{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:41:34Z","timestamp":1790635294981,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.chemosphere.2023.137873","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T08:28:50Z","timestamp":1674030530000},"page":"137873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Association between blood metal exposures and hyperuricemia in the U.S. general adult: A subgroup analysis from NHANES"],"prefix":"10.1016","volume":"318","author":[{"given":"Yuxuan","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiong","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huojie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanzhu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.137873_bib1","first-page":"163","article-title":"Cadmium blood and urine concentrations as measures of exposure","volume":"24","year":"2014","journal-title":"NHANES 1999\u20132010"},{"key":"10.1016\/j.chemosphere.2023.137873_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.sjbs.2010.10.004","article-title":"Antioxidant effect of vitamin E treatment on some heavy metals-induced renal and testicular injuries in male mice","volume":"18","author":"Al-Attar","year":"2011","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137873_bib3","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1007\/s11356-018-3819-8","article-title":"Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits","volume":"26","author":"Ali","year":"2019","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.chemosphere.2023.137873_bib4","first-page":"315","article-title":"Effect of zinc supplementation on urate pathway enzymes in spermatozoa and seminal plasma of Iraqi asthenozoospermic patients: a randomized controlled trial","volume":"13","author":"Alsalman","year":"2020","journal-title":"International journal of fertility & sterility"},{"key":"10.1016\/j.chemosphere.2023.137873_bib5","first-page":"186","volume":"vol. 26","author":"Bardin","year":"2014"},{"key":"10.1016\/j.chemosphere.2023.137873_bib6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/eurjhf\/hfp042","article-title":"Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure","volume":"11","author":"Bergamini","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.chemosphere.2023.137873_bib7","first-page":"67","article-title":"Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression","volume":"17","author":"Bobb","year":"2018","journal-title":"EH (Environ. Health) (Lond.)"},{"key":"10.1016\/j.chemosphere.2023.137873_bib8","series-title":"Lead in Drinking Water and Human Blood Lead Levels in the United States","author":"Brown","year":"2012"},{"key":"10.1016\/j.chemosphere.2023.137873_bib9","series-title":"Survey 2011\u20132014.","first-page":"397","article-title":"Multiple metal exposures and metabolic syndrome: a cross-sectional analysis of the National Health and Nutrition Examination","volume":"vol. 168","author":"Bulka","year":"2019"},{"key":"10.1016\/j.chemosphere.2023.137873_bib10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/art.40807","article-title":"Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the national health and nutrition examination survey, 2007-2016","volume":"71","author":"Chen-Xu","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.chemosphere.2023.137873_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109760","article-title":"Exercise attenuates the association between household pesticide exposure and depressive symptoms: evidence from NHANES, 2005\u20132014","volume":"188","author":"Chen","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib12","series-title":"Associations of Blood and Urinary Heavy Metals with Rheumatoid Arthritis Risk Among Adults in NHANES","volume":"vol. 289","author":"Chen","year":"2022"},{"key":"10.1016\/j.chemosphere.2023.137873_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7612172","article-title":"Mechanisms and disease pathogenesis underlying metal-induced oxidative stress","volume":"2018","author":"Chen","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.chemosphere.2023.137873_bib14","series-title":"Questionnaires, Datasets, and Related Documentation","author":"Control","year":"2016"},{"key":"10.1016\/j.chemosphere.2023.137873_bib15","first-page":"9672","article-title":"The effects of lead exposure on serum uric acid and hyperuricemia in Chinese adults","volume":"12","author":"Dai","year":"2015","journal-title":"A Cross-Sectional Study"},{"key":"10.1016\/j.chemosphere.2023.137873_bib16","series-title":"Estrogenic Activity of Cadmium, Copper and Zinc in the Yeast Estrogen Screen","first-page":"569","volume":"vol. 23","author":"Denier","year":"2009"},{"key":"10.1016\/j.chemosphere.2023.137873_bib17","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2023.137873_bib18","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2023.137873_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1289\/ehp.9310057","article-title":"Mechanisms of kidney cell injury from metals","volume":"100","author":"Fowler","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.137873_bib20","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41598-017-02392-x","article-title":"Serum uric acid is associated with erectile dysfunction: a population-based cross-sectional study in Chinese men","volume":"7","author":"Gao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2023.137873_bib21","series-title":"Exposure to Cadmium, Lead, Mercury and Arsenic and Uric Acid Levels: Results from NHANES 2007-2016","author":"Gao","year":"2021"},{"key":"10.1016\/j.chemosphere.2023.137873_bib22","series-title":"Exposure to Cadmium, Lead, Mercury, and Arsenic and Uric Acid Levels: Results from NHANES 2007\u20132016","author":"Gao","year":"2022"},{"key":"10.1016\/j.chemosphere.2023.137873_bib23","series-title":"Concentrations of Lead, Mercury, Selenium, and Manganese in Blood and Hand Grip Strength Among Adults Living in the United States (NHANES 2011\u20132014)","first-page":"189","volume":"vol. 9","author":"Gbemavo","year":"2021"},{"key":"10.1016\/j.chemosphere.2023.137873_bib24","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/aje\/kws392","article-title":"Positive association between perfluoroalkyl chemicals and hyperuricemia in children","volume":"177","author":"Geiger","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2023.137873_bib25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/j.ajkd.2018.02.358","article-title":"Blood lead levels and decreased kidney function in a population-based cohort","volume":"72","author":"Harari","year":"2018","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.chemosphere.2023.137873_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111338","article-title":"The effects of chronic lead exposure on the ovaries of female juvenile Japanese quails (Coturnix japonica): developmental delay, histopathological alterations, hormone release disruption and gene expression disorder","volume":"205","author":"He","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2023.137873_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.envres.2005.03.004","article-title":"Lead blood concentrations and renal function evaluation: study in an exposed Mexican population","volume":"100","author":"Hern\u00e1ndez-Serrato","year":"2006","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF02974233","article-title":"Effect of sex hormones on lipid peroxidation in rat liver","volume":"17","author":"Huh","year":"1994","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.chemosphere.2023.137873_bib29","series-title":"Associations of Co-exposure to Metals with Serum Uric Acid and Hyperuricemia: A Cross-Sectional Study","author":"Jiang","year":"2020"},{"key":"10.1016\/j.chemosphere.2023.137873_bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/j.ajkd.2017.12.009","article-title":"Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the national kidney foundation","volume":"71","author":"Johnson","year":"2018","journal-title":"Am. J. Kidney Dis. : the official journal of the National Kidney Foundation"},{"key":"10.1016\/j.chemosphere.2023.137873_bib31","first-page":"1435","article-title":"Associations between blood lead, cadmium, and mercury levels with hyperuricemia in the Korean general population","volume":"22","author":"Jung","year":"2019","journal-title":"A retrospective analysis of population\u2010based nationally representative data"},{"key":"10.1016\/j.chemosphere.2023.137873_bib32","first-page":"175","article-title":"Indukcja aktywno\u015bci oksydazy ksantynowej przez o\u0142\u00f3w u zawodowo nara\u017conych pracownik\u00f3w","volume":"64","author":"Kasperczyk","year":"2013","journal-title":"Med. Pr."},{"key":"10.1016\/j.chemosphere.2023.137873_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmedr.2019.100895","article-title":"Associations of smoking indicators and cotinine levels with telomere length: National Health and Nutrition Examination Survey","volume":"15","author":"Khan","year":"2019","journal-title":"Preventive Medicine Reports"},{"key":"10.1016\/j.chemosphere.2023.137873_bib34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/0003-4819-157-4-201208210-00003","article-title":"Low-level lead exposure and the prevalence of gout: an observational study","volume":"157","author":"Krishnan","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.chemosphere.2023.137873_bib35","first-page":"326","article-title":"Nephroprotective effects of Berberis Vulgaris L. total extract on lead acetate-induced toxicity in mice","volume":"78","author":"Laamech","year":"2016","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.chemosphere.2023.137873_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.scitotenv.2008.04.004","article-title":"Renal dysfunction and hyperuricemia with low blood lead levels and ethnicity in community-based study","volume":"401","author":"Lai","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.137873_bib37","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/j.1523-1755.2005.00365.x","article-title":"Definition and classification of chronic kidney disease: a position statement from Kidney Disease: improving Global Outcomes (KDIGO)","volume":"67","author":"Levey","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.chemosphere.2023.137873_bib38","first-page":"3167","article-title":"Update on the epidemiology, genetics, and therapeutic options of hyperuricemia","volume":"12","author":"Li","year":"2020","journal-title":"Am. J. Tourism Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12944-020-01211-z","article-title":"Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008-2012)","volume":"19","author":"Liu","year":"2020","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.chemosphere.2023.137873_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134416","article-title":"Combined exposure to multiple metals on serum uric acid in NHANES under three statistical models","volume":"301","author":"Ma","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.137873_bib41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40292-020-00368-z","article-title":"Hyperuricemia and risk of cardiovascular outcomes: the experience of the URRAH (uric acid right for heart health) Project","volume":"27","author":"Maloberti","year":"2020","journal-title":"High Blood Pres. Cardiovasc. Prev. : the official journal of the Italian Society of Hypertension"},{"key":"10.1016\/j.chemosphere.2023.137873_bib42","article-title":"Association between blood lead level and uncontrolled hypertension in the US population","volume":"9","author":"Miao","year":"2020","journal-title":"NHANES 1999\u20132016)"},{"key":"10.1016\/j.chemosphere.2023.137873_bib43","series-title":"NHANES Laboratory Procedures Manual","year":"2011"},{"key":"10.1016\/j.chemosphere.2023.137873_bib44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1297-319X(02)00420-7","article-title":"Lead-related gout. A case report","volume":"69","author":"Niamane","year":"2002","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.chemosphere.2023.137873_bib45","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12011-020-02152-5","article-title":"Associations of blood heavy metals with uric acid in the Korean general population: analysis of data from the 2016-2017 Korean national health and nutrition examination survey","volume":"199","author":"Park","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12011-012-9566-7","article-title":"Body fat percentage and hemoglobin levels are related to blood lead, cadmium, and mercury concentrations in a Korean Adult Population (KNHANES 2008-2010)","volume":"151","author":"Park","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/127596","article-title":"Relationship between hyperuricemia and lipid profiles in US adults","volume":"2015","author":"Peng","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.chemosphere.2023.137873_bib48","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/jama.1994.03520040046039","article-title":"The decline in blood lead levels in the United States: the national health and nutrition examination surveys (NHANES)","volume":"272","author":"Pirkle","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.chemosphere.2023.137873_bib49","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1289\/ehp.7386","article-title":"Impact of occupational exposure on lead levels in women","volume":"113","author":"Popovic","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.137873_bib50","doi-asserted-by":"crossref","DOI":"10.5812\/numonthly.7(3)2015.27233","article-title":"Associations between hyperuricemia and chronic kidney disease: a review","volume":"7","author":"Prasad Sah","year":"2015","journal-title":"Nephro-Urol. Mon."},{"key":"10.1016\/j.chemosphere.2023.137873_bib51","series-title":"Lasso Regression: Estimation and Shrinkage via the Limit of Gibbs Sampling","first-page":"153","volume":"vol. 78","author":"Rajaratnam","year":"2016"},{"key":"10.1016\/j.chemosphere.2023.137873_bib52","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0140-6736(09)60883-7","article-title":"Gout","volume":"375","author":"Richette","year":"2010","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.chemosphere.2023.137873_bib53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.2042-7158.1994.tb03832.x","article-title":"Induction of the conversion of xanthine dehydrogenase to oxidase in rabbit liver by Cu2+,Zn2+ and selenium ions","volume":"46","author":"Sakuma","year":"1994","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.137873_bib54","first-page":"86","article-title":"Cadmium and lead exposure","volume":"8","author":"Satarug","year":"2020","journal-title":"Nephrotoxicity, and Mortality"},{"key":"10.1016\/j.chemosphere.2023.137873_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127446","article-title":"Perfluoroalkyl acids, hyperuricemia and gout in adults: analyses of NHANES 2009\u20132014","volume":"259","author":"Scinicariello","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.137873_bib56","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1136\/annrheumdis-2013-204647","article-title":"The global burden of gout: estimates from the Global Burden of Disease 2010 study","volume":"73","author":"Smith","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.chemosphere.2023.137873_bib57","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJM199207163270303","article-title":"Impairment of renal function with increasing blood lead concentrations in the general population. The Cadmibel Study Group","volume":"327","author":"Staessen","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2023.137873_bib58","series-title":"Initial Treatment of Hypertension","first-page":"636","volume":"vol. 378","year":"2018"},{"key":"10.1016\/j.chemosphere.2023.137873_bib59","series-title":"Environmental Lead Exposure: a Public Health Problem of Global Dimensions","first-page":"1068","volume":"vol. 78","author":"Tong","year":"2000"},{"key":"10.1016\/j.chemosphere.2023.137873_bib60","series-title":"Introduction to Generalized Linear Models. Rapport Technique","author":"Turner","year":"2008"},{"key":"10.1016\/j.chemosphere.2023.137873_bib61","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.envres.2006.08.003","article-title":"Gender differences in the disposition and toxicity of metals","volume":"104","author":"Vahter","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib62","series-title":"A Cross-Sectional Study in a Mid-aged and Older Population of China","article-title":"Associations of plasma multiple metals with risk of hyperuricemia","volume":"vol. 287","author":"Wang","year":"2022"},{"key":"10.1016\/j.chemosphere.2023.137873_bib63","article-title":"Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys","volume":"11","author":"Wang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2023.137873_bib64","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2023.137873_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105445","article-title":"Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013\u20132014)","volume":"136","author":"Xie","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2023.137873_bib66","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1521","article-title":"Plasma metal concentrations and incident coronary heart disease in Chinese adults: the dongfeng-tongji cohort","volume":"125","author":"Yuan","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.137873_bib67","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s12011-021-02700-7","article-title":"Association between low-level blood cadmium exposure and hyperuricemia in the American general population: a cross-sectional study","volume":"200","author":"Zeng","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2023.137873_bib68","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0300-483X(02)00725-4","article-title":"Changes of serum sex hormone levels and MT mRNA expression in rats orally exposed to cadmium","volume":"186","author":"Zeng","year":"2003","journal-title":"Toxicology"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565352300139X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565352300139X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:44:19Z","timestamp":1758631459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004565352300139X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":68,"alternative-id":["S004565352300139X"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.137873","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between blood metal exposures and hyperuricemia in the U.S. general adult: A subgroup analysis from NHANES","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.137873","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"137873"}}