{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:34:03Z","timestamp":1782480843088,"version":"3.54.5"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK123285"],"award-info":[{"award-number":["R01DK123285"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES009089"],"award-info":[{"award-number":["P30ES009089"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES019776"],"award-info":[{"award-number":["P30ES019776"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES010349"],"award-info":[{"award-number":["P42ES010349"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES033719"],"award-info":[{"award-number":["P42ES033719"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES028805"],"award-info":[{"award-number":["R01ES028805"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES030945"],"award-info":[{"award-number":["R01ES030945"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES032831"],"award-info":[{"award-number":["R01ES032831"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.chemosphere.2023.137998","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T02:39:37Z","timestamp":1675478377000},"page":"137998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Metabolomic changes associated with chronic arsenic exposure in a Bangladeshi population"],"prefix":"10.1016","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-0249","authenticated-orcid":false,"given":"Haotian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrinda","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Niedzwiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianthi-Anna","family":"Kioumourtzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Ilievski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Navas-Acien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4169-1162","authenticated-orcid":false,"given":"Mary V.","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.137998_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/sj.jea.7500449","article-title":"Health effects of arsenic longitudinal study (HEALS): description of a multidisciplinary epidemiologic investigation","volume":"16","author":"Ahsan","year":"2006","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib3","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1503\/cmaj.071456","article-title":"Arsenic threat reaching global dimensions","volume":"177","author":"Bagchi","year":"2007","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"key":"10.1016\/j.chemosphere.2023.137998_bib4","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-021-03026-0","article-title":"LC\/MS\/MS-Based liver metabolomics to identify chronic liver injury biomarkers following exposure to arsenic in rats","author":"Bi","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2023.137998_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/ajcn\/nqy148","article-title":"Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh","volume":"109","author":"Bozack","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.chemosphere.2023.137998_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/BJ20150837","article-title":"Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?","volume":"472","author":"Brosnan","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.chemosphere.2023.137998_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00405933","article-title":"Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man","volume":"48","author":"Buchet","year":"1981","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.chemosphere.2023.137998_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Gout. Nat Rev Dis Primers"},{"key":"10.1016\/j.chemosphere.2023.137998_bib9","doi-asserted-by":"crossref","first-page":"W510","DOI":"10.1093\/nar\/gky299","article-title":"iPath3.0: interactive pathways explorer v3","volume":"46","author":"Darzi","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chemosphere.2023.137998_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature13236","article-title":"Quantitative flux analysis reveals folate-dependent NADPH production","volume":"510","author":"Fan","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2023.137998_bib12","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1002\/jcp.28112","article-title":"The role of arsenic in obesity and diabetes","volume":"234","author":"Farkhondeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/ajcn\/86.4.1202","article-title":"Folic acid supplementation lowers blood arsenic","volume":"86","author":"Gamble","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.chemosphere.2023.137998_bib14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.envres.2017.04.016","article-title":"Arsenic metabolism and cancer risk: a meta-analysis","volume":"156","author":"Gamboa-Loira","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2023.137998_bib15","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00775-019-01740-8","article-title":"Arsenic-induced neurotoxicity: a mechanistic appraisal","volume":"24","author":"Garza-Lomb\u00f3","year":"2019","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.chemosphere.2023.137998_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.taap.2014.09.011","article-title":"Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh","volume":"281","author":"Huda","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/toxsci\/kfr184","article-title":"Arsenic exposure and toxicology: a historical perspective","volume":"123","author":"Hughes","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib18","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1039\/c0an00333f","article-title":"A practical approach to detect unique metabolic patterns for personalized medicine","volume":"135","author":"Johnson","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.chemosphere.2023.137998_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jat.1649","article-title":"Arsenic: toxicity, oxidative stress and human disease","volume":"31","author":"Jomova","year":"2011","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib20","doi-asserted-by":"crossref","first-page":"F1327","DOI":"10.1152\/ajprenal.00272.2019","article-title":"Uric acid and inflammation in kidney disease","volume":"318","author":"Jung","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1515\/reveh-2016-0068","article-title":"Arsenic and breast cancer: a systematic review of epidemiologic studies","volume":"32","author":"Khanjani","year":"2017","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.chemosphere.2023.137998_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212394","article-title":"Uric acid in inflammation and the pathogenesis of atherosclerosis","volume":"22","author":"Kimura","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000484283","article-title":"Uric acid as a cause of the metabolic syndrome","volume":"192","author":"King","year":"2018","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/CRD.0000000000000357","article-title":"Association between arsenic exposure and cardiovascular disease","volume":"29","author":"Kononenko","year":"2021","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.chemosphere.2023.137998_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jtemb.2019.03.009","article-title":"A urinary metabolomics study of a Polish subpopulation environmentally exposed to arsenic","volume":"54","author":"Koz\u0142owska","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.envint.2014.11.015","article-title":"Arsenic exposure, hyperuricemia, and gout in US adults","volume":"76","author":"Kuo","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2023.137998_bib27","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/ijms20051149","article-title":"An updated review of lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40885-020-00146-y","article-title":"Uric acid and cardiometabolic diseases","volume":"26","author":"Lee","year":"2020","journal-title":"Clin Hypertens"},{"key":"10.1016\/j.chemosphere.2023.137998_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003123","article-title":"Predicting network activity from high throughput metabolomics","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.chroma.2016.12.007","article-title":"Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women","volume":"1479","author":"Li","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.chemosphere.2023.137998_bib31","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1021\/acs.analchem.0c00338","article-title":"Reference standardization for quantification and harmonization of large-scale metabolomics","volume":"92","author":"Liu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chemosphere.2023.137998_bib32","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/acs.est.9b05835","article-title":"Assessing the impact of drought on arsenic exposure from private domestic wells in the conterminous United States","volume":"55","author":"Lombard","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib33","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.bbamcr.2016.01.023","article-title":"Carnitine transport and fatty acid oxidation","volume":"1863","author":"Longo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chemosphere.2023.137998_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfw093","article-title":"From the cover: arsenite uncouples mitochondrial respiration and induces a warburg-like effect in Caenorhabditis elegans","volume":"152","author":"Luz","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib35","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3390\/nu12092867","article-title":"B vitamins and one-carbon metabolism: implications in human health and disease","volume":"12","author":"Lyon","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.chemosphere.2023.137998_bib36","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/toxsci\/kfu318","article-title":"Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico","volume":"144","author":"Martin","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib37","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cmet.2020.03.012","article-title":"NADH ties one-carbon metabolism to cellular respiration","volume":"31","author":"Maynard","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0892-0362(97)00066-4","article-title":"Effects of lead-arsenic combined exposure on central monoaminergic systems","volume":"19","author":"Mej\u00eda","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib39","doi-asserted-by":"crossref","first-page":"E3418","DOI":"10.3390\/ijms20143418","article-title":"Arsenic neurotoxicity in humans","volume":"20","author":"Mochizuki","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jes.2016.10.004","article-title":"Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing","volume":"49","author":"Moe","year":"2016","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.7326\/0003-4819-159-10-201311190-00719","article-title":"Association between low to moderate arsenic exposure and incident cardiovascular disease. A prospective cohort study","volume":"159","author":"Moon","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.chemosphere.2023.137998_bib42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00196547","article-title":"Regional alterations in the levels of brain biogenic amines, glutamate, GABA, and GAD activity due to chronic consumption of inorganic arsenic in developing and adult rats","volume":"50","author":"Nagaraja","year":"1993","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11892-019-1272-9","article-title":"Early-life arsenic exposure, nutritional status, and adult diabetes risk","volume":"19","author":"Navas-Acien","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.chemosphere.2023.137998_bib44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cca.2018.05.046","article-title":"Uric acid and cardiovascular disease","volume":"484","author":"Ndrepepa","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.chemosphere.2023.137998_bib45","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chemosphere.2023.137998_bib46","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1289\/ehp.1409396","article-title":"Folic acid and creatine as therapeutic approaches to lower blood arsenic: a randomized controlled trial","volume":"123","author":"Peters","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.137998_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1999.8872","article-title":"Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes","volume":"163","author":"Petrick","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib48","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature15726","article-title":"Oxidative stress inhibits distant metastasis by human melanoma cells","volume":"527","author":"Piskounova","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2023.137998_bib49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jat.3256","article-title":"Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: a review","volume":"36","author":"Prakash","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib50","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1021\/acs.jafc.1c00724","article-title":"Metallothionein attenuated arsenic-induced cytotoxicity: the underlying mechanism reflected by metabolomics and lipidomics","volume":"69","author":"Qi","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2023.137998_bib51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fncel.2015.00021","article-title":"Neurological effects of inorganic arsenic exposure: altered cysteine\/glutamate transport, NMDA expression and spatial memory impairment","volume":"9","author":"Ramos-Ch\u00e1vez","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4978018","article-title":"Lipid metabolism alterations in a rat model of chronic and intergenerational exposure to arsenic","volume":"2019","author":"Rivas-Santiago","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.chemosphere.2023.137998_bib53","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1289\/ehp.7719205","article-title":"Effects of arsenic on pyruvate dehydrogenase activation","volume":"19","author":"Schiller","year":"1977","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.137998_bib54","first-page":"1093","article-title":"Contamination of drinking-water by arsenic in Bangladesh: a public health emergency","volume":"78","author":"Smith","year":"2000","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.chemosphere.2023.137998_bib55","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1007\/s11306-011-0332-1","article-title":"High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome","volume":"9","author":"Soltow","year":"2013","journal-title":"Metabolomics"},{"issue":"Suppl. 1","key":"10.1016\/j.chemosphere.2023.137998_bib56","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1093\/toxsci\/kfq342","article-title":"Arsenic, stem cells, and the developmental basis of adult cancer","volume":"120","author":"Tokar","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2023.137998_bib57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.aogh.2014.09.005","article-title":"The developmental neurotoxicity of arsenic: cognitive and behavioral consequences of early life exposure","volume":"80","author":"Tolins","year":"2014","journal-title":"Annals of Global Health"},{"key":"10.1016\/j.chemosphere.2023.137998_bib58","series-title":"Toxicological Profile for Arsenic","year":"2007"},{"key":"10.1016\/j.chemosphere.2023.137998_bib59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2105-14-15","article-title":"xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data","volume":"14","author":"Uppal","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.chemosphere.2023.137998_bib60","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/acs.chemrestox.6b00179","article-title":"Computational metabolomics: a framework for the million metabolome","volume":"29","author":"Uppal","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib61","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.analchem.6b01214","article-title":"An R package for network-based annotation of high-resolution metabolomics data","volume":"89","author":"Uppal","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chemosphere.2023.137998_bib62","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.chemosphere.2023.137998_bib63","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1039\/b102420p","article-title":"Arsenic extraction and speciation in carrots using accelerated solvent extraction, liquid chromatography and plasma mass spectrometry","volume":"126","author":"Vela","year":"2001","journal-title":"Analyst"},{"key":"10.1016\/j.chemosphere.2023.137998_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112935","article-title":"Changes in metabolomics and lipidomics in brain tissue and their correlations with the gut microbiome after chronic food-derived arsenic exposure in mice","volume":"228","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2023.137998_bib65","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.envint.2018.05.037","article-title":"A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh","volume":"118","author":"Wasserman","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2023.137998_bib66","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/C8TX00298C","article-title":"A review of arsenic exposure and lung cancer","volume":"8","author":"Wei","year":"2019","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.chemosphere.2023.137998_bib67","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cmet.2020.02.017","article-title":"Serine catabolism feeds NADH when respiration is impaired","volume":"31","author":"Yang","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib68","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1093\/bioinformatics\/btu430","article-title":"Improving peak detection in high-resolution LC\/MS metabolomics data using preexisting knowledge and machine learning approach","volume":"30","author":"Yu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chemosphere.2023.137998_bib69","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/bioinformatics\/btp291","article-title":"apLCMS--adaptive processing of high-resolution LC\/MS data","volume":"25","author":"Yu","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chemosphere.2023.137998_bib70","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/pr301053d","article-title":"Hybrid feature detection and information accumulation using high-resolution LC- MS metabolomics data","volume":"12","author":"Yu","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.chemosphere.2023.137998_bib71","doi-asserted-by":"crossref","first-page":"12265","DOI":"10.1021\/es503659w","article-title":"Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.137998_bib72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-7075-11-10","article-title":"The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility","volume":"11","author":"Zhang","year":"2014","journal-title":"Nutr. Metabol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523002655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523002655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:45:10Z","timestamp":1758631510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523002655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":71,"alternative-id":["S0045653523002655"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.137998","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic changes associated with chronic arsenic exposure in a Bangladeshi population","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.137998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137998"}}