{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:21:47Z","timestamp":1788952907219,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41977207"],"award-info":[{"award-number":["41977207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42177262"],"award-info":[{"award-number":["42177262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011405"],"award-info":[{"award-number":["2021A1515011405"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.chemosphere.2022.137594","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T07:29:11Z","timestamp":1671262151000},"page":"137594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Thyroid endocrine disruption and neurotoxicity of gestodene in adult female mosquitofish (Gambusia affinis)"],"prefix":"10.1016","volume":"313","author":[{"given":"Jiefeng","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2022.137594_bib2","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1021\/es202680q","article-title":"Effect of growth promotants on the occurrence of endogenous and synthetic steroid hormones on feedlot soils and in runoff from beef cattle feeding operations","volume":"46","author":"Bartelt","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408440601123529","article-title":"The hypothalamic-pituitary-thyroid (HPT) axis in fish and its role in fish development and reproduction","volume":"37","author":"Blanton","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/cne.24352","article-title":"Neuronal expression of brain derived neurotrophic factor in the injured telencephalon of adult zebrafish","volume":"526","author":"Cacialli","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib5","first-page":"5190","article-title":"Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations","volume":"35","author":"Carrie","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.scitotenv.2017.01.156","article-title":"Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity","volume":"584\u2013585","author":"Chen","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.137594_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144570","article-title":"Reproductive potential of mosquitofish is reduced by the masculinizing effect of a synthetic progesterone, gestodene: evidence from morphology, courtship behaviour, ovary histology, sex hormones and gene expressions","volume":"769","author":"Chen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.137594_bib10","article-title":"Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio)","volume":"236","author":"Chen","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117374","article-title":"Fish toxicity testing for identification of thyroid disrupting chemicals","volume":"284","author":"Dang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.137594_bib12","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1210\/endo.137.6.8641203","article-title":"Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat","volume":"137","author":"Escobar","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2022.137594_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envint.2015.06.012","article-title":"Progestins as endocrine disrupters in aquatic ecosystems: concentrations, effects and risk assessment","volume":"84","author":"Fent","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2022.137594_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1089\/thy.2005.15.823","article-title":"The roles of the iodothyronine deiodinases in mammalian development","volume":"15","author":"Galton","year":"2005","journal-title":"Thyroid"},{"key":"10.1016\/j.chemosphere.2022.137594_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113293","article-title":"Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish","volume":"409","author":"Giacomini","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.chemosphere.2022.137594_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1152\/physrev.00015.2019","article-title":"Current principles of motor control, with special reference to vertebrate locomotion","volume":"100","author":"Grillner","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chemosphere.2022.137594_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2015.06.013","article-title":"The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations","volume":"166","author":"Hua","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ecoenv.2018.07.049","article-title":"Endocrine disruption in Chinese rare minnow (Gobiocypris rarus) after long-term exposure to low environmental concentrations of progestin megestrol acetate","volume":"163","author":"Hua","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.137594_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.envint.2018.11.066","article-title":"Swine farm wastewater discharge causes masculinization of western mosquitofish (Gambusia affinis)","volume":"123","author":"Huang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2022.137594_bib22","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1897\/08-485.1","article-title":"Effects of synthetic gestagens on fish reproduciton","volume":"28","author":"Jana","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2022.137594_bib24","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","article-title":"Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. Streams, 1999-2000: a National Reconnaissance","volume":"36","author":"Kolpin","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150460","article-title":"Cyclophosphamide affects eye development and locomotion in zebrafish (Danio rerio)","volume":"805","author":"Li","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.137594_bib26","doi-asserted-by":"crossref","first-page":"11894","DOI":"10.1021\/acs.est.1c03457","article-title":"Dietary seleno-l-methionine causes alterations in neurotransmitters, ultrastructure of the brain, and behaviors in zebrafish (Danio rerio)","volume":"55","author":"Li","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib27","first-page":"242","article-title":"The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio)","author":"Liang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2022.137594_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquatox.2015.01.006","article-title":"Long-term exposure to environmentally relevant concentrations of progesterone and norgestrel affects sex differentiation in zebrafish (Danio rerio)","volume":"160","author":"Liang","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.envpol.2012.07.016","article-title":"Fate and occurrence of steroids in swine and dairy cattle farms with different farming scales and wastes disposal systems","volume":"170","author":"Liu","year":"2012","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.137594_bib31","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.chroma.2011.01.014","article-title":"Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"1218","author":"Liu","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2022.137594_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.chemosphere.2022.137594_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ecoenv.2017.12.022","article-title":"The progestin norethisterone affects thyroid hormone-dependent metamorphosis of Xenopus laevis tadpoles at environmentally relevant concentrations","volume":"150","author":"Lorenz","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.137594_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.aquatox.2016.05.011","article-title":"The synthetic gestagen levonorgestrel directly affects gene expression in thyroid and pituitary glands of Xenopus laevis tadpoles","volume":"177","author":"Lorenz","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103155","article-title":"BDNF, brain, and regeneration: insights from zebrafish","volume":"19","author":"Lucini","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2022.137594_bib62","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1021\/acs.est.5b04083","article-title":"Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling","volume":"49","author":"Neale","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.aquatox.2014.01.012","article-title":"Levonorgestrel exposure to fathead minnows (Pimephales promelas) alters survival, growth, steroidogenic gene expression and hormone production","volume":"148","author":"Overturf","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.aquatox.2010.05.001","article-title":"Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone","volume":"99","author":"Paulos","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2019.01.020","article-title":"A multidimensional concept for mercury neuronal and sensory toxicity in fish from toxicokinetics and biochemistry to morphometry and behavior","volume":"1863","author":"Pereira","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.chemosphere.2022.137594_bib39","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.neuro.2012.03.005","article-title":"Endosulfan exposure inhibits brain AChE activity and impairs swimming performance in adult zebrafish (Danio rerio)","volume":"33","author":"Pereira","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.chemosphere.2022.137594_bib64","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ygcen.2011.02.023","article-title":"The role of thyroid hormones in stress response of fish","volume":"172","author":"Peter","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib41","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1021\/es3048834","article-title":"Several synthetic progestins with different potencies adversely affect reproduction of fish","volume":"47","author":"Runnalls","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib42","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1080\/10807039.2010.526503","article-title":"Pharmaceuticals in the aquatic environment: steroids and anti-steroids as high priorities for research","volume":"16","author":"Runnalls","year":"2010","journal-title":"Hum. Ecol. Risk Assess."},{"key":"10.1016\/j.chemosphere.2022.137594_bib63","doi-asserted-by":"crossref","first-page":"109912","DOI":"10.1016\/j.ecoenv.2019.109912","article-title":"Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng\/L level caused intersex","volume":"188","author":"Sauer","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.137594_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12035-012-8243-3","article-title":"Evaluation of acetylcholinesterase in an animal model of maple syrup urine disease","volume":"45","author":"Scaini","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib44","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/376243","article-title":"Alterations along the hypothalamic-pituitary-thyroid axis of the zebrafish (Danio rerio) after exposure to propylthiouracil","author":"Schmidt","year":"2011","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.chemosphere.2022.137594_bib45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.watres.2018.01.030","article-title":"Trace analysis of 61 natural and synthetic progestins in river water and sewage effluents by ultra-high performance liquid chromatography-tandem mass spectrometry","volume":"133","author":"Shen","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2022.137594_bib46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00128-017-2046-1","article-title":"Transcriptional and biochemical alterations in zebrafish eleuthero-embryos (Danio rerio) after exposure to synthetic progestogen dydrogesterone","volume":"99","author":"Shi","year":"2017","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.maturitas.2004.01.001","article-title":"Pharmacological profile of progestins","volume":"47","author":"Sitruk","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.chemosphere.2022.137594_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-0760(98)00027-2","article-title":"An updated review of environmental estrogen and androgen mimics and antagonists","volume":"65","author":"Sonnenschein","year":"1998","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib49","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.scitotenv.2018.11.071","article-title":"Effects of 25 thyroid hormone disruptors on zebrafish embryos: a literature review of potential biomarkers","volume":"656","author":"Spaan","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.137594_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125581","article-title":"Environmentally relevant concentrations of microplastics influence the locomotor activity of aquatic biota","volume":"414","author":"Sun","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2022.137594_bib51","series-title":"The Interactive Effects of Ethinylestradiol and Progesterone on Transcriptional Expression of Genes along the Hypothalamus\u2013Pituitary\u2013Thyroid axis in Embryonic Zebrafish (Danio rerio)","first-page":"805","author":"Tan","year":"2022"},{"key":"10.1016\/j.chemosphere.2022.137594_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116773","article-title":"Pharmaceuticals in two watersheds in Eastern China and their ecological risks","volume":"277","author":"Tang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2022.137594_bib65","doi-asserted-by":"crossref","first-page":"11182","DOI":"10.1021\/acs.est.0c02434","article-title":"Ecological Risk Dynamics of Pharmaceuticals in Micro-Estuary Environments","volume":"54","author":"Topaz","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib53","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1210\/en.2008-0457","article-title":"Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish","volume":"150","author":"Walpita","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2022.137594_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113334","article-title":"Developmental toxicity of bromoacetamide via the thyroid hormone receptors-mediated disruption of thyroid hormone homeostasis in zebrafish embryos","volume":"233","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2022.137594_bib55","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.1021\/acs.est.9b02831","article-title":"Bioconcentration, biotransformation, and thyroid endocrine disruption of decabromodiphenyl ethane (Dbdpe), a novel brominated flame retardant, in zebrafish larvae","volume":"53","author":"Wang","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib56","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ijdevneu.2019.10.001","article-title":"Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish","volume":"78","author":"Wessler","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.chemosphere.2022.137594_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118038","article-title":"Occurrence and removal of progestogens from wastewater treatment plants in China: spatiotemporal variation and process comparison","volume":"211","author":"Yu","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2022.137594_bib58","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1021\/acs.est.7b01231","article-title":"Occurrence and ecotoxicological effects of free, conjugated, and halogenated steroids including 17\u03b1-hydroxypregnanolone and pregnanediol in swiss wastewater and surface water","volume":"51","author":"Zhang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib59","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.1021\/es501226h","article-title":"Emission estimation and multimedia fate modeling of seven steroids at the river basin scale in China","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2022.137594_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140979","article-title":"Exposure to microplastics cause gut damage, locomotor dysfunction, epigenetic silencing, and aggravate cadmium (Cd) toxicity in drosophila","volume":"744","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2022.137594_bib61","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1021\/es505575v","article-title":"Synthetic progestins medroxyprogesterone acetate and dydrogesterone and their binary mixtures adversely affect reproduction and lead to histological and transcriptional alterations in zebrafish (Danio rerio)","volume":"49","author":"Zhao","year":"2015","journal-title":"Environ. Sci. Technol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522040875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653522040875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T16:19:26Z","timestamp":1736353166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653522040875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":57,"alternative-id":["S0045653522040875"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.137594","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thyroid endocrine disruption and neurotoxicity of gestodene in adult female mosquitofish (Gambusia affinis)","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2022.137594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137594"}}