{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:46:40Z","timestamp":1792154800989,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2020KTSCX133"],"award-info":[{"award-number":["2020KTSCX133"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.chemosphere.2022.133910","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T05:26:01Z","timestamp":1644211561000},"page":"133910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Fumonisin B1 induces hepatotoxicity in mice through the activation of oxidative stress, apoptosis and fibrosis"],"prefix":"10.1016","volume":"296","author":[{"given":"Changyu","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxi","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2022.133910_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060244","article-title":"Fusarium molds and mycotoxins: potential species-specific effects","volume":"10","author":"Bertero","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.chemosphere.2022.133910_bib2","first-page":"158","article-title":"Aging and cardiac fibrosis","volume":"2","author":"Biernacka","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.chemosphere.2022.133910_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/hep.29833","article-title":"Expression of microRNA-155 in inflammatory cells modulates liver injury","volume":"68","author":"Blaya","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.chemosphere.2022.133910_bib4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0278-6915(00)00084-3","article-title":"A comparison of clinical, histopathological and cell-cycle markers in rats receiving the fungal toxins fumonisin B1 or fumonisin B2 by intraperitoneal injection","volume":"38","author":"Bondy","year":"2000","journal-title":"Food Chem. Toxicol. : Int. J. Pub. British Industrial biol. Res. Assoc."},{"issue":"5","key":"10.1016\/j.chemosphere.2022.133910_bib5","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/jcm9051294","article-title":"Inhibition of protein-tyrosine phosphatase PTP1B and LMPTP promotes palmitate\/oleate-challenged HepG2 cell survival by reducing lipoapoptosis, improving mitochondrial dynamics and mitigating oxidative and endoplasmic reticulum stress","volume":"9","author":"Bourebaba","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.chemosphere.2022.133910_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fct.2018.03.004","article-title":"Modulation of key lipid raft constituents in primary rat hepatocytes by fumonisin B(1) - implications for cancer promotion in the liver","volume":"115","author":"Burger","year":"2018","journal-title":"Food Chem. Toxicol. : Int. J. Pub. British Industrial biol. Res. Assoc."},{"key":"10.1016\/j.chemosphere.2022.133910_bib7","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1053\/jhep.2003.50472","article-title":"Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression","volume":"38","author":"Canbay","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.chemosphere.2022.133910_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/hep.20051","article-title":"Apoptosis: the nexus of liver injury and fibrosis","volume":"39","author":"Canbay","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.chemosphere.2022.133910_bib9","doi-asserted-by":"crossref","first-page":"111274","DOI":"10.1016\/j.fct.2020.111274","article-title":"Transcriptome study reveals apoptosis of porcine kidney cells induced by fumonisin B1 via TNF signalling pathway","volume":"139","author":"Chen","year":"2020","journal-title":"Food Chem. Toxicol. : Int. J. Pub. British Industrial biol. Res. Assoc."},{"key":"10.1016\/j.chemosphere.2022.133910_bib10","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fmicb.2017.02317","article-title":"Lactobacillus plantarum MYS6 ameliorates fumonisin B1-induced hepatorenal damage in broilers","volume":"8","author":"Deepthi","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chemosphere.2022.133910_bib11","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/acs.chemrestox.8b00188","article-title":"Mechanisms of fumonisin B1 toxicity: a computational perspective beyond the ceramide synthases inhibition","volume":"31","author":"Dellafiora","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.133910_bib12","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.3390\/ijms12085213","article-title":"Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways","volume":"12","author":"Doi","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2022.133910_bib13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.yexcr.2018.07.011","article-title":"Treatment-damaged hepatocellular carcinoma promotes activities of hepatic stellate cells and fibrosis through GDF15","volume":"370","author":"Dong","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.chemosphere.2022.133910_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/61.1.6","article-title":"Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example","volume":"61","author":"Dragan","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2022.133910_bib15","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.bcp.2012.02.007","article-title":"The low intestinal and hepatic toxicity of hydrolyzed fumonisin B\u2081 correlates with its inability to alter the metabolism of sphingolipids","volume":"83","author":"Grenier","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chemosphere.2022.133910_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/nt.2620030512","article-title":"Effects of intravenous fumonisin B1 in rabbits: nephrotoxicity and sphingolipid alterations","volume":"3","author":"Gumprecht","year":"1995","journal-title":"Nat. Toxins"},{"key":"10.1016\/j.chemosphere.2022.133910_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fct.2014.11.020","article-title":"Effects of orally administered fumonisin B\u2081 (FB\u2081), partially hydrolysed FB\u2081, hydrolysed FB\u2081 and N-(1-deoxy-D-fructos-1-yl) FB\u2081 on the sphingolipid metabolism in rats","volume":"76","author":"Hahn","year":"2015","journal-title":"Food Chem. Toxicol. : Int. J. Pub. British Industrial biol. Res. Assoc."},{"key":"10.1016\/j.chemosphere.2022.133910_bib18","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/01.CIR.0000085658.98621.49","article-title":"Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?","volume":"108","author":"Jugdutt","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.chemosphere.2022.133910_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.rvsc.2016.07.011","article-title":"Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida","volume":"108","author":"Kov\u00e1cs","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.chemosphere.2022.133910_bib21","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s10695-020-00845-1","article-title":"Short-term effects of deoxynivalenol, T-2 toxin, fumonisin B1 or ochratoxin on lipid peroxidation and glutathione redox system and its regulatory genes in common carp (Cyprinus carpio L.) liver","volume":"46","author":"K\u00f6vesi","year":"2020","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.chemosphere.2022.133910_bib22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/faat.1997.2380","article-title":"Lack of embryotoxicity of fumonisin B1 in New Zealand white rabbits","volume":"40","author":"LaBorde","year":"1997","journal-title":"Fund. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.chemosphere.2022.133910_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13287-020-1552-y","article-title":"TGF-\u03b2\/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment","volume":"11","author":"Li","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.chemosphere.2022.133910_bib25","doi-asserted-by":"crossref","first-page":"115461","DOI":"10.1016\/j.envpol.2020.115461","article-title":"Fumonisins B1 exposure triggers intestinal tract injury via activating nuclear xenobiotic receptors and attracting inflammation response","volume":"267","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.133910_bib26","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s00204-014-1323-6","article-title":"New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver","volume":"89","author":"Loiseau","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.133910_bib27","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1007\/s10620-019-05588-5","article-title":"Locostatin alleviates liver fibrosis induced by carbon tetrachloride in mice","volume":"64","author":"Ma","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.chemosphere.2022.133910_bib28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/00071669708418024","article-title":"Disease outbreak in laying hens arising from the consumption of fumonisin-contaminated food","volume":"38","author":"Prathapkumar","year":"1997","journal-title":"Br. Poultry Sci."},{"key":"10.1016\/j.chemosphere.2022.133910_bib29","doi-asserted-by":"crossref","first-page":"L1026","DOI":"10.1152\/ajplung.00183.2003","article-title":"Unbalanced collagenases\/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis","volume":"285","author":"Ruiz","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.chemosphere.2022.133910_bib30","doi-asserted-by":"crossref","first-page":"111140","DOI":"10.1016\/j.fct.2020.111140","article-title":"Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans","volume":"137","author":"Schelstraete","year":"2020","journal-title":"Food Chem. Toxicol. : Int. J. Pub. British Industrial biol. Res. Assoc."},{"key":"10.1016\/j.chemosphere.2022.133910_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0041-008X(03)00262-X","article-title":"Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites","volume":"192","author":"Seefelder","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2022.133910_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081365","article-title":"Melatonin alleviates liver apoptosis in bile duct ligation young rats","volume":"17","author":"Sheen","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2022.133910_bib33","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s13071-017-2538-1","article-title":"Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes","volume":"10","author":"Shi","year":"2017","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.chemosphere.2022.133910_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10110465","article-title":"Dose and exposure time-dependent renal and hepatic effects of intraperitoneally administered fumonisin B\u2081 in rats","volume":"10","author":"Szab\u00f3","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.chemosphere.2022.133910_bib35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/jb\/mvaa013","article-title":"Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1","volume":"167","author":"Tang","year":"2020","journal-title":"J. Biochem."},{"key":"10.1016\/j.chemosphere.2022.133910_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/A:1006810916344","article-title":"In vivo effects of fumonisin B1-producing and fumonisin B1-nonproducing Fusarium moniliforme isolates are similar: fumonisins B2 and B3 cause hepato- and nephrotoxicity in rats","volume":"141","author":"Voss","year":"1998","journal-title":"Mycopathologia"},{"key":"10.1016\/j.chemosphere.2022.133910_bib37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3892\/etm.2013.1364","article-title":"Stimulation of the proliferation of human normal esophageal epithelial cells by fumonisin B(1) and its mechanism","volume":"7","author":"Wang","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.chemosphere.2022.133910_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.toxicon.2020.04.094","article-title":"Ochratoxin A and fumonisin B(1) exhibit synergistic cytotoxic effects by inducing apoptosis on rat liver cells","volume":"181","author":"Wang","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.chemosphere.2022.133910_bib39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-4781(00)00002-6","article-title":"Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription","volume":"1490","author":"White","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.chemosphere.2022.133910_bib40","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/molecules21030384","article-title":"Casticin inhibits A375.S2 human melanoma cell migration\/invasion through downregulating NF-\u03baB and matrix metalloproteinase-2 and -1","volume":"21","author":"Wu","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.chemosphere.2022.133910_bib41","first-page":"291","article-title":"Heme oxygenase-1 exerts pro-apoptotic effects on hepatic stellate cells in vitro through regulation of nuclear factor-\u03baB","volume":"16","author":"Yang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.chemosphere.2022.133910_bib42","doi-asserted-by":"crossref","first-page":"122087","DOI":"10.1016\/j.jhazmat.2020.122087","article-title":"Effects of mycotoxin-contaminated feed on farm animals","volume":"389","author":"Yang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.133910_bib43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41467-017-00204-4","article-title":"The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGF\u03b2 and Notch pathways","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522004039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522004039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:50:48Z","timestamp":1736347848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653522004039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":41,"alternative-id":["S0045653522004039"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.133910","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fumonisin B1 induces hepatotoxicity in mice through the activation of oxidative stress, apoptosis and fibrosis","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.133910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"133910"}}