{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:56:08Z","timestamp":1768038968940,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.chemosphere.2023.140369","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:29:33Z","timestamp":1696397373000},"page":"140369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Gestational exposure to ambient fine particulate matter disrupts maternal hepatic lipid metabolism"],"prefix":"10.1016","volume":"344","author":[{"given":"Yunlu","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1312-6064","authenticated-orcid":false,"given":"Yirun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rucheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-8811","authenticated-orcid":false,"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.140369_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2040-4603.2018.tb00008.x","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr Physiol."},{"key":"10.1016\/j.chemosphere.2023.140369_bib2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s42255-020-0211-z","article-title":"Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism","volume":"2","author":"Aregger","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.chemosphere.2023.140369_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2023.100959","article-title":"The effect of maternal obesity and lipid profile on first-trimester serum progesterone levels","volume":"5","author":"Bartha","year":"2023","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.chemosphere.2023.140369_bib4","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7944","article-title":"Ambient fine particulate matter air pollution and risk of weight gain and obesity in United States Veterans: an observational Cohort study","volume":"129","author":"Bowe","year":"2021","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.chemosphere.2023.140369_bib5","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00018-020-03674-w","article-title":"Regulation of maternal-fetal metabolic communication","volume":"78","author":"Bowman","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.chemosphere.2023.140369_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.fertnstert.2017.01.017","article-title":"Obesity and female infertility: potential mediators of obesity's impact","volume":"107","author":"Broughton","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.chemosphere.2023.140369_bib7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1515\/jpm-2021-0028","article-title":"Maternal and neonatal outcomes in women with disorders of lipid metabolism","volume":"49","author":"Cai","year":"2021","journal-title":"J Perinat Med"},{"key":"10.1016\/j.chemosphere.2023.140369_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145812","article-title":"Long-term exposure to ambient PM(2.5) increase obesity risk in Chinese adults: a cross-sectional study based on a nationwide survey in China","volume":"778","author":"Cao","year":"2021","journal-title":"Sci Total Environ."},{"key":"10.1016\/j.chemosphere.2023.140369_bib9","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4591","article-title":"Glucose homeostasis following diesel Exhaust particulate matter exposure in a Lung Epithelial Cell-Specific IKK2-deficient mouse model","volume":"127","author":"Chen","year":"2019","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.chemosphere.2023.140369_bib10","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2337\/dc15-1795","article-title":"Ambient air pollutants have adverse effects on insulin and glucose homeostasis in Mexican Americans","volume":"39","author":"Chen","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.chemosphere.2023.140369_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214680","article-title":"Combined effects of ambient particulate matter exposure and a high-fat diet on oxidative stress and steatohepatitis in mice","volume":"14","author":"Ding","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.140369_bib12","volume":"vol. 208","author":"Dong","year":"2021"},{"key":"10.1016\/j.chemosphere.2023.140369_bib13","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.chemosphere.2023.140369_bib14","first-page":"232","article-title":"Relationship between lipid alterations during pregnancy and adverse pregnancy outcomes","volume":"28","author":"Ferriols","year":"2016","journal-title":"Clin Investig Arterioscler"},{"key":"10.1016\/j.chemosphere.2023.140369_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/1389201015666140330192345","article-title":"Lipid metabolism during pregnancy and its implications for fetal growth","volume":"15","author":"Herrera","year":"2014","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.chemosphere.2023.140369_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121347","article-title":"Airborne PM2.5 pollution: a double-edged sword modulating hepatic lipid metabolism in middle-aged male mice","volume":"324","author":"Hu","year":"2023","journal-title":"Environ Pollut"},{"key":"10.1016\/j.chemosphere.2023.140369_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112524","article-title":"Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model","volume":"222","author":"Hu","year":"2021","journal-title":"Ecotoxicol Environ Saf."},{"key":"10.1016\/j.chemosphere.2023.140369_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/toxsci\/kfx166","article-title":"Exposure of pregnant mice to triclosan causes insulin resistance via thyroxine reduction","volume":"160","author":"Hua","year":"2017","journal-title":"Toxicol Sci."},{"key":"10.1016\/j.chemosphere.2023.140369_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113680","article-title":"Ambient fine particulate matter exposure disrupts placental autophagy and fetal development in gestational mice","volume":"239","author":"Li","year":"2022","journal-title":"Ecotoxicol Environ Saf."},{"key":"10.1016\/j.chemosphere.2023.140369_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12989-020-00343-5","article-title":"Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice","volume":"17","author":"Li","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140369_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114179","article-title":"Ambient fine particulate matter disrupts hepatic circadian oscillation and lipid metabolism in a mouse model","volume":"262","author":"Li","year":"2020","journal-title":"Environ Pollut"},{"key":"10.1016\/j.chemosphere.2023.140369_bib22","article-title":"Lipidomics insight into chronic exposure to ambient air pollution in mice","volume":"262","author":"Li","year":"2020","journal-title":"Environ Pollut [J]"},{"key":"10.1016\/j.chemosphere.2023.140369_bib23","doi-asserted-by":"crossref","DOI":"10.1177\/2042018819897046","article-title":"Association between air pollution and type 2 diabetes: an updated review of the literature","volume":"10","author":"Li","year":"2019","journal-title":"Ther Adv Endocrinol Metab."},{"key":"10.1016\/j.chemosphere.2023.140369_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12989-020-00391-x","article-title":"The critical role of endothelial function in fine particulate matter-induced atherosclerosis","volume":"17","author":"Liang","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140369_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.1306841","article-title":"Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice","volume":"122","author":"Liu","year":"2014","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.chemosphere.2023.140369_bib26","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jshs.2022.01.004","article-title":"Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence","volume":"11","author":"Liu","year":"2022","journal-title":"J Sport Health Sci."},{"key":"10.1016\/j.chemosphere.2023.140369_bib27","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fphys.2018.01091","article-title":"The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation","volume":"9","author":"Napso","year":"2018","journal-title":"Front Physiol."},{"key":"10.1016\/j.chemosphere.2023.140369_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111464","article-title":"Hypothalamic-pituitary-adrenal axis mediates ambient PM2.5 exposure-induced pulmonary inflammation","volume":"208","author":"Pan","year":"2021","journal-title":"Ecotoxicol Environ Saf."},{"key":"10.1016\/j.chemosphere.2023.140369_bib29","article-title":"Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults","volume":"2020","author":"Qin","year":"2021","journal-title":"Occup. Environ. Med. oemed"},{"key":"10.1016\/j.chemosphere.2023.140369_bib30","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1172\/JCI137315","article-title":"Metabolic effects of air pollution exposure and reversibility","volume":"130","author":"Rajagopalan","year":"2020","journal-title":"J Clin Invest."},{"key":"10.1016\/j.chemosphere.2023.140369_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53716-y","article-title":"Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice","volume":"9","author":"Reyes-Caballero","year":"2019","journal-title":"Sci Rep."},{"key":"10.1016\/j.chemosphere.2023.140369_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr Physiol [J]"},{"key":"10.1016\/j.chemosphere.2023.140369_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5830\/CVJA-2016-021","article-title":"Physiological changes in pregnancy","volume":"27","author":"Soma-Pillay","year":"2016","journal-title":"Cardiovasc J Afr."},{"key":"10.1016\/j.chemosphere.2023.140369_bib34","series-title":"Association of Short-Term Exposure to PM2.5 with Blood Lipids and the Modification Effects of Insulin Resistance: a Panel Study in Wuhan","first-page":"10","author":"Sun","year":"2022"},{"key":"10.1016\/j.chemosphere.2023.140369_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/toxsci\/kfy079","article-title":"Central IKK2 inhibition ameliorates air pollution-mediated hepatic glucose and lipid metabolism dysfunction in mice with type II diabetes","volume":"164","author":"Sun","year":"2018","journal-title":"Toxicol Sci."},{"key":"10.1016\/j.chemosphere.2023.140369_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114648","article-title":"Maternal exposure to ambient PM2.5 perturbs the metabolic homeostasis of maternal serum and placenta in mice","volume":"216","author":"Tao","year":"2023","journal-title":"Environ. Res. J."},{"key":"10.1016\/j.chemosphere.2023.140369_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136591","article-title":"Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice","volume":"308","author":"Wang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.140369_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12989-018-0252-6","article-title":"Exposure to concentrated ambient PM2.5 alters the composition of gut microbiota in a murine model","volume":"15","author":"Wang","year":"2018","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140369_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126392","article-title":"Ambient fine particulate matter exposure perturbed circadian rhythm and oscillations of lipid metabolism in adipose tissues","volume":"251","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.140369_bib40","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/ije\/dyaa235","article-title":"The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study","volume":"50","author":"Woo","year":"2021","journal-title":"Int J Epidemiol."},{"key":"10.1016\/j.chemosphere.2023.140369_bib41","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.0318","article-title":"Association of long-term exposure to ambient air pollutants with risk factors for cardiovascular disease in China","volume":"2","author":"Yang","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.chemosphere.2023.140369_bib42","doi-asserted-by":"crossref","first-page":"40701","DOI":"10.1007\/s11356-022-18862-3","article-title":"High-normal blood pressure (prehypertension) is associated with PM2.5 exposure in young adults","volume":"29","author":"Ye","year":"2022","journal-title":"Environ Sci Pollut Res Int."},{"key":"10.1016\/j.chemosphere.2023.140369_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153415","article-title":"PM2.5 induces the abnormal lipid metabolism and leads to atherosclerosis via Notch signaling pathway in rats","volume":"485","author":"Zhao","year":"2023","journal-title":"Toxicology"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523026395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523026395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:29:27Z","timestamp":1758634167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523026395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":43,"alternative-id":["S0045653523026395"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140369","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational exposure to ambient fine particulate matter disrupts maternal hepatic lipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140369","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"140369"}}