{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:21:43Z","timestamp":1784233303213,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["GSKY202201012"],"award-info":[{"award-number":["GSKY202201012"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0802701"],"award-info":[{"award-number":["2019YFA0802701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91839102"],"award-info":[{"award-number":["91839102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900281"],"award-info":[{"award-number":["81900281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91943301"],"award-info":[{"award-number":["91943301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20340"],"award-info":[{"award-number":["U21A20340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.chemosphere.2022.134398","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T06:27:03Z","timestamp":1648016823000},"page":"134398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Associations of genetic risk factors and air pollution with incident hypertension among participants in the UK Biobank study"],"prefix":"10.1016","volume":"299","author":[{"given":"Zhenkun","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2022.134398_bib1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/jnci\/djz241","article-title":"Genetic factors, adherence to healthy lifestyle behavior, and risk of invasive breast cancer among women in the UK biobank","volume":"112","author":"Arthur","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.chemosphere.2022.134398_bib2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00001648-199605000-00012","article-title":"Confidence intervals for measures of interaction","volume":"7","author":"Assmann","year":"1996","journal-title":"Epidemiology"},{"key":"10.1016\/j.chemosphere.2022.134398_bib3","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/CIRCULATIONAHA.118.034856","article-title":"Association between ambient air pollution and cardiac morpho-functional phenotypes: insights from the UK biobank population imaging study","volume":"138","author":"Aung","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.chemosphere.2022.134398_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000212","article-title":"DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments","volume":"2","author":"Bellavia","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.chemosphere.2022.134398_bib5","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1161\/01.CIR.0000128587.30041.C8","article-title":"Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association","volume":"109","author":"Brook","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.chemosphere.2022.134398_bib6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jash.2009.08.005","article-title":"Particulate matter, air pollution, and blood pressure","volume":"3","author":"Brook","year":"2009","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.chemosphere.2022.134398_bib7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/HYPERTENSIONAHA.109.130237","article-title":"Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans","volume":"54","author":"Brook","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/HYPERTENSIONAHA.116.07218","article-title":"Associations of short-term and long-term exposure to ambient air pollutants with hypertension: a systematic review and meta-analysis","volume":"68","author":"Cai","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib9","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/S0140-6736(03)13722-1","article-title":"Genome-wide mapping of human loci for essential hypertension","volume":"361","author":"Caulfield","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2022.134398_bib10","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/CIRCULATIONAHA.113.003532","article-title":"Spatial association between ambient fine particulate matter and incident hypertension","volume":"129","author":"Chen","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.chemosphere.2022.134398_bib11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1289\/ehp.1408771","article-title":"Associations between long-term air pollutant exposures and blood pressure in elderly residents of Taipei city: a cross-sectional study","volume":"123","author":"Chen","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2022.134398_bib12","first-page":"202","article-title":"PM2.5 and diabetes and hypertension incidence in the black Women's health study","volume":"27","author":"Coogan","year":"2016","journal-title":"Epidemiology"},{"key":"10.1016\/j.chemosphere.2022.134398_bib13","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/es301948k","article-title":"Development of Land Use Regression models for PM(2.5), PM(2.5) absorbance, PM(10) and PM(coarse) in 20 European study areas; results of the ESCAPE project","volume":"46","author":"Eeftens","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.134398_bib14","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","article-title":"Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits","volume":"50","author":"Evangelou","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chemosphere.2022.134398_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/1381612822666151109111712","article-title":"Air pollution exposure and blood pressure: an updated review of the literature","volume":"22","author":"Giorgini","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.chemosphere.2022.134398_bib16","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1016\/j.scitotenv.2010.06.042","article-title":"The relationship between particulate air pollution and emergency hospital visits for hypertension in Beijing, China","volume":"408","author":"Guo","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.134398_bib17","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/HYPERTENSIONAHA.119.12666","article-title":"Long-term exposure to fine particulate matter and hypertension incidence in China","volume":"73","author":"Huang","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","article-title":"Air pollution, genetic factors and the risk of lung cancer: a prospective study in the UK biobank","volume":"204","author":"Huang","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.chemosphere.2022.134398_bib19","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01831-2019","article-title":"Genetic susceptibility to asthma increases the vulnerability to indoor air pollution","volume":"55","author":"Huls","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.chemosphere.2022.134398_bib20","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/aje\/kwu214","article-title":"Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium","volume":"180","author":"Joshi","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2022.134398_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2022.134398_bib22","doi-asserted-by":"crossref","first-page":"10889","DOI":"10.1038\/ncomms10889","article-title":"Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank","volume":"7","author":"Lane","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chemosphere.2022.134398_bib23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ng.384","article-title":"Genome-wide association study of blood pressure and hypertension","volume":"41","author":"Levy","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chemosphere.2022.134398_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.annepidem.2006.10.009","article-title":"Test for additive interaction in proportional hazards models","volume":"17","author":"Li","year":"2007","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.chemosphere.2022.134398_bib25","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1097\/HJH.0000000000000342","article-title":"Effect of exposure to PM2.5 on blood pressure: a systematic review and meta-analysis","volume":"32","author":"Liang","year":"2014","journal-title":"J. Hypertens."},{"key":"10.1016\/j.chemosphere.2022.134398_bib26","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/HYPERTENSIONAHA.116.08839","article-title":"Long-term effects of ambient PM2.5 on hypertension and blood pressure and attributable risk among older Chinese adults","volume":"69","author":"Lin","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib27","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.envpol.2015.10.056","article-title":"Particle size and chemical constituents of ambient particulate pollution associated with cardiovascular mortality in Guangzhou, China","volume":"208","author":"Lin","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134398_bib28","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1136\/heartjnl-2012-302883","article-title":"Genetic discoveries in hypertension: steps on the road to therapeutic translation","volume":"99","author":"Lind","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.chemosphere.2022.134398_bib29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1056\/NEJMoa1817364","article-title":"Ambient particulate air pollution and daily mortality in 652 cities","volume":"381","author":"Liu","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2022.134398_bib30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.envint.2016.03.028","article-title":"Associations between long-term exposure to ambient particulate air pollution and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China","volume":"92\u201393","author":"Liu","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2022.134398_bib31","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/HYPERTENSIONAHA.121.16739","article-title":"Can single nucleotide polymorphisms beat schnuffel?: assessing hypertension polygenic risk scores","volume":"77","author":"Luft","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1289\/ehp.1306755","article-title":"Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project","volume":"122","author":"MacIntyre","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2022.134398_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.envint.2018.11.001","article-title":"Association of long-term PM2.5 exposure with traditional and novel lipid measures related to cardiovascular disease risk","volume":"122","author":"McGuinn","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2022.134398_bib34","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1042\/BST20140090","article-title":"The role of oxidative stress in the cardiovascular actions of particulate air pollution","volume":"42","author":"Miller","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.chemosphere.2022.134398_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.chemosphere.2022.134398_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ncpcardio1399","article-title":"Adverse cardiovascular effects of air pollution","volume":"6","author":"Mills","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.chemosphere.2022.134398_bib37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41569-020-00466-4","article-title":"Genomics of hypertension: the road to precision medicine","volume":"18","author":"Padmanabhan","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.chemosphere.2022.134398_bib38","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1289\/ehp.1002705","article-title":"Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children","volume":"119","author":"Perera","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2022.134398_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12012-014-9272-0","article-title":"Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure","volume":"15","author":"Perez","year":"2015","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.134398_bib40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/CIRCRESAHA.116.305060","article-title":"Relationships between fine particulate air pollution, cardiometabolic disorders, and cardiovascular mortality","volume":"116","author":"Pope","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2022.134398_bib41","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/HYPERTENSIONAHA.120.15373","article-title":"Exposure to particulate matter is associated with elevated blood pressure and incident hypertension in Urban India","volume":"76","author":"Prabhakaran","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(95)90173-6","article-title":"Particulate air pollution and acute health effects","volume":"345","author":"Seaton","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2022.134398_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.chemosphere.2022.134398_bib44","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/HYPERTENSIONAHA.112.195370","article-title":"Short-term increase in particulate matter blunts nocturnal blood pressure dipping and daytime urinary sodium excretion","volume":"60","author":"Tsai","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib45","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/HYPERTENSIONAHA.120.16471","article-title":"Polygenic risk scores predict hypertension onset and cardiovascular risk","volume":"77","author":"Vaura","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.chemosphere.2022.134398_bib46","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehaa1031","article-title":"Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank","volume":"42","author":"Wang","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.chemosphere.2022.134398_bib47","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00439-019-02004-w","article-title":"A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers","volume":"138","author":"Ward-Caviness","year":"2019","journal-title":"Hum. Genet."},{"key":"10.1016\/j.chemosphere.2022.134398_bib48","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.envpol.2018.01.001","article-title":"Global association between ambient air pollution and blood pressure: a systematic review and meta-analysis","volume":"235","author":"Yang","year":"2018","journal-title":"Environ. Pollut."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522008918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522008918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:35:42Z","timestamp":1778661342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653522008918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":48,"alternative-id":["S0045653522008918"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134398","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of genetic risk factors and air pollution with incident hypertension among participants in the UK Biobank study","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134398"}}