{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:33:28Z","timestamp":1793147608508,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41907366"],"award-info":[{"award-number":["41907366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010382"],"award-info":[{"award-number":["2019A1515010382"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008326","name":"Guangdong University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.chemosphere.2021.131047","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T06:45:47Z","timestamp":1622184347000},"page":"131047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Development and validation of sensitive methods for simultaneous determination of 9 antiviral drugs in different various environmental matrices by UPLC-MS\/MS"],"prefix":"10.1016","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-1460","authenticated-orcid":false,"given":"Li","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2021.131047_bib1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.chemosphere.2018.02.105","article-title":"LC-MS\/MS determination of antiretroviral drugs in influents and effluents from wastewater treatment plants in KwaZulu-Natal, South Africa","volume":"200","author":"Abafe","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131047_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.scitotenv.2017.08.162","article-title":"Suspended solids moderate the degradation and sorption of waste water-derived pharmaceuticals in estuarine waters","volume":"612","author":"Aminot","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131047_bib3","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1007\/s00216-015-9017-3","article-title":"Development and application of a multi-residue method for the determination of 53 pharmaceuticals in water, sediment, and suspended solids using liquid chromatography-tandem mass spectrometry","volume":"407","author":"Aminot","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2021.131047_bib4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/jaoac\/86.2.412","article-title":"Fast and easy multiresidue method employing acetonitrile extraction\/partitioning and \"dispersive solid-phase extraction\" for the determination of pesticide residues in produce","volume":"86","author":"Anastassiades","year":"2003","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.chemosphere.2021.131047_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrd703","article-title":"Strategies in the design of antiviral drugs","volume":"1","author":"De Clercq","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chemosphere.2021.131047_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/nrd2485","article-title":"Three decades of antiviral drugs","volume":"6","author":"De Clercq","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chemosphere.2021.131047_bib7","doi-asserted-by":"crossref","first-page":"125830","DOI":"10.1016\/j.chemosphere.2020.125830","article-title":"Bioaccumulation and glutathione S-transferase activity on Rhinella arenarum tadpoles after short-term exposure to antiretrovirals","volume":"246","author":"Fern\u00e1ndez","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131047_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.watres.2016.03.045","article-title":"Identification of transformation products of antiviral drugs formed during biological wastewater treatment and their occurrence in the urban water cycle","volume":"98","author":"Funke","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2021.131047_bib9","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1128\/AAC.00886-15","article-title":"Influenza A (H7N9) virus acquires resistance-related neuraminidase I222T substitution when infected mallards are exposed to low levels of oseltamivir in water","volume":"59","author":"Gillman","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chemosphere.2021.131047_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jchromb.2015.03.008","article-title":"Development of a SPE-HPLC-MS\/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples","volume":"990","author":"Gurke","year":"2015","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chemosphere.2021.131047_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00244-005-0236-z","article-title":"Development of stable isotope dilution quantification liquid chromatography-mass spectrometry method for estimation of exposure levels of bisphenol A, 4-tert-octylphenol, 4-nonylphenol, tetrabromobisphenol A, and pentachlorophenol in indoor air","volume":"51","author":"Inoue","year":"2006","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.131047_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scitotenv.2012.07.052","article-title":"From multi-residue screening to target analysis of pharmaceuticals in water: development of a new approach based on magnetic sector mass spectrometry and application in the Nairobi River basin, Kenya","volume":"437","author":"K'Oreje","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131047_bib13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.chemosphere.2016.01.095","article-title":"Occurrence patterns of pharmaceutical residues in wastewater, surface water and groundwater of Nairobi and Kisumu city, Kenya","volume":"149","author":"K'Oreje","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131047_bib14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/jaoac\/88.2.630","article-title":"Evaluation of two fast and easy methods for pesticide residue analysis in fatty food matrixes","volume":"88","author":"Lehotay","year":"2005","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.chemosphere.2021.131047_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.chroma.2014.06.088","article-title":"A statistical approach to determine fluxapyroxad and its three metabolites in soils, sediment and sludge based on a combination of chemometric tools and a modified quick, easy, cheap, effective, rugged and safe method","volume":"1358","author":"Li","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2021.131047_bib16","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.scitotenv.2013.05.034","article-title":"Treatment of micropollutants in municipal wastewater: ozone or powdered activated carbon?","volume":"461\u2013462","author":"Margot","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131047_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.chroma.2014.11.079","article-title":"Assessment of two extraction methods to determine pesticides in soils, sediments and sludges. Application to the Turia River Basin","volume":"1378","author":"Masia","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2021.131047_bib18","doi-asserted-by":"crossref","first-page":"121067","DOI":"10.1016\/j.jhazmat.2019.121067","article-title":"Determination of selected antiretroviral drugs in wastewater, surface water and aquatic plants using hollow fibre liquid phase microextraction and liquid chromatography-tandem mass spectrometry","volume":"382","author":"Mlunguza","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2021.131047_bib19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11356-014-3361-2","article-title":"Determination of pesticide residues in fish tissues by modified QuEChERS method and dual-d-SPE clean-up coupled to gas chromatography\u2013mass spectrometry","volume":"22","author":"Molina-Ruiz","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2021.131047_bib20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.chemosphere.2018.12.205","article-title":"Simultaneous quantification of commonly prescribed antiretroviral drugs and their selected metabolites in aqueous environmental samples by direct injection and solid phase extraction liquid chromatography-tandem mass spectrometry","volume":"220","author":"Mosekiemang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131047_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.teac.2019.e00071","article-title":"Analytical strategies for the determination of antiviral drugs in the aquatic environment","volume":"24","author":"Nannou","year":"2019","journal-title":"Trends Environ. Anal. Chem."},{"key":"10.1016\/j.chemosphere.2021.131047_bib22","doi-asserted-by":"crossref","first-page":"134322","DOI":"10.1016\/j.scitotenv.2019.134322","article-title":"Antiviral drugs in aquatic environment and wastewater treatment plants: a review on occurrence, fate, removal and ecotoxicity","volume":"699","author":"Nannou","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131047_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.watres.2018.08.017","article-title":"Environmental fate and ecotoxicological effects of antiretrovirals: a current global status and future perspectives","volume":"145","author":"Ncube","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2021.131047_bib24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.scitotenv.2015.08.139","article-title":"Occurrence of selected antibiotics and antiretroviral drugs in Nairobi River Basin, Kenya","volume":"539","author":"Ngumba","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131047_bib25","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.1039\/C6AY01695B","article-title":"A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS\/MS and matrix-matched standards","volume":"8","author":"Ngumba","year":"2016","journal-title":"Anal. Methods."},{"key":"10.1016\/j.chemosphere.2021.131047_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2989\/16085914.2019.1571477","article-title":"Nevirapine in African surface waters induces liver histopathology in Oreochromis mossambicus: a laboratory exposure study","volume":"44","author":"Nibamureke","year":"2019","journal-title":"Afr. J. Aquat. Sci."},{"key":"10.1016\/j.chemosphere.2021.131047_bib27","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1021\/es903216p","article-title":"Antiviral drugs in wastewater and surface waters: a new pharmaceutical class of environmental relevance?","volume":"44","author":"Prasse","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.131047_bib28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.scitotenv.2018.01.263","article-title":"Contaminants of emerging concern in the Hartbeespoort Dam catchment and the uMngeni River estuary 2016 pollution incident, South Africa. South Africa","volume":"627","author":"Rimayi","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131047_bib29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.etap.2017.09.017","article-title":"The potential effects of efavirenz on Oreochromis mossambicus after acute exposure","volume":"56","author":"Robson","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.131047_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.emcon.2017.09.001","article-title":"The impact of a wastewater treatment works in Southern Gauteng, South Africa on efavirenz and nevirapine discharges into the aquatic environment","volume":"3","author":"Schoeman","year":"2017","journal-title":"Emerging Contam"},{"key":"10.1016\/j.chemosphere.2021.131047_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jchromb.2013.04.041","article-title":"Selective extraction of lamivudine in human serum and urine using molecularly imprinted polymer technique","volume":"931","author":"Shekarchi","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.chemosphere.2021.131047_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1289\/ehp.9574","article-title":"Potential risks associated with the proposed widespread use of Tamiflu","volume":"115","author":"Singer","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2021.131047_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25374","article-title":"Mobilizing civil society for the HIV treatment cascade: a global analysis on democracy and its association with people living with HIV who know their status","volume":"22","author":"Tan","year":"2019","journal-title":"J. Int. AIDS Soc."},{"key":"10.1016\/j.chemosphere.2021.131047_bib34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.envpol.2015.01.030","article-title":"The occurrence of anti-retroviral compounds used for HIV treatment in South African surface water","volume":"199","author":"Wood","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2021.131047_bib35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.chroma.2017.03.057","volume":"1496","author":"Wooding","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2021.131047_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.chroma.2018.04.003","article-title":"Determination of 24 personal care products in fish bile using hybrid solvent precipitation and dispersive solid phase extraction cleanup with ultrahigh performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry","volume":"1551","author":"Yao","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2021.131047_bib37","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1007\/s00216-016-9924-y","article-title":"Simultaneous determination of 24 personal care products in fish muscle and liver tissues using QuEChERS extraction coupled with ultra pressure liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometer analyses","volume":"408","author":"Yao","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2021.131047_bib38","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/cbdd.13512","article-title":"Design, synthesis, and evaluation of novel heteroaryldihydropyrimidine derivatives as non-nucleoside hepatitis B virus inhibitors by exploring the solvent-exposed region","volume":"95","author":"Yu","year":"2020","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.chemosphere.2021.131047_bib39","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/hep.27034","article-title":"Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice","volume":"60","author":"Zhang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.chemosphere.2021.131047_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.chroma.2007.03.105","article-title":"Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction\u2013liquid chromatography\u2013tandem mass spectrometry","volume":"1154","author":"Zhang","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2021.131047_bib41","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jhazmat.2016.11.024","article-title":"Analysis of azole fungicides in fish muscle tissues: multi-factor optimization and application to environmental samples","volume":"324","author":"Zhong","year":"2017","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2021.131047_bib42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chroma.2012.04.076","article-title":"Simultaneous determination of human and veterinary antibiotics in various environmental matrices by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"1244","author":"Zhou","year":"2012","journal-title":"J. Chromatogr. A"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521015198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521015198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:00:21Z","timestamp":1758628821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653521015198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":42,"alternative-id":["S0045653521015198"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131047","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of sensitive methods for simultaneous determination of 9 antiviral drugs in different various environmental matrices by UPLC-MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"131047"}}