{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:55:24Z","timestamp":1789077324091,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100013035","name":"Taiwan Forestry Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007841","name":"Council of Agriculture","doi-asserted-by":"publisher","award":["104"],"award-info":[{"award-number":["104"]}],"id":[{"id":"10.13039\/100007841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.chemosphere.2020.129267","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T23:17:49Z","timestamp":1607815069000},"page":"129267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Active food ingredients production from cold pressed processing residues of Camellia oleifera and Camellia sinensis seeds for regulation of blood pressure and vascular function"],"prefix":"10.1016","volume":"267","author":[{"given":"Shen-Shih","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Shu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-4492","authenticated-orcid":false,"given":"Chen-Yeon","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2020.129267_bib1","first-page":"1095","article-title":"Effect of captopril in L-NAME-induced hypertension on the rat myocardium, aorta, brain, and kidney","volume":"84","author":"Bern\u00e1tov\u00e1","year":"1999","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.chemosphere.2020.129267_bib2","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.3390\/nu7075222","article-title":"Ellagic acid prevents L-NAME-induced hypertension via restoration of eNOS and p47phox expression in rats","volume":"7","author":"Berkban","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.chemosphere.2020.129267_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aanat.2017.03.007","article-title":"Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47phox and iNOS in nitric oxide deficient rats","volume":"212","author":"Boonprom","year":"2017","journal-title":"Ann. Anat. Anatomischer Anzeiger"},{"key":"10.1016\/j.chemosphere.2020.129267_bib4","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/1440-1681.12472","article-title":"Asiatic acid alleviates cardiovascular remodeling in rats with L-NAME induced hypertension","volume":"42","author":"Bunbupha","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.chemosphere.2020.129267_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.eujim.2016.06.001","article-title":"Efficacy and safety of oral Antrodia cinnamomea mycelium in mildly hypertensive adults: a randomized controlled pilot clinical study","volume":"8","author":"Chen","year":"2016","journal-title":"Eur. J. Integr. Med."},{"key":"10.1016\/j.chemosphere.2020.129267_bib6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jfoodeng.2006.10.018","article-title":"Microwave-assisted extraction used for the isolation of total triterpenoid saponins from Ganoderma atrium","volume":"81","author":"Chen","year":"2007","journal-title":"J.\u00a0Food Eng."},{"key":"10.1016\/j.chemosphere.2020.129267_bib7","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1111\/1750-3841.14913","article-title":"Role of Camellia brevistyla (Hayata) Coh. Stuart seed pomace extract on hypertension and vascular function in L-NAME\u2013treated mice","volume":"84","author":"Chiang","year":"2019","journal-title":"J.\u00a0Food Sci."},{"key":"10.1016\/j.chemosphere.2020.129267_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/HYPERTENSIONAHA.110.159889","article-title":"Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress","volume":"57","author":"Ebrahimian","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2020.129267_bib9","series-title":"Straightforward Statistics for the Behavioral Sciences","author":"Evans","year":"1996"},{"key":"10.1016\/j.chemosphere.2020.129267_bib10","series-title":"Evaluation method of supplementary blood pressure function of health food","year":"2006"},{"key":"10.1016\/j.chemosphere.2020.129267_bib11","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.foodchem.2010.06.048","article-title":"Kaempferol acetylated glycosides from the seed cake of Camellia oleifera","volume":"124","author":"Gao","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.chemosphere.2020.129267_bib12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0196-9781(03)00160-8","article-title":"Ghrelin-induced feeding is dependent on nitric oxide","volume":"24","author":"Gaskin","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.chemosphere.2020.129267_bib13","first-page":"1","article-title":"Review of pharmacological effects of Antrodia camphorata and its bioactive compounds","volume":"2011","author":"Geethangili","year":"2011","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.chemosphere.2020.129267_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jff.2017.04.035","article-title":"The red wine polyphenol, resveratrol improves hemodynamics, oxidative defense, and aortal structure in essential and malignant hypertension","volume":"34","author":"Grujic-Milanovic","year":"2017","journal-title":"J.\u00a0Funct. Foods"},{"key":"10.1016\/j.chemosphere.2020.129267_bib15","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/j.1365-2621.2012.03020.x","article-title":"Extraction of saponin from Camellia oleifera cake and evaluation of its antioxidant activity","volume":"47","author":"Hu","year":"2012","journal-title":"Int. J. Food Sci. Technol."},{"key":"10.1016\/j.chemosphere.2020.129267_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/HYPERTENSIONAHA.113.02034","article-title":"Hypertension guidelines: more challenges highlighted by Europe","volume":"62","author":"Jennings","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2020.129267_bib17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0308-8146(98)00102-2","article-title":"The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals","volume":"64","author":"Jia","year":"1999","journal-title":"Food Chem."},{"key":"10.1016\/j.chemosphere.2020.129267_bib18","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0022-3565(25)09620-X","article-title":"Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats","volume":"273","author":"Kim","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.chemosphere.2020.129267_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1271\/bbb.60268","article-title":"Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-Chih) in spontaneously hypertensive rats","volume":"71","author":"Liu","year":"2007","journal-title":"Biosc. Biotech. Biochem."},{"key":"10.1016\/j.chemosphere.2020.129267_bib20","series-title":"Ameliorative Effects of Fruit Oil and Seed Pomace Ethanol Extract of Camellia Brevistyla (Hayata) Coh.-Stuart in L-NAME Induced Hypertension Mice","author":"Liu","year":"2016"},{"key":"10.1016\/j.chemosphere.2020.129267_bib21","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/abbs\/gmu071","article-title":"Anti-inflammatory activity of total flavonoids from seeds of Camellia oleifera Abel","volume":"46","author":"Liu","year":"2014","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.chemosphere.2020.129267_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pharmthera.2013.04.001","article-title":"Recent research and development of Antrodia cinnamomea","volume":"139","author":"Lu","year":"2013","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.chemosphere.2020.129267_bib23","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/heart.89.9.1104","article-title":"Cardiac and vascular pathophysiology in hypertension","volume":"89","author":"Mayet","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.chemosphere.2020.129267_bib24","first-page":"1","article-title":"Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB","volume":"7","author":"Miguel-Carrasco","year":"2010","journal-title":"J.\u00a0Inflamm."},{"key":"10.1016\/j.chemosphere.2020.129267_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/CS20100384","article-title":"Novel nox homologues in the vasculature: focusing on Nox4 and Nox5","volume":"120","author":"Montezano","year":"2011","journal-title":"Clin. Sci."},{"key":"10.1016\/j.chemosphere.2020.129267_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00210-011-0624-z","article-title":"Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension","volume":"383","author":"Nakmareong","year":"2011","journal-title":"N.\u00a0Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.chemosphere.2020.129267_bib27","first-page":"37","article-title":"Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants","volume":"389","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2020.129267_bib28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.HYP.20.3.298","article-title":"Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension","volume":"20","author":"Ribeiro","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2020.129267_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.lfs.2015.01.005","article-title":"Role of angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension","volume":"124","author":"Rincon","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.chemosphere.2020.129267_bib30","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.chemosphere.2011.06.089","article-title":"Apolipophorin III and transmission electron microscopy as toxicity indicators for harmaline and tea saponin in Spodoptera exigua (Noctuidae: Lepidoptera)","volume":"85","author":"Rizwan-ul-Haq","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2020.129267_bib31","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1248\/yakushi1947.116.5_388","article-title":"Effect of tea-leaf saponin on blood pressure of spontaneously hypertensive rats","volume":"116","author":"Sagesaka-Mitane","year":"1996","journal-title":"Yakugaku Zasshi: J. Pharm. Soc. Jpn."},{"key":"10.1016\/j.chemosphere.2020.129267_bib32","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/BF02542169","article-title":"Chia seeds as a source of natural lipid antioxidants","volume":"61","author":"Taga","year":"1984","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chemosphere.2020.129267_bib33","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/01.HYP.30.6.1621","article-title":"Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis","volume":"30","author":"Takemoto","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2020.129267_bib34","doi-asserted-by":"crossref","first-page":"14553","DOI":"10.1523\/JNEUROSCI.3287-09.2009","article-title":"Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels","volume":"29","author":"Tsai","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chemosphere.2020.129267_bib35","doi-asserted-by":"crossref","first-page":"H540","DOI":"10.1152\/ajpheart.91478.2007","article-title":"TGF-\u03b2 through Smad 3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation","volume":"297","author":"Tsai","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.chemosphere.2020.129267_bib36","first-page":"388","article-title":"Effect of tea saponin on blood pressure in spontaneously hypertensive rats","volume":"116","author":"Yang","year":"2007","journal-title":"Chin. J. Clin. Hepatol."},{"key":"10.1016\/j.chemosphere.2020.129267_bib37","first-page":"1","article-title":"21-O-angeloyltheasapogenol E3, a novel triterpenoid saponin from the seeds of tea plants, inhibits macrophage-mediated inflammatory responses in a NF-\u03baB-dependent manner","author":"Yang","year":"2014","journal-title":"Med. Inflam. 2014"},{"key":"10.1016\/j.chemosphere.2020.129267_bib38","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s12272-013-0138-y","article-title":"Anti-inflammatory and analgesic activities of the hydrolyzed sasanquasaponins from the defatted seeds of Camellia oleifera","volume":"36","author":"Ye","year":"2013","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.chemosphere.2020.129267_bib39","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/ajh\/hpt268","article-title":"L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-\u03b3","volume":"27","author":"Zambrano","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.chemosphere.2020.129267_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fitote.2015.05.001","article-title":"Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells","volume":"104","author":"Zong","year":"2015","journal-title":"Fitoterapia"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520334640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653520334640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:08:13Z","timestamp":1777464493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653520334640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":40,"alternative-id":["S0045653520334640"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129267","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Active food ingredients production from cold pressed processing residues of Camellia oleifera and Camellia sinensis seeds for regulation of blood pressure and vascular function","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129267"}}