as unexpected precursors","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127278"}}