{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:44:14Z","timestamp":1792691054497,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771543"],"award-info":[{"award-number":["81771543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.chemosphere.2021.132244","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T12:13:12Z","timestamp":1631621592000},"page":"132244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"P3","title":["Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors."],"prefix":"10.1016","volume":"287","author":[{"given":"Yuming","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.chemosphere.2021.132244_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/iub.130","article-title":"Laccase treatment impairs bisphenol A-induced cancer cell proliferation affecting estrogen receptor alpha-dependent rapid signals","volume":"60","author":"Bolli","year":"2008","journal-title":"IUBMB Life"},{"issue":"9","key":"10.1016\/j.chemosphere.2021.132244_bib2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/iub.370","article-title":"Bisphenol A impairs estradiol-induced protective effects against DLD-1 colon cancer cell growth","volume":"62","author":"Bolli","year":"2010","journal-title":"IUBMB Life"},{"issue":"6","key":"10.1016\/j.chemosphere.2021.132244_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1634\/theoncologist.7-6-477","article-title":"FDA drug approval summaries: fulvestrant","volume":"7","author":"Bross","year":"2002","journal-title":"Oncol."},{"issue":"9","key":"10.1016\/j.chemosphere.2021.132244_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1358\/dot.2004.40.9.850495","article-title":"Fulvestrant: a new type of estrogen receptor antagonist for the treatment of advanced breast cancer","volume":"40","author":"Buzdar","year":"2004","journal-title":"Drugs Today"},{"issue":"9","key":"10.1016\/j.chemosphere.2021.132244_bib5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1358\/dot.2008.44.9.1256862","article-title":"Fulvestrant--a novel estrogen receptor antagonist for the treatment of advanced breast cancer","volume":"44","author":"Buzdar","year":"2008","journal-title":"Drugs Today"},{"issue":"2","key":"10.1016\/j.chemosphere.2021.132244_bib6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/kft198","article-title":"Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro","volume":"136","author":"Dankers","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"137","key":"10.1016\/j.chemosphere.2021.132244_bib7","article-title":"Synthetic estrogenic agents without the phenanthrene nucleus","author":"Dodds Lw","year":"1936","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.chemosphere.2021.132244_bib8","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1096\/fj.07-8688com","article-title":"The ABC transporter BCRP\/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction","volume":"21","author":"Evseenko","year":"2007","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1124\/dmd.106.011411","article-title":"Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta","volume":"35","author":"Grube","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.chemosphere.2021.132244_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxrep.2017.12.013","article-title":"Bisphenol A (BPA) the mighty and the mutagenic","volume":"5","author":"Jalal","year":"2018","journal-title":"Toxicol Rep"},{"issue":"4","key":"10.1016\/j.chemosphere.2021.132244_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","article-title":"Estrogen receptor alpha and beta in health and disease","volume":"29","author":"Jia","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.132244_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/JME-15-0248","article-title":"Interaction of steroid receptor coactivators and estrogen receptors in the human placenta","volume":"56","author":"Kim","year":"2016","journal-title":"J. Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib13","first-page":"5","article-title":"Health risk of exposure to Bisphenol A (BPA)","volume":"66","author":"Konieczna","year":"2015","journal-title":"Rocz. Panstw. Zakl. Hig."},{"issue":"6","key":"10.1016\/j.chemosphere.2021.132244_bib14","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1210\/me.2008-0371","article-title":"Estrogen receptor alpha (ERalpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta","volume":"23","author":"Kumar","year":"2009","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molimm.2014.05.002","article-title":"Demethylation within the proximal promoter region of human estrogen receptor alpha gene correlates with its enhanced expression: implications for female bias in lupus","volume":"61","author":"Liu","year":"2014","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.chemosphere.2021.132244_bib16","first-page":"769","article-title":"[Expression and localization of estrogen receptor ERalpha and the kinds of ERbeta mRNA on placenta]","volume":"37","author":"Luo","year":"2006","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-014-9668-6","article-title":"Role of the breast cancer resistance protein (BCRP\/ABCG2) in drug transport--an update","volume":"17","author":"Mao","year":"2015","journal-title":"AAPS J."},{"issue":"2","key":"10.1016\/j.chemosphere.2021.132244_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/toxsci\/kfs167","article-title":"Human and rat ABC transporter efflux of bisphenol a and bisphenol a glucuronide: interspecies comparison and implications for pharmacokinetic assessment","volume":"128","author":"Mazur","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.chemosphere.2021.132244_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00418-018-1699-0","article-title":"Human trophoblast invasion: new and unexpected routes and functions","volume":"150","author":"Moser","year":"2018","journal-title":"Histochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.132244_bib20","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1073\/pnas.1322910111","article-title":"The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor alpha AF-2 is modified","volume":"111","author":"Moverare-Skrtic","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemosphere.2021.132244_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: a review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/bph.12122","article-title":"Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells","volume":"169","author":"Sengupta","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.chemosphere.2021.132244_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0897.2010.00837.x","article-title":"Placental apoptosis in health and disease","volume":"64","author":"Sharp","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.chemosphere.2021.132244_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mce.2016.03.034","article-title":"The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures","volume":"429","author":"Sieppi","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1\u20135","key":"10.1016\/j.chemosphere.2021.132244_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jsbmb.2006.12.104","article-title":"Demethylation of promoter C region of estrogen receptor alpha gene is correlated with its enhanced expression in estrogen-ablation resistant MCF-7 cells","volume":"105","author":"Sogon","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0143-4004(95)90080-2","article-title":"Trophoblast differentiation during formation of anchoring villi in a model of the early human placenta in vitro","volume":"16","author":"Vicovac","year":"1995","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.chemosphere.2021.132244_bib27","doi-asserted-by":"crossref","first-page":"E798","DOI":"10.1152\/ajpendo.00397.2005","article-title":"Regulation of BCRP\/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells","volume":"290","author":"Wang","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"30","key":"10.1016\/j.chemosphere.2021.132244_bib28","doi-asserted-by":"crossref","first-page":"49005","DOI":"10.18632\/oncotarget.16923","article-title":"Low concentration of BPA induces mice spermatocytes apoptosis via GPR30","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.chemosphere.2021.132244_bib29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/jcmm.16030","article-title":"Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization","volume":"25","author":"Xiong","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"Pt B","key":"10.1016\/j.chemosphere.2021.132244_bib30","doi-asserted-by":"crossref","first-page":"115748","DOI":"10.1016\/j.envpol.2020.115748","article-title":"BPA modulates the WDR5\/TET2 complex to regulate ERbeta expression in eutopic endometrium and drives the development of endometriosis","volume":"268","author":"Xue","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2021.132244_bib31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.chemosphere.2019.05.133","article-title":"A mechanism for the effect of endocrine disrupting chemicals on placentation","volume":"231","author":"Yang","year":"2019","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521027168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653521027168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:08:58Z","timestamp":1758629338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653521027168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":31,"alternative-id":["S0045653521027168"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132244","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors.","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2021.132244","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"132244"}}