{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:10:45Z","timestamp":1791443445365,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.chemosphere.2021.131210","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T09:33:01Z","timestamp":1623663181000},"page":"131210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Hepatotoxicity in carp (Cyprinus carpio) exposed to environmental levels of norfloxacin (NOR): Some latest evidences from transcriptomics analysis, biochemical parameters and histopathological changes"],"prefix":"10.1016","volume":"283","author":[{"given":"Si-Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Ying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Han","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2021.131210_bib1","doi-asserted-by":"crossref","first-page":"139505","DOI":"10.1016\/j.scitotenv.2020.139505","article-title":"Histological and molecular changes in gill and liver of fish ( Astyanax lacustris L\u00fctken, 1875) exposed to water from the Doce basin after the rupture of a mining tailings dam in Mariana, MG, Brazil","volume":"735","author":"Aksm","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131210_bib2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11356-018-3563-0","article-title":"Antibiotics in hospital effluents: occurrence, contribution to urban wastewater, removal in a wastewater treatment plant, and environmental risk assessment","volume":"26","author":"Aydin","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2021.131210_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00374-003-0620-7","article-title":"Novel antibiotics as inhibitors for the selective respiratory inhibition method of measuring fungal:bacterial ratios in soil","volume":"38","author":"Bailey","year":"2003","journal-title":"Biol. Fertil. Soils"},{"key":"10.1016\/j.chemosphere.2021.131210_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tem.2005.03.010","article-title":"FoxO proteins in insulin action and metabolism","volume":"16","author":"Barthel","year":"2005","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.chemosphere.2021.131210_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","article-title":"Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: a review","volume":"169","author":"Ben","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2021.131210_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","volume":"76","author":"Bessone","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chemosphere.2021.131210_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.22630\/AAS.2018.57.3.20","article-title":"Physiological and histological effects of herbicides in fish","volume":"57","author":"Bojarski","year":"2018","journal-title":"Annals of Warsaw University of Life Sciences - SGGW - Animal Science"},{"key":"10.1016\/j.chemosphere.2021.131210_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ph13080189","article-title":"Antibacterials in aquatic environment and their toxicity to fish","volume":"13","author":"Bojarski","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.chemosphere.2021.131210_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chemosphere.2021.131210_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cbpc.2018.06.005","article-title":"Zebrafish (Danio rerio): a valuable tool for predicting the metabolism of xenobiotics in humans?","volume":"212","author":"de Souza Anselmo","year":"2018","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.131210_bib11","first-page":"1752","article-title":"Detection of antibiotics in hospital effluents in India","volume":"97","author":"Diwan","year":"2009","journal-title":"Curr. Sci."},{"key":"10.1016\/j.chemosphere.2021.131210_bib12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.chemosphere.2011.11.019","article-title":"Occurrence of antibiotics in eight sewage treatment plants in Beijing, China","volume":"86","author":"Gao","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131210_bib13","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/s10620-011-1994-2","article-title":"Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD","volume":"57","author":"Gawrieh","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.chemosphere.2021.131210_bib14","first-page":"323","article-title":"Effect of oxytetracycline on Thai Silver Barb (Barbonymus gonionotus) and on it's culture environment","volume":"10","author":"Islam","year":"2015","journal-title":"J. Fish. Aquat. Sci."},{"key":"10.1016\/j.chemosphere.2021.131210_bib15","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/etc.3552","article-title":"Implications of fluoroquinolone contamination for the aquatic environment-A review","volume":"35","author":"Janecko","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2021.131210_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.envint.2017.09.013","article-title":"Integrating human and environmental health in antibiotic risk assessment: a critical analysis of protection goals, species sensitivity and antimicrobial resistance","volume":"109","author":"Le Page","year":"2017","journal-title":"Environ. Int"},{"key":"10.1016\/j.chemosphere.2021.131210_bib17","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8216","article-title":"Heatstroke-induced hepatocyte exosomes promote liver injury by activating the NOD-like receptor signaling pathway in mice","volume":"7","author":"Li","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.chemosphere.2021.131210_bib18","first-page":"1582","article-title":"Distribution and risk assessment of toxic pollutants in surface water of the lower Yellow river, China","volume":"13","author":"Li","year":"2021","journal-title":"Water-Sui"},{"key":"10.1016\/j.chemosphere.2021.131210_bib19","article-title":"Chronic exposure to Tributyltin induces brain functional damage in juvenile common carp (Cyprinus carpio)","volume":"10","author":"Li","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.chemosphere.2021.131210_bib20","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.watres.2010.10.032","article-title":"Evaluating environmental impact of STPs situated on streams in the Czech Republic: an integrated approach to biomonitoring the aquatic environment","volume":"45","author":"Li","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2021.131210_bib21","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s10646-015-1457-1","article-title":"Effects of norfloxacin on hepatic genes expression of P450 isoforms (CYP1A and CYP3A), GST and P-glycoprotein (P-gp) in Swordtail fish (Xiphophorus helleri)","volume":"24","author":"Liang","year":"2015","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2021.131210_bib22","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.chemosphere.2004.09.015","article-title":"Determination of antibiotic substances in hospital sewage water using solid phase extraction and liquid chromatography\/mass spectrometry and group analogue internal standards","volume":"57","author":"Lindberg","year":"2004","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131210_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ecoenv.2014.01.014","article-title":"A multi-biomarker assessment of single and combined effects of norfloxacin and sulfamethoxazole on male goldfish (Carassius auratus)","volume":"102","author":"Liu","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2021.131210_bib24","doi-asserted-by":"crossref","first-page":"11063","DOI":"10.1007\/s11356-018-1290-1","article-title":"Occurrence, source, and ecological risk of antibiotics in Dongting Lake, China","volume":"25","author":"Liu","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2021.131210_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.envpol.2017.01.003","article-title":"Usage, residue, and human health risk of antibiotics in Chinese aquaculture: a review","volume":"223","author":"Liu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2021.131210_bib26","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1105\/tpc.19.00981","article-title":"Transcription factors FHY3 and FAR1 regulate light-induced CIRCADIAN CLOCK ASSOCIATED1 gene expression in Arabidopsis","volume":"32","author":"Liu","year":"2020","journal-title":"Plant Cell"},{"key":"10.1016\/j.chemosphere.2021.131210_bib27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.aquatox.2008.07.009","article-title":"Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver","volume":"89","author":"Liu","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2021.131210_bib28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.chemosphere.2004.08.097","article-title":"Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography-mass spectrometry and fluorescence detection","volume":"58","author":"Nakata","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131210_bib29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","article-title":"Liver lipid metabolism","volume":"92","author":"Nguyen","year":"2008","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.chemosphere.2021.131210_bib30","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature01667","article-title":"Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction","volume":"423","author":"Puigserver","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2021.131210_bib31","first-page":"237","article-title":"The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation","volume":"61","author":"Raj","year":"2015","journal-title":"J. Reprod"},{"key":"10.1016\/j.chemosphere.2021.131210_bib32","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1086\/605630","article-title":"Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship","volume":"49","author":"Roberts","year":"2009","journal-title":"Clin. Inf. Disp."},{"key":"10.1016\/j.chemosphere.2021.131210_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1897\/04-210R.1","article-title":"Toxicity of fluoroquinolone antibiotics to aquatic organisms","volume":"24","author":"Robinson","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2021.131210_bib34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ecoenv.2018.07.124","article-title":"Oxytetracycline effects in specific biochemical pathways of detoxification, neurotransmission and energy production in Oncorhynchus mykiss","volume":"164","author":"Rodrigues","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2021.131210_bib35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.etap.2017.05.012","article-title":"Histological alterations in gills and liver of rainbow trout (Oncorhynchus mykiss) after exposure to the antibiotic oxytetracycline","volume":"53","author":"Rodrigues","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.131210_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecoenv.2019.05.067","article-title":"Histopathological effects of the antibiotic erythromycin on the freshwater fish species Oncorhynchus mykiss","volume":"181","author":"Rodrigues","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2021.131210_bib37","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.scitotenv.2018.04.291","article-title":"Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio","volume":"636","author":"Santangeli","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2021.131210_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.agwat.2013.08.007","article-title":"Global, regional, and country level need for data on wastewater generation, treatment, and use","volume":"130","author":"Sato","year":"2013","journal-title":"Agric. Water Manag."},{"key":"10.1016\/j.chemosphere.2021.131210_bib39","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.aquaculture.2008.08.032","article-title":"Oxidative stress response of black tiger shrimp (Penaeus monodon) to enrofloxacin and to culture system","volume":"285","author":"Silvestre","year":"2008","journal-title":"Aquaculture"},{"key":"10.1016\/j.chemosphere.2021.131210_bib40","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.chemosphere.2018.11.070","article-title":"Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish","volume":"217","author":"Wan","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131210_bib41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.envint.2019.05.056","article-title":"Bioaccumulation in the gut and liver causes gut barrier dysfunction and hepatic metabolism disorder in mice after exposure to low doses of OBS","volume":"129","author":"Wang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2021.131210_bib42","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.chemosphere.2009.09.038","article-title":"Adverse effects of enrofloxacin when associated with environmental stress in Tra catfish (Pangasianodon hypophthalmus)","volume":"77","author":"Wang","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2021.131210_bib43","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ecoenv.2017.02.042","article-title":"Reproductive toxicity of beta-diketone antibiotic mixtures to zebrafish (Danio rerio)","volume":"141","author":"Wang","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2021.131210_bib44","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.envpol.2006.05.038","article-title":"Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"145","author":"Xu","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2021.131210_bib45","doi-asserted-by":"crossref","first-page":"108840","DOI":"10.1016\/j.cbpc.2020.108840","article-title":"A review of the toxicity in fish exposed to antibiotics","volume":"237","author":"Yang","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2021.131210_bib46","doi-asserted-by":"crossref","first-page":"10652","DOI":"10.1021\/es2026592","article-title":"Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish","volume":"45","author":"Yu","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2021.131210_bib47","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ecoenv.2012.03.002","article-title":"Occurrence and risks of antibiotics in the Laizhou Bay, China: impacts of river discharge","volume":"80","author":"Zhang","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2021.131210_bib48","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.envpol.2017.12.073","article-title":"Environmental concentrations of antibiotics impair zebrafish gut health","volume":"235","author":"Zhou","year":"2018","journal-title":"Environ. Pollut."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521016829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521016829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:00:13Z","timestamp":1731499213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653521016829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":48,"alternative-id":["S0045653521016829"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131210","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatotoxicity in carp (Cyprinus carpio) exposed to environmental levels of norfloxacin (NOR): Some latest evidences from transcriptomics analysis, biochemical parameters and histopathological changes","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.131210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"131210"}}