{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:43:10Z","timestamp":1790714590089,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.chemosphere.2022.135751","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T12:53:35Z","timestamp":1658148815000},"page":"135751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"P1","title":["The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos"],"prefix":"10.1016","volume":"307","author":[{"given":"Huilin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2022.135751_bib1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1163\/1568539X-00003020","article-title":"Zebrafish embryos and larvae in behavioural assays","volume":"149","author":"Ahmad","year":"2012","journal-title":"Behaviour"},{"key":"10.1016\/j.chemosphere.2022.135751_bib2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuro.2008.04.021","article-title":"Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex","volume":"29","author":"Alm","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.chemosphere.2022.135751_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ydbio.2012.03.001","article-title":"Characterization and regulation of the hb9\/mnx1 beta-cell progenitor specificenhancer in zebrafish","volume":"365","author":"Arkhipova","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00002324","article-title":"Effects of metals on fish behavior: a review","volume":"18","author":"Atchison","year":"1987","journal-title":"Environ. Biol. Fish."},{"key":"10.1016\/j.chemosphere.2022.135751_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224132","article-title":"Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells","volume":"14","author":"B\u00e9nit","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2022.135751_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopha.2015.07.025","article-title":"Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight","volume":"74","author":"Bhat","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.chemosphere.2022.135751_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128781","article-title":"Bixafen, a succinate dehydrogenase inhibitor fungicide, causes microcephaly and motor neuron axon defects during development","volume":"265","author":"Brenet","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.135751_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105842","article-title":"Environmentally relevant concentrations of triclocarban affect morphological traits and melanogenesis in zebrafish larvae","volume":"236","author":"Caioni","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib10","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1007\/s11356-016-6236-x","article-title":"Acute and short-term developmental toxicity of cyhalofop-butyl to zebrafish (Danio rerio)","volume":"23","author":"Cao","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2022.135751_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0092-8674(03)00199-5","article-title":"The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance","volume":"113","author":"Charron","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2022.135751_bib13","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1021\/acs.jafc.6b03253","article-title":"Effective monitoring of fluxapyroxad and its three biologically active metabolites in vegetables, fruits, and cereals by optimized QuEChERS treatment based on UPLC-MS\/MS","volume":"64","author":"Chen","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2022.135751_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ana.22337","article-title":"Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients","volume":"69","author":"Dutta","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib16","author":"Estimates","year":"2012"},{"key":"10.1016\/j.chemosphere.2022.135751_bib17","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.2903\/j.efsa.2012.2522","article-title":"Conclusion on the peer review of the pesticide risk assessment of the active substance fluxapyroxad (BAS 700 F)","volume":"10","year":"2012","journal-title":"EFSA J."},{"key":"10.1016\/j.chemosphere.2022.135751_bib18","first-page":"4223","article-title":"Modification of the existing maximum residue levels for fluxapyroxad in grapes and potatoes","volume":"13","year":"2015","journal-title":"EFSA J."},{"key":"10.1016\/j.chemosphere.2022.135751_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ntt.2009.04.065","article-title":"Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening","volume":"32","author":"Fan","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib20","first-page":"333","article-title":"Swimming speeds in larval fishes: from escaping predators to the potential for long distance migration","author":"Fisher","year":"2010","journal-title":"Fish Locomot.: Eco-Ethol. Perspect."},{"key":"10.1016\/j.chemosphere.2022.135751_bib21","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1358\/dof.2004.029.12.869227","article-title":"The role of neurotransmitters and neuropeptides in Parkinson's disease: implications for therapy","volume":"29","author":"Gilgun-Sherki","year":"2004","journal-title":"Drugs Future"},{"key":"10.1016\/j.chemosphere.2022.135751_bib22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1054-3589(08)60846-7","article-title":"The cortical dopamine system: role in memory and cognition","volume":"42","author":"Goldman-Rakic","year":"1997","journal-title":"Adv. Pharmacol. Pharm."},{"key":"10.1016\/j.chemosphere.2022.135751_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142315","article-title":"Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae","volume":"754","author":"Gu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.135751_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150210","article-title":"A systematic comparison of neurotoxicity of bisphenol A and its derivatives in zebrafish","volume":"805","author":"Gu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.135751_bib25","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1007\/s00216-014-8073-4","article-title":"Online solid phase extraction LC\u2013MS\/MS method for the analysis of succinate dehydrogenase inhibitor fungicides and its applicability to surface water samples","volume":"406","author":"Gulkowska","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2022.135751_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128045","article-title":"Developmental neurotoxicity of low concentrations of bisphenol A and S exposure in zebrafish","volume":"262","author":"Gyimah","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.135751_bib27","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1007\/s11356-015-5750-6","article-title":"Concentrations and dissipation of difenoconazole and fluxapyroxad residues in apples and soil, determined by ultrahigh-performance liquid chromatography electrospray ionization tandem mass spectrometry","volume":"23","author":"He","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2022.135751_bib28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2022.135751_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jhazmat.2018.01.016","article-title":"Characterization of acrylamide-induced oxidative stress and cardiovascular toxicity in zebrafish embryos","volume":"347","author":"Huang","year":"2018","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.135751_bib30","series-title":"Water Quality-Determination of the Acute Lethal Toxicity of Substances to a Freshwater Fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)]","year":"1996"},{"key":"10.1016\/j.chemosphere.2022.135751_bib31","series-title":"Botryotinia and Botrytis Species: Taxonomy, Physiology and Pathogenicity-A Guide to the Literature","author":"Jarvis","year":"1977"},{"key":"10.1016\/j.chemosphere.2022.135751_bib74","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using imageJ","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat. Rec."},{"key":"10.1016\/j.chemosphere.2022.135751_bib32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.aquatox.2009.10.003","article-title":"Developmental toxicity of bifenthrin in embryo-larval stages of zebrafish","volume":"95","author":"Jin","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jat.1751","article-title":"Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish","volume":"33","author":"Kanungo","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s1012601-0053-4","article-title":"Generating transparent zebrafish: a refined method to improve detection of gene expression during embryonic development","volume":"3","author":"Karlsson","year":"2001","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib35","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1523\/JNEUROSCI.4938-04.2005","article-title":"Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration","volume":"25","author":"Kolpak","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.chemosphere.2022.135751_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1097-0177(199809)213:1<92::AID-AJA9>3.0.CO;2-T","article-title":"Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation","volume":"213","author":"Korzh","year":"1998","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.chemosphere.2022.135751_bib37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10545-016-9927-z","article-title":"Mitochondrial dysfunction in liver failure requiring transplantation","volume":"39","author":"Lane","year":"2016","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.chemosphere.2022.135751_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-015-0579-2","article-title":"Analysis of zebrafish (Danio rerio) behavior in response to bacterial infection using a self-organizing map","volume":"11","author":"Lee","year":"2015","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.chemosphere.2022.135751_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.chroma.2014.06.088","article-title":"A statistical approach to determine fluxapyroxad and its three metabolites in soils, sediment and sludge based on a combination of chemometric tools and a modified quick, easy, cheap, effective, rugged and safe method","volume":"1358","author":"Li","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2022.135751_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00128-015-1556-y","article-title":"Degradation of fluxapyroxad in soils and water\/sediment systems under aerobic or anaerobic conditions","volume":"95","author":"Li","year":"2015","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chemosphere.2018.12.011","article-title":"Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae","volume":"219","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.135751_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127037","article-title":"Fluxapyroxad induces developmental delay in zebrafish (Danio rerio)","volume":"256","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.135751_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144519","article-title":"Toxic effects and potential mechanisms of Fluxapyroxad to zebrafish (Danio rerio) embryos","volume":"769","author":"Lin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.135751_bib44","doi-asserted-by":"crossref","first-page":"6617","DOI":"10.1021\/acs.est.8b00776","article-title":"Thyroid disruption by bisphenol S analogues via thyroid hormone receptor \u03b2: in vitro, in vivo, and molecular dynamics simulation study","volume":"52","author":"Lu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib45","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1021\/acs.jafc.8b05373","article-title":"Developmental toxicity of a neonicotinoid insecticide, acetamiprid to zebrafish embryos","volume":"67","author":"Ma","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2022.135751_bib46","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1021\/acs.jafc.7b03199","article-title":"Fluxapyroxad haptens and antibodies for highly sensitive immunoanalysis of Food samples","volume":"65","author":"Mercader","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2022.135751_bib47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0361-9230(01)00694-3","article-title":"Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain","volume":"57","author":"Mueller","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.chemosphere.2022.135751_bib48","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1242\/dev.126.10.2103","article-title":"Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord","volume":"126","author":"Muller","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2022.135751_bib75","series-title":"OECD Guidelines for the Testing of Chemicals","article-title":"OECD guideline for testing of chemicals. test no. 236, Fish Embryo Acute Toxicity (FET) Test","author":"Organisation for Economic Co-operation and Development (OECD)","year":"2013"},{"key":"10.1016\/j.chemosphere.2022.135751_bib49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-neuro-071714-033857","article-title":"Zebrafish behavior: opportunities and challenges","volume":"40","author":"Orger","year":"2017","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.chemosphere.2022.135751_bib50","first-page":"259","article-title":"Alpers-Huttenlocher syndrome first presented with hepatic failure: can liver transplantation be considered as treatment option? Pediatric gastroenterology","volume":"20","author":"Park","year":"2017","journal-title":"Hepatol. Nutr."},{"key":"10.1016\/j.chemosphere.2022.135751_bib51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tig.2004.08.001","article-title":"Subfunction partitioning, the teleost radiation and the annotation of the human genome","volume":"20","author":"Postlethwait","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.chemosphere.2022.135751_bib52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.chemosphere.2018.09.117","article-title":"Effects of penthiopyrad on the development and behaviour of zebrafish in early-life stages","volume":"214","author":"Qian","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.135751_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124083","article-title":"Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems","volume":"404","author":"Qian","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.135751_bib55","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Rihel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2022.135751_bib56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0165-3806(02)00354-1","article-title":"Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study","volume":"137","author":"Rink","year":"2002","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.chemosphere.2022.135751_bib57","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/jmor.10558","article-title":"Development of the swimbladder and its innervation in the zebrafish, Danio rerio","volume":"268","author":"Robertson","year":"2007","journal-title":"J. Morphol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib58","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aquatox.2018.08.001","article-title":"Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae","volume":"203","author":"Shi","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib59","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10735-012-9462-7","article-title":"HuC-eGFP mosaic labelling of neurons in zebrafish enables in vivo live cell imaging of growth cones","volume":"43","author":"St John","year":"2012","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib60","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.aquatox.2009.10.008","article-title":"Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development","volume":"95","author":"Stanley","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib61","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ntt.2016.03.003","article-title":"Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity","volume":"55","author":"Sun","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.chroma.2015.03.056","article-title":"Simultaneous analysis of multiple neurotransmitters by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry","volume":"1395","author":"Tufi","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2022.135751_bib63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/jhep.2001.25921","article-title":"Navajo neurohepatopathy: a mitochondrial DNA depletion syndrome?","volume":"34","author":"Vu","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.chemosphere.2022.135751_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11270-015-2387-5","article-title":"Dissipation and degradation dynamics of thifluzamide in rice field","volume":"226","author":"Wei","year":"2015","journal-title":"Water, Air, Soil Pollut."},{"key":"10.1016\/j.chemosphere.2022.135751_bib65","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Brachydanio reriro)","author":"Westerfield","year":"1993"},{"key":"10.1016\/j.chemosphere.2022.135751_bib67","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.envpol.2016.03.048","article-title":"Microcystin-LR exposure induces developmental neurotoxicity in zebrafish embryo","volume":"213","author":"Wu","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.135751_bib68","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00128-013-1101-9","article-title":"Effects of di-n-butyl phthalate and diethyl phthalate on acetylcholinesterase activity and neurotoxicity related gene expression in embryonic zebrafish","volume":"91","author":"Xu","year":"2013","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212362","article-title":"SDHI fungicide toxicity and associated adverse outcome pathways: what can zebrafish tell us?","volume":"22","author":"Yanicostas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2022.135751_bib70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.chemosphere.2018.01.046","article-title":"The embryonic developmental effect of sedaxane on zebrafish (Danio rerio)","volume":"197","author":"Yao","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.135751_bib71","first-page":"62","article-title":"Excellent fungicide fluxapyroxad","volume":"40","author":"Ye","year":"2018","journal-title":"World Pesticides"},{"key":"10.1016\/j.chemosphere.2022.135751_bib72","doi-asserted-by":"crossref","first-page":"14638","DOI":"10.1021\/acs.est.9b04097","article-title":"Bisphenol F-induced neurotoxicity toward zebrafish embryos","volume":"53","author":"Yuan","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.135751_bib73","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/02772248.2019.1587442","article-title":"Impacts of benzovindiflupyr on the embryonic development of zebrafish (Danio rerio)","volume":"100","author":"Zhou","year":"2018","journal-title":"Toxicol. Environ. Chem."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522022445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522022445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:41:11Z","timestamp":1762224071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653522022445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":70,"alternative-id":["S0045653522022445"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.135751","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.135751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135751"}}