{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:41:34Z","timestamp":1790635294449,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803191"],"award-info":[{"award-number":["81803191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0206505"],"award-info":[{"award-number":["2016YFC0206505"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.chemosphere.2020.128217","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T20:08:45Z","timestamp":1599509325000},"page":"128217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Multiple metals exposure and arterial stiffness: A panel study in China"],"prefix":"10.1016","volume":"263","author":[{"given":"Liangle","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2020.128217_bib1","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1161\/CIR.0b013e318276fbcb","article-title":"Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association","volume":"126","author":"Aboyans","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.chemosphere.2020.128217_bib2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tiv.2014.12.007","article-title":"Oxidative and pro-inflammatory effects of cobalt and titanium oxide nanoparticles on aortic and venous endothelial cells","volume":"29","author":"Alinovi","year":"2015","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2020.128217_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.envint.2018.11.020","article-title":"Multiple metals exposure and chromosome damage: exploring the mediation effects of microRNAs and their potentials in lung carcinogenesis","volume":"122","author":"Chen","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2020.128217_bib4","article-title":"Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis","volume":"362","author":"Chowdhury","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.chemosphere.2020.128217_bib5","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease","volume":"116","author":"Criqui","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2020.128217_bib6","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/ije\/dyz061","article-title":"The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study","volume":"48","author":"Domingo-Relloso","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1365-2796.2012.02578.x","article-title":"Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women","volume":"272","author":"Fagerberg","year":"2012","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.chemosphere.2020.128217_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1289\/ehp.1307563","article-title":"Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China","volume":"123","author":"Feng","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.128217_bib9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2105\/AJPH.79.3.340","article-title":"Modeling and variable selection in epidemiologic analysis","volume":"79","author":"Greenland","year":"1989","journal-title":"Am. J. Publ. Health"},{"key":"10.1016\/j.chemosphere.2020.128217_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2013.01.014","article-title":"Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells","volume":"306","author":"Han","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2020.128217_bib11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cca.2005.09.013","article-title":"Biomonitoring of 30 trace elements in urine of children and adults by ICP-MS","volume":"365","author":"Heitland","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.chemosphere.2020.128217_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pcad.2010.12.006","article-title":"Investigating air pollution and atherosclerosis in humans: concepts and outlook","volume":"53","author":"Kunzli","year":"2011","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.chemosphere.2020.128217_bib13","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/ATVBAHA.119.313880","article-title":"Total white blood cell count mediated the association between increased arterial stiffness and risk of type 2 diabetes mellitus in Chinese adults","volume":"40","author":"Liu","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib14","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.amjcard.2006.05.056","article-title":"Relation of borderline peripheral arterial disease to cardiovascular disease risk","volume":"98","author":"Menke","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-8977-8-32","article-title":"Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2)","volume":"8","author":"Mikkelsen","year":"2011","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1289\/ehp.7329","article-title":"Metals in urine and peripheral arterial disease","volume":"113","author":"Navas-Acien","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.128217_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.jhh.1001300","article-title":"An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis","volume":"16","author":"Nawrot","year":"2002","journal-title":"J.\u00a0Hum. Hypertens."},{"key":"10.1016\/j.chemosphere.2020.128217_bib18","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1055\/s-2007-965073","article-title":"Home-based walking improves cardiopulmonary function and health-related QOL in community-dwelling adults","volume":"28","author":"Okamoto","year":"2007","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.chemosphere.2020.128217_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/10408444.2013.779633","article-title":"A\u00a0review of the health hazards posed by cobalt","volume":"43","author":"Paustenbach","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2041-210X.2010.00061.x","article-title":"Using false discovery rates for multiple comparisons in ecology and evolution","volume":"2","author":"Pike","year":"2011","journal-title":"Methods in Ecology and Evolution"},{"key":"10.1016\/j.chemosphere.2020.128217_bib21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/HYPERTENSIONAHA.110.156323","article-title":"Relationship between urinary salt excretion and pulse pressure and central aortic hemodynamics independent of steady state pressure in the general population","volume":"56","author":"Redelinghuys","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2020.128217_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1743-8977-10-15","article-title":"Titanium dioxide nanoparticles: a review of current toxicological data","volume":"10","author":"Shi","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.chemosphere.2019.06.099","article-title":"Urinary metal\/metalloid levels in relation to hypertension among occupationally exposed workers","volume":"234","author":"Shi","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.128217_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jinorgbio.2017.10.006","article-title":"Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus","volume":"178","author":"Sun","year":"2018","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.chemosphere.2020.128217_bib25","first-page":"165","article-title":"Cobalt:a review","volume":"32","author":"Taylor","year":"1978","journal-title":"J\u00a0Hum Nutr"},{"key":"10.1016\/j.chemosphere.2020.128217_bib26","doi-asserted-by":"crossref","first-page":"k3435","DOI":"10.1136\/bmj.k3435","article-title":"Environmental metals and cardiovascular disease","volume":"362","author":"Tellez-Plaza","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.chemosphere.2020.128217_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1467-9868.2011.00771.x","article-title":"Regression shrinkage and selection via the lasso: a retrospective","volume":"73","author":"Tibshirani","year":"2011","journal-title":"J.\u00a0Roy. Stat. Soc. B Stat. Methodol."},{"key":"10.1016\/j.chemosphere.2020.128217_bib28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/oemed-2018-104996","article-title":"Metals in urine in relation to the prevalence of pre-diabetes, diabetes and atherosclerosis in rural India","volume":"75","author":"Velmurugan","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.chemosphere.2020.128217_bib29","first-page":"223","article-title":"Titanium dioxide and zinc oxide nanoparticles in sunscreens: a review of toxicological data","volume":"70","author":"Vujovic","year":"2019","journal-title":"J.\u00a0Cosmet. Sci."},{"key":"10.1016\/j.chemosphere.2020.128217_bib30","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1289\/ehp.1409551","article-title":"Variability of metal levels in spot, first morning, and 24-hour urine samples over a 3-month period in healthy adult Chinese men","volume":"124","author":"Wang","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.128217_bib31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/JOM.0000000000000427","article-title":"The relationship between occupational metal exposure and arterial compliance","volume":"57","author":"Wong","year":"2015","journal-title":"J.\u00a0Occup. Environ. Med."},{"key":"10.1016\/j.chemosphere.2020.128217_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.5665\/sleep.5544","article-title":"Longer sleep duration and midday napping are associated with a higher risk of CHD incidence in middle-aged and older Chinese: the dongfeng-tongji cohort study","volume":"39","author":"Yang","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.chemosphere.2020.128217_bib33","first-page":"1","article-title":"Quantitative assessment of environmental exposure of delivery men in Wuhan","author":"Yang","year":"2020","journal-title":"Arch. Environ. Occup. Health"},{"key":"10.1016\/j.chemosphere.2020.128217_bib34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jhazmat.2014.08.015","article-title":"Changes of serum parameters of TiO(2) nanoparticle-induced atherosclerosis in mice","volume":"280","author":"Yu","year":"2014","journal-title":"J.\u00a0Hazard Mater."},{"key":"10.1016\/j.chemosphere.2020.128217_bib35","doi-asserted-by":"crossref","first-page":"107007","DOI":"10.1289\/EHP1521","article-title":"Plasma metal concentrations and incident coronary heart disease in Chinese adults: the dongfeng-tongji cohort","volume":"125","author":"Yuan","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.128217_bib36","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1289\/ehp.1002251","article-title":"HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study","volume":"118","author":"Zhang","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2020.128217_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.atherosclerosis.2018.01.006","article-title":"Environment-wide association study to identify novel factors associated with peripheral arterial disease: evidence from the National Health and Nutrition Examination Survey (1999-2004)","volume":"269","author":"Zhuang","year":"2018","journal-title":"Atherosclerosis"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520324127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520324127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T14:23:21Z","timestamp":1731594201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520324127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"alternative-id":["S0045653520324127"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.128217","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple metals exposure and arterial stiffness: A panel study in China","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.128217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128217"}}