{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T02:34:25Z","timestamp":1775356465997,"version":"3.50.1"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.chemosphere.2024.141567","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T11:33:54Z","timestamp":1708947234000},"page":"141567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Toxicity of low dose bisphenols in human iPSC-derived cardiomyocytes and human cardiac organoids \u2013 Impact on contractile function and hypertrophy"],"prefix":"10.1016","volume":"353","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-7121","authenticated-orcid":false,"given":"Jianyong","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3614-8774","authenticated-orcid":false,"given":"Christian","family":"Grube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2024.141567_bib1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00424-021-02536-z","article-title":"Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research","volume":"473","author":"Andrysiak","year":"2021","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.chemosphere.2024.141567_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/JMAU.JMAU_53_18","article-title":"Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: a Histological and immunohistochemical study","volume":"7","author":"Bahey","year":"2019","journal-title":"J Microsc Ultrastruct"},{"key":"10.1016\/j.chemosphere.2024.141567_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0008-6363(97)00272-1","article-title":"Alterations in calcium handling in cardiac hypertrophy and heart failure","volume":"37","author":"Balke","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.chemosphere.2024.141567_bib4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1210\/en.2014-1847","article-title":"Bisphenol A alters autonomic tone and extracellular matrix structure and induces sex-specific effects on cardiovascular function in male and female CD-1 mice","volume":"156","author":"Belcher","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2024.141567_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.591581","article-title":"Current state of the art in ventricle tissue engineering","volume":"7","author":"Birla","year":"2020","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10.1016\/j.chemosphere.2024.141567_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110300","article-title":"Relationship between urinary bisphenol a levels and cardiovascular diseases in the U.S. adult population, 2003\u20132014","volume":"192","author":"Cai","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.141567_bib8","doi-asserted-by":"crossref","first-page":"11423","DOI":"10.1021\/acs.est.7b03336","article-title":"Bisphenol AF and bisphenol B exert higher estrogenic effects than bisphenol A via G protein-coupled estrogen receptor pathway","volume":"51","author":"Cao","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib9","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/1087057113500812","article-title":"Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy","volume":"18","author":"Carlson","year":"2013","journal-title":"J. Biomol. Screen"},{"key":"10.1016\/j.chemosphere.2024.141567_bib10","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity\u25a1 a review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1385\/CT:1:4:267","article-title":"Molecular mechanisms of cardiac hypertrophy induced by toxicants","volume":"1","author":"Chen","year":"2001","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10565-021-09615-y","article-title":"Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ER\u03b2 and calcineurin A-DRP1 signaling pathway","volume":"38","author":"Cheng","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114850","article-title":"Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: a comparison between XX and XY cardiomyocytes","volume":"388","author":"Cheng","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib14","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.7150\/thno.67661","article-title":"From engineered heart tissue to cardiac organoid","volume":"12","author":"Cho","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.chemosphere.2024.141567_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.chemosphere.2024.141567_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","article-title":"A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound","volume":"103","author":"Eladak","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.chemosphere.2024.141567_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117567","article-title":"Effects of bisphenol A exposure during cardiac cell differentiation","volume":"286","author":"Escarda-Castro","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.141567_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1289\/ehp.1408679","article-title":"Rapid responses and mechanism of action for low-dose bisphenol S on ex vivo rat hearts and isolated myocytes: evidence of female-specific proarrhythmic effects","volume":"123","author":"Gao","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2024.141567_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.toxlet.2017.05.011","article-title":"Effects of bisphenol A on incidence and severity of cardiac lesions in the NCTR-Sprague-Dawley rat: a CLARITY-BPA study","volume":"275","author":"Gear","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2024.141567_bib20","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/j.fct.2012.07.059","article-title":"A review of dietary and non-dietary exposure to bisphenol-A","volume":"50","author":"Geens","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/CIRCRESAHA.110.221531","article-title":"The multiple phases and faces of wnt signaling during cardiac differentiation and development","volume":"107","author":"Gessert","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2024.141567_bib22","author":"Harker"},{"key":"10.1016\/j.chemosphere.2024.141567_bib23","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/j.2040-4603.2015.tb00642.x","article-title":"Wnt signaling in cardiac disease","volume":"5","author":"Hermans","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s13287-022-03215-1","article-title":"Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases","volume":"13","author":"Ho","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.chemosphere.2024.141567_bib25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3389\/fphys.2012.00346","article-title":"Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias","volume":"3","author":"Hoekstra","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2016.03.008","article-title":"Bisphenol A, an environmental estrogen-like toxic chemical, induces cardiac fibrosis by activating the ERK1\/2 pathway","volume":"250\u2013251","author":"Hu","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2024.141567_bib27","article-title":"Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2024.141567_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115696","article-title":"Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes","volume":"428","author":"Hyun","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib29","series-title":"Self-Assembling Human Pluripotent Stem Cell-Derived Heart Organoids for the Study of Heart Development and Congenital Heart Disease","author":"Israeli","year":"2023"},{"key":"10.1016\/j.chemosphere.2024.141567_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0024-3205(97)00105-7","article-title":"Endothelins and cardiac hypertrophy","volume":"61","author":"Ito","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113639","article-title":"Association of bisphenol A and its alternatives bisphenol S and F exposure with hypertension and blood pressure: a cross-sectional study in China","volume":"257","author":"Jiang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.141567_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tox.2015.01.001","article-title":"BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1\u03b1 contributes to cardiomyopathy in male rats","volume":"329","author":"Jiang","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2024.141567_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/toxsci\/kfz198","article-title":"Gestational exposure to bisphenol A and bisphenol S leads to fetal skeletal muscle hypertrophy independent of sex","volume":"172","author":"Jing","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib34","article-title":"Cardiac hypertrophy in a dish: a human stem cell based model","volume":"9","author":"Johansson","year":"2020","journal-title":"Biol Open"},{"key":"10.1016\/j.chemosphere.2024.141567_bib35","doi-asserted-by":"crossref","DOI":"10.1289\/EHP3802","article-title":"Use of a mouse model of experimentally induced endometriosis to evaluate and compare the effects of bisphenol A and bisphenol AF exposure","volume":"126","author":"Jones","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2024.141567_bib36","doi-asserted-by":"crossref","first-page":"H1321","DOI":"10.1152\/ajpheart.00435.2020","article-title":"Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart","volume":"320","author":"Kabir","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1161\/CIRCRESAHA.117.305349","article-title":"Cardiac nonmyocytes in the hub of cardiac hypertrophy","volume":"117","author":"Kamo","year":"2015","journal-title":"Circ. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.chemosphere.2024.141567_bib38","first-page":"27","article-title":"Molecular and cellular mechanisms of cardiotoxicity","volume":"109","author":"Kang","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2024.141567_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2024.141567_bib40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/03009734.2016.1225870","article-title":"Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue","volume":"122","author":"Klint","year":"2016","journal-title":"Ups. J. Med. Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib41","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00204-023-03519-y","article-title":"A review on immunomodulatory effects of BPA analogues","author":"Kodila","year":"2023","journal-title":"Arch. Toxicol. 97(7)"},{"key":"10.1016\/j.chemosphere.2024.141567_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/156652412800620020","article-title":"Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins","volume":"12","author":"Landstrom","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.chemosphere.2024.141567_bib43","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/CIRCRESAHA.117.310083","article-title":"Calcium signaling and cardiac arrhythmias","volume":"120","author":"Landstrom","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2024.141567_bib44","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/jama.300.11.1303","article-title":"Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults","volume":"300","author":"Lang","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.chemosphere.2024.141567_bib45","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1021\/acsomega.8b00824","article-title":"Exposure to bisphenol A, bisphenol F, and bisphenol S in U.S. Adults and children: the national health and nutrition examination survey 2013\u20132014","volume":"3","author":"Lehmler","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.chemosphere.2024.141567_bib46","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2024.141567_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/biom11091277","article-title":"Heart organoids and engineered heart tissues: novel tools for modeling human cardiac biology and disease","volume":"11","author":"Lewis-Israeli","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.chemosphere.2024.141567_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1059243","article-title":"Wnt signaling directs human pluripotent stem cells into vascularized cardiac organoids with chamber-like structures","volume":"10","author":"Liang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1289\/ehp.1307491","article-title":"Cellular mechanism of the nonmonotonic dose response of bisphenol A in rat cardiac myocytes","volume":"122","author":"Liang","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2024.141567_bib50","article-title":"Perinatal combinational exposure to bisphenol A and a high-fat diet contributes to transgenerational dysregulation of cardiovascular and metabolic systems in mice","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib51","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.envpol.2019.01.004","article-title":"Cardiogenesis impairment promoted by bisphenol A exposure is successfully counteracted by epigallocatechin gallate","volume":"246","author":"Lomb\u00f3","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.141567_bib52","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jat.4401","article-title":"Associations of bisphenol F and S, as substitutes for bisphenol A, with cardiovascular disease in American adults","volume":"43","author":"Lu","year":"2023","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113589","article-title":"Acute exposure to low-dose bisphenol A delays cardiac repolarization in female canine heart - implication for proarrhythmic toxicity in large animals","volume":"172","author":"Ma","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138562","article-title":"Proarrhythmic toxicity of low dose bisphenol A and its analogs in human iPSC-derived cardiomyocytes and human cardiac organoids through delay of cardiac repolarization","volume":"328","author":"Ma","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.141567_bib55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tiv.2017.02.018","article-title":"Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study)","volume":"41","author":"Ma\u0107czak","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2024.141567_bib56","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy: a systematic review","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.chemosphere.2024.141567_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1056\/NEJMoa021332","article-title":"Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy","volume":"348","author":"Maron","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chemosphere.2024.141567_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008673","article-title":"Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003\/06","volume":"5","author":"Melzer","year":"2010","journal-title":"PLoS One"},{"issue":"Suppl. 1","key":"10.1016\/j.chemosphere.2024.141567_bib59","first-page":"223","article-title":"Pathophysiology of cardiac hypertrophy and failure of human working myocardium: abnormalities in calcium handling","volume":"87","author":"Meuse","year":"1992","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S204017441600057X","article-title":"Effects of prenatal bisphenol-A exposure and postnatal overfeeding on cardiovascular function in female sheep","volume":"8","author":"MohanKumar","year":"2017","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.chemosphere.2024.141567_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142941","article-title":"Effects of bisphenol A on cardiovascular disease: an epidemiological study using National Health and Nutrition Examination Survey 2003\u20132016 and meta-analysis","volume":"763","author":"Moon","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.141567_bib62","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1021\/acs.est.7b03283","article-title":"Acute toxicity, teratogenic, and estrogenic effects of bisphenol A and its alternative replacements bisphenol S, bisphenol F, and bisphenol AF in zebrafish embryo-larvae","volume":"51","author":"Moreman","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120106","article-title":"Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population","volume":"313","author":"Moreno-G\u00f3mez-Toledano","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.141567_bib64","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jat.1647","article-title":"Bisphenol A decreases atrial contractility involving NO-dependent G-cyclase signaling pathway","volume":"31","author":"Pant","year":"2011","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/toxsci\/kft026","article-title":"Lifelong exposure to bisphenol a alters cardiac structure\/function, protein expression, and DNA methylation in adult mice","volume":"133","author":"Patel","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib66","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.toxrep.2015.09.008","article-title":"Sex-specific cardiovascular responses to control or high fat diet feeding in C57bl\/6 mice chronically exposed to bisphenol A","volume":"2","author":"Patel","year":"2015","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.chemosphere.2024.141567_bib67","doi-asserted-by":"crossref","first-page":"H267","DOI":"10.1152\/ajpheart.00272.2015","article-title":"Physiological response of cardiac tissue to bisphenol A: alterations in ventricular pressure and contractility","volume":"309","author":"Posnack","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib68","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/toxsci\/kfab083","article-title":"Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology, as compared with bisphenol A","volume":"183","author":"Prudencio","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib69","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1038\/s41598-020-61014-1","article-title":"Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3\/CamKII dependent pathway","volume":"10","author":"Reventun","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chemosphere.2024.141567_bib70","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: a review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib71","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1161\/CIRCRESAHA.117.312067","article-title":"MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo","volume":"122","author":"Sala","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.chemosphere.2024.141567_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413180","article-title":"From spheroids to organoids: the next generation of model systems of human cardiac regeneration in a dish","volume":"22","author":"Scalise","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib73","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0092-8674(01)00242-2","article-title":"The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms","volume":"104","author":"Seidman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.141567_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.855763","article-title":"Human engineered heart tissue models for disease modeling and drug discovery","volume":"10","author":"Tani","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib75","doi-asserted-by":"crossref","DOI":"10.1289\/EHP3189","article-title":"Evaluation of prenatal exposure to bisphenol analogues on development and long-term health of the mammary gland in female mice","volume":"126","author":"Tucker","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2024.141567_bib76","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118079","article-title":"Low-dose PCB126 exposure disrupts cardiac metabolism and causes hypertrophy and fibrosis in mice","volume":"290","author":"Wang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.141567_bib78","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2022.02.027","article-title":"Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS\/NLRP3\/Caspase-1 pathway","volume":"182","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2024.141567_bib79","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12302-021-00586-9","article-title":"The bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013\u20132016","volume":"34","author":"Wang","year":"2022","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.chemosphere.2024.141567_bib80","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1210\/en.2005-1159","article-title":"Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure","volume":"147","author":"Welshons","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2024.141567_bib81","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.reprotox.2007.05.010","article-title":"In vitro molecular mechanisms of bisphenol A action","volume":"24","author":"Wetherill","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib82","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jhazmat.2015.10.004","article-title":"Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5","volume":"302","author":"Wu","year":"2016","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.141567_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025455","article-title":"Bisphenol A and 17\u03b2-estradiol promote arrhythmia in the female heart via alteration of calcium handling","volume":"6","author":"Yan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2024.141567_bib84","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fct.2013.02.011","article-title":"Low-dose bisphenol A and estrogen increase ventricular arrhythmias following ischemia-reperfusion in female rat hearts","volume":"56","author":"Yan","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152380","article-title":"Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER\/CAM\/eNOS pathway","volume":"432","author":"Yang","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2024.141567_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043365","article-title":"Calcium handling in inherited cardiac diseases: a focus on catecholaminergic polymorphic ventricular tachycardia and hypertrophic cardiomyopathy","volume":"24","author":"Zaffran","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2024.141567_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137952","article-title":"Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S","volume":"723","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.141567_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103434","article-title":"Combined effects of BPA and PFOS on fetal cardiac development: in vitro and in vivo experiments","volume":"80","author":"Zhou","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.141567_bib89","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1210\/en.2012-1422","article-title":"Endocrine-disrupting chemicals and public health protection: a statement of principles from the Endocrine Society","volume":"153","author":"Zoeller","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.chemosphere.2024.141567_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119236","article-title":"Urban fine particulate matter causes cardiac hypertrophy through calcium-mediated mitochondrial bioenergetics dysfunction in mice hearts and human cardiomyocytes","volume":"305","author":"Zou","year":"2022","journal-title":"Environ. Pollut."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524004600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524004600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:38:23Z","timestamp":1758634703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524004600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":90,"alternative-id":["S0045653524004600"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.141567","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicity of low dose bisphenols in human iPSC-derived cardiomyocytes and human cardiac organoids \u2013 Impact on contractile function and hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.141567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"141567"}}