{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:53:08Z","timestamp":1790787188435,"version":"4.1.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000963","name":"American Diabetes Association Research Foundation","doi-asserted-by":"publisher","award":["1-lB-IDF-063"],"award-info":[{"award-number":["1-lB-IDF-063"]}],"id":[{"id":"10.13039\/100000963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["5T32HL120822-09"],"award-info":[{"award-number":["5T32HL120822-09"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5T32GM142519-02"],"award-info":[{"award-number":["5T32GM142519-02"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES030991"],"award-info":[{"award-number":["P42ES030991"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES033171"],"award-info":[{"award-number":["R01ES033171"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.chemosphere.2023.138738","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T14:41:55Z","timestamp":1681915315000},"page":"138738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life"],"prefix":"10.1016","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-9051","authenticated-orcid":false,"given":"Lisa","family":"Koshko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Debarba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-6581","authenticated-orcid":false,"given":"Lukas","family":"Stilgenbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Fakhoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashan","family":"Jayarathne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Eduardo","family":"Perez-Mojica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-7676","authenticated-orcid":false,"given":"Ellen","family":"Griggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2621-9532","authenticated-orcid":false,"given":"Adelheid","family":"Lempradl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Sadagurski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.138738_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/jcbfm.2013.206","article-title":"Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion","volume":"34","author":"Allard","year":"2014","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ejhg.2015.218","article-title":"De novo variants in sporadic cases of childhood onset schizophrenia","volume":"24","author":"Ambalavanan","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.chemosphere.2023.138738_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ame2.12084","article-title":"Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL\/6J mouse model of obesity","volume":"2","author":"Avtanski","year":"2019","journal-title":"Anim. Model Exp Med"},{"key":"10.1016\/j.chemosphere.2023.138738_bib4","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1093\/hmg\/ddv166","article-title":"Spatiotemporal dynamics of the postnatal developing primate brain transcriptome","volume":"24","author":"Bakken","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.chemosphere.2023.138738_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2156-11-26","article-title":"Identification of type 2 diabetes-associated combination of SNPs using support vector machine","volume":"11","author":"Ban","year":"2010","journal-title":"BMC Genet."},{"key":"10.1016\/j.chemosphere.2023.138738_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12967-015-0690-y","article-title":"Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review","volume":"13","author":"Banderali","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.chemosphere.2023.138738_bib7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ije\/dyv334","article-title":"Parental smoking during pregnancy and the risk of gestational diabetes in the daughter","volume":"45","author":"Bao","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib8","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2337\/diabetes.51.4.1233","article-title":"Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice","volume":"51","author":"Bartels","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.chemosphere.2023.138738_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1289\/ehp.1205404","article-title":"Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review","volume":"121","author":"Behl","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2023.138738_bib10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/geroni\/igy023.3223","article-title":"The neuroinflammation hypothesis of urban air pollution effects in the brain","volume":"2","author":"Block","year":"2018","journal-title":"Innov Aging"},{"key":"10.1016\/j.chemosphere.2023.138738_bib11","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neuro.2012.08.014","article-title":"The outdoor air pollution and brain health workshop","volume":"33","author":"Block","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.chemosphere.2023.138738_bib12","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1021\/es505316f","article-title":"New look at BTEX: are ambient levels a problem?","volume":"49","author":"Bolden","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbi.2013.10.029","article-title":"Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring","volume":"37","author":"Bolton","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.chemosphere.2023.138738_bib14","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1096\/fj.12-210989","article-title":"Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner","volume":"26","author":"Bolton","year":"2012","journal-title":"Faseb. J."},{"key":"10.1016\/j.chemosphere.2023.138738_bib15","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/glia.23753","article-title":"Microglia and sexual differentiation of the developing brain: a focus on ontogeny and intrinsic factors","volume":"68","author":"Bordt","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.chemosphere.2023.138738_bib16","series-title":"Appetite and Food Intake: Central Control, Boca Raton (FL)","first-page":"135","article-title":"Development of hypothalamic circuits that control food intake and energy balance","author":"Bouret","year":"2017"},{"key":"10.1016\/j.chemosphere.2023.138738_bib17","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1523\/JNEUROSCI.2277-11.2012","article-title":"Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits","volume":"32","author":"Bouret","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cmet.2007.12.001","article-title":"Hypothalamic neural projections are permanently disrupted in diet-induced obese rats","volume":"7","author":"Bouret","year":"2008","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmet.2017.03.001","article-title":"Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons","volume":"6","author":"Cady","year":"2017","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063549","article-title":"Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology","volume":"8","author":"Carlin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.138738_bib21","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1210\/en.2007-0822","article-title":"Leptin sensitivity in the developing rat hypothalamus","volume":"148","author":"Carlo","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2023.138738_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103305","article-title":"Ambient BTEX exposure and mid-pregnancy inflammatory biomarkers in pregnant African American women","volume":"145","author":"Cassidy-Bushrow","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13064-018-0125-6","article-title":"An ancient role for collier\/Olf\/Ebf (COE)-type transcription factors in axial motor neuron development","volume":"14","author":"Catela","year":"2019","journal-title":"Neural Dev."},{"key":"10.1016\/j.chemosphere.2023.138738_bib24","doi-asserted-by":"crossref","first-page":"e6259","DOI":"10.1371\/journal.pone.0006259","article-title":"Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment","volume":"4","author":"Chen","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.138738_bib25","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1152\/ajpendo.00336.2017","article-title":"Prenatal exposure to diesel exhaust PM2.5 causes offspring \u03b2 cell dysfunction in adulthood","volume":"315","author":"Chen","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.chemosphere.2023.138738_bib26","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1152\/ajpendo.00336.2017","article-title":"Prenatal exposure to diesel exhaust PM(2.5) causes offspring beta cell dysfunction in adulthood","volume":"315","author":"Chen","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.chemosphere.2023.138738_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.630318","article-title":"Adenylate kinase 4 promotes inflammatory gene expression via Hif1alpha and AMPK in macrophages","volume":"12","author":"Chin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s42255-021-00362-2","article-title":"STK3\/STK4 signalling in adipocytes regulates mitophagy and energy expenditure","volume":"3","author":"Cho","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.chemosphere.2023.138738_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2018.06.011","article-title":"An integrated view of sex differences in metabolic physiology and disease","volume":"15","author":"Clegg","year":"2018","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.00215","article-title":"Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice","volume":"130","author":"Corradi","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2023.138738_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.937281","article-title":"Benzene exposure leads to lipodystrophy and alters endocrine activity in vivo and in vitro","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib32","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cub.2007.08.034","article-title":"Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease","volume":"17","author":"Davenport","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbi.2020.05.073","article-title":"Acarbose protects from central and peripheral metabolic imbalance induced by benzene exposure","volume":"89","author":"Debarba","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.chemosphere.2023.138738_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2350-14-19","article-title":"Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study","volume":"14","author":"di Giuseppe","year":"2013","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.chemosphere.2023.138738_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chemosphere.2023.138738_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14556","article-title":"Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice","volume":"8","author":"Dorfman","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chemosphere.2023.138738_bib37","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1203\/00006450-197607000-00013","article-title":"The transplacental migration and accumulation in blood of volatile organic constituents","volume":"10","author":"Dowty","year":"1976","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.chemosphere.2023.138738_bib38","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chemosphere.2023.138738_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.06.011","article-title":"Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity","volume":"105","author":"Gokhale","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.chemosphere.2023.138738_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104715","article-title":"Glial smog: interplay between air pollution and astrocyte-microglia interactions","volume":"136","author":"Gomez-Budia","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.chemosphere.2023.138738_bib41","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial brain region-dependent diversity and selective regional sensitivities to aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib42","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.cub.2017.07.011","article-title":"Identification of chlamydomonas central Core centriolar proteins reveals a role for human WDR90 in ciliogenesis","volume":"27","author":"Hamel","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib43","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.conb.2017.10.007","article-title":"Environment matters: microglia function and dysfunction in a changing world","volume":"47","author":"Hanamsagar","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib44","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00018-015-1967-2","article-title":"Roles of connexins and pannexins in (neuro)endocrine physiology","volume":"72","author":"Hodson","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/cns.13569","article-title":"Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms","volume":"27","author":"Huang","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.chemosphere.2023.138738_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004642","article-title":"Regulation of p53 and Rb links the alternative NF-kappaB pathway to EZH2 expression and cell senescence","volume":"10","author":"Iannetti","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.chemosphere.2023.138738_bib47","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123000","article-title":"Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity","volume":"3","author":"Iqbal","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.chemosphere.2023.138738_bib48","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.2337\/dc13-1679","article-title":"Fetal exposure to parental smoking and the risk of type 2 diabetes in adult women","volume":"37","author":"Jaddoe","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.chemosphere.2023.138738_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbrc.2007.05.070","article-title":"Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells","volume":"359","author":"Kakudo","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chemosphere.2023.138738_bib50","first-page":"2347","article-title":"FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice","volume":"118","author":"Kamagate","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chemosphere.2023.138738_bib51","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijdevneu.2016.06.005","article-title":"Maternal obesity leads to increased proliferation and numbers of astrocytes in the developing fetal and neonatal mouse hypothalamus","volume":"53","author":"Kim","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib52","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cmet.2019.08.010","article-title":"Microglial UCP2 mediates inflammation and obesity induced by high-fat feeding","volume":"30","author":"Kim","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12974-017-0871-0","article-title":"Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity","volume":"14","author":"Kirkley","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.chemosphere.2023.138738_bib54","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.mehy.2006.02.033","article-title":"Hypothalamic pathogenesis of type 2 diabetes","volume":"67","author":"Koshiyama","year":"2006","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.chemosphere.2023.138738_bib55","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/toxsci\/kfab010","article-title":"In utero maternal benzene exposure predisposes to the metabolic imbalance in the offspring","volume":"180","author":"Koshko","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib56","series-title":"FelixKrueger\/TrimGalore: v0.6.0","author":"Krueger","year":"2021"},{"key":"10.1016\/j.chemosphere.2023.138738_bib57","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fnins.2014.00313","article-title":"CART in the regulation of appetite and energy homeostasis","volume":"8","author":"Lau","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2023.138738_bib59","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/JCP.0b013e31828bf288","article-title":"Genetic variants of microsomal triglyceride transfer protein (MTTP) are associated with metabolic syndrome in schizophrenic patients treated with atypical antipsychotics","volume":"33","author":"Liou","year":"2013","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12986-021-00569-w","article-title":"STAT3 phosphorylation in central leptin resistance","volume":"18","author":"Liu","year":"2021","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.chemosphere.2023.138738_bib61","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib62","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chemosphere.2023.138738_bib63","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.12763","article-title":"Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort","volume":"16","author":"Maguire","year":"2021","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.chemosphere.2023.138738_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106287","article-title":"Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure","author":"Maxwell","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.chemosphere.2023.138738_bib65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fncel.2017.00069","article-title":"Microglial intracellular Ca(2+) signaling in synaptic development and its alterations in neurodevelopmental disorders","volume":"11","author":"Mizoguchi","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.29024\/aogh.910","article-title":"Volatile organic compounds in air: sources, distribution, exposure and associated illnesses in children","author":"Montero-Montoya","year":"2018","journal-title":"Ann Glob Health"},{"key":"10.1016\/j.chemosphere.2023.138738_bib67","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00125-013-2846-8","article-title":"Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding","volume":"56","author":"Montgomery","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.chemosphere.2023.138738_bib68","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cne.1414","article-title":"Connexin26 in adult rodent central nervous system: demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43","volume":"441","author":"Nagy","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib69","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.nurpra.2013.07.009","article-title":"Maternal smoking during pregnancy and metabolic syndrome in their children","volume":"9","author":"Nuananong Seal","year":"2013","journal-title":"J. Nurse Pract."},{"key":"10.1016\/j.chemosphere.2023.138738_bib70","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12933-022-01597-3","article-title":"The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles","volume":"21","author":"Ormazabal","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173055","article-title":"Benzene formation in electronic cigarettes","volume":"12","author":"Pankow","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.138738_bib72","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nn.3662","article-title":"Connexin 30 sets synaptic strength by controlling astroglial synapse invasion","volume":"17","author":"Pannasch","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib73","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1210\/en.2010-0401","article-title":"Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese","volume":"151","author":"Patterson","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2023.138738_bib74","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/ntr\/ntw118","article-title":"Mainstream smoke levels of volatile organic compounds in 50 U.S. Domestic cigarette brands smoked with the ISO and Canadian intense protocols","volume":"18","author":"Pazo","year":"2016","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.chemosphere.2023.138738_bib75","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.reprotox.2010.12.055","article-title":"Prenatal environmental exposures, epigenetics, and disease","volume":"31","author":"Perera","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib76","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1089\/neu.2019.6498","article-title":"TMEM176A and TMEM176B are candidate regulators of inhibition of dendritic cell maturation and function after chronic spinal cord injury","volume":"37","author":"Picotto","year":"2020","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.chemosphere.2023.138738_bib77","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3389\/fimmu.2019.01299","article-title":"Ikaros zinc finger transcription factors: regulators of cytokine signaling pathways and CD4(+) T helper cell differentiation","volume":"10","author":"Powell","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib78","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/jmedgenet-2018-105623","article-title":"MAB21L1 loss of function causes a syndromic neurodevelopmental disorder with distinctive cerebellar, ocular, craniofacial and genital features (COFG syndrome)","volume":"56","author":"Rad","year":"2019","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.chemosphere.2023.138738_bib79","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41398-022-02265-6","article-title":"Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions","volume":"12","author":"Reemst","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.chemosphere.2023.138738_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.950105","article-title":"The PNA mouse may be the best animal model of polycystic ovary syndrome","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib81","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/bdr2.1550","article-title":"Smoking and pregnancy: epigenetics and developmental origins of the metabolic syndrome","volume":"111","author":"Rogers","year":"2019","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.chemosphere.2023.138738_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111690","article-title":"Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner","volume":"200","author":"Rousseau-Ralliard","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2023.138738_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110310","article-title":"Sex differences in developmental patterns of neocortical astroglia: a mouse translatome database","volume":"38","author":"Rurak","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.chemosphere.2023.138738_bib84","doi-asserted-by":"crossref","first-page":"E1305","DOI":"10.1152\/ajpendo.00031.2014","article-title":"Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis","volume":"306","author":"Sadagurski","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.chemosphere.2023.138738_bib85","article-title":"Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice","volume":"3","author":"Sadagurski","year":"2015","journal-title":"Phys. Rep."},{"key":"10.1016\/j.chemosphere.2023.138738_bib86","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cmet.2012.04.011","article-title":"IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action","volume":"15","author":"Sadagurski","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib87","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00125-009-1580-8","article-title":"Human IL6 enhances leptin action in mice","volume":"53","author":"Sadagurski","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.chemosphere.2023.138738_bib88","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.biopsych.2016.02.026","article-title":"Fibroblast growth factor 2 modulates hypothalamic pituitary Axis activity and anxiety behavior through glucocorticoid receptors","volume":"80","author":"Salmaso","year":"2016","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.chemosphere.2023.138738_bib89","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3389\/fnins.2019.01232","article-title":"Neurobehavioral consequences of traffic-related air pollution","volume":"13","author":"Salvi","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib90","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tips.2015.10.004","article-title":"Cyclin-Dependent kinases as coregulators of inflammatory gene expression","volume":"37","author":"Schmitz","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib91","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tips.2015.10.004","article-title":"Cyclin-Dependent kinases as coregulators of inflammatory gene expression","volume":"37","author":"Schmitz","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.chemosphere.2023.138738_bib92","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/dc21-2489","article-title":"Novel subgroups of type 2 diabetes display different epigenetic patterns that associate with future diabetic complications","volume":"45","author":"Schrader","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.chemosphere.2023.138738_bib93","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0014-4886(73)90187-8","article-title":"Time of neuron origin in mouse hypothalamic nuclei","volume":"41","author":"Shimada","year":"1973","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib94","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1186\/s12889-022-14319-x","article-title":"Association of metabolites of benzene and toluene with lipid profiles in Korean adults: Korean National Environmental Health Survey (2015-2017)","volume":"22","author":"Shin","year":"2022","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.chemosphere.2023.138738_bib95","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemosphere.2023.138738_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13111068","article-title":"Benzene exposure alters expression of enzymes involved in fatty acid beta-oxidation in male C3H\/He mice","volume":"13","author":"Sun","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2023.138738_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.138738_bib98","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2337\/diab.37.9.1163","article-title":"Diet-induced type II diabetes in C57BL\/6J mice","volume":"37","author":"Surwit","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.chemosphere.2023.138738_bib99","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/dmm.026609","article-title":"Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity","volume":"10","author":"Timper","year":"2017","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.chemosphere.2023.138738_bib100","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.beem.2014.02.006","article-title":"Mitochondrial UCP2 in the central regulation of metabolism","volume":"28","author":"Toda","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib101","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yfrne.2018.11.003","article-title":"Sexual differentiation of microglia","volume":"52","author":"Villa","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib102","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cell.2014.01.008","article-title":"Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding","volume":"156","author":"Vogt","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2023.138738_bib103","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1210\/en.2010-0505","article-title":"Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes","volume":"151","author":"Vucetic","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2023.138738_bib104","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1086\/660885","article-title":"The impact of maternal smoking during pregnancy on early child neurodevelopment","volume":"5","author":"Wehby","year":"2011","journal-title":"J. Hum. Cap."},{"key":"10.1016\/j.chemosphere.2023.138738_bib105","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/aje\/kwy256","article-title":"Ambient volatile organic compounds and racial\/ethnic disparities in gestational diabetes mellitus: are asian\/pacific islander women at greater risk?","volume":"188","author":"Williams","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.chemosphere.2023.138738_bib106","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/s12276-021-00644-5","article-title":"Hypothalamic primary cilium: a hub for metabolic homeostasis","volume":"53","author":"Yang","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.chemosphere.2023.138738_bib107","article-title":"Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ","volume":"136","author":"Young","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.chemosphere.2023.138738_bib108","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/bioinformatics\/bty895","article-title":"Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences","volume":"35","author":"Zhu","year":"2019","journal-title":"Bioinformatics"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523010056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523010056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:18:33Z","timestamp":1777465113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523010056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":108,"alternative-id":["S0045653523010056"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.138738","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.138738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"138738"}}