{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:08:17Z","timestamp":1777756097372,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU\\u2013CC\\u2013112L893502"],"award-info":[{"award-number":["NTU\\u2013CC\\u2013112L893502"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["L4000-1"],"award-info":[{"award-number":["L4000-1"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.chemosphere.2023.140717","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T05:13:15Z","timestamp":1700111595000},"page":"140717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Early-life long-term ibuprofen exposure reduces reproductive capacity involved in spermatogenesis impairment and associated with the transcription factor DAF-5 in Caenorhabditis elegans"],"prefix":"10.1016","volume":"347","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-0871","authenticated-orcid":false,"given":"Chan-Wei","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ling","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-3826","authenticated-orcid":false,"given":"Chun Ming","family":"How","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-9028","authenticated-orcid":false,"given":"Yu-Hsuan","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-9953","authenticated-orcid":false,"given":"Vivian","family":"Hsiu-Chuan Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2023.140717_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jinsphys.2019.03.002","article-title":"Inhibition of prostaglandin biosynthesis leads to suppressed ovarian development in Spodoptera exigua","volume":"114","author":"Abdullah Al Baki","year":"2019","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114442","article-title":"Anti-inflammatory drugs in the marine environment: bioconcentration, metabolism and sub-lethal effects in marine bivalves","volume":"263","author":"Almeida","year":"2020","journal-title":"Environ. Pollut."},{"issue":"Suppl. 1","key":"10.1016\/j.chemosphere.2023.140717_bib3","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1093\/jhered\/esq003","article-title":"Outcrossing and the maintenance of males within C. elegans populations","volume":"101","author":"Anderson","year":"2010","journal-title":"J. Hered."},{"key":"10.1016\/j.chemosphere.2023.140717_bib4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.etap.2017.08.016","article-title":"Cumulative effects of ibuprofen and air emersion in zebra mussels Dreissena polymorpha","volume":"55","author":"Andr\u00e9","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ecoenv.2016.10.029","article-title":"Ecological risk assessment of pharmaceuticals in the receiving environment of pharmaceutical wastewater in Pakistan","volume":"136","author":"Ashfaq","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2023.140717_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/21679169.2021.1976272","article-title":"Mitigating the environmental impact of NSAIDs-physiotherapy as a contribution to one health and the SDGs","volume":"25","author":"Banerjee","year":"2023","journal-title":"Eur. J. Physiother."},{"key":"10.1016\/j.chemosphere.2023.140717_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/and.13228","article-title":"Effect of ibuprofen on semen quality","volume":"51","author":"Banihani","year":"2019","journal-title":"Andrologia"},{"key":"10.1016\/j.chemosphere.2023.140717_bib8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/15287394.2020.1786483","article-title":"Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation","volume":"83","author":"Barbosa","year":"2020","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.chemosphere.2023.140717_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105767","article-title":"Nonsteroidal anti-inflammatory drugs act as endocrine disruptors in Astyanax lacustris (Teleostei: characidae) reproduction: an ex vivo approach","volume":"232","author":"Branco","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04087","article-title":"Ibuprofen as an emerging organic contaminant in environment, distribution and remediation","volume":"6","author":"Chopra","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.chemosphere.2023.140717_bib11","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/etc.4742","article-title":"Ibuprofen: fish short-term reproduction assay with zebrafish (Danio rerio) based on an extended OECD 229 protocol","volume":"39","author":"Constantine","year":"2020","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2023.140717_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1242\/dev.00922","article-title":"DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development","volume":"131","author":"da Graca","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2023.140717_bib13","doi-asserted-by":"crossref","first-page":"11279","DOI":"10.1007\/s11356-019-04519-1","article-title":"Intergenerational reproductive toxicity of chlordecone in male Caenorhabditis elegans","volume":"26","author":"Dai","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2023.140717_bib14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3390\/md17070428","article-title":"Prostaglandins in marine organisms: a review","volume":"17","author":"Di Costanzo","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.chemosphere.2023.140717_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.emcon.2016.12.004","article-title":"Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment","volume":"3","author":"Ebele","year":"2017","journal-title":"Emerging Contam."},{"key":"10.1016\/j.chemosphere.2023.140717_bib16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/em.21946","article-title":"Models of germ cell development and their application for toxicity studies","volume":"56","author":"Ferreira","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.chemosphere.2023.140717_bib17","doi-asserted-by":"crossref","first-page":"36133","DOI":"10.1007\/s11356-021-13245-6","article-title":"Effect of ibuprofen in vivo and in vitro on the sperm quality of the striped catfish Pseudoplatystoma magdaleniatum","volume":"28","author":"Gallego-R\u00edos","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2023.140717_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1534\/genetics.105.047340","article-title":"spe-10 encodes a DHHC-CRD zinc-finger membrane protein required for endoplasmic reticulum\/Golgi membrane morphogenesis during Caenorhabditis elegans spermatogenesis","volume":"172","author":"Gleason","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.chemosphere.2023.140717_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114135","article-title":"Morphological deformation of Daphnia magna embryos caused by prolonged exposure to ibuprofen","volume":"261","author":"Grzesiuk","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2023.140717_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112793","article-title":"A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans","volume":"225","author":"Gu\u00e9don","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2023.140717_bib21","series-title":"TGF-\u0392 Signaling in C. elegans","first-page":"1","author":"Gumienny","year":"2013"},{"key":"10.1016\/j.chemosphere.2023.140717_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.106040","article-title":"Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish","volume":"242","author":"Hamid","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib23","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/dvdy.296","article-title":"Mechanisms of TGF\u03b2 in prostaglandin synthesis and sperm guidance in Caenorhabditis elegans","volume":"250","author":"Hu","year":"2021","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.chemosphere.2023.140717_bib24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4614-4015-4_5","article-title":"Physiological control of germline development","volume":"757","author":"Hubbard","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jat.3357","article-title":"The C. elegans model in toxicity testing","volume":"37","author":"Hunt","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jhazmat.2013.03.036","article-title":"Effects of non-steroidal anti-inflammatory drugs on hormones and genes of the hypothalamic-pituitary-gonad axis, and reproduction of zebrafish","volume":"254\u2013255","author":"Ji","year":"2013","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2023.140717_bib27","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans","volume":"2","author":"Kamath","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib28","doi-asserted-by":"crossref","first-page":"E715","DOI":"10.1073\/pnas.1715035115","article-title":"Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism","volume":"115","author":"Kristensen","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemosphere.2023.140717_bib29","series-title":"Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health","first-page":"305","article-title":"Chapter 19 - environmental toxicants\u2013induced male reproductive toxicity: role of Oxidative Stress","author":"Kumar","year":"2018"},{"key":"10.1016\/j.chemosphere.2023.140717_bib30","series-title":"C. elegans II","article-title":"Spermatogenesis","author":"L'Hernault","year":"1997"},{"key":"10.1016\/j.chemosphere.2023.140717_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140613","article-title":"Ibuprofen and diclofenac restrict migration and proliferation of human glioma cells by distinct molecular mechanisms","volume":"10","author":"Leidgens","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2023.140717_bib32","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3390\/ijerph13100993","article-title":"The use of the nematode Caenorhabditis elegans to evaluate the adverse effects of epoxiconazole exposure on spermatogenesis","volume":"13","author":"Li","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2023.140717_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.634536","article-title":"Genes regulating spermatogenesis and sperm function associated with rare dsorders","volume":"9","author":"Linn","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105454","article-title":"Ecological risk assessment of fifty pharmaceuticals and personal care products (PPCPs) in Chinese surface waters: a proposed multiple-level system","volume":"136","author":"Liu","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2023.140717_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112584","article-title":"Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans","volume":"208","author":"Marlatt","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2023.140717_bib36","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.1250598","article-title":"Neurosensory perception of environmental cues modulates sperm motility critical for fertilization","volume":"344","author":"McKnight","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2023.140717_bib37","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1534\/genetics.111.137463","article-title":"Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans","volume":"190","author":"Meneely","year":"2012","journal-title":"Genetics"},{"key":"10.1016\/j.chemosphere.2023.140717_bib38","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.chemosphere.2018.01.148","article-title":"Long-term exposure of Mytilus galloprovincialis to diclofenac, ibuprofen and ketoprofen: insights into bioavailability, biomarkers and transcriptomic changes","volume":"198","author":"Mezzelani","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.140717_bib39","doi-asserted-by":"crossref","first-page":"a022251","DOI":"10.1101\/cshperspect.a022251","article-title":"The TGF-\u03b2 family in the reproductive tract","volume":"9","author":"Monsivais","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib40","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ydbio.2010.07.022","article-title":"The C. elegans adult male germline: stem cells and sexual dimorphism","volume":"346","author":"Morgan","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148251","article-title":"Metabolism of non-steroidal anti-inflammatory drugs by non-target wild-living organisms","volume":"791","author":"Mulkiewicz","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.140717_bib42","series-title":"Sexual Reproduction in Animals and Plants","first-page":"199","article-title":"Functional roles of spe genes in the male germline during reproduction of Caenorhabditis elegans","author":"Nishimura","year":"2014"},{"key":"10.1016\/j.chemosphere.2023.140717_bib43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.scitotenv.2008.02.059","article-title":"Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta, South China","volume":"397","author":"Peng","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2023.140717_bib44","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/ede.12170","article-title":"Evolutionarily divergent thermal sensitivity of germline development and fertility in hermaphroditic Caenorhabditis nematodes","volume":"17","author":"Poullet","year":"2015","journal-title":"Evol. Dev."},{"key":"10.1016\/j.chemosphere.2023.140717_bib45","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/10408444.2019.1626801","article-title":"Caenorhabditis elegans as a tool for environmental risk assessment: emerging and promising applications for a \"nobelized worm\"","volume":"49","author":"Queir\u00f3s","year":"2019","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib46","first-page":"703","article-title":"Early and late effects of ibuprofen on mouse sperm parameters, chromatin condensation, and DNA integrity in mice","volume":"13","author":"Roodbari","year":"2015","journal-title":"Iran. J. Reproductive Med."},{"key":"10.1016\/j.chemosphere.2023.140717_bib47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s42003-019-0552-x","article-title":"In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice","volume":"2","author":"Rossitto","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118078","article-title":"Developmental alterations, teratogenic effects, and oxidative disruption induced by ibuprofen, aluminum, and their binary mixture on Danio rerio","volume":"291","author":"S\u00e1nchez-Aceves","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2023.140717_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/genetics\/119.1.43","article-title":"fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans","volume":"119","author":"Schedl","year":"1988","journal-title":"Genetics"},{"key":"10.1016\/j.chemosphere.2023.140717_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002392","article-title":"For male Caenorhabditis elegans, sperm activation is a \"just-in-time\" event","volume":"7","author":"Shakes","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.chemosphere.2023.140717_bib51","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.4049\/jimmunol.1200005","article-title":"TGF-\u03b2 mediates proinflammatory seminal fluid signaling in human cervical epithelial cells","volume":"189","author":"Sharkey","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib52","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.reprotox.2020.08.005","article-title":"Selenium ameliorates ibuprofen induced testicular toxicity by redox regulation: running head: Se protects against NSAID induced testicular toxicity","volume":"96","author":"Sharma","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002375","article-title":"TRY-5 is a sperm-activating protease in Caenorhabditis elegans seminal fluid","volume":"7","author":"Smith","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.chemosphere.2023.140717_bib54","series-title":"Advances in Insect Physiology","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/bs.aiip.2019.01.003","article-title":"Chapter Eight - insect prostaglandins and other eicosanoids: from molecular to physiological actions","author":"Stanley","year":"2019"},{"key":"10.1016\/j.chemosphere.2023.140717_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1895\/wormbook.1.179.1","article-title":"The C. elegans eggshell","author":"Stein","year":"2018","journal-title":"WormBook"},{"key":"10.1016\/j.chemosphere.2023.140717_bib56","article-title":"Toxic effects of per- and polyfluoroalkyl substances on sperm: epidemiological and experimental evidence","volume":"14","author":"Sun","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib57","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1038\/s41467-018-06236-8","article-title":"Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis","volume":"9","author":"Tabuchi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chemosphere.2023.140717_bib58","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3390\/metabo11120853","article-title":"Sperm-guiding unconventional prostaglandins in C. elegans: synthesis and signaling","volume":"11","author":"Tiwary","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.chemosphere.2023.140717_bib59","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1242\/dev.088013","article-title":"PUF-8 negatively regulates RAS\/MAPK signalling to promote differentiation of C. elegans germ cells","volume":"140","author":"Vaid","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.chemosphere.2023.140717_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbpc.2015.08.010","article-title":"Gene response of CYP360A, CYP314, and GST and whole-organism changes in Daphnia magna exposed to ibuprofen","volume":"179","author":"Wang","year":"2016","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chemosphere.2015.05.086","article-title":"Occurrence, bioaccumulation, and trophic magnification of pharmaceutically active compounds in Taihu Lake, China","volume":"138","author":"Xie","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2023.140717_bib62","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.envpol.2016.12.026","article-title":"Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater lake","volume":"222","author":"Xie","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2023.140717_bib63","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s11356-020-10530-8","article-title":"Male reproductive toxicity involved in spermatogenesis induced by perfluorooctane sulfonate and perfluorooctanoic acid in Caenorhabditis elegans","volume":"28","author":"Yin","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2023.140717_bib64","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2015.10.029","article-title":"TGF-\u03b2 superfamily signaling in testis formation and early male germline development","volume":"45","author":"Young","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.chemosphere.2023.140717_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125173","article-title":"Long-term nanoplastics exposure results in multi and trans-generational reproduction decline associated with germline toxicity and epigenetic regulation in Caenorhabditis elegans","volume":"412","author":"Yu","year":"2021","journal-title":"J. Hazard Mater."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523029879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653523029879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:21:13Z","timestamp":1777465273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653523029879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":65,"alternative-id":["S0045653523029879"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140717","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early-life long-term ibuprofen exposure reduces reproductive capacity involved in spermatogenesis impairment and associated with the transcription factor DAF-5 in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"140717"}}