{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:36:52Z","timestamp":1785883012878,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.chemosphere.2021.131149","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T08:40:06Z","timestamp":1623400806000},"page":"131149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis"],"prefix":"10.1016","volume":"282","author":[{"given":"Huijuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-3670","authenticated-orcid":false,"given":"Jinxuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3893-6325","authenticated-orcid":false,"given":"Zhaoqian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-8801","authenticated-orcid":false,"given":"Kaiyan","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-3786","authenticated-orcid":false,"given":"Huan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2021.131149_bib1","doi-asserted-by":"crossref","first-page":"109576","DOI":"10.1016\/j.ecoenv.2019.109576","article-title":"Low concentrations of FA exhibits the Hormesis effect by affecting cell division and the Warburg effect","volume":"183","author":"An","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.chemosphere.2021.131149_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41590-020-0666-9","article-title":"Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal","volume":"21","author":"Baumann","year":"2020","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.131149_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.intimp.2014.08.002","article-title":"THP-1 cell line: an in vitro cell model for immune modulation approach","volume":"23","author":"Chanput","year":"2014","journal-title":"Int. Immunopharm."},{"issue":"Pt A","key":"10.1016\/j.chemosphere.2021.131149_bib4","doi-asserted-by":"crossref","first-page":"108740","DOI":"10.1016\/j.envres.2019.108740","article-title":"Occupational exposure to formaldehyde and early biomarkers of cancer risk, immunotoxicity and susceptibility","volume":"179","author":"Costa","year":"2019","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.chemosphere.2021.131149_bib5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11033-015-3858-x","article-title":"Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K","volume":"42","author":"Courtnay","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.chemosphere.2021.131149_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jim.2017.10.004","article-title":"Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators","volume":"452","author":"Elisia","year":"2018","journal-title":"J. Immunol. Methods"},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.chemosphere.2021.131149_bib8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.15171\/hpp.2015.035","article-title":"Occupational exposure and health impairments of formaldehyde on employees of a wood industry","volume":"5","author":"Jafari","year":"2016","journal-title":"Health Promot. Perspect."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.131149_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1389557033488187","article-title":"Biological role of formaldehyde, and cycles related to methylation, demethylation, and formaldehyde production","volume":"3","author":"Kal\u00e1sz","year":"2003","journal-title":"Mini Rev. Med. Chem."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.131149_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metabol."},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179231","article-title":"Differential effects of formaldehyde exposure on airway inflammation and bronchial hyperresponsiveness in BALB\/c and C57BL\/6 mice","volume":"12","author":"Li","year":"2017","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.chemosphere.2021.131149_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.14336\/AD.2016.0323","article-title":"Brain formaldehyde is related to water intake behavior","volume":"7","author":"Li","year":"2016","journal-title":"Aging Dis"},{"key":"10.1016\/j.chemosphere.2021.131149_bib13","doi-asserted-by":"crossref","first-page":"152650","DOI":"10.1016\/j.tox.2020.152650","article-title":"Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect","volume":"448","author":"Li","year":"2021","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.chemosphere.2021.131149_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-4347(00)00552-1","article-title":"Determination of formaldehyde in blood plasma by high-performance liquid chromatography with fluorescence detection","volume":"753","author":"Luo","year":"2001","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"issue":"9","key":"10.1016\/j.chemosphere.2021.131149_bib15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/02772248.2020.1815202","article-title":"Formaldehyde inhibits development of T lymphocytes in mice","volume":"102","author":"Ma","year":"2020","journal-title":"Toxicol. Environ. Chem."},{"key":"10.1016\/j.chemosphere.2021.131149_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.chemosphere.2021.131149_bib17","doi-asserted-by":"crossref","first-page":"113729","DOI":"10.1016\/j.bcp.2019.113729","article-title":"PI3K\/AKT\/mTOR signaling as a molecular target in head and neck cancer","volume":"172","author":"Marquard","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.131149_bib18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.yrtph.2007.04.006","article-title":"Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers","volume":"48","author":"Marsh","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.131149_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1289\/ehp.0901143","article-title":"Formaldehyde exposure and asthma in children: a systematic review","volume":"118","author":"McGwin","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"7203","key":"10.1016\/j.chemosphere.2021.131149_bib20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2021.131149_bib21","article-title":"Measurement and analysis of extracellular acid production to determine glycolytic rate","volume":"106","author":"Mookerjee","year":"2015","journal-title":"JoVE"},{"key":"10.1016\/j.chemosphere.2021.131149_bib22","doi-asserted-by":"crossref","first-page":"101850","DOI":"10.1016\/j.redox.2020.101850","article-title":"The toxic side of one-carbon metabolism and epigenetics","volume":"40","author":"Morellato","year":"2021","journal-title":"Redox Biol"},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib23","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/CIRCRESAHA.119.312321","article-title":"Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation","volume":"126","author":"Mouton","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2021.131149_bib24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.131149_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13058-018-1095-7","article-title":"Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK\/ERK\/SMAD1 pathway activation in breast cancer","volume":"21","author":"Nokin","year":"2019","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.chemosphere.2021.131149_bib26","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.131149_bib27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/JLB.3A0520-745RR","article-title":"Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response","volume":"109","author":"Prantner","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.chemosphere.2021.131149_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bios.2019.03.010","article-title":"Methylglyoxal - an emerging biomarker for diabetes mellitus diagnosis and its detection methods","volume":"133","author":"Ramachandra Bhat","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.etp.2017.02.008","article-title":"The exposure to formaldehyde causes renal dysfunction, inflammation and redox imbalance in rats","volume":"69","author":"Ramos","year":"2017","journal-title":"Exp. Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.131149_bib30","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1038\/s41598-018-25907-6","article-title":"E-cigarettes can emit formaldehyde at high levels under conditions that have been reported to be non-averse to users","volume":"8","author":"Salamanca","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.chemosphere.2021.131149_bib31","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","volume":"123","author":"Semenza","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.chemosphere.2021.131149_bib32","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.chemosphere.2021.131149_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/bph.13389","article-title":"Inflammation: maladies, models, mechanisms and molecules","volume":"173","author":"Stewart","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1152\/physiol.00016.2017","article-title":"Lactic acid: No longer an inert and end-product of glycolysis","volume":"32","author":"Sun","year":"2017","journal-title":"Physiology"},{"issue":"7","key":"10.1016\/j.chemosphere.2021.131149_bib35","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1096\/fj.201701239R","article-title":"Formaldehyde induces diabetes-associated cognitive impairments","volume":"32","author":"Tan","year":"2018","journal-title":"Faseb. J."},{"issue":"7444","key":"10.1016\/j.chemosphere.2021.131149_bib36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2021.131149_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.peptides.2014.08.009","article-title":"Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin\/orphanin FQ system","volume":"61","author":"Thomas","year":"2014","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.chemosphere.2021.131149_bib38","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/glia.22292","article-title":"Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes","volume":"60","author":"Tulpule","year":"2012","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.chemosphere.2021.131149_bib39","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jnc.12170","article-title":"Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons","volume":"125","author":"Tulpule","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.chemosphere.2021.131149_bib40","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chemosphere.2021.131149_bib41","doi-asserted-by":"crossref","first-page":"115001","DOI":"10.1016\/j.taap.2020.115001","article-title":"Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells","volume":"396","author":"Wang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"20","key":"10.1016\/j.chemosphere.2021.131149_bib42","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1021\/acs.analchem.0c02447","article-title":"Fluorophore-promoted facile deprotonation and exocyclic five-membered ring cyclization for selective and dynamic tracking of labile glyoxals","volume":"92","author":"Xu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chemosphere.2021.131149_bib43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cbpc.2018.08.010","article-title":"Functional suppression of macrophages derived from THP-1 cells by environmentally-relevant concentrations of arsenite","volume":"214","author":"Xu","year":"2018","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"26","key":"10.1016\/j.chemosphere.2021.131149_bib44","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007146","article-title":"Association between formaldehyde exposure and miscarriage in Chinese women","volume":"96","author":"Xu","year":"2017","journal-title":"Medicine"},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib45","first-page":"8358","article-title":"Relationship between the concentration of formaldehyde in the air and asthma in children: a meta-analysis","volume":"8","author":"Yao","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.chemosphere.2021.131149_bib46","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","article-title":"Endothelial lactate controls muscle regeneration from ischemia by inducing M2-like macrophage polarization","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.131149_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/08830185.2014.969421","article-title":"Cellular metabolism and macrophage functional polarization","volume":"34","author":"Zhu","year":"2015","journal-title":"Int. Rev. Immunol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521016210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521016210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:14:10Z","timestamp":1758629650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653521016210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":47,"alternative-id":["S0045653521016210"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131149","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"131149"}}