{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:41:29Z","timestamp":1790808089459,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31402264"],"award-info":[{"award-number":["31402264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["321611603"],"award-info":[{"award-number":["321611603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.chemosphere.2022.134566","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T08:23:29Z","timestamp":1649492609000},"page":"134566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["Combined effect of arsenic and polystyrene-nanoplastics at environmentally relevant concentrations in mice liver: Activation of apoptosis, pyroptosis and excessive autophagy"],"prefix":"10.1016","volume":"300","author":[{"given":"Gaolong","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2022.134566_bib1","doi-asserted-by":"crossref","first-page":"9175","DOI":"10.1021\/es201811s","article-title":"Accumulation of microplastic on shorelines woldwide: sources and sinks","volume":"45","author":"Browne","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.134566_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bulcan.2020.11.004","article-title":"An overview of autophagy: mechanism, regulation and research progress","volume":"108","author":"Cao","year":"2021","journal-title":"Bull. Cancer"},{"key":"10.1016\/j.chemosphere.2022.134566_bib3","doi-asserted-by":"crossref","first-page":"147620","DOI":"10.1016\/j.scitotenv.2021.147620","article-title":"A critical review on the interactions of microplastics with heavy metals: mechanism and their combined effect on organisms and humans","volume":"788","author":"Cao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.134566_bib4","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1021\/tx500264s","article-title":"Toxic metals and autophagy","volume":"27","author":"Chatterjee","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.134566_bib5","doi-asserted-by":"crossref","first-page":"116524","DOI":"10.1016\/j.envpol.2021.116524","article-title":"Canidin-3-glucoside prevents nano-plastics induced toxicity via activating autophagy and promoting discharge","volume":"274","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.chemosphere.2022.134566_bib7","doi-asserted-by":"crossref","first-page":"116974","DOI":"10.1016\/j.envpol.2021.116974","article-title":"Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells","volume":"280","author":"Ding","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib8","doi-asserted-by":"crossref","first-page":"124792","DOI":"10.1016\/j.chemosphere.2019.124792","article-title":"As(III) adsorption onto different-sized polystyrene microplastic particles and its mechanism","volume":"239","author":"Dong","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.134566_bib9","doi-asserted-by":"crossref","first-page":"113892","DOI":"10.1016\/j.envpol.2019.113892","article-title":"Microplastic particles increase arsenic toxicity to rice seedlings","volume":"259","author":"Dong","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib10","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.envpol.2018.01.024","article-title":"Current opinion: what is a nanoplastic?","volume":"235","author":"Gigault","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib11","doi-asserted-by":"crossref","first-page":"123864","DOI":"10.1016\/j.jhazmat.2020.123864","article-title":"Nanopolystyrene particles at environmentally relevant concentrations causes behavioral and biochemical changes in juvenile grass carp (Ctenopharyngodon idella)","volume":"403","author":"Guimaraes","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.134566_bib12","doi-asserted-by":"crossref","first-page":"112012","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/Caspase-1 signaling pathway in rats","volume":"212","author":"Hou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.134566_bib13","doi-asserted-by":"crossref","first-page":"105772","DOI":"10.1016\/j.aquatox.2021.105772","article-title":"Arsenic exposure combined with nano- or microplastic induces different effects in the marine rotifer Brachionus plicatilis","volume":"233","author":"Kang","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.134566_bib14","doi-asserted-by":"crossref","first-page":"112885","DOI":"10.1016\/j.ecoenv.2021.112885","article-title":"Nanoplastics aggravate the toxicity of arsenic to AGS cells by disrupting ABC transporter and cytoskeleton","volume":"227","author":"Lin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.134566_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice","volume":"631\u2013632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.134566_bib16","doi-asserted-by":"crossref","first-page":"126770","DOI":"10.1016\/j.jhazmat.2021.126770","article-title":"Size-dependent effects of polystyrene nanoplastics on autophagy response in human umbilical vein endothelial cells","volume":"421","author":"Lu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.134566_bib17","doi-asserted-by":"crossref","first-page":"113300","DOI":"10.1016\/j.envpol.2019.113300","article-title":"Acute effects of nanoplastics and microplastics on periphytic biofilms depending on particle size, concentration and surface modification","volume":"255","author":"Miao","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib18","doi-asserted-by":"crossref","first-page":"109821","DOI":"10.1016\/j.cbi.2022.109821","article-title":"Arsenic trioxide-induced autophagy affected the antioxidant capacity and apoptosis rate of chicken hepatocytes","volume":"354","author":"Ning","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.chemosphere.2022.134566_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41419-020-2724-5","article-title":"Autophagy as a modulator of cell death machinery","volume":"11","author":"Noguchi","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.chemosphere.2022.134566_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1590\/1519-6984.228437","article-title":"Apoptosis (programmed cell death) and its signals - a review","volume":"81","author":"Obeng","year":"2021","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.chemosphere.2022.134566_bib21","doi-asserted-by":"crossref","first-page":"116860","DOI":"10.1016\/j.envpol.2021.116860","article-title":"Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene","volume":"277","author":"Pang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib22","doi-asserted-by":"crossref","first-page":"115090","DOI":"10.1016\/j.envpol.2020.115090","article-title":"Nanoplastics impact the zebrafish (Danio rerio) transcriptome: associated developmental and neurobehavioral consequences","volume":"266","author":"Pedersen","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib23","doi-asserted-by":"crossref","first-page":"134455","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental exposure to microplastics: an overview on possible human health effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.134566_bib24","doi-asserted-by":"crossref","first-page":"127842","DOI":"10.1016\/j.jhazmat.2021.127842","article-title":"Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis","volume":"425","author":"Qin","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.134566_bib25","doi-asserted-by":"crossref","first-page":"117940","DOI":"10.1016\/j.envpol.2021.117940","article-title":"Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management","volume":"289","author":"Rahaman","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib26","doi-asserted-by":"crossref","first-page":"102290","DOI":"10.1016\/j.eti.2022.102290","article-title":"Microplastics waste in environment: a perspective on recycling issues from PPE kits and face masks during the COVID-19 pandemic","volume":"26","author":"Ray","year":"2022","journal-title":"Environ. Technol. Innovat."},{"key":"10.1016\/j.chemosphere.2022.134566_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool: a prospective case series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.chemosphere.2022.134566_bib28","doi-asserted-by":"crossref","first-page":"148130","DOI":"10.1016\/j.scitotenv.2021.148130","article-title":"Neglected microplastics pollution in global COVID-19: disposable surgical masks","volume":"790","author":"Shen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.134566_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chemosphere.2022.134566_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1021\/pr400719u","article-title":"Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced Fatty liver disease","volume":"13","author":"Shi","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.chemosphere.2022.134566_bib31","doi-asserted-by":"crossref","first-page":"106622","DOI":"10.1016\/j.envint.2021.106622","article-title":"Hazardous metal additives in plastics and their environmental impacts","volume":"156","author":"Turner","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2022.134566_bib32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1126\/science.abe5041","article-title":"Microplastics and human health","volume":"371","author":"Vethaak","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2022.134566_bib33","doi-asserted-by":"crossref","first-page":"110158","DOI":"10.1016\/j.ecoenv.2019.110158","article-title":"Long-term exposure to copper induces autophagy and apoptosis through oxidative stress in rat kidneys","volume":"190","author":"Wan","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.134566_bib34","doi-asserted-by":"crossref","first-page":"121157","DOI":"10.1016\/j.jhazmat.2019.121157","article-title":"Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells","volume":"383","author":"Wang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.134566_bib35","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/tox.23095","article-title":"The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3\/Caspase-1 signaling pathway and oxidative stress in Wistar rats","volume":"36","author":"Wei","year":"2021","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.134566_bib36","doi-asserted-by":"crossref","first-page":"109612","DOI":"10.1016\/j.ecoenv.2019.109612","article-title":"Environmental occurrences, fate, and impacts of microplastics","volume":"184","author":"Wu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.134566_bib37","doi-asserted-by":"crossref","first-page":"118184","DOI":"10.1016\/j.envpol.2021.118184","article-title":"Results of a 30-day safety assessment in young mice orally exposed to polystyrene nanoparticles","volume":"292","author":"Xiao","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.134566_bib38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chemosphere.2018.03.192","article-title":"Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes","volume":"204","author":"Yang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.134566_bib39","doi-asserted-by":"crossref","first-page":"124888","DOI":"10.1016\/j.jhazmat.2020.124888","article-title":"Exposure to copper induces mitochondria-mediated apoptosis by inhibiting mitophagy and the PINK1\/parkin pathway in chicken (Gallus gallus) livers","volume":"408","author":"Yang","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.134566_bib40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.chemosphere.2022.134566_bib41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tox.2018.09.010","article-title":"Long-term arsenite exposure induces testicular toxicity by redox imbalance, G2\/M cell arrest and apoptosis in mice","volume":"411","author":"Zeng","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2022.134566_bib42","doi-asserted-by":"crossref","first-page":"113099","DOI":"10.1016\/j.ecoenv.2021.113099","article-title":"In vivo assessment of molybdenum and cadmium co-induce nephrotoxicity via causing calcium homeostasis disorder and autophagy in ducks (Anas platyrhyncha)","volume":"230","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.134566_bib43","doi-asserted-by":"crossref","first-page":"113117","DOI":"10.1016\/j.ecoenv.2021.113117","article-title":"Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK\/PGC-1alpha signaling pathway and also induces apoptosis and dysregulated mitophagy in the duck liver","volume":"230","author":"Zhong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.134566_bib44","doi-asserted-by":"crossref","first-page":"147780","DOI":"10.1016\/j.scitotenv.2021.147780","article-title":"Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks","volume":"788","author":"Zhong","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.134566_bib45","doi-asserted-by":"crossref","first-page":"111396","DOI":"10.1016\/j.jinorgbio.2021.111396","article-title":"The protective role of autophagy against arsenic trioxide-induced cytotoxicity and ROS-dependent pyroptosis in NCTC-1469 cells","volume":"217","author":"Zhong","year":"2021","journal-title":"J. Inorg. Biochem."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522010591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522010591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:14:22Z","timestamp":1777464862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653522010591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":45,"alternative-id":["S0045653522010591"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134566","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined effect of arsenic and polystyrene-nanoplastics at environmentally relevant concentrations in mice liver: Activation of apoptosis, pyroptosis and excessive autophagy","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134566"}}