{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:35:10Z","timestamp":1788474910615,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.chemosphere.2024.141772","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T19:37:06Z","timestamp":1711481826000},"page":"141772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Multilevel assessment of carbamazepine effects: An integrative approach using zebrafish early-life stages"],"prefix":"10.1016","volume":"355","author":[{"given":"Muriel Lopes da","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1755-8900","authenticated-orcid":false,"given":"Thayres Sousa","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando Andr\u00e9 Rios","family":"Villacis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Sousa-Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-9167","authenticated-orcid":false,"given":"In\u00eas","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Almeida","family":"Lisboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00edchollas Serafim","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Pic-Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-3857","authenticated-orcid":false,"given":"Rhaul de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-1577","authenticated-orcid":false,"given":"Cesar Koppe","family":"Grisolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2024.141772_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pestbp.2007.01.001","article-title":"Biochemical alteration induced by monocrotophos in the blood plasma of fish, Channa punctatus (Bloch)","volume":"88","author":"Agrahari","year":"2007","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib3","first-page":"1313","volume":"vol. 582","author":"Ajima","year":"2008"},{"key":"10.1016\/j.chemosphere.2024.141772_bib4","first-page":"6164","volume":"vol. 34","author":"Arranz","year":"2014"},{"key":"10.1016\/j.chemosphere.2024.141772_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/etc.3339","article-title":"Pharmaceuticals in the environment-Global occurrences and perspectives","volume":"35","author":"aus der Beek","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2024.141772_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nn788","article-title":"Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo","volume":"5","author":"Behra","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chemosphere.2024.141772_bib7","first-page":"248","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal","volume":"72","author":"Bradford","year":"1976","journal-title":"Biochem"},{"key":"10.1016\/j.chemosphere.2024.141772_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.aquatox.2013.10.005","article-title":"Short-term effects of neuroactive pharmaceutical drugs on a fish species: biochemical and behavioural effects","volume":"144\u2013145","author":"Brand\u00e3o","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib9","first-page":"266","volume":"vol. 274","author":"Chang","year":"2010"},{"issue":"23","key":"10.1016\/j.chemosphere.2024.141772_bib10","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.3390\/ijerph17238882","article-title":"Development and molecular investigation into the effects of carbamazepine exposure in the zebrafish (Danio rerio)","volume":"17","author":"Chen","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2024.141772_bib11","series-title":"Neuron-Specific Expression of Atp6v0c2 in Zebrafish CNS","first-page":"2501","author":"Chung","year":"2010"},{"key":"10.1016\/j.chemosphere.2024.141772_bib12","volume":"vol. 7","author":"Coutellier","year":"2012"},{"key":"10.1016\/j.chemosphere.2024.141772_bib13","first-page":"441","volume":"vol. 71","author":"Dai","year":"2009"},{"key":"10.1016\/j.chemosphere.2024.141772_bib14","first-page":"847","volume":"vol. 25","author":"Delprat","year":"2005"},{"key":"10.1016\/j.chemosphere.2024.141772_bib15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0045-6535(01)00029-7","article-title":"Lactate dehydrogenase activity as an effect criterion in toxicity tests with Daphnia magna straus","volume":"45","author":"Diamantino","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.141772_bib16","first-page":"338","article-title":"Comparative Biochemistry and Physiology, Part C Biomarkers as a tool to assess effects of chromium (VI): comparison of responses in zebra fish early life stages and adults \u2606","volume":"152","author":"Domingues","year":"2010","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.chemosphere.2024.141772_bib17","first-page":"88","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem","volume":"7","author":"Ellman","year":"1961","journal-title":"Pharmacol"},{"key":"10.1016\/j.chemosphere.2024.141772_bib18","volume":"vol. 25","author":"En","year":"2008"},{"key":"10.1016\/j.chemosphere.2024.141772_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquatox.2014.10.013","article-title":"Characterization of glutathione-S-transferases in zebrafish (Danio rerio)","volume":"158","author":"Glisic","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib20","first-page":"2313","article-title":"The zebrafish lens proteome during development and aging. Mol","author":"Greiling","year":"2009","journal-title":"Vis"},{"key":"10.1016\/j.chemosphere.2024.141772_bib21","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1021\/es8005173","article-title":"Evolutionary conservation of human drug targets in organisms used for environmental risk assessments","volume":"42","author":"Gunnarsson","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib22","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2024.141772_bib23","series-title":"Evolution of Trace Amine \u2013 Associated Receptor (TAAR) Gene Family in Vertebrates : Lineage-specific Expansions and Degradations of a Second Class of Vertebrate Chemosensory Receptors Expressed in the Olfactory Epithelium","author":"Hashiguchi","year":"2006"},{"key":"10.1016\/j.chemosphere.2024.141772_bib24","volume":"vol. 3","author":"Hussain","year":"2013"},{"key":"10.1016\/j.chemosphere.2024.141772_bib25","series-title":"Acoustic Sensory Transduction","first-page":"1","author":"Inoue","year":"2013"},{"key":"10.1016\/j.chemosphere.2024.141772_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ntt.2009.04.066","article-title":"Acute neuroactive drug exposures alter locomotor activity in larval zebrafish","volume":"32","author":"Irons","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.eplepsyres.2009.07.005","article-title":"Antiepileptic drugs in epilepsy and other disorders-A population-based study of prescriptions","volume":"87","author":"Johannessen Landmark","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.chemosphere.2024.141772_bib28","first-page":"1","volume":"vol. 8","author":"Jung","year":"2013"},{"issue":"3","key":"10.1016\/j.chemosphere.2024.141772_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.chemosphere.2024.141772_bib30","first-page":"17","volume":"vol. 356","author":"Kumamaru","year":"2004"},{"key":"10.1016\/j.chemosphere.2024.141772_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/nn.4146","article-title":"GDF10 is a signal for axonal sprouting and functional recovery after stroke","author":"Li","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chemosphere.2024.141772_bib32","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s10646-010-0468-1","article-title":"Enzymatic alterations and RNA\/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine","volume":"19","author":"Li","year":"2010","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2024.141772_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ecoenv.2010.09.008","article-title":"Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD","volume":"74","author":"Li","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.141772_bib34","doi-asserted-by":"crossref","first-page":"707e715","DOI":"10.1016\/j.chemosphere.2016.11.004","article-title":"Glutathione and zebrafish: old assays to address a current issue","volume":"168","author":"Massarsky","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.141772_bib35","doi-asserted-by":"crossref","first-page":"12530","DOI":"10.33263\/BRIAC115.1253012546","article-title":"Ecotoxicity, occurrence, and removal of pharmaceuticals and Illicit drugs from aquatic systems","volume":"11","author":"Mohan","year":"2021","journal-title":"Biointerface Research in Applied Chemistry"},{"key":"10.1016\/j.chemosphere.2024.141772_bib36","first-page":"1","article-title":"Test No. 236: fish embryo acute toxicity (FET) test. OECD Guidel","volume":"vol. 2","year":"2013"},{"key":"10.1016\/j.chemosphere.2024.141772_bib37","doi-asserted-by":"crossref","DOI":"10.1088\/1748-9326\/ab0071","article-title":"Aquatic risks from human pharmaceuticals\u2014modelling temporal trends of carbamazepine and ciprofloxacin at the global scale","volume":"14","author":"Oldenkamp","year":"2019","journal-title":"Environ. Res. Lett."},{"issue":"6","key":"10.1016\/j.chemosphere.2024.141772_bib38","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ntt.2011.08.005","article-title":"Assessing locomotor activity in larval zebrafish: influence of extrinsic and intrinsic variables","volume":"33","author":"Padilla","year":"2011","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.chemosphere.2024.141772_bib39","series-title":"Immunomodulatory Effect of Prolactin on Atlantic Salmon (Salmo salar) Macrophage Function","author":"Paredes","year":"2013"},{"key":"10.1016\/j.chemosphere.2024.141772_bib40","first-page":"568","article-title":"A panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos. Reprod","volume":"34","author":"Pruvot","year":"2012","journal-title":"Toxicol"},{"key":"10.1016\/j.chemosphere.2024.141772_bib41","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s10646-016-1694-y","article-title":"Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior","volume":"25","author":"Qiang","year":"2016","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.chemosphere.2024.141772_bib42","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.jhazmat.2010.12.037","article-title":"GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers","volume":"186","author":"Ramaswamy","year":"2011","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.141772_bib43","series-title":"Valve Morphogenesis through Fibronectin Synthesis","author":"Ramspacher","year":"2016"},{"key":"10.1016\/j.chemosphere.2024.141772_bib44","doi-asserted-by":"crossref","first-page":"130909","DOI":"10.1016\/j.jhazmat.2023.130909","article-title":"Carbamazepine, venlafaxine, tramadol, and their main metabolites: toxicological effects on zebrafish embryos and larvae","volume":"448","author":"Rodrigues","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.141772_bib45","first-page":"170","volume":"vol. 147","author":"Romero","year":"2012"},{"key":"10.1016\/j.chemosphere.2024.141772_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161324","article-title":"Effects of common antiepileptic drugs on teleost fishes","volume":"866","author":"Salahinejad","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.141772_bib48","first-page":"24","volume":"vol. 147","author":"Sakamoto","year":"2006"},{"key":"10.1016\/j.chemosphere.2024.141772_bib49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ecoenv.2018.08.015","article-title":"Chronic effects of carbamazepine on zebrafish: behavioral, reproductive and biochemical endpoints","volume":"164","author":"Santos","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.141772_bib50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ecoenv.2018.08.015","article-title":"Chronic effects of carbamazepine on zebrafish: behavioral, reproductive and biochemical endpoints","volume":"164","author":"Silva Santos","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.chemosphere.2024.141772_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/app9071362","article-title":"Ecotoxicological effect of Single and Combined exposure of carbamazepine and Cadmium on female Danio rerio: a Multibiomarker study","volume":"9","author":"Shi","year":"2019","journal-title":"Appl. Sci."},{"key":"10.1016\/j.chemosphere.2024.141772_bib52","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.tiv.2010.03.018","article-title":"In vitro effects of antiepileptic drugs on acetylcholinesterase and ectonucleotidase activities in zebrafish (Danio rerio) brain","volume":"24","author":"Siebel","year":"2010","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.chemosphere.2024.141772_bib53","first-page":"1","volume":"vol. 11","author":"Theodoridi","year":"2017"},{"key":"10.1016\/j.chemosphere.2024.141772_bib54","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pharmthera.2005.10.017","article-title":"Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects","volume":"111","author":"Tsiftsoglou","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.chemosphere.2024.141772_bib55","series-title":"Methods of Enzymatic Analysis, Enzymes: Oxireductases, Transferase","first-page":"118","article-title":"Lactate dehydrogenase","author":"Vassault","year":"1983"},{"issue":"8","key":"10.1016\/j.chemosphere.2024.141772_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world's rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.chemosphere.2024.141772_bib57","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ultsonch.2015.09.008","article-title":"Removal of carbamazepine from aqueous solution using sono-activated persulfate process","volume":"29","author":"Wang","year":"2016","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.chemosphere.2024.141772_bib58","first-page":"1","article-title":"Olfactory receptor for prostaglandin F 2 a mediates male fish courtship behavior","author":"Yabuki","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chemosphere.2024.141772_bib59","first-page":"134","volume":"244","author":"Yang","year":"2016","journal-title":"HHS Public Access"},{"key":"10.1016\/j.chemosphere.2024.141772_bib60","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.chemosphere.2008.07.086","article-title":"Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies","volume":"73","author":"Zhang","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.141772_bib61","first-page":"49","volume":"vol. 49","author":"Zhu","year":"2002"},{"key":"10.1016\/j.chemosphere.2024.141772_bib62","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.chemosphere.2015.02.031","article-title":"An efficient laboratory workflow for environmental risk assessment of organic chemicals","volume":"131","author":"Zhu","year":"2015","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524006659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524006659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T16:09:15Z","timestamp":1730736555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524006659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":61,"alternative-id":["S0045653524006659"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.141772","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multilevel assessment of carbamazepine effects: An integrative approach using zebrafish early-life stages","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.141772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"141772"}}