{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:50:01Z","timestamp":1782701401251,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.chemosphere.2024.141382","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T07:50:39Z","timestamp":1707205839000},"page":"141382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Metronidazole promotes oxidative stress and DNA fragmentation-mediated myocardial injury in albino mice"],"prefix":"10.1016","volume":"352","author":[{"given":"Fatmanur","family":"Co\u015fkun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fclti\u011fin","family":"\u00c7avu\u015fo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib1","first-page":"62","article-title":"Study of some hematological and physiological parameters and electrolytes in cardiomyopathy Iraqi patients","volume":"22","author":"Al-Khayatt","year":"2023","journal-title":"IJB"},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98206-2","article-title":"Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice","volume":"11","author":"Bakr","year":"2021","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.chemosphere.2024.141382_bib3","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.biocel.2008.02.020","article-title":"Molecular regulation of cardiac hypertrophy","volume":"40","author":"Barry","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.chemosphere.2024.141382_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1383-5742(02)00007-8","article-title":"Is metronidazole carcinogenic?","volume":"511","author":"Bendesky","year":"2002","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.chemosphere.2024.141382_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chemosphere.2024.141382_bib6","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1093\/carcin\/18.12.2373","article-title":"Oxidative DNA damage estimated by oxo8dG in the liver of Guinea-pigs supplemented with graded dietary doses of ascorbic acid and \u03b1-tocopherol","volume":"18","author":"Cadenas","year":"1997","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib7","first-page":"397","article-title":"Therapeutic uses of metronidazole and its side effects: an update","volume":"23","author":"Ceruelos","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141382_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10661-008-0361-z","article-title":"Evaluation of genotoxicity of coal fly ash in Allium cepa root cells by combining comet assay with the Allium test","volume":"153","author":"Chakraborty","year":"2009","journal-title":"Environ. Monit. Assess."},{"issue":"2","key":"10.1016\/j.chemosphere.2024.141382_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jac\/dkx351","article-title":"Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms","volume":"73","author":"Dingsdag","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.chemosphere.2024.141382_bib10","first-page":"1365","article-title":"Comet assay for determining of DNA damage: review","volume":"30","author":"Din\u00e7er","year":"2010","journal-title":"J. Med. Sci."},{"issue":"5","key":"10.1016\/j.chemosphere.2024.141382_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1742-7843.2004.pto940505.x","article-title":"Reproductive and cytogenetic toxicity of metronidazole in male mice","volume":"94","author":"El-Nahas","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141382_bib12","series-title":"StatPearls [Internet]","article-title":"Biochemistry, lactate dehydrogenase","author":"Farhana","year":"2023"},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ajcp\/110.1.70","article-title":"Comparison of cardiac troponin I, creatine kinase-MB, and myoglobin for detection of acute ischemic myocardial injury in a swine model","volume":"110","author":"Feng","year":"1998","journal-title":"Am. J. Clin. Pathol."},{"issue":"22","key":"10.1016\/j.chemosphere.2024.141382_bib14","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib15","first-page":"397","article-title":"Therapeutic uses of metronidazole and its side effects: an update","volume":"23","author":"Hernandez Ceruelos","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141382_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","article-title":"Cardiac fibrosis\u2013A short review of causes and therapeutic strategies","volume":"146","author":"Hinderer","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.chemosphere.2024.141382_bib17","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12028-014-0102-9","article-title":"Metronidazole-induced encephalopathy: not always a reversible situation","volume":"22","author":"Hobbs","year":"2015","journal-title":"Neurocritical Care"},{"issue":"8","key":"10.1016\/j.chemosphere.2024.141382_bib18","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1001\/archinte.1988.00380080054016","article-title":"Serum myoglobin levels in patients with ischemic myocardial insult","volume":"148","author":"Isakov","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.chemosphere.2024.141382_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40816-020-00199-4","article-title":"Cardioprotective effect of garlic extract in isoproterenol-induced myocardial infarction in a rat model: assessment of pro-apoptotic caspase-3 gene expression","volume":"6","author":"Islam","year":"2020","journal-title":"Clin. Phytoscience."},{"key":"10.1016\/j.chemosphere.2024.141382_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130278","article-title":"Cytogenotoxicity evaluation of a heavy metal mixture, detected in a polluted urban wetland: micronucleus and comet induction in the Indian green frog (Euphlyctis hexadactylus) erythrocytes and the Allium cepa bioassay","volume":"277","author":"Jayawardena","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.141382_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/568193","article-title":"Metronidazole induced liver injury: a rare immune mediated drug reaction","author":"Kancherla","year":"2013","journal-title":"Case Rep. Gastrointest. Med."},{"issue":"4","key":"10.1016\/j.chemosphere.2024.141382_bib22","first-page":"397","article-title":"High cardiac troponin I plasma concentration in a calf with myocarditis","volume":"51","author":"Karapinar","year":"2010","journal-title":"Can. Vet. J."},{"issue":"6","key":"10.1016\/j.chemosphere.2024.141382_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/WNF.0b013e3182334b35","article-title":"Metronidazole-induced central nervous system toxicity: a systematic review","volume":"34","author":"Kuriyama","year":"2011","journal-title":"Clin. Neuropharmacol."},{"issue":"5","key":"10.1016\/j.chemosphere.2024.141382_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2165\/00003088-199936050-00004","article-title":"Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials","volume":"36","author":"Lamp","year":"1999","journal-title":"Clin. Pharmacokinet."},{"issue":"4","key":"10.1016\/j.chemosphere.2024.141382_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1902\/jop.1991.62.4.247","article-title":"Effects of metronidazole on periodontal treatment needs","volume":"62","author":"Loesche","year":"1991","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1086\/647939","article-title":"Metronidazole is still the drug of choice for treatment of anaerobic infections","volume":"50","author":"Lofmark","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"24","key":"10.1016\/j.chemosphere.2024.141382_bib27","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2024.141382_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0027-5107(01)00136-1","article-title":"DNA breakage due to metronidazole treatment","volume":"478","author":"Men\u00e9ndez","year":"2001","journal-title":"Mutat. Res. Fund. Mol. Mec. Mutagen"},{"issue":"12","key":"10.1016\/j.chemosphere.2024.141382_bib29","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.cardfail.2010.07.245","article-title":"Serum levels of high-sensitivity troponin T: a novel marker for cardiac remodeling in hypertrophic cardiomyopathy","volume":"16","author":"Moreno","year":"2010","journal-title":"J. Card. Fail."},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib30","first-page":"67\u201278","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib31","first-page":"165","article-title":"Mode of action of metronidazole on anaerobic bacteria and protozoa","volume":"93","author":"M\u00fcller","year":"1983","journal-title":"Surgery"},{"issue":"7636","key":"10.1016\/j.chemosphere.2024.141382_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.chemosphere.2024.141382_bib33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/ncpcardio0710","article-title":"Mechanisms of disease: apoptosis in heart failure\u2014seeing hope in death","volume":"3","author":"Narula","year":"2006","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.chemosphere.2024.141382_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0192623310362248","article-title":"Ameliorative effects of curcumin on the seminiferous epithelium in metronidazole-treated mice: a stereological study","volume":"38","author":"Noorafshan","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.chemosphere.2024.141382_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7083486","article-title":"Effect of metronidazole on the oxidoreductive processes in the submandibular and parotid glands in experimental research","author":"Onopiuk","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.chemosphere.2024.141382_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jphotobiol.2014.05.015","article-title":"In vitro DNA binding studies of anticancer drug idarubicin using spectroscopic techniques","volume":"138","author":"Ozluer","year":"2014","journal-title":"J. Photochem. Photobiol., B"},{"issue":"14","key":"10.1016\/j.chemosphere.2024.141382_bib37","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1093\/cvr\/cvx183","article-title":"Cardiac troponins: from myocardial infarction to chronic disease","volume":"113","author":"Park","year":"2017","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.chemosphere.2024.141382_bib38","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1124\/dmd.113.052548","article-title":"The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst","volume":"41","author":"Pearce","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.chemosphere.2024.141382_bib39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s00244-009-9330-y","article-title":"Evaluation of DNA damage induced by environmental exposure to mercury in Liza aurata using the comet assay","volume":"58","author":"Pereira","year":"2010","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"4","key":"10.1016\/j.chemosphere.2024.141382_bib40","first-page":"415","article-title":"Troponin I release at rest and after exercise in patients with hypertrophic cardiomyopathy and the effect of betablockade","volume":"76","author":"Pop","year":"2006","journal-title":"Arch. Cardiol. Mex."},{"issue":"8","key":"10.1016\/j.chemosphere.2024.141382_bib41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1134\/S1023193522080109","article-title":"Investigation of metronidazole\u2013DNA interactions by using electrochemical and spectroscopic techniques","volume":"58","author":"Rafique","year":"2022","journal-title":"Russ. J. Electrochem."},{"key":"10.1016\/j.chemosphere.2024.141382_bib42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2015.03.024","article-title":"Studying non-covalent drug\u2013DNA interactions","volume":"576","author":"Rehman","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0736-4679(98)00129-2","article-title":"Creatine kinase and its CK-MB isoenzyme: the conventional marker for the diagnosis of acute myocardial infarction","volume":"17","author":"Robinson","year":"1999","journal-title":"J. Emerg. Med."},{"issue":"6","key":"10.1016\/j.chemosphere.2024.141382_bib44","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ihj.2017.12.002","article-title":"Biochemical and histological changes in the heart of post-partum rats exposed to Natron","volume":"70","author":"Saidu","year":"2018","journal-title":"Indian Heart J."},{"issue":"2","key":"10.1016\/j.chemosphere.2024.141382_bib45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.14712\/23362936.2014.27","article-title":"Curcumin protects metronidazole and X-ray induced cytotoxicity and oxidative stress in male germ cells in mice","volume":"114","author":"Singh","year":"2013","journal-title":"Prague Med. Rep."},{"key":"10.1016\/j.chemosphere.2024.141382_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00415-018-9147-6","article-title":"Metronidazole-induced encephalopathy: a systematic review","volume":"267","author":"S\u00f8rensen","year":"2020","journal-title":"J. Neurol."},{"issue":"12","key":"10.1016\/j.chemosphere.2024.141382_bib47","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1128\/AAC.48.12.4597-4605.2004","article-title":"Pharmacokinetics and pharmacodynamics of intravenous levofloxacin at 750 milligrams and various doses of metronidazole in healthy adult subjects","volume":"48","author":"Sprandel","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.chemosphere.2024.141382_bib48","first-page":"FF13","article-title":"Myocardial salvaging effects of berberine in experimental diabetes co-existing with myocardial infarction","volume":"10","author":"Suman","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"issue":"1","key":"10.1016\/j.chemosphere.2024.141382_bib49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal. Biochem."},{"issue":"6","key":"10.1016\/j.chemosphere.2024.141382_bib50","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/1574-6976.12026","article-title":"Antimicrobial strategies centered around reactive oxygen species \u2013 bactericidal antibiotics, photodynamic therapy, and beyond","volume":"37","author":"Vatansever","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.chemosphere.2024.141382_bib51","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/0002-8703(91)90458-T","article-title":"Three rapid immunoassays for the determination of creatine kinase MB: an analytical, clinical, and interpretive evaluation","volume":"122","author":"Wolfson","year":"1991","journal-title":"Am. Heart J."},{"key":"10.1016\/j.chemosphere.2024.141382_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1532-429X-18-S1-P121","article-title":"Prognostic implications of myocardial fibrosis and troponin levels measured by a highly sensitive assay in non-ischemic cardiomyopathy","volume":"18","author":"Yang","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.chemosphere.2024.141382_bib53","series-title":"StatPearls [Internet]","article-title":"Serum myoglobin","author":"Zafar Gondal","year":"2023"},{"key":"10.1016\/j.chemosphere.2024.141382_bib54","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/IJGM.S337517","article-title":"Serum level of lactate dehydrogenase is associated with cardiovascular disease risk as determined by the framingham risk score and arterial stiffness in a health-examined population in China","volume":"15","author":"Zhu","year":"2022","journal-title":"Int. J. Gen. Med."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524002753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524002753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:25:43Z","timestamp":1739510743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524002753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":54,"alternative-id":["S0045653524002753"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.141382","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metronidazole promotes oxidative stress and DNA fragmentation-mediated myocardial injury in albino mice","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.141382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"141382"}}