{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:58:08Z","timestamp":1791359888802,"version":"4.3.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1602602"],"award-info":[{"award-number":["2018YFC1602602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.chemosphere.2023.140087","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:57:16Z","timestamp":1693904236000},"page":"140087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1"],"prefix":"10.1016","volume":"341","author":[{"given":"Chi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.140087_bib1","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00044.2017","article-title":"Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells","volume":"314","author":"Adedoyin","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cbi.2019.01.009","article-title":"The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy","volume":"300","author":"Chen","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.chemosphere.2023.140087_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113262","article-title":"T-2 toxin and its cardiotoxicity: new insights on the molecular mechanisms and therapeutic implications","volume":"167","author":"Dai","year":"2022","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.chemosphere.2023.140087_bib4","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1007\/s00204-019-02577-5","article-title":"T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction","volume":"93","author":"Dai","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/toxics11040395","article-title":"Ferroptosis as a potential therapeutic target of traditional Chinese medicine for mycotoxicosis: a review","volume":"11","author":"Ding","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.chemosphere.2023.140087_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.toxlet.2016.06.2103","article-title":"T-2 toxin inhibits murine ES cells cardiac differentiation and mitochondrial biogenesis by ROS and p-38 MAPK-mediated pathway","volume":"258","author":"Fang","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2023.140087_bib8","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.chemosphere.2023.140087_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/toxins11070375","article-title":"Global mycotoxin occurrence in feed: a ten-year survey","volume":"11","author":"Gruber-Dorninger","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.chemosphere.2023.140087_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103221","article-title":"Efficacy of methylprednisolone on T-2 toxin-induced cardiotoxicity in vivo: a pathohistological study","volume":"71","author":"Jacevic","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111138","article-title":"Cardiomyopathy induced by T-2 toxin in rats","volume":"137","author":"Jacevic","year":"2020","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.chemosphere.2023.140087_bib12","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.3390\/molecules26226868","article-title":"T-2 toxin-the most toxic trichothecene mycotoxin: metabolism, toxicity, and decontamination strategies","volume":"26","author":"Janik","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.chemosphere.2023.140087_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/cmi.2014.65","article-title":"Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells","volume":"12","author":"Jhang","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/antiox10081313","article-title":"Effects of Fusarium mycotoxin exposure on lipid peroxidation and glutathione redox system in the liver of laying hens","volume":"10","author":"Kulcs\u00e1r","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.chemosphere.2023.140087_bib16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/ars.2016.6659","article-title":"Heme oxygenase-1 in kidney health and disease","volume":"25","author":"Lever","year":"2016","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.chemosphere.2023.140087_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110008","article-title":"Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model","volume":"363","author":"Li","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.chemosphere.2023.140087_bib18","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s12011-020-02279-5","article-title":"Protective effect of organic selenium on oxidative damage and inflammatory reaction of rabbit kidney induced by T-2 toxin","volume":"199","author":"Liu","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2023.140087_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130245","article-title":"Deficiency in Beclin1 attenuates alcohol-induced cardiac dysfunction via inhibition of ferroptosis","volume":"1866","author":"Liu","year":"2022","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.chemosphere.2023.140087_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112183","article-title":"PPAR-\u03b3 with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats","volume":"152","author":"Lu","year":"2021","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.chemosphere.2023.140087_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2023.106410","article-title":"Melatonin protects Leydig cells from HT-2 toxin-induced ferroptosis and apoptosis via glucose-6-phosphate dehydrogenase\/glutathione -dependent pathway","volume":"159","author":"Ma","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib22","doi-asserted-by":"crossref","first-page":"8300","DOI":"10.3390\/ijms23158300","article-title":"Counteraction of myocardial ferritin heavy chain deficiency by heme oxygenase-1","volume":"23","author":"Machado","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2023.140087_bib23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s12640-018-9981-4","article-title":"Developmental exposure of mice to T-2 toxin increases astrocytes and hippocampal neural stem cells expressing metallothionein","volume":"35","author":"Nakajima","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.chemosphere.2023.140087_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116167","article-title":"NRF2\/PGC-1\u03b1-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells","volume":"451","author":"Pang","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cell.2004.10.017","article-title":"Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species","volume":"119","author":"Pham","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2023.140087_bib26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/molecules26020454","article-title":"Trichothecenes in food and feed, relevance to human and animal health and methods of detection: a systematic review","volume":"26","author":"Polak-Sliwinska","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.chemosphere.2023.140087_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111140","article-title":"Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans","volume":"137","author":"Schelstraete","year":"2020","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.chemosphere.2023.140087_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164472","article-title":"Ferritinophagy activation and sideroflexin1-dependent mitochondrial iron overload contribute to patulin-induced cardiac inflammation and fibrosis","volume":"892","author":"Sun","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.140087_bib31","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s00204-022-03337-8","article-title":"Toxicokinetics and metabolism of deoxynivalenol in animals and humans","volume":"96","author":"Sun","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140087_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.chemosphere.2023.140087_bib33","doi-asserted-by":"crossref","first-page":"15716","DOI":"10.1021\/acs.jafc.1c05393","article-title":"T-2 toxin induces ferroptosis by increasing lipid reactive oxygen species (ROS) and downregulating solute carrier family 7 member 11 (SLC7A11)","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2023.140087_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120717","article-title":"Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis","volume":"317","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2023.140087_bib36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/toxics11040393","article-title":"Nrf2: a main responsive element of the toxicity effect caused by trichothecene (T-2) mycotoxin","volume":"11","author":"Wang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.chemosphere.2023.140087_bib37","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.4238\/2011.December.2.1","article-title":"Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China","volume":"10","author":"Wei","year":"2011","journal-title":"Genet. Mol. Res. : GMR"},{"key":"10.1016\/j.chemosphere.2023.140087_bib38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0378-4274(82)90264-8","article-title":"Blood pressure changes and cardiovascular lesions found in rats given T-2 toxin, a trichothecene secondary metabolite of certain Fusarium microfungi","volume":"10","author":"Wilson","year":"1982","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2023.140087_bib39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/toxins11010045","article-title":"Autophagy and apoptosis interact to modulate T-2 toxin-induced toxicity in liver cells","volume":"11","author":"Wu","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.chemosphere.2023.140087_bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cbi.2018.01.021","article-title":"Selenium deficiency aggravates T-2 toxin-induced injury of primary neonatal rat cardiomyocytes through ER stress","volume":"285","author":"Xu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.chemosphere.2023.140087_bib41","first-page":"88","article-title":"Determination of trichothecenes A (T-2 toxin, HT-2 toxin, and diacetoxyscirpenol) in the tissues of broilers using liquid chromatography coupled to tandem mass spectrometry","volume":"942\u2013943","author":"Yang","year":"2013","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chemosphere.2023.140087_bib42","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1021\/acs.jafc.7b02575","article-title":"Metabolism of T-2 toxin in farm animals and human in vitro and in chickens in vivo using ultra highperformance liquid chromatography- quadrupole\/time-of-flight hybrid mass spectrometry along with online hydrogen\/deuterium exchange technique","volume":"65","author":"Yang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2023.140087_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2023.140087_bib44","first-page":"7409","article-title":"The effect of dexmedetomidine on myocardial ischemia\/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: a meta-analysis","volume":"25","author":"Zhang","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.chemosphere.2023.140087_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112027","article-title":"The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway","volume":"149","author":"Zhang","year":"2021","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.chemosphere.2023.140087_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5695723","article-title":"The nrf-2\/HO-1 signaling Axis: a ray of hope in cardiovascular diseases","volume":"2020","author":"Zhang","year":"2020","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.chemosphere.2023.140087_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112320","article-title":"Selenium mitigated aflatoxin B1-induced cardiotoxicity with potential regulation of 4 selenoproteins and ferroptosis signaling in chicks","volume":"154","author":"Zhao","year":"2021","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.chemosphere.2023.140087_bib48","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Cent. Sci."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523023573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523023573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:47:16Z","timestamp":1758635236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523023573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":45,"alternative-id":["S0045653523023573"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140087","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"140087"}}