{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:03:52Z","timestamp":1770329032320,"version":"3.49.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.chemosphere.2022.136354","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T12:40:06Z","timestamp":1662554406000},"page":"136354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"P2","title":["The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae"],"prefix":"10.1016","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-5260","authenticated-orcid":false,"given":"Gang","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-0225","authenticated-orcid":false,"given":"Cao-xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-4952","authenticated-orcid":false,"given":"Yu","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai-dong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2022.136354_bib1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1586\/14737140.2014.929501","article-title":"Risk of thyroid dysfunction in patients with solid tumors treated with VEGF receptor tyrosine kinase inhibitors: a critical literature review and meta analysis","volume":"14","author":"Abdel-Rahman","year":"2014","journal-title":"Expet Rev. Anticancer Ther."},{"key":"10.1016\/j.chemosphere.2022.136354_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155237","article-title":"Human exposures to bisphenol A, bisphenol F and chlorinated bisphenol A derivatives and thyroid function","volume":"11","author":"Andrianou","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2022.136354_bib3","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1080\/14756366.2020.1822829","article-title":"Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases","volume":"35","author":"Aspatwar","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.chemosphere.2022.136354_bib4","doi-asserted-by":"crossref","first-page":"H547","DOI":"10.1152\/ajpheart.00616.2005","article-title":"Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling","volume":"290","author":"Baffert","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.semcancer.2020.12.008","article-title":"Effects of tyrosine kinase inhibitors on thyroid function and thyroid hormone metabolism","volume":"79","author":"Basolo","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1530\/eje.0.1310331","article-title":"Variable biological activity of thyroid-stimulating hormone","volume":"131","author":"Beck-Peccoz","year":"1994","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.clgc.2012.08.002","article-title":"Thyroid dysfunction in patients treated with sunitinib or sorafenib","volume":"10","author":"Clemons","year":"2012","journal-title":"Clin. Genitourin. Cancer"},{"key":"10.1016\/j.chemosphere.2022.136354_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9093056","article-title":"Characterization of fetal thyroid levels at delivery among appalachian infants","volume":"9","author":"Crank","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.chemosphere.2022.136354_bib9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/379458a0","article-title":"Cloning and characterization of the thyroid iodide transporter","volume":"379","author":"Dai","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2022.136354_bib10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.scitotenv.2012.04.010","article-title":"Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water","volume":"427\u2013428","author":"de Jongh","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib11","first-page":"34","article-title":"Zebrafish (Danio rerio): a valuable tool for predicting the metabolism of xenobiotics in humans? Comparative biochemistry and physiology","volume":"212","author":"de Souza Anselmo","year":"2018","journal-title":"Toxicol. Pharmacol.: CBP"},{"key":"10.1016\/j.chemosphere.2022.136354_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1179\/1973947812Y.0000000022","article-title":"Extreme hypothyroidism associated with sunitinib treatment for metastatic renal cancer","volume":"24","author":"Del Fabbro","year":"2012","journal-title":"J. Chemother."},{"key":"10.1016\/j.chemosphere.2022.136354_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10040198","article-title":"Environmental Co-exposure to potassium perchlorate and Cd caused toxicity and thyroid endocrine disruption in zebrafish embryos and larvae (Danio rerio)","volume":"10","author":"Di Paola","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.chemosphere.2022.136354_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00427-002-0279-3","article-title":"Phenylthiourea disrupts thyroid function in developing zebrafish","volume":"212","author":"Elsalini","year":"2003","journal-title":"Dev. Gene. Evol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib15","first-page":"723","article-title":"Thyroid dysfunctions induced by tyrosine kinase inhibitors","volume":"13","author":"Fallahi","year":"2014","journal-title":"Expet Opin. Drug Saf."},{"key":"10.1016\/j.chemosphere.2022.136354_bib16","series-title":"Global pediatric health","article-title":"Incidence and interrelated factors in patients with congenital hypothyroidism as detected by newborn screening in guangxi, China","volume":"2","author":"Fan","year":"2015"},{"key":"10.1016\/j.chemosphere.2022.136354_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00216-010-4300-9","article-title":"Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research","volume":"399","author":"Fatta-Kassinos","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2022.136354_bib18","first-page":"974","volume":"vol. 48","author":"Feldt","year":"2012"},{"key":"10.1016\/j.chemosphere.2022.136354_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111207","article-title":"Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae","volume":"206","author":"Fu","year":"2020","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"10.1016\/j.chemosphere.2022.136354_bib20","article-title":"Transthyretin-binding activity of complex mixtures representing the composition of thyroid-hormone disrupting contaminants in house dust and human serum","volume":"128","author":"Hamers","year":"2020","journal-title":"Environ. Health [erspect."},{"key":"10.1016\/j.chemosphere.2022.136354_bib21","article-title":"A roadmap to the structure-related metabolism pathways of per- and polyfluoroalkyl substances in the early life stages of zebrafish (Danio rerio)","volume":"129","author":"Han","year":"2021","journal-title":"Environ. Health [erspect."},{"key":"10.1016\/j.chemosphere.2022.136354_bib22","doi-asserted-by":"crossref","first-page":"8339","DOI":"10.1021\/es801038y","article-title":"Detection, occurrence and fate of indirubin in municipal sewage treatment plants","volume":"42","author":"Hu","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18115835","article-title":"Application of green nanoemulsion for elimination of rifampicin from a bulk aqueous solution","volume":"18","author":"Hussain","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2022.136354_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155762","article-title":"The effects of disturbance on hypothalamus-pituitary-thyroid (HPT) Axis in zebrafish larvae after exposure to DEHP","volume":"11","author":"Jia","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2022.136354_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145963","article-title":"The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish","volume":"776","author":"Jin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chemosphere.2017.02.081","article-title":"Adverse effects of BDE-47 on in vivo developmental parameters, thyroid hormones, and expression of hypothalamus-pituitary-thyroid (HPT) axis genes in larvae of the self-fertilizing fish Kryptolebias marmoratus","volume":"176","author":"Kang","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.136354_bib27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3803\/EnM.2020.920","article-title":"DEHP down-regulates tshr gene expression in rat thyroid tissues and FRTL-5 rat thyrocytes: a potential mechanism of thyroid disruption","volume":"36","author":"Kim","year":"2021","journal-title":"Endocrinol. Metab.(Seoul, Korea)"},{"key":"10.1016\/j.chemosphere.2022.136354_bib28","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.ejrad.2011.06.035","article-title":"Thyroid size change by CT monitoring after sorafenib or sunitinib treatment in patients with renal cell carcinoma: comparison with thyroid function","volume":"81","author":"Kitajima","year":"2012","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.129075","article-title":"Microbial influenced corrosion of processing industry by re-circulating waste water and its control measures - a review","volume":"265","author":"Kokilaramani","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.136354_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127994","article-title":"Effects of methylisothiazolinone and octylisothiazolinone on development and thyroid endocrine system in zebrafish larvae","volume":"425","author":"Lee","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.136354_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/toxsci\/kfw022","article-title":"Estimating margin of exposure to thyroid peroxidase inhibitors using high-throughput in vitro data, high-throughput exposure modeling, and physiologically based pharmacokinetic\/pharmacodynamic modeling","volume":"151","author":"Leonard","year":"2016","journal-title":"Toxicol. Sci. : Off. J. Soc. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.scitotenv.2019.04.177","article-title":"Thyroid endocrine disruption effects of perfluoroalkyl phosphinic acids on zebrafish at early development","volume":"676","author":"Liu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ecoenv.2018.11.058","article-title":"Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish","volume":"170","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"10.1016\/j.chemosphere.2022.136354_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/srep37775","article-title":"The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity","volume":"6","author":"Malhab","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2022.136354_bib35","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1210\/jc.2007-0586","article-title":"A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake","volume":"92","author":"Mannavola","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chemosphere.2022.136354_bib36","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/431718","article-title":"EGF and TGF-\u03b21 effects on thyroid function","author":"Mincione","year":"2011","journal-title":"J. Thyroid Res. 2011"},{"key":"10.1016\/j.chemosphere.2022.136354_bib37","first-page":"867","article-title":"Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer immunology, immunotherapy","volume":"58","author":"Molhoek","year":"2009","journal-title":"CII"},{"key":"10.1016\/j.chemosphere.2022.136354_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103648","article-title":"SCREENED: a multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner","volume":"21","author":"Moroni","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2022.136354_bib39","first-page":"6410","article-title":"Zebrafish as an IN VIVO model for sustainable chemical design","volume":"18","author":"Noyes","year":"2016","journal-title":"Green Chem. : Int. J. Green Chem. Res. : GC"},{"key":"10.1016\/j.chemosphere.2022.136354_bib40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2017.09.129","article-title":"A case study to identify priority cytostatic contaminants in hospital effluents","volume":"190","author":"Olalla","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.136354_bib41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.scitotenv.2012.10.046","article-title":"Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data","volume":"442","author":"Oosterhuis","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.envres.2018.01.039","article-title":"A cross sectional study of urinary phthalates, phenols and perchlorate on thyroid hormones in US adults using structural equation models (NHANES 2007-2008)","volume":"163","author":"Przybyla","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2022.136354_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143914","article-title":"Toxicogenomic fin(ger)prints for thyroid disruption AOP refinement and biomarker identification in zebrafish embryos","volume":"760","author":"Reinwald","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0300-9084(89)90062-X","article-title":"In vitro studies of the thyroglobulin degradation pathway: endocytosis and delivery of thyroglobulin to lysosomes, release of thyroglobulin cleavage products--iodotyrosines and iodothyronines","volume":"71","author":"Rousset","year":"1989","journal-title":"Biochimie"},{"key":"10.1016\/j.chemosphere.2022.136354_bib45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00244-021-00823-5","article-title":"OctylPhenol (OP) alone and in combination with NonylPhenol (NP) alters the structure and the function of thyroid gland of the lizard Podarcis siculus","volume":"80","author":"Sciarrillo","year":"2021","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.envint.2018.11.015","article-title":"Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women","volume":"122","author":"Skarha","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2022.136354_bib47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrclinonc.2009.4","article-title":"Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy","volume":"6","author":"Torino","year":"2009","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2012.04.028","article-title":"Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment--a review","volume":"429","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib49","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s40618-015-0288-5","article-title":"Heterogeneous phenotype in children affected by non-autoimmune hypothyroidism: an update","volume":"38","author":"Vigone","year":"2015","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.chemosphere.2022.136354_bib50","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10456-018-9598-5","article-title":"Platelet function is disturbed by the angiogenesis inhibitors sunitinib and sorafenib, but unaffected by bevacizumab","volume":"21","author":"Walraven","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.chemosphere.2022.136354_bib51","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cmet.2021.08.012","article-title":"The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy","volume":"33","author":"Wei","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12986-020-00440-4","article-title":"Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning","volume":"17","author":"Wei","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.chemosphere.2022.136354_bib53","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1007\/s00216-015-8736-9","article-title":"Tracing thyroid hormone-disrupting compounds: database compilation and structure-activity evaluation for an effect-directed analysis of sediment","volume":"407","author":"Weiss","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.chemosphere.2022.136354_bib54","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.1210\/jc.2005-1049","article-title":"Serum thyroid hormones in preterm infants: associations with postnatal illnesses and drug usage","volume":"90","author":"Williams","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.chemosphere.2022.136354_bib55","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/thy.2006.0308","article-title":"Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity","volume":"17","author":"Wong","year":"2007","journal-title":"Thyroid : Off. J. Am. Thyroid Ass."},{"key":"10.1016\/j.chemosphere.2022.136354_bib56","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.2147\/DDDT.S270210","article-title":"Acquired hypothyroidism in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors","volume":"14","author":"Wu","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.chemosphere.2022.136354_bib57","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.scitotenv.2018.11.037","article-title":"Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor","volume":"653","author":"Xu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.136354_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127040","article-title":"Polystyrene microplastics decrease F-53B bioaccumulation but induce inflammatory stress in larval zebrafish","volume":"255","author":"Yang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.136354_bib59","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/s41436-021-01237-3","article-title":"Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis","volume":"23","author":"Yang","year":"2021","journal-title":"Genet. Med. : Off. J. Am. Coll. Med. Genet."},{"key":"10.1016\/j.chemosphere.2022.136354_bib60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ecoenv.2017.02.043","article-title":"Semicarbazide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus) and its potential mechanisms","volume":"140","author":"Yue","year":"2017","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"10.1016\/j.chemosphere.2022.136354_bib61","first-page":"4230","article-title":"Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters","volume":"12","author":"Zannini","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chemosphere.2022.136354_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113283","article-title":"Perfluorohexanoic acid caused disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae","volume":"232","author":"Zhang","year":"2022","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"10.1016\/j.chemosphere.2022.136354_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10408440601123446","article-title":"General background on the hypothalamic-pituitary-thyroid (HPT) axis","volume":"37","author":"Zoeller","year":"2007","journal-title":"Crit. Rev. Toxicol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522028478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522028478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:07:26Z","timestamp":1736341646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653522028478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":63,"alternative-id":["S0045653522028478"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.136354","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.136354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136354"}}