{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:25:17Z","timestamp":1768677917774,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.chemosphere.2020.127556","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T20:29:45Z","timestamp":1594326585000},"page":"127556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL\/6 mice inoculated with B16\u2013F10\u00a0cells"],"prefix":"10.1016","volume":"260","author":[{"given":"Patricia Manuitt","family":"Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stellee Marcela Petris","family":"Biscaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugstenio Lima","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandia Batscheuer","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelma","family":"Le\u00e3o-Buchir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-1928","authenticated-orcid":false,"given":"Aliciane","family":"de Almeida Roque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-5987","authenticated-orcid":false,"given":"Daniel","family":"de Lima Bellan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edvaldo","family":"da Silva Trindade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-2242","authenticated-orcid":false,"given":"Francisco","family":"Filipak Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro Alberto","family":"de Oliveira Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2020.127556_bib1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/B978-0-12-091302-2.50032-3","article-title":"Catalase","author":"Aebi","year":"1974","journal-title":"Methods Enzym. Anal."},{"key":"10.1016\/j.chemosphere.2020.127556_bib2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/aje\/kwu358","article-title":"Polybrominated diphenyl ethers and thyroid cancer risk in the prostate, colorectal, lung, and ovarian cancer screening trial cohort","volume":"181","author":"Aschebrook-Kilfoy","year":"2015","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib3","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/etc.5620210629","article-title":"Integrated biomarker response: a useful tool for ecological risk assessment","volume":"21","author":"Beliaeff","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2020.127556_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.envpol.2014.01.021","article-title":"Concentrations of polybrominated diphenyl ethers (PBDEs) in central air-conditioner filter dust and relevance of non-dietary exposure in occupational indoor environments in Greece","volume":"188","author":"Besis","year":"2014","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2020.127556_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chemosphere.2020.127556_bib6","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.tiv.2010.07.016","article-title":"Responses of hepatocytes to DDT and methyl mercury exposure","volume":"24","author":"Bussolaro","year":"2010","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2020.127556_bib7","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1089\/ars.2010.3547","article-title":"Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities","volume":"15","author":"Chiurchi\u00f9","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.chemosphere.2020.127556_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01219329","article-title":"Effect of streptozotocin on erythrocyte and retinal superoxide dismutase","volume":"15","author":"Crouch","year":"1978","journal-title":"Diabetologia"},{"key":"10.1016\/j.chemosphere.2020.127556_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/ITT.S134842","article-title":"Melanoma treatment in review","volume":"7","author":"Domingues","year":"2018","journal-title":"ImmunoTargets Ther."},{"key":"10.1016\/j.chemosphere.2020.127556_bib10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jglr.2014.12.023","article-title":"Hepatic polybrominated diphenyl ether (PBDE) levels in Wisconsin river otters (Lontra canadensis) and Michigan bald eagles (Haliaeetus leucocephalus)","volume":"41","author":"Dornbos","year":"2015","journal-title":"J.\u00a0Great Lake. Res."},{"key":"10.1016\/j.chemosphere.2020.127556_bib11","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.canep.2015.03.017","article-title":"European Code against cancer 4th edition: environment, occupation and cancer","volume":"39","author":"Espina","year":"2015","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.chemosphere.2020.127556_bib12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chemosphere.2015.01.012","article-title":"Simulating long-term occupational exposure to decabrominated diphenyl ether using C57BL\/6 mice: biodistribution and pathology","volume":"128","author":"Feng","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.127556_bib13","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.tiv.2008.07.006","article-title":"Toxic effects of DDT and methyl mercury on the hepatocytes from Hoplias malabaricus","volume":"22","author":"Filipak Neto","year":"2008","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2020.127556_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrc3001","article-title":"Mouse models of advanced spontaneous metastasis for experimental therapeutics","volume":"11","author":"Francia","year":"2011","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.chemosphere.2020.127556_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.taap.2008.06.018","article-title":"Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels","volume":"232","author":"Giordano","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib16","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1021\/acsomega.7b00559","article-title":"Pollution status and human exposure of decabromodiphenyl ether (BDE-209) in China","volume":"2","author":"Ji","year":"2017","journal-title":"ACS Omega"},{"key":"10.1016\/j.chemosphere.2020.127556_bib17","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0003-2697(92)90122-N","article-title":"Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein","volume":"202","author":"Jiang","year":"1992","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chemosphere.2020.127556_bib18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1177\/0960327109350669","article-title":"Polybrominated diphenyl ethers cause oxidative stress in human umbilical vein endothelial cells","volume":"28","author":"Kawashiro","year":"2009","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib19","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1016\/S0021-9258(20)81842-0","article-title":"Mechanism for the several activities of the glutathione S transferases","volume":"251","author":"Keen","year":"1976","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chemosphere.2020.127556_bib20","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1021\/es070728g","article-title":"Evidence of debromination of decabromodiphenyl ether (BDE-209) in biota from a wastewater receiving stream","volume":"41","author":"La Guardia","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1289\/ehp.1104051","article-title":"Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells","volume":"120","author":"Li","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.127556_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcancer.2019.08.012","article-title":"Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets","volume":"60","author":"Liang","year":"2019","journal-title":"Semin. Canc. Biol."},{"issue":"5","key":"10.1016\/j.chemosphere.2020.127556_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.chemosphere.2020.127556_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/692467","article-title":"The PBDE-209 exposure during pregnancy and lactation impairs immune function in rats","author":"Liu","year":"2012","journal-title":"Mediators Inflamm. 2012"},{"key":"10.1016\/j.chemosphere.2020.127556_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40608-014-0031-3","article-title":"Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency","volume":"2","author":"McIntyre","year":"2015","journal-title":"BMC Obes"},{"key":"10.1016\/j.chemosphere.2020.127556_bib26","first-page":"1","article-title":"Role of the endothelium during tumor cell metastasis: is the endothelium a barrier or a promoter for cell invasion and metastasis?","author":"Mierke","year":"2008","journal-title":"J.\u00a0Biophys. 2008"},{"key":"10.1016\/j.chemosphere.2020.127556_bib27","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1007\/s11356-015-5921-5","article-title":"Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats","volume":"25","author":"Milovanovic","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2020.127556_bib28","first-page":"16","article-title":"New insights into cancer immunoediting and its three component phases\u2014elimination, equilibrium and escape","volume":"27","author":"Mittal","year":"2014","journal-title":"Current opinion in immunology. 2014 Apr 1;27:16-25. Curr Opin Immunol"},{"key":"10.1016\/j.chemosphere.2020.127556_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125600","article-title":"Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells","volume":"245","author":"Montalbano","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.127556_bib30","first-page":"73","article-title":"Experimental models of in\u00a0vivo murine melanoma","volume":"15","author":"Nunes da Silva","year":"2013","journal-title":"Bios"},{"key":"10.1016\/j.chemosphere.2020.127556_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<310::AID-PATH525>3.0.CO;2-P","article-title":"Interactions between cancer cells and the endothelium in metastasis","volume":"190","author":"Orr","year":"2000","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib32","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1080\/15287394.2017.1357370","article-title":"Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death","volume":"80","author":"Pereira","year":"2017","journal-title":"J.\u00a0Toxicol. Environ. Health Part A Curr. Issues"},{"key":"10.1016\/j.chemosphere.2020.127556_bib33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.watres.2017.08.033","article-title":"Solid surface-mediated photochemical transformation of decabromodiphenyl ether (BDE-209) in aqueous solution","volume":"125","author":"Qu","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2020.127556_bib34","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.chemosphere.2020.127556_bib35","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer","volume":"49","author":"Reuter","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2020.127556_bib36","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s11356-012-1359-1","article-title":"A\u00a0novel \u201cIntegrated Biomarker Response\u201d calculation based on reference deviation concept","volume":"20","author":"Sanchez","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2020.127556_bib37","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1289\/ehp.6466","article-title":"Polybrominated diphenyl ethers (PBDEs) in U.S. mothers\u2019 milk","volume":"111","author":"Schecter","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.127556_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chemosphere.2020.127556_bib39","series-title":"An\u00e1lise de biomarcadores em jundi\u00e1s (Rhamdia quelen) expostos in situ como uma ferramenta de avalia\u00e7\u00e3o ambiental. Universidade federal de santa maria. Pos-gradua\u00e7\u00e3o em Biodiversidade Animal","author":"Severo","year":"2017"},{"key":"10.1016\/j.chemosphere.2020.127556_bib40","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.chemosphere.2007.08.075","article-title":"Concentration of polybrominated diphenyl ethers (PBDEs) in household dust from various countries","volume":"73","author":"Sj\u00f6din","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.127556_bib41","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.chemosphere.2020.127556_bib42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jamaoncol.2016.3834","article-title":"Estimating survival in patients with lung cancer and brain metastases an update of the graded prognostic assessment for lung cancer using molecular markers (Lung-molGPA)","volume":"3","author":"Sperduto","year":"2017","journal-title":"JAMA Oncol"},{"issue":"2","key":"10.1016\/j.chemosphere.2020.127556_bib43","first-page":"1","article-title":"History of cancer, ancient and modern treatment methods","volume":"1","author":"Sudhakar","year":"2009","journal-title":"J.\u00a0Canc. Sci. Ther."},{"issue":"3","key":"10.1016\/j.chemosphere.2020.127556_bib44","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jat.2550050306","article-title":"The effect of handling techniques on serum ALT activity in mice","volume":"5","author":"Swaim","year":"1985","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tiv.2009.08.020","article-title":"Low concentrations of the brominated flame retardants BDE-47 and BDE-99 induce synergistic oxidative stress-mediated neurotoxicity in human neuroblastoma cells","volume":"24","author":"Tagliaferri","year":"2010","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2020.127556_bib46","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/1091581811411109","article-title":"Effects of BDE-85 on the oxidative status and nerve conduction in rodents","volume":"30","author":"Vagula","year":"2011","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib47","first-page":"3083","article-title":"Detection of circulating tumor cells in colorectal and gastric cancer using a multiplex PCR assay","volume":"34","author":"Vaiopoulos","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.chemosphere.2020.127556_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-018-4374-x","article-title":"Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies","volume":"18","author":"Vosoughi","year":"2018","journal-title":"BMC Canc."},{"key":"10.1016\/j.chemosphere.2020.127556_bib49","article-title":"NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin production","volume":"1\u20138","author":"Wu","year":"2019","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib50","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.fct.2018.09.024","article-title":"Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human macrophages via augmenting Toll-like receptor 4-dependent lipid uptake","volume":"121","author":"Zhi","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.127556_bib51","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.chemosphere.2019.02.003","article-title":"The effects of decabromodiphenyl ether on glycolipid metabolism and related signaling pathways in mice","volume":"222","author":"Zhu","year":"2019","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520317513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520317513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:26:56Z","timestamp":1758626816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520317513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":51,"alternative-id":["S0045653520317513"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127556","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL\/6 mice inoculated with B16\u2013F10\u00a0cells","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.127556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127556"}}