{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:58:05Z","timestamp":1777755485378,"version":"3.51.4"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["213076\/H10"],"award-info":[{"award-number":["213076\/H10"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["204361\/H10"],"award-info":[{"award-number":["204361\/H10"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.chemosphere.2021.130123","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T20:30:02Z","timestamp":1614717002000},"page":"130123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus"],"prefix":"10.1016","volume":"276","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8635-4699","authenticated-orcid":false,"given":"Oddvar","family":"Myhre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin E.","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra M.","family":"Hudecova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine E.A.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdolrahman","family":"Khezri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-8008","authenticated-orcid":false,"given":"Hanne F.","family":"Berntsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidar","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan L.","family":"Lyche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-9733","authenticated-orcid":false,"given":"Siddhartha","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Duale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-0705","authenticated-orcid":false,"given":"Erik","family":"Ropstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2021.130123_bib1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/s13104-016-2224-y","article-title":"Comparison of blood RNA isolation methods from samples stabilized in Tempus tubes and stored at a large human biobank","volume":"9","author":"Aarem","year":"2016","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.chemosphere.2021.130123_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.chemosphere.2009.03.053","article-title":"Temporal trends of polyfluoroalkyl compounds in harbor seals (Phoca vitulina) from the German Bight, 1999-2008","volume":"76","author":"Ahrens","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.130123_bib3","first-page":"1","article-title":"Scientific opinion on polybrominated diphenyl ethers (PBDEs) in food EFSA panel on contaminants in the food chain (CONTAM)","volume":"9","author":"Alexander","year":"2011","journal-title":"EFSA journal"},{"key":"10.1016\/j.chemosphere.2021.130123_bib4","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/etc.2294","article-title":"Simplifying complexity: mixture toxicity assessment in the last 20 years","volume":"32","author":"Altenburger","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2021.130123_bib5","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Can. Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.toxlet.2011.07.008","article-title":"Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO\u2082-PCBs","volume":"206","author":"Antunes-Fernandes","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2021.130123_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092270","article-title":"Sex-dependent effects of perinatal inflammation on the brain: implication for neuro-psychiatric disorders","volume":"20","author":"Ardalan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.14573\/altex.1712081","article-title":"Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity","volume":"35","author":"Bal-Price","year":"2018","journal-title":"ALTEX"},{"key":"10.1016\/j.chemosphere.2021.130123_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0077579","article-title":"Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"J.\u00a0Comp. Physiol. Psychol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gep.2009.11.005","article-title":"Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology","volume":"10","author":"Bedogni","year":"2010","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.chemosphere.2021.130123_bib11","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1210\/jc.2014-4323","article-title":"Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union","volume":"100","author":"Bellanger","year":"2015","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chemosphere.2021.130123_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(01)00244-3","article-title":"Hyperactivity and impulsiveness in rats fed diets supplemented with either Aroclor 1248 or PCB-contaminated St. Lawrence river fish","volume":"126","author":"Berger","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib13","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1080\/15287394.2017.1354439","article-title":"The design of an environmentally relevant mixture of persistent organic pollutants for use in in\u00a0vivo and in\u00a0vitro studies","volume":"80","author":"Berntsen","year":"2017","journal-title":"J.\u00a0Toxicol. Environ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib14","doi-asserted-by":"crossref","first-page":"106240","DOI":"10.1016\/j.envint.2020.106240","article-title":"Effects of a human-based mixture of persistent organic pollutants on the in\u00a0vivo exposed cerebellum and cerebellar neuronal cultures exposed in\u00a0vitro","volume":"146","author":"Berntsen","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1476-069X-7-50","article-title":"Potential developmental neurotoxicity of pesticides used in Europe","volume":"7","author":"Bjorling-Poulsen","year":"2008","journal-title":"Environ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib16","first-page":"1","article-title":"Summary health statistics for U.S. Children: national health interview survey, 2009","volume":"10","author":"Bloom","year":"2010","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.chemosphere.2021.130123_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.envint.2018.07.037","article-title":"Current EU research activities on combined exposure to multiple chemicals","volume":"120","author":"Bopp","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuro.2004.11.005","article-title":"Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route","volume":"26","author":"Branchi","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.reprotox.2009.01.004","article-title":"Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats","volume":"27","author":"Butenhoff","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib20","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1016\/j.scitotenv.2010.03.015","article-title":"Levels and trends of poly- and perfluorinated compounds in the arctic environment","volume":"408","author":"Butt","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.130123_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/REVEH.2006.21.1.1","article-title":"Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health","volume":"21","author":"Carpenter","year":"2006","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.envres.2015.12.020","article-title":"Determinants of plasma PCB, brominated flame retardants, and organochlorine pesticides in pregnant women and 3 year old children in the Norwegian Mother and Child Cohort Study","volume":"146","author":"Caspersen","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00204-008-0359-x","article-title":"Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin","volume":"83","author":"Chen","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib24","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1016\/j.febslet.2006.08.076","article-title":"Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations","volume":"580","author":"Choi","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.chemosphere.2021.130123_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/096032719601500314","article-title":"Organochlorine compounds in human brain","volume":"15","author":"Corrigan","year":"1996","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/exnr.1998.6776","article-title":"Diorthosubstituted polychlorinated biphenyls in caudate nucleus in Parkinson\u2019s disease","volume":"150","author":"Corrigan","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib27","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/sj.npp.1301230","article-title":"Quantitative changes in Galphaolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants","volume":"32","author":"Corvol","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s40572-017-0135-2","article-title":"Developmental neurotoxicity of traffic-related air pollution: focus on autism","volume":"4","author":"Costa","year":"2017","journal-title":"Curr Environ Health Rep"},{"key":"10.1016\/j.chemosphere.2021.130123_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ntt.2015.08.009","article-title":"Prenatal exposure to polybrominated diphenyl ethers and child attention problems at 3-7 years","volume":"52","author":"Cowell","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib30","first-page":"1","article-title":"A\u00a0simple role for BDNF in learning and memory?","volume":"3","author":"Cunha","year":"2010","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib31","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1890\/07-0539.1","article-title":"Random forests for classification in ecology","volume":"88","author":"Cutler","year":"2007","journal-title":"Ecology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib32","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/ajmg.b.30877","article-title":"A\u00a0comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study","volume":"147B","author":"DasBanerjee","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.chemosphere.2021.130123_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.reprotox.2020.12.013","article-title":"Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation","volume":"100","author":"Davidsen","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib34","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0045-6535(01)00225-9","article-title":"An overview of brominated flame retardants in the environment","volume":"46","author":"de Wit","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.130123_bib35","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.99107823","article-title":"Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland","volume":"107","author":"Dewailly","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib36","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1289\/ehp.9860","article-title":"Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus","volume":"115","author":"Dingemans","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib37","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/1756-0500-5-510","article-title":"Human blood RNA stabilization in samples collected and transported for a large biobank","volume":"5","author":"Duale","year":"2012","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.chemosphere.2021.130123_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1186\/1756-0500-7-633","article-title":"Long-term storage of blood RNA collected in RNA stabilizing Tempus tubes in a large biobank--evaluation of RNA quality and stability","volume":"7","author":"Duale","year":"2014","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.chemosphere.2021.130123_bib39","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/glia.440050407","article-title":"Heme oxygenase is a heat shock protein and PEST protein in rat astroglial cells","volume":"5","author":"Dwyer","year":"1992","journal-title":"Glia"},{"key":"10.1016\/j.chemosphere.2021.130123_bib40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envres.2015.01.015","article-title":"Brain region-specific perfluoroalkylated sulfonate (PFSA) and carboxylic acid (PFCA) accumulation and neurochemical biomarker responses in east Greenland polar bears (Ursus maritimus)","volume":"138","author":"Eggers Pedersen","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.etap.2005.10.001","article-title":"Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD)","volume":"21","author":"Eriksson","year":"2006","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/1382-6689(96)00015-4","article-title":"Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse","volume":"1","author":"Eriksson","year":"1996","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/1382-6689(95)00017-8","article-title":"Neonatal exposure to 2,2\u2019,5,5\u2019-tetrachlorobiphenyl causes increased susceptibility in the cholinergic transmitter system at adult age","volume":"1","author":"Eriksson","year":"1996","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1542\/peds.2005-3117","article-title":"In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children","volume":"118","author":"Eskenazi","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.chemosphere.2021.130123_bib45","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1742-7843.2007.00171.x","article-title":"Pesticide toxicity and the developing brain","volume":"102","author":"Eskenazi","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/pr.114.009001","article-title":"The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology","volume":"67","author":"Esser","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.chemosphere.2021.130123_bib47","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ajmg.a.37454","article-title":"Exonic deletions of AUTS2 in Chinese patients with developmental delay and intellectual disability","volume":"170A","author":"Fan","year":"2016","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.chemosphere.2021.130123_bib48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0022-3476(84)80139-0","article-title":"Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age","volume":"105","author":"Fein","year":"1984","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.chemosphere.2021.130123_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.taap.2018.02.004","article-title":"Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes","volume":"354","author":"Fritsche","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxlet.2005.11.013","article-title":"Interactions in developmental toxicology: concurrent exposure to perfluorooctane sulfonate (PFOS) and stress in pregnant mice","volume":"164","author":"Fuentes","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2021.130123_bib51","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxlet.2007.05.006","article-title":"Influence of maternal restraint stress on the long-lasting effects induced by prenatal exposure to perfluorooctane sulfonate (PFOS) in mice","volume":"171","author":"Fuentes","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2021.130123_bib52","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/toxsci\/kfm121","article-title":"Concurrent exposure to perfluorooctane sulfonate and restraint stress during pregnancy in mice: effects on postnatal development and behavior of the offspring","volume":"98","author":"Fuentes","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib53","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.envint.2010.12.005","article-title":"Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age","volume":"37","author":"Gascon","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib54","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-3476(88)80569-9","article-title":"Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk","volume":"113","author":"Gladen","year":"1988","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.chemosphere.2021.130123_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2016.12.005","article-title":"Review: the blood-brain barrier; protecting the developing fetal brain","volume":"54","author":"Goasdoue","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.chemosphere.2021.130123_bib56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2202\/1544-6115.1691","article-title":"Random forests for genetic association studies","volume":"10","author":"Goldstein","year":"2011","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib57","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.scitotenv.2015.10.017","article-title":"Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: the Hokkaido Study","volume":"541","author":"Goudarzi","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.130123_bib58","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2021.130123_bib59","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib60","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/etc.2107","article-title":"Brain region distribution and patterns of bioaccumulative perfluoroalkyl carboxylates and sulfonates in east Greenland polar bears (Ursus maritimus)","volume":"32","author":"Greaves","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2021.130123_bib61","doi-asserted-by":"crossref","first-page":"11575","DOI":"10.1021\/es303400f","article-title":"Tissue-specific concentrations and patterns of perfluoroalkyl carboxylates and sulfonates in East Greenland polar bears","volume":"46","author":"Greaves","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib62","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/10408444.2014.999365","article-title":"Metabolism and metabolites of polychlorinated biphenyls","volume":"45","author":"Grimm","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib63","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1021\/es103712g","article-title":"Perfluorochemical (PFC) exposure in children: associations with impaired response inhibition","volume":"45","author":"Gump","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib64","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.envint.2018.03.025","article-title":"Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition","volume":"115","author":"Harris","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib65","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.neuro.2012.08.002","article-title":"Association between polychlorinated biphenyls and Parkinson\u2019s disease neuropathology","volume":"33","author":"Hatcher-Martin","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib66","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1289\/ehp.0901340","article-title":"Prenatal exposure to PBDEs and neurodevelopment","volume":"118","author":"Herbstman","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib67","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s12640-017-9833-7","article-title":"Restoration of cognitive performance in mice carrying a deficient allele of 8-oxoguanine DNA glycosylase by X-ray irradiation","volume":"33","author":"Hofer","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib68","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0166-4328(97)00181-2","article-title":"Behavioural hyperactivity in rats following postnatal exposure to sub-toxic doses of polychlorinated biphenyl congeners 153 and 126","volume":"94","author":"Holene","year":"1998","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib69","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1006\/jmcc.1996.0177","article-title":"Heme oxygenase-1 expression and its relation to oxidative stress during primary culture of cardiomyocytes","volume":"28","author":"Hoshida","year":"1996","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib70","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.chemosphere.2018.01.085","article-title":"A\u00a0human exposure based mixture of persistent organic pollutants affects the stress response in female mice and their offspring","volume":"197","author":"Hudecova","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.130123_bib71","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1037\/a0020761","article-title":"A\u00a0general approach to causal mediation analysis","volume":"15","author":"Imai","year":"2010","journal-title":"Psychol. Methods"},{"key":"10.1016\/j.chemosphere.2021.130123_bib72","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1242\/dev.140350","article-title":"The GDNF-GFR alpha 1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM","volume":"143","author":"Irala","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2021.130123_bib73","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/074823379601200315","article-title":"Dose-response in perinatal exposure to polychlorinated biphenyls (PCBs): the Michigan and North Carolina cohort studies","volume":"12","author":"Jacobson","year":"1996","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib74","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<338::AID-TERA6>3.0.CO;2-V","article-title":"Teratogen update: polychlorinated biphenyls","volume":"55","author":"Jacobson","year":"1997","journal-title":"Teratology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib75","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuro.2007.10.008","article-title":"Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice","volume":"29","author":"Johansson","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib76","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0269-7491(99)00098-6","article-title":"Persistent organic pollutants (POPs): state of the science","volume":"100","author":"Jones","year":"1999","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2021.130123_bib77","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1365-2443.2006.01010.x","article-title":"Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb","volume":"11","author":"Kaneko","year":"2006","journal-title":"Gene Cell."},{"key":"10.1016\/j.chemosphere.2021.130123_bib78","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2021.130123_bib79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1073\/pnas.86.1.99","article-title":"Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite","volume":"86","author":"Keyse","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemosphere.2021.130123_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020291","article-title":"A\u00a0mixture of persistent organic pollutants and perfluorooctanesulfonic acid induces similar behavioural responses, but different gene expression profiles in zebrafish larvae","volume":"18","author":"Khezri","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib81","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.taap.2017.06.019","article-title":"Maternal exposure to a mixture of persistent organic pollutants (POPs) affects testis histology, epididymal sperm count and induces sperm DNA fragmentation in mice","volume":"329","author":"Khezri","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib82","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/es0619197","article-title":"Fate of higher brominated PBDEs in lactating cows","volume":"41","author":"Kierkegaard","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib83","first-page":"690","article-title":"Protracted neurotoxicity from chlordane sprayed to kill termites","volume":"103","author":"Kilburn","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib84","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ntt.2012.09.005","article-title":"Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL\/6J mice","volume":"34","author":"Koenig","year":"2012","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib85","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/MOP.0b013e3282f6a4e9","article-title":"Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment","volume":"20","author":"Korrick","year":"2008","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.chemosphere.2021.130123_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05868-0","article-title":"Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory","volume":"9","author":"Kwapis","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chemosphere.2021.130123_bib87","doi-asserted-by":"crossref","first-page":"96002","DOI":"10.1289\/EHP1954","article-title":"Infant dietary exposures to environmental chemicals and infant\/child health: a critical assessment of the literature","volume":"126","author":"LaKind","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib88","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/kfg122","article-title":"Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation","volume":"74","author":"Lau","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib89","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/mp.2015.115","article-title":"A2A adenosine receptor deletion is protective in a mouse model of Tauopathy","volume":"21","author":"Laurent","year":"2016","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.chemosphere.2021.130123_bib90","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/toxsci\/kfj052","article-title":"Heme-oxygenase-1 promotes polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress and dopaminergic cell injury","volume":"90","author":"Lee","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib91","doi-asserted-by":"crossref","first-page":"96001","DOI":"10.1289\/EHP1953","article-title":"Environmental chemicals in breast milk and formula: exposure and risk assessment implications","volume":"126","author":"Lehmann","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib92","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.scitotenv.2009.10.038","article-title":"Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish","volume":"408","author":"Letcher","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.130123_bib93","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00204-015-1457-1","article-title":"Human exposure to PBDE and critical evaluation of health hazards","volume":"89","author":"Linares","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib94","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1021\/es202963p","article-title":"Guest comment: perfluoroalkyl acid focus issue","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib95","first-page":"235","article-title":"Pesticide exposure and child neurodevelopment: summary and implications","volume":"60","author":"Liu","year":"2012","journal-title":"Workplace Health & Saf."},{"key":"10.1016\/j.chemosphere.2021.130123_bib96","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/ajmg.a.37050","article-title":"De novo exon 1 deletion of AUTS2 gene in a patient with autism spectrum disorder and developmental delay: a case report and a brief literature review","volume":"167","author":"Liu","year":"2015","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.chemosphere.2021.130123_bib97","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.chemosphere.2021.130123_bib98","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev.publhealth.18.1.211","article-title":"The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health","volume":"18","author":"Longnecker","year":"1997","journal-title":"Annu. Rev. Publ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib99","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408440500534164","article-title":"Neurochemical targets and behavioral effects of organohalogen compounds: an update","volume":"36","author":"Mariussen","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib100","doi-asserted-by":"crossref","DOI":"10.1289\/EHP826","article-title":"A\u00a0human mixture risk assessment for neurodevelopmental toxicity associated with polybrominated diphenyl ethers used as flame retardants","volume":"125","author":"Martin","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib101","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/WCO.0000000000000714","article-title":"Sex differences in neurodevelopmental disorders","volume":"32","author":"May","year":"2019","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib102","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/mrdd.10033","article-title":"Environmental factors associated with a spectrum of neurodevelopmental deficits","volume":"8","author":"Mendola","year":"2002","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.chemosphere.2021.130123_bib103","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1523\/JNEUROSCI.5175-06.2007","article-title":"NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1","volume":"27","author":"Metzler","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib104","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ntt.2014.06.009","article-title":"Prenatal exposure to the brominated flame retardant hexabromocyclododecane (HBCD) impairs measures of sustained attention and increases age-related morbidity in the Long-Evans rat","volume":"45","author":"Miller-Rhodes","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.schres.2017.04.015","article-title":"Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review","volume":"192","author":"Misiak","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib106","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/em.21722","article-title":"Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder","volume":"53","author":"Mitchell","year":"2012","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.chemosphere.2021.130123_bib107","doi-asserted-by":"crossref","first-page":"14637","DOI":"10.1523\/JNEUROSCI.0901-09.2009","article-title":"Disruption of the ether-a-go-go K+ channel gene BEC1\/KCNH3 enhances cognitive function","volume":"29","author":"Miyake","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib108","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/s41598-018-20327-y","article-title":"Repeated five-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL\/6 mice - lack of adverse cognitive effects","volume":"8","author":"Myhre","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2021.130123_bib109","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.taap.2018.03.015","article-title":"Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit\/hyperactivity disorder (ADHD): need for novel strategies for mechanisms and causalities","volume":"354","author":"Myhre","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003221","article-title":"Function and regulation of AUTS2, a gene implicated in autism and human evolution","volume":"9","author":"Oksenberg","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.chemosphere.2021.130123_bib111","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib112","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1476-069X-9-51","article-title":"Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study","volume":"9","author":"Park","year":"2010","journal-title":"Environ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib113","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci8080154","article-title":"Sex: a significant risk factor for neurodevelopmental and neurodegenerative disorders","volume":"8","author":"Pinares-Garcia","year":"2018","journal-title":"Brain Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib114","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yrtph.2019.05.008","article-title":"Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria","volume":"106","author":"Pizzurro","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib115","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.envint.2007.05.009","article-title":"Exposure to polybrominated diphenyl ethers among workers at an electronic waste dismantling region in Guangdong, China","volume":"33","author":"Qu","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13050511","article-title":"Prenatal exposure to perfluoroalkyl substances and behavioral development in children","volume":"13","author":"Quaak","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib117","doi-asserted-by":"crossref","DOI":"10.1542\/peds.111.5.e580","article-title":"Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants","volume":"111","author":"Ribas-Fito","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.chemosphere.2021.130123_bib118","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1289\/ehp.9314","article-title":"Exposure to hexachlorobenzene during pregnancy and children\u2019s social behavior at 4 years of age","volume":"115","author":"Ribas-Fito","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib119","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2009.11.001","article-title":"Combined effects of perfluorooctane sulfonate (PFOS) and maternal restraint stress on hypothalamus adrenal axis (HPA) function in the offspring of mice","volume":"243","author":"Ribes","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.chemosphere.2021.130123_bib120","first-page":"511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib121","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1006\/enrs.1998.3917","article-title":"Behavioral impairment produced by low-level postnatal PCB exposure in monkeys","volume":"80","author":"Rice","year":"1999","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib122","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0022-3476(86)80397-3","article-title":"Neonatal effects of transplacental exposure to PCBs and DDE","volume":"109","author":"Rogan","year":"1986","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.chemosphere.2021.130123_bib123","doi-asserted-by":"crossref","first-page":"10068","DOI":"10.1073\/pnas.0509598103","article-title":"Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient","volume":"103","author":"Rousseau","year":"2006","journal-title":"P\u00a0Natl Acad Sci USA"},{"key":"10.1016\/j.chemosphere.2021.130123_bib124","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1289\/ehp.0901015","article-title":"Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age","volume":"117","author":"Roze","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1071\/EN10142","article-title":"Perfluorinated compounds in red-throated divers from the German Baltic Sea: new findings from their distribution in 10 different tissues","volume":"8","author":"Rubarth","year":"2011","journal-title":"Environ. Chem."},{"key":"10.1016\/j.chemosphere.2021.130123_bib126","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1021\/es2020378","article-title":"Discontinued and alternative brominated flame retardants in the atmosphere and precipitation from the great lakes basin","volume":"45","author":"Salamova","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib127","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0892-0362(96)90001-X","article-title":"Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?","volume":"18","author":"Schantz","year":"1996","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib128","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3109\/10408449609037481","article-title":"Epidemiological and laboratory evidence of PCB-induced neurotoxicity","volume":"26","author":"Seegal","year":"1996","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib129","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1289\/ehp.0901334","article-title":"Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation","volume":"118","author":"Seelbach","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib130","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/toxsci\/kfq066","article-title":"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos","volume":"115","author":"Shi","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib131","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijheh.2019.10.003","article-title":"Prenatal exposure to perfluoroalkyl substances and associations with symptoms of attention-deficit\/hyperactivity disorder and cognitive functions in preschool children","volume":"223","author":"Skogheim","year":"2020","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib132","first-page":"129","article-title":"Developmental neurotoxicity - challenges in the 21st century and in\u00a0vitro opportunities","volume":"31","author":"Smirnova","year":"2014","journal-title":"ALTEX"},{"key":"10.1016\/j.chemosphere.2021.130123_bib133","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11065-010-9148-4","article-title":"The basics of brain development","volume":"20","author":"Stiles","year":"2010","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.chemosphere.2021.130123_bib134","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10715769009148577","article-title":"Induction of haem oxygenase as a defence against oxidative stress","volume":"9","author":"Stocker","year":"1990","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.chemosphere.2021.130123_bib135","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.etap.2017.02.006","article-title":"PBDE-209 exposure damages learning and memory ability in rats potentially through increased autophagy and apoptosis in the hippocampus neuron","volume":"50","author":"Sun","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib136","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S2215-0366(16)30376-5","article-title":"Neurodevelopmental disorders","volume":"4","author":"Thapar","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.chemosphere.2021.130123_bib137","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0892-0362(90)90095-T","article-title":"Polychlorinated biphenyls and the developing nervous system: cross-species comparisons","volume":"12","author":"Tilson","year":"1990","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib138","article-title":"Mediation: R package for causal mediation analysis","volume":"59","author":"Tingley","year":"2014","journal-title":"J.\u00a0Stat. Software"},{"key":"10.1016\/j.chemosphere.2021.130123_bib139","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1289\/ehp.1205034","article-title":"Prenatal p,p -DDE exposure and neurodevelopment among children 3.5-5 years of age","volume":"121","author":"Torres-Sanchez","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib140","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/bdr2.1021","article-title":"Gestational and lactational exposure to an environmentally-relevant mixture of brominated flame retardants: effects on neurodevelopment and metabolism","volume":"109","author":"Tung","year":"2017","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.chemosphere.2021.130123_bib141","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1749-6632.1979.tb56609.x","article-title":"Present state of yusho patients","volume":"320","author":"Urabe","year":"1979","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib142","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0041-008X(03)00217-5","article-title":"Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice","volume":"192","author":"Viberg","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib143","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tox.2012.12.013","article-title":"Adult dose-dependent behavioral and cognitive disturbances after a single neonatal PFHxS dose","volume":"304","author":"Viberg","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib144","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1021\/es101158e","article-title":"Comparative tissue distribution, biotransformation and associated biological effects by decabromodiphenyl ethane and decabrominated diphenyl ether in male rats after a 90-day oral exposure study","volume":"44","author":"Wang","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib145","doi-asserted-by":"crossref","first-page":"13553","DOI":"10.1021\/acs.est.8b04550","article-title":"Penetration of PFASs across the blood cerebrospinal fluid barrier and its determinants in humans","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.130123_bib146","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ijheh.2015.07.002","article-title":"Prenatal exposure to perfluroalkyl substances and children\u2019s IQ: the Taiwan maternal and infant cohort study","volume":"218","author":"Wang","year":"2015","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.chemosphere.2021.130123_bib147","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1471-4159.2010.06992.x","article-title":"Effect of age on proliferation-regulating factors in human adult neurogenic regions","volume":"115","author":"Werry","year":"2010","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.chemosphere.2021.130123_bib148","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0378-4274(98)00334-8","article-title":"Developmental neurotoxicity of polychlorinated biphenyls (PCBS): cognitive and psychomotor functions in 7-month old children","volume":"102\u2013103","author":"Winneke","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2021.130123_bib149","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.envint.2008.11.001","article-title":"Polybrominated diphenyl ether flame retardants in the U.S. marine environment: a review","volume":"35","author":"Yogui","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib150","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2015.03.012","article-title":"SIRP\/CD47 signaling in neurological disorders","volume":"1623","author":"Zhang","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.chemosphere.2021.130123_bib151","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1289\/EHP478","article-title":"Prenatal PBDE and PCB exposures and reading, cognition, and externalizing behavior in children","volume":"125","author":"Zhang","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.130123_bib152","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.envint.2017.11.031","article-title":"Prenatal and childhood perfluoroalkyl substances exposures and children\u2019s reading skills at ages 5 and 8years","volume":"111","author":"Zhang","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.130123_bib153","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tox.2011.02.003","article-title":"Tissue distribution of decabrominated diphenyl ether (BDE-209) and its metabolites in sucking rat pups after prenatal and\/or postnatal exposure","volume":"283","author":"Zhang","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2021.130123_bib154","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nn.2610","article-title":"Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy","volume":"13","author":"Zhang","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chemosphere.2021.130123_bib155","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.envpol.2016.08.091","article-title":"Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site","volume":"218","author":"Zhao","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2021.130123_bib156","doi-asserted-by":"crossref","first-page":"12434","DOI":"10.1021\/es401791s","article-title":"PI3K\/Akt pathway mediates Nrf2\/ARE activation in human L02 hepatocytes exposed to low-concentration HBCDs","volume":"47","author":"Zou","year":"2013","journal-title":"Environ. Sci. Technol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521005920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521005920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:09:09Z","timestamp":1777464549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653521005920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":156,"alternative-id":["S0045653521005920"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.130123","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.130123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"130123"}}