{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:50:40Z","timestamp":1791474640999,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870239"],"award-info":[{"award-number":["81870239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171689"],"award-info":[{"award-number":["82171689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.chemosphere.2023.138249","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T11:32:16Z","timestamp":1677238336000},"page":"138249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Regulation of Cx43 and its role in trichloroethylene-induced cardiac toxicity in H9C2 rat cardiomyocytes"],"prefix":"10.1016","volume":"323","author":[{"given":"Zhongkun","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Aniagu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.138249_bib2","article-title":"Quantitation of volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry","volume":"832","author":"Blount","year":"2006","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.chemosphere.2023.138249_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00395-009-0007-5","article-title":"Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria","volume":"104","author":"Boengler","year":"2009","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1289\/ehp.1205879","article-title":"Human health effects of trichloroethylene: key findings and scientific issues","volume":"121","author":"Chiu","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.138249_bib5","doi-asserted-by":"crossref","DOI":"10.1080\/00039890109604068","article-title":"Recent chemical exposures and blood volatile organic compound levels in a large population-based sample","volume":"56","author":"Churchill","year":"2001","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.chemosphere.2023.138249_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152283","article-title":"The trichloroethylene metabolite s-(1,2-dichlorovinyl)-l-cysteine induces progressive mitochondrial dysfunction in htr-8\/svneo trophoblasts","volume":"427","author":"Elkin","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2023.138249_bib7","series-title":"Wnt Signaling in Cardiac and Vascular Disease","first-page":"68","volume":"vol. 70","author":"Foulquier","year":"2018"},{"key":"10.1016\/j.chemosphere.2023.138249_bib8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1124\/pr.117.013896","article-title":"Wnt signaling in cardiac and vascular disease","volume":"70","author":"Foulquier","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.chemosphere.2023.138249_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-017-0618-1","article-title":"Mitochondrial cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart","volume":"112","author":"Gadicherla","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.21288","article-title":"Trichloroethylene: parkinsonism and complex 1 mitochondrial neurotoxicity","volume":"63","author":"Gash","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib11","first-page":"252","article-title":"The interplay between mitochondrial reactive oxygen species","volume":"35","author":"Hartwick Bjorkman","year":"2021","journal-title":"endoplasmic reticulum stress, and nrf2 signaling in cardiometabolic health"},{"key":"10.1016\/j.chemosphere.2023.138249_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1039\/C9EM00565J","article-title":"Developmental toxicity of trichloroethylene in zebrafish (danio rerio)","volume":"22","author":"Horzmann","year":"2020","journal-title":"Environ Sci Process Impacts"},{"key":"10.1016\/j.chemosphere.2023.138249_bib13","article-title":"The role of the antioxidant response in mitochondrial dysfunction in degenerative diseases: cross-talk between antioxidant defense","author":"Huang","year":"2019","journal-title":"autophagy, and apoptosis"},{"key":"10.1016\/j.chemosphere.2023.138249_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126610","article-title":"Downregulation of mir-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish","volume":"251","author":"Huang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.138249_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152697","article-title":"Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos","volume":"452","author":"Huang","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2023.138249_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.scitotenv.2011.12.055","article-title":"Blood\/air distribution of volatile organic compounds (vocs) in a nationally representative sample","volume":"419","author":"Jia","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.138249_bib17","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/tox.22142","article-title":"Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene","volume":"31","author":"Jiang","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib18","first-page":"208","article-title":"The role of mir-182-5p in hepatocarcinogenesis of trichloroethylene in mice","volume":"156","author":"Jiang","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2023.138249_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121521","article-title":"Ahr-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos","volume":"385","author":"Jin","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2023.138249_bib20","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.3346\/jkms.2018.33.e106","article-title":"Trichloroethylene hypersensitivity syndrome: should be considered when diagnosing dress syndrome","volume":"33","author":"Kang","year":"2018","journal-title":"J. Kor. Med. Sci."},{"key":"10.1016\/j.chemosphere.2023.138249_bib21","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.fct.2009.04.002","article-title":"Effect of trichloroethylene (tce) toxicity on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in kidney and other rat tissues","volume":"47","author":"Khan","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib22","series-title":"The Cardiac Connexome: Non-canonical Functions of Connexin43 and Their Role in Cardiac Arrhythmias","first-page":"13","volume":"vol. 50","author":"Leo-Macias","year":"2016"},{"key":"10.1016\/j.chemosphere.2023.138249_bib23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1471-4159.2009.06497.x","article-title":"Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats","volume":"112","author":"Liu","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.chemosphere.2023.138249_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2021.09.010","article-title":"Maternal trichloroethylene exposure and metabolic gene polymorphisms may interact during fetal cardiovascular malformation","volume":"106","author":"Liu","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12012-012-9180-0","article-title":"Low-dose trichloroethylene alters cytochrome p450-2c subfamily expression in the developing chick heart","volume":"13","author":"Makwana","year":"2013","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib26","series-title":"Connexin43 in Cardiomyocyte Mitochondria Contributes to Mitochondrial Potassium Uptake","first-page":"747","volume":"vol. 83","author":"Miro-Casas","year":"2009"},{"key":"10.1016\/j.chemosphere.2023.138249_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2014.11.005","article-title":"The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury","volume":"78","author":"Ong","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111599","article-title":"Diazoxide needs mitochondrial connexin43 to exert its cytoprotective effect in a cellular model of cocl2-induced hypoxia","volume":"22","author":"Pecoraro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2023.138249_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094413","article-title":"Connexins in the heart: regulation, function and involvement in cardiac disease","volume":"22","author":"Rodriguez-Sinovas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2023.138249_bib30","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1089\/ars.2009.2513","article-title":"Redox control of the cell cycle in health and disease","volume":"11","author":"Sarsour","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.chemosphere.2023.138249_bib31","first-page":"346","article-title":"[trichloroethylene interferes with heart development of zebrafish via inhibiting wnt signal pathway]","volume":"35","author":"Shi","year":"2019","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"10.1016\/j.chemosphere.2023.138249_bib32","series-title":"Ros Dependent Wnt\/\u03b2-Catenin Pathway and its Regulation on Defined Micro-pillars-a Combined in Vitro and in Silico Study","volume":"vol. 9","author":"Staehlke","year":"2020"},{"key":"10.1016\/j.chemosphere.2023.138249_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152427","article-title":"Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects","volume":"436","author":"Urban","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2023.138249_bib34","series-title":"Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy","first-page":"926","volume":"vol. 126","author":"Wallace","year":"2020"},{"key":"10.1016\/j.chemosphere.2023.138249_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.freeradbiomed.2019.08.014","article-title":"Redox regulation of hepatic nlrp3 inflammasome activation and immune dysregulation in trichloroethene-mediated autoimmunity","volume":"143","author":"Wang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2023.138249_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.800185","article-title":"Hypoglycemia-exacerbated mitochondrial connexin 43 accumulation aggravates cardiac dysfunction in diabetic cardiomyopathy","volume":"9","author":"Wei","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.chemosphere.2023.138249_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/acs.chemrestox.5b00402","article-title":"Mitochondrial dysfunction, disruption of f-actin polymerization, and transcriptomic alterations in zebrafish larvae exposed to trichloroethylene","volume":"29","author":"Wirbisky","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.138249_bib38","article-title":"Cx43 overexpression is involved in the hyper-proliferation effect of trichloroethylene on human embryonic stem cells","volume":"465","author":"Xia","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2023.138249_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/stem.1685","article-title":"Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating e-cadherin","volume":"30","author":"Yu","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.chemosphere.2023.138249_bib40","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ros) and ros-induced ros release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523005167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523005167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:49:22Z","timestamp":1758631762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523005167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":39,"alternative-id":["S0045653523005167"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.138249","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of Cx43 and its role in trichloroethylene-induced cardiac toxicity in H9C2 rat cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.138249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"138249"}}