{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:54:18Z","timestamp":1790391258558,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0803900"],"award-info":[{"award-number":["2020YFA0803900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.chemosphere.2023.140496","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:41:55Z","timestamp":1697704915000},"page":"140496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Prenatal exposure to acetaminophen at different doses, courses and time causes testicular dysplasia in offspring mice and its mechanism"],"prefix":"10.1016","volume":"345","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.chemosphere.2023.140496_bib1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1148\/rg.2020190111","article-title":"Absent, abnormal, or reduced flow in the testis: thinking beyond torsion","volume":"40","author":"Alexander","year":"2020","journal-title":"Radiographics"},{"issue":"5","key":"10.1016\/j.chemosphere.2023.140496_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.joen.2015.01.024","article-title":"Acetaminophen: old drug, new issues","volume":"41","author":"Aminoshariae","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.chemosphere.2023.140496_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.earlhumdev.2020.104997","article-title":"Prenatal exposure to methadone or buprenorphine and long-term outcomes: a meta-analysis","volume":"143","author":"Andersen","year":"2020","journal-title":"Early Hum. Dev."},{"issue":"11","key":"10.1016\/j.chemosphere.2023.140496_bib4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/jamapediatrics.2020.3080","article-title":"Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit\/hyperactivity disorder mediated by frontoparietal network brain connectivity","volume":"174","author":"Baker","year":"2020","journal-title":"JAMA Pediatr."},{"issue":"16","key":"10.1016\/j.chemosphere.2023.140496_bib5","doi-asserted-by":"crossref","first-page":"20104","DOI":"10.1007\/s11356-020-08274-6","article-title":"Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and\/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis","volume":"27","author":"Balci","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/ppe.12595","article-title":"Acetaminophen use in pregnancy: examining prevalence, timing, and indication of use in a prospective birth cohort","volume":"34","author":"Bandoli","year":"2020","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.chemosphere.2023.140496_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.taap.2019.01.001","article-title":"In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat","volume":"365","author":"Beverly","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.140496_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ydbio.2012.08.018","article-title":"Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse","volume":"371","author":"Bialecka","year":"2012","journal-title":"Dev. Biol."},{"issue":"7","key":"10.1016\/j.chemosphere.2023.140496_bib9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/ejp.621","article-title":"Acetaminophen\/paracetamol: a history of errors, failures and false decisions","volume":"19","author":"Brune","year":"2015","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.chemosphere.2023.140496_bib10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.placenta.2020.12.002","article-title":"Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells","volume":"104","author":"Burman","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.chemosphere.2023.140496_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mce.2016.10.010","article-title":"Leydig cell stem cells: identification, proliferation and differentiation","volume":"445","author":"Chen","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.chemosphere.2023.140496_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tox.2017.05.004","article-title":"Prenatal exposure to di-n-butyl phthalate disrupts the development of adult Leydig cells in male rats during puberty","volume":"386","author":"Chen","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2023.140496_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115514","article-title":"In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development","volume":"419","author":"Chen","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.140496_bib14","article-title":"Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring","author":"Chen","year":"2022","journal-title":"Cell Biol. Toxicol."},{"issue":"6","key":"10.1016\/j.chemosphere.2023.140496_bib15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"issue":"26","key":"10.1016\/j.chemosphere.2023.140496_bib16","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1056\/NEJMoa2022398","article-title":"Antenatal dexamethasone for early preterm birth in low-resource countries","volume":"383","author":"Collaborators","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"10.1016\/j.chemosphere.2023.140496_bib17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1556\/650.2020.31713","article-title":"DOHaD: a disease-oriented, epoch-making, British-originated theory with Hungarian roots","volume":"161","author":"Csaba","year":"2020","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.chemosphere.2023.140496_bib18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ygcen.2018.09.004","article-title":"Testis structure, spermatogonial niche and Sertoli cell efficiency in Neotropical fish","volume":"273","author":"de Siqueira-Silva","year":"2019","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.chemosphere.2023.140496_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.reprotox.2018.04.001","article-title":"Gestational exposure to tetrabutyltin blocks rat fetal Leydig cell development","volume":"78","author":"Dong","year":"2018","journal-title":"Reprod. Toxicol."},{"issue":"11","key":"10.1016\/j.chemosphere.2023.140496_bib20","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/humrep\/dew196","article-title":"Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants","volume":"31","author":"Fisher","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.chemosphere.2023.140496_bib21","series-title":"Body Surface Area","author":"Flint","year":"2021"},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/taap.2002.9421","article-title":"Metabolism and toxicity of trichloroethylene in epididymis and testis","volume":"182","author":"Forkert","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.140496_bib23","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-15-0366","article-title":"Blood-testis barrier and Sertoli cell function: lessons from SCCx43KO mice","volume":"151","author":"Gerber","year":"2016","journal-title":"Reproduction"},{"issue":"7","key":"10.1016\/j.chemosphere.2023.140496_bib24","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1111\/jcmm.13641","article-title":"Induced pluripotent stem cell-derived conditional medium promotes Leydig cell anti-apoptosis and proliferation via autophagy and Wnt\/beta-catenin pathway","volume":"22","author":"Guo","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"21","key":"10.1016\/j.chemosphere.2023.140496_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218275","article-title":"Crosstalk between androgen-ZIP9 signaling and notch pathway in rodent Sertoli cells","volume":"21","author":"Kaminska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib26","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-12-0455","article-title":"Testosterone: a metabolic hormone in health and disease","volume":"217","author":"Kelly","year":"2013","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.140496_bib27","first-page":"849","article-title":"PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells","volume":"19","author":"Kim","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.chemosphere.2023.140496_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40572-020-00301-5","article-title":"Intrauterine exposure to acetaminophen and adverse developmental outcomes: epidemiological findings and methodological issues","volume":"8","author":"Liew","year":"2021","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.chemosphere.2023.140496_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2018.06.005","article-title":"Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats","volume":"408","author":"Liu","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2023.140496_bib30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2741\/4763","article-title":"Regulation of follicular development and differentiation by intra-ovarian factors and endocrine hormones","volume":"24","author":"Liu","year":"2019","journal-title":"Front Biosci-Landmrk"},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/15592294.2019.1581595","article-title":"Corticosterone rather than ethanol epigenetic programmed testicular dysplasia caused by prenatal ethanol exposure in male offspring rats","volume":"14","author":"Liu","year":"2019","journal-title":"Epigenetics"},{"key":"10.1016\/j.chemosphere.2023.140496_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114420","article-title":"Prenatal dexamethasone exposure induces nonalcoholic fatty liver disease in male rat offspring via the miR-122\/YY1\/ACE2-MAS1 pathway","volume":"185","author":"Liu","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.140496_bib33","article-title":"Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids","author":"Liu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.chemosphere.2023.140496_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115018","article-title":"MiR-466b-3p\/HDAC7 meditates transgenerational inheritance of testicular testosterone synthesis inhibition induced by prenatal dexamethasone exposure","volume":"199","author":"Liu","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.chemosphere.2023.140496_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/and.13413","article-title":"Notch signaling inhibition induces G0\/G1 arrest in murine Leydig cells","volume":"51","author":"Lu","year":"2019","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.chemosphere.2023.140496_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12940-020-00639-1","article-title":"Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2","volume":"19","author":"Ma","year":"2020","journal-title":"Environ. Health"},{"key":"10.1016\/j.chemosphere.2023.140496_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127792","article-title":"Gestational exposure to tebuconazole affects the development of rat fetal Leydig cells","volume":"262","author":"Ma","year":"2021","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.chemosphere.2023.140496_bib38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1210\/er.2018-00140","volume":"40","author":"Makela","year":"2019","journal-title":"Endocr. Rev."},{"issue":"19","key":"10.1016\/j.chemosphere.2023.140496_bib39","first-page":"1781","article-title":"Which drugs can be used during pregnancy?","volume":"132","author":"Malm","year":"2016","journal-title":"Duodecim"},{"issue":"8","key":"10.1016\/j.chemosphere.2023.140496_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072767","article-title":"Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle","volume":"8","author":"Murta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.140496_bib41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.reprotox.2021.01.014","article-title":"Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F1 rats","volume":"101","author":"Navin","year":"2021","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.chemosphere.2023.140496_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-2000-13474","article-title":"Sexual differentiation","volume":"18","author":"Ostrer","year":"2000","journal-title":"Semin. Reprod. Med."},{"issue":"5","key":"10.1016\/j.chemosphere.2023.140496_bib43","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/ppe.12660","article-title":"Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage","volume":"34","author":"Palmsten","year":"2020","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"1","key":"10.1016\/j.chemosphere.2023.140496_bib44","doi-asserted-by":"crossref","first-page":"M17","DOI":"10.1530\/JOE-18-0684","article-title":"The GC-IGF1 axis-mediated testicular dysplasia caused by prenatal caffeine exposure","volume":"242","author":"Pei","year":"2019","journal-title":"J. Endocrinol."},{"issue":"311","key":"10.1016\/j.chemosphere.2023.140496_bib45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.morpho.2011.07.118","article-title":"[The Sertoli cell]","volume":"95","author":"Ravel","year":"2011","journal-title":"Morphologie"},{"issue":"4","key":"10.1016\/j.chemosphere.2023.140496_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/genes12040578","article-title":"Testis development and differentiation in Amphibians","volume":"12","author":"Roco","year":"2021","journal-title":"Genes"},{"issue":"4","key":"10.1016\/j.chemosphere.2023.140496_bib47","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.fertnstert.2019.08.001","article-title":"Before the beginning: environmental exposures and reproductive and obstetrical outcomes","volume":"112","author":"Segal","year":"2019","journal-title":"Fertil. Steril."},{"issue":"1\u20133","key":"10.1016\/j.chemosphere.2023.140496_bib48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000342221","article-title":"Genetic control of testis development","volume":"7","author":"Sekido","year":"2013","journal-title":"Sex. Dev."},{"key":"10.1016\/j.chemosphere.2023.140496_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114414","article-title":"Low-activity programming of the PDGFRbeta\/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure","volume":"185","author":"Shangguan","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.chemosphere.2023.140496_bib50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000211359","article-title":"Acetaminophen-induced toxicity to human epidermoid cell line A431 and hepatoblastoma cell line Hep G2, in vitro, is diminished by silymarin","volume":"8","author":"Shear","year":"1995","journal-title":"Skin Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2023.140496_bib51","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2010.12.017","article-title":"Regulation of steroid production: analysis of Cyp11a1 promoter","volume":"336","author":"Shih","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6","key":"10.1016\/j.chemosphere.2023.140496_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2019.07.044","article-title":"Prenatal oxidative balance and risk of asthma and allergic disease in adolescence","volume":"144","author":"Sordillo","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib53","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1017\/S2040174417000691","article-title":"The developing world of DOHaD","volume":"9","author":"Suzuki","year":"2018","journal-title":"J. Dev. Orig. Health Dis."},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/ppe.12659","article-title":"Prenatal acetaminophen exposure and neurodevelopment: state of the evidence","volume":"34","author":"Talge","year":"2020","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"5","key":"10.1016\/j.chemosphere.2023.140496_bib55","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4314\/tjpr.v22i5.13","article-title":"Evaluation of the therapeutic potential of vomit seed (Strychnos nux-vomica) homeopathic treatment in acute acetaminophen-induced toxicity","volume":"22","author":"Toumi","year":"2023","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.chemosphere.2023.140496_bib56","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.mce.2006.12.016","article-title":"Steroidogenic factor-1 is a sphingolipid binding protein","volume":"265\u2013266","author":"Urs","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.chemosphere.2023.140496_bib57","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/MED.0b013e3283537cb8","article-title":"Prenatal exposure to smoking and male reproductive health","volume":"19","author":"Virtanen","year":"2012","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"2","key":"10.1016\/j.chemosphere.2023.140496_bib58","doi-asserted-by":"crossref","DOI":"10.4161\/spmg.25465","article-title":"NC1 domain of collagen alpha3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics","volume":"3","author":"Wong","year":"2013","journal-title":"Spermatogenesis"},{"issue":"2","key":"10.1016\/j.chemosphere.2023.140496_bib59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/aja.aja_83_18","article-title":"Regulation of anti-Mullerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility","volume":"21","author":"Xu","year":"2019","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.chemosphere.2023.140496_bib60","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/bs.ctdb.2019.04.008","article-title":"Heterogeneous, dynamic, and stochastic nature of mammalian spermatogenic stem cells","volume":"135","author":"Yoshida","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"issue":"5","key":"10.1016\/j.chemosphere.2023.140496_bib61","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3840","article-title":"Prenatal exposure to acetaminophen and risk of ADHD","volume":"140","author":"Ystrom","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.chemosphere.2023.140496_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152664","article-title":"Prenatal dexamethasone exposure caused fetal rats liver dysplasia by inhibiting autophagy-mediated cell proliferation","volume":"449","author":"Zhang","year":"2021","journal-title":"Toxicology"},{"issue":"14","key":"10.1016\/j.chemosphere.2023.140496_bib63","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s00018-019-03101-9","article-title":"The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis","volume":"76","author":"Zhou","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.chemosphere.2023.140496_bib64","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523027662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523027662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:20:57Z","timestamp":1777465257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523027662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":64,"alternative-id":["S0045653523027662"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140496","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal exposure to acetaminophen at different doses, courses and time causes testicular dysplasia in offspring mice and its mechanism","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"140496"}}