{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:26:39Z","timestamp":1773102399615,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2007013"],"award-info":[{"award-number":["XLYC2007013"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42276167"],"award-info":[{"award-number":["42276167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3105600"],"award-info":[{"award-number":["2022YFC3105600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.chemosphere.2023.139174","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T08:45:02Z","timestamp":1686213902000},"page":"139174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Bisphenol A decreases the developmental toxicity and histopathological alterations caused by polystyrene nanoplastics in developing marine medaka Oryzias melastigma"],"prefix":"10.1016","volume":"336","author":[{"given":"Fuwei","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5810-035X","authenticated-orcid":false,"given":"Fei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadi","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaochuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-9326","authenticated-orcid":false,"given":"Baojun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5756-3336","authenticated-orcid":false,"given":"Jingwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.139174_bib1","article-title":"Metal sorption onto nanoscale plastic debris and trojan horse effects in Daphnia magna: role of dissolved organic matter","volume":"186","author":"Abdolahpur Monikh","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.chemosphere.2023.139174_bib2","article-title":"Thiobencarb induces phenotypic abnormalities, apoptosis, and cardiovascular toxicity in zebrafish embryos through oxidative stress and inflammation","volume":"261","author":"An","year":"2022","journal-title":"Comp. Biochem. Physiol.: Toxicology & Pharmacology"},{"key":"10.1016\/j.chemosphere.2023.139174_bib3","article-title":"First approach to assess the effects of nanoplastics on the soil species Folsomia candida: a mixture design with bisphenol A and diphenhydramine","volume":"29","author":"Barreto","year":"2023","journal-title":"NanoImpact"},{"issue":"1","key":"10.1016\/j.chemosphere.2023.139174_bib4","first-page":"1891","article-title":"A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo","volume":"13","author":"Bashirova","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2023.139174_bib5","article-title":"Toxicological interactions of microplastics\/nanoplastics and environmental contaminants: current knowledge and future perspectives","volume":"405","author":"Bhagat","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2023.139174_bib6","article-title":"Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma","volume":"158","author":"Chen","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2023.139174_bib7","first-page":"1022","article-title":"Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity","volume":"584\u2013585","author":"Chen","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.139174_bib8","first-page":"1312","article-title":"Enhanced uptake of BPA in the presence of nanoplastics can lead to neurotoxic effects in adult zebrafish","volume":"609","author":"Chen","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.139174_bib9","article-title":"Charge-dependent negative effects of polystyrene nanoplastics on Oryzias melastigma under ocean acidification conditions","volume":"865","author":"Chen","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.139174_bib10","article-title":"Effects of short-term exposure to environmentally-relevant concentrations of benzo(a)pyrene-sorbed polystyrene to White seabass (Atractoscion nobilis)","volume":"263","author":"Coffin","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2023.139174_bib11","first-page":"93","article-title":"Ingestion, egestion and post-exposure effects of polystyrene microspheres on marine medaka (Oryzias melastigma)","volume":"228","author":"Cong","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.139174_bib13","series-title":"The Handbook of Histopathological Practices in Aquatic Environments","first-page":"191","author":"Costa","year":"2018"},{"key":"10.1016\/j.chemosphere.2023.139174_bib12","first-page":"11","article-title":"The embryotoxicity of ZnO nanoparticles to marine medaka, Oryzias melastigma","volume":"185","author":"Cong","year":"2017","journal-title":"Aquat. Toxicol."},{"issue":"6622","key":"10.1016\/j.chemosphere.2023.139174_bib14","first-page":"841","article-title":"Global plastic treaty should address chemicals","volume":"378","author":"Dey","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2023.139174_bib15","article-title":"MS-222 induces biochemical and transcriptional changes related to oxidative stress, cell proliferation and apoptosis in zebrafish embryos","volume":"237","author":"F\u00e9lix","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"36","key":"10.1016\/j.chemosphere.2023.139174_bib16","first-page":"32153","article-title":"Polystyrene nanoplastic exposure induces developmental toxicity by activating the oxidative stress response and base excision repair pathway in zebrafish (Danio rerio)","volume":"7","author":"Feng","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.chemosphere.2023.139174_bib17","article-title":"Co-exposure to nanoplastics and acetaminophen causes skeletal dysplasia and behavioral abnormalities in zebrafish","volume":"253","author":"Gao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.chemosphere.2023.139174_bib18","first-page":"501","article-title":"Nanoplastics are neither microplastics nor engineered nanoparticles","volume":"16","author":"Gigault","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"13","key":"10.1016\/j.chemosphere.2023.139174_bib19","first-page":"5768","article-title":"Micro and nano plastics distribution in fish as model organisms: histopathology, blood response and bioaccumulation in different organs","volume":"11","author":"Guerrera","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.chemosphere.2023.139174_bib20","article-title":"Parental exposure to sulfamethazine and nanoplastics alters the gut microbial communities in the offspring of marine madaka (Oryzias melastigma)","volume":"423","author":"He","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2023.139174_bib21","first-page":"752","article-title":"Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses","volume":"595","author":"Huang","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.chemosphere.2023.139174_bib22","first-page":"2506","article-title":"Embryonic exposure to low concentration of bisphenol A affects the development of Oryzias melastigma larvae","volume":"19","author":"Huang","year":"2012","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"Pt A","key":"10.1016\/j.chemosphere.2023.139174_bib23","first-page":"914","article-title":"New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure","volume":"242","author":"Huang","year":"2018","journal-title":"Environmental Pollut."},{"issue":"16","key":"10.1016\/j.chemosphere.2023.139174_bib24","first-page":"8403","article-title":"Fate of bisphenol A in terrestrial and aquatic environments","volume":"50","author":"Im","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.chemosphere.2023.139174_bib25","first-page":"11886","article-title":"Chemical analysis of microplastics and nanoplastics: challenges, advanced methods, and perspectives","volume":"121","author":"Ivleva","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chemosphere.2023.139174_bib26","article-title":"Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea)","volume":"419","author":"Lai","year":"2021","journal-title":"J. Hazard Mater."},{"issue":"19","key":"10.1016\/j.chemosphere.2023.139174_bib27","first-page":"11278","article-title":"Size-dependent effects of micro polystyrene particles in the marine copepod Tigriopus japonicus","volume":"47","author":"Lee","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.chemosphere.2023.139174_bib28","first-page":"1748","article-title":"Emergence of nanoplastic in the environment and possible impact on human health","volume":"53","author":"Lehner","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.139174_bib29","article-title":"Nanoplastic adsorption characteristics of bisphenol A: the roles of pH, metal ions, and suspended sediments","volume":"178","author":"Li","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2023.139174_bib30","article-title":"Long-term exposure to bisphenol A and its analogues alters the behavior of marine medaka (Oryzias melastigma) and causes hepatic injury","volume":"841","author":"Li","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.139174_bib31","article-title":"Nanoplastics induce more severe multigenerational life-history trait changes and metabolic responses in marine rotifer Brachionus plicatilis: comparison with microplastics","volume":"449","author":"Li","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2023.139174_bib32","article-title":"The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage","volume":"818","author":"Ling","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.chemosphere.2023.139174_bib33","first-page":"4017","article-title":"Nanoplastic state and fate in aquatic environments: multiscale modeling","volume":"56","author":"Lins","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"17","key":"10.1016\/j.chemosphere.2023.139174_bib34","first-page":"10188","article-title":"Microplastics as both a sink and a source of bisphenol A in the marine environment","volume":"53","author":"Liu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.139174_bib35","article-title":"Bisphenol A and its analogues in sedimentary microplastics of Hong Kong","volume":"164","author":"Lo","year":"2021","journal-title":"Mar. Pollut. Bull."},{"issue":"7","key":"10.1016\/j.chemosphere.2023.139174_bib36","first-page":"4054","article-title":"Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver","volume":"50","author":"Lu","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.139174_bib37","article-title":"Nanoplastics and ultrafine microplastic in the Dutch Wadden Sea - the hidden plastics debris?","volume":"846","author":"Materic","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.139174_bib38","first-page":"162","article-title":"Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes)","volume":"190","author":"Mu","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.139174_bib39","series-title":"Medaka: Biology, Management, and Experimental Protocols","first-page":"281","author":"Murata","year":"2019"},{"key":"10.1016\/j.chemosphere.2023.139174_bib40","article-title":"Microplastic contamination in seawater across global marine protected areas boundaries","volume":"316","author":"Nunes","year":"2023","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.139174_bib41","first-page":"246","article-title":"Temporal and spatial distributions of bisphenol A in marine and freshwaters in Turkey","volume":"76","author":"Ozhan","year":"2019","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"Pt 3","key":"10.1016\/j.chemosphere.2023.139174_bib42","article-title":"Microplastics induced developmental toxicity with microcirculation dysfunction in zebrafish embryos","volume":"286","author":"Park","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.139174_bib43","article-title":"Micro- and nano-plastics in marine environment: source, distribution and threats \u2014 a review","volume":"698","author":"Peng","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.139174_bib44","article-title":"Nanoplastics in the oceans: theory, experimental evidence and real world","volume":"157","author":"Piccardo","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2023.139174_bib45","first-page":"185","article-title":"Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)","volume":"194","author":"Pitt","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.139174_bib46","first-page":"177","article-title":"Impact of bisphenol-A on early embryonic development and reproductive maturation","volume":"25","author":"Ramakrishnan","year":"2008","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.139174_bib47","first-page":"280","article-title":"Microplastics reduce short-term effects of environmental contaminants. Part I: effects of bisphenol A on freshwater zooplankton are lower in presence of polyamide particles","volume":"15","author":"Rehse","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2023.139174_bib48","first-page":"511","article-title":"Recent advances in toxicological research of nanoplastics in the environment: a review","volume":"252","author":"Shen","year":"2019","journal-title":"Environ. Pollut."},{"issue":"14","key":"10.1016\/j.chemosphere.2023.139174_bib49","first-page":"8405","article-title":"Nanoplastics decrease the toxicity of a complex PAH mixture but impair mitochondrial energy production in developing zebrafish","volume":"53","author":"Trevisan","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2023.139174_bib50","article-title":"The combined toxic effects of polyvinyl chloride microplastics and di(2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)","volume":"440","author":"Wang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2023.139174_bib51","article-title":"Novel insights into iron regulation and requirement in marine medaka Oryzias melastigma","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2023.139174_bib52","first-page":"21","article-title":"Toxic effects of polystyrene nanoplastics and polybrominated diphenyl ethers to zebrafish (Danio rerio)","volume":"126","author":"Wang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.139174_bib53","first-page":"551","volume":"37","author":"Wang","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2023.139174_bib54","article-title":"Polystyrene microplastics alleviate adverse effects of benzo[a]pyrene on tissues and cells of the marine mussel, Mytilus galloprovincialis","volume":"256","author":"Wang","year":"2023","journal-title":"Aquat. Toxicol."},{"issue":"11","key":"10.1016\/j.chemosphere.2023.139174_bib55","first-page":"2490","article-title":"Effects of nanopolystyrene on the feeding behavior of the blue mussel (Mytilus edulis L.)","volume":"31","author":"Wegner","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2023.139174_bib56","first-page":"1","article-title":"Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production","volume":"125","author":"Wu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"7","key":"10.1016\/j.chemosphere.2023.139174_bib57","first-page":"1925","article-title":"Effect of bisphenol a on the early life stage in Japanese medaka (Oryzias latipes)","volume":"19","author":"Yokota","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2023.139174_bib58","article-title":"Separation and characterization of microplastic and nanoplastic particles in marine environment","volume":"297","author":"Zhao","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2023.139174_bib59","article-title":"Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos","volume":"872","author":"Zhou","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523014418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523014418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:04:07Z","timestamp":1758632647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523014418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":59,"alternative-id":["S0045653523014418"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.139174","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphenol A decreases the developmental toxicity and histopathological alterations caused by polystyrene nanoplastics in developing marine medaka Oryzias melastigma","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.139174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"139174"}}