{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:42:23Z","timestamp":1787056943182,"version":"build-2736575974"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES10563"],"award-info":[{"award-number":["R01ES10563"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028075","name":"Promise","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100028075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["6066532"],"award-info":[{"award-number":["6066532"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.chemosphere.2024.142441","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T18:38:48Z","timestamp":1716575928000},"page":"142441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Thyroid under siege: Unravelling the toxic impact of real-life metal mixture exposures in Wistar rats"],"prefix":"10.1016","volume":"360","author":[{"given":"\u0110ur\u0111ica","family":"Mari\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Barali\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-2565","authenticated-orcid":false,"given":"Dragana","family":"Vukeli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Milo\u0161evi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-0580","authenticated-orcid":false,"given":"Anja","family":"Nikoli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Antonijevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"\u0110uki\u0107-\u0106osi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9830-8772","authenticated-orcid":false,"given":"Zorica","family":"Bulat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-7040","authenticated-orcid":false,"given":"Aleksandra Buha","family":"Djordjevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2024.142441_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/1559325819858266","article-title":"Gestational arsenic trioxide exposure acts as a developing neuroendocrine-disruptor by downregulating Nrf2\/PPAR\u03b3 and upregulating caspase-3\/NF-\u0138B\/Cox2\/BAX\/iNOS\/ROS","volume":"17","author":"Ahmed","year":"2019","journal-title":"Dose Response"},{"key":"10.1016\/j.chemosphere.2024.142441_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.33899\/ijvs.2019.153852","article-title":"Effects of cadmium chloride on some endocrine glands (thyroid and adrenal) in male rats (Rattus norvegicus)","volume":"32","author":"Al- Derawi","year":"2019","journal-title":"IJVS"},{"key":"10.1016\/j.chemosphere.2024.142441_bib3","first-page":"703","volume":"vol. 33","author":"Alva-S\u00e1nchez","year":"2012"},{"key":"10.1016\/j.chemosphere.2024.142441_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138698","article-title":"Cadmium and lead implication in testis cancer; is there a connection?","volume":"330","author":"An\u0111elkovi\u0107","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.142441_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/1721727X221122719","article-title":"Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity","volume":"20","author":"Anka","year":"2022","journal-title":"Eur. J. Inflamm."},{"key":"10.1016\/j.chemosphere.2024.142441_bib6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/26896583.2020.1782116","article-title":"Current mechanistic perspectives on male reproductive toxicity induced by heavy metals","volume":"38","author":"Anyanwu","year":"2020","journal-title":"Journal of Environmental Science and Health, Part C"},{"key":"10.1016\/j.chemosphere.2024.142441_bib7","series-title":"Toxicological Profile for Chromium","year":"2002"},{"key":"10.1016\/j.chemosphere.2024.142441_bib8","series-title":"Toxicological Profile for Nickel","year":"2005"},{"key":"10.1016\/j.chemosphere.2024.142441_bib9","first-page":"1","article-title":"Toxicological profile for cadmium","year":"2012","journal-title":"US Public Heal Serv Agency Toxic Subst Dis Regist"},{"key":"10.1016\/j.chemosphere.2024.142441_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.taap.2018.02.014","article-title":"A systems biology approach to predictive developmental neurotoxicity of a larvicide used in the prevention of Zika virus transmission","volume":"354","author":"Audouze","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107313","article-title":"Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: data set from human study","volume":"165","author":"Barali\u0107","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2024.142441_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165181","article-title":"Effects of the real-life metal(oid)s mixture on female reproductive function: less is different","volume":"895","author":"Barali\u0107","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.142441_bib13","doi-asserted-by":"crossref","unstructured":"Bergman, \u00c5., Heindel, J.J., Jobling, S., Kidd, K.A., Zoeller, R.T., n.d. State of the Science of Endocrine Disrupting Chemicals - 2012: an Assessment of the State of the Science of Endocrine Disruptors Prepared by a Group of Experts for the United Nations Environment Programme (UNEP) and WHO. United National Environment Programme : World Health Organization, Geneva, Switzerland.","DOI":"10.1016\/j.toxlet.2012.03.020"},{"key":"10.1016\/j.chemosphere.2024.142441_bib14","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1172\/JCI29812","article-title":"Deiodinases: implications of the local control of thyroid hormone action","volume":"116","author":"Bianco","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chemosphere.2024.142441_bib15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/toxsci\/kfj018","article-title":"Toxicogenomics in risk assessment: applications and needs","volume":"89","author":"Boverhof","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2024.142441_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.toxlet.2013.06.216","article-title":"The impact of prolonged cadmium exposure and co-exposure with polychlorinated biphenyls on thyroid function in rats","volume":"221","author":"Buha","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.chemosphere.2024.142441_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/medicina56010040","article-title":"To treat or not to treat subclinical hypothyroidism, what is the evidence?","volume":"56","author":"Calissendorff","year":"2020","journal-title":"Medicina"},{"key":"10.1016\/j.chemosphere.2024.142441_bib18","article-title":"Cadmium induces apoptosis in pancreatic \u03b2-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-jun N-terminal kinase activation","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2024.142441_bib19","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jtemb.2019.02.003","article-title":"Sex-specific effects of blood cadmium on thyroid hormones and thyroid function status: Korean nationwide cross-sectional study","volume":"53","author":"Chung","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2605.2007.00857.x","article-title":"Thyroid disrupting chemicals: mechanisms and mixtures","volume":"31","author":"Crofton","year":"2008","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.chemosphere.2024.142441_bib22","doi-asserted-by":"crossref","first-page":"D786","DOI":"10.1093\/nar\/gkn580","article-title":"Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks","volume":"37","author":"Davis","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115889","article-title":"Subacute exposure to lead promotes disruption in the thyroid gland function in male and female rats","volume":"274","author":"de Lima Junior","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.142441_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.chemosphere.2024.142441_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/351864","article-title":"TSH and thyrotropic agonists: key actors in thyroid homeostasis","author":"Dietrich","year":"2012","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2016.00057","article-title":"Calculated parameters of thyroid homeostasis: emerging tools for differential diagnosis and clinical research","volume":"7","author":"Dietrich","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114283","article-title":"Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: possible role of arsenic as a metabolic disruptor","volume":"215","author":"\u0110uki\u0107-\u0106osi\u0107","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib28","doi-asserted-by":"crossref","first-page":"22563","DOI":"10.1007\/s11356-020-12268-9","article-title":"Protective effects of selenium and zinc against potassium dichromate\u2013induced thyroid disruption, oxidative stress, and DNA damage in pregnant Wistar rats","volume":"28","author":"Fedala","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109881","article-title":"Regulation of nitric oxide production in hypothyroidism","volume":"124","author":"Gluvic","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.chemosphere.2024.142441_bib30","doi-asserted-by":"crossref","DOI":"10.4172\/jpb.1000195","article-title":"A signaling network of thyroid-stimulating hormone","author":"Goel","year":"2011","journal-title":"JPB 04"},{"key":"10.1016\/j.chemosphere.2024.142441_bib31","series-title":"Toxicological Risk Assessment and Multi-System Health Impacts from Exposure","first-page":"147","article-title":"Endocrine disruption and human health risk assessment in the light of real-life risk simulation","author":"Goumenou","year":"2021"},{"key":"10.1016\/j.chemosphere.2024.142441_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s12020-019-02125-2","article-title":"Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: the PREVEND study","volume":"67","author":"Gruppen","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.chemosphere.2024.142441_bib33","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.envint.2018.10.038","article-title":"Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: a cross-sectional study","volume":"121","author":"Guo","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2024.142441_bib34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12011-008-8194-8","article-title":"Reversal of cadmium-induced thyroid dysfunction by selenium, zinc, or their combination in rat","volume":"126","author":"Hammouda","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109259","article-title":"Identification of environmental chemicals targeting miscarriage genes and pathways using the comparative toxicogenomics database","volume":"184","author":"Harris","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T 4 , and thyroid antibodies in the United States population (1988 to 1994): national health and nutrition examination Survey (NHANES III)","volume":"87","author":"Hollowell","year":"2002","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib37","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.mam.2012.05.008","article-title":"The SLC30 family of zinc transporters \u2013 a review of current understanding of their biological and pathophysiological roles","volume":"34","author":"Huang","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.chemosphere.2024.142441_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2221-1691(11)60187-1","article-title":"Effect of lead acetate toxicity on experimental male albino rat","volume":"2","author":"Ibrahim","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.chemosphere.2024.142441_bib39","unstructured":"INCHEM, d. Lead (evaluation of health risk to infants and children). URL https:\/\/inchem.org\/documents\/jecfa\/jecmono\/v21je16.htm#:\u223c:text=TheCommitteeestablishedaprovisional,applytoinfantsandchildren. (Accessed 27 July 2023), n.d."},{"key":"10.1016\/j.chemosphere.2024.142441_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1631\/jzus.2007.B0001","article-title":"Assessing potential dietary toxicity of heavy metals in selected vegetables and food crops","volume":"8","author":"Islam","year":"2007","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.chemosphere.2024.142441_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120428","article-title":"Exploring the endocrine disrupting potential of lead through benchmark modelling \u2013 study in humans","volume":"316","author":"Javorac","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.142441_bib42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S2213-8587(20)30129-7","article-title":"Endocrine-disrupting chemicals: implications for human health","volume":"8","author":"Kahn","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib43","doi-asserted-by":"crossref","first-page":"16727","DOI":"10.1007\/s11356-019-04886-9","article-title":"Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits","volume":"26","author":"Khan","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.etap.2004.03.001","article-title":"The effects of low-esterified pectin on lead-induced thyroid injury in rats","volume":"17","author":"Khotimchenko","year":"2004","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113413","article-title":"Associations of exposure to metal and metal mixtures with thyroid hormones: results from the NHANES 2007\u20132012","volume":"212","author":"Kim","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib46","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3390\/antiox10091442","article-title":"The influence of oxidative stress on thyroid diseases","volume":"10","author":"Kochman","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.chemosphere.2024.142441_bib47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.beem.2007.04.001","article-title":"Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination","volume":"21","author":"K\u00f6hrle","year":"2007","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2022.09.024","article-title":"Deiodinases control local cellular and systemic thyroid hormone availability","volume":"193","author":"K\u00f6hrle","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2024.142441_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3803\/EnM.2018.33.1.44","article-title":"Evidence of the possible harm of endocrine-disrupting chemicals in humans: ongoing debates and key issues","volume":"33","author":"Lee","year":"2018","journal-title":"Endocrinol Metab"},{"key":"10.1016\/j.chemosphere.2024.142441_bib50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/taap.2001.9356","article-title":"Enhancement of platelet aggregation and thrombus formation by arsenic in drinking water: a contributing factor to cardiovascular disease","volume":"179","author":"Lee","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib51","article-title":"Sex-specific genetic influence on thyroid-stimulating hormone and free thyroxine levels, and interactions between measurements: knhanes 2013\u20132015","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2024.142441_bib52","article-title":"Thyroid disrupting effects of multiple metals exposure: comprehensive investigation from the thyroid parenchyma to hormonal function in a prospective cohort study","volume":"459","author":"Li","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.142441_bib53","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1021\/acs.est.1c06562","article-title":"Assessment of thyroid endocrine disruption effects of parabens using in vivo, in vitro, and in silico approaches","volume":"56","author":"Liang","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib54","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12011-019-01825-0","article-title":"The association between thyroid injury and apoptosis, and alterations of bax, bcl-2, and caspase-3 mRNA\/protein expression induced by nickel sulfate in wistar rats","volume":"195","author":"Liu","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117905","article-title":"Associations of exposure to cadmium, antimony, lead and their mixture with gestational thyroid homeostasis","volume":"289","author":"Margetaki","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.142441_bib56","first-page":"1052","article-title":"Puzzling relationship between levels of toxic metals in blood and serum levels of reproductive hormones: benchmark dose approach in cross-sectional study","volume":"15","author":"Mari\u0107","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.chemosphere.2024.142441_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1145153","article-title":"Nickel as a potential disruptor of thyroid function: benchmark modelling of human data","volume":"14","author":"Maric","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib58","doi-asserted-by":"crossref","first-page":"468","DOI":"10.5937\/arhfarm72-40122","article-title":"Exposure to mercury and thyroid function: is there a connection?","volume":"72","author":"Mari\u0107","year":"2022","journal-title":"Arhiv za farmaciju"},{"key":"10.1016\/j.chemosphere.2024.142441_bib59","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12011-008-8162-3","article-title":"Dietary intake of arsenic, cadmium, mercury, and lead by the population of catalonia, Spain","volume":"125","author":"Mart\u00ed-Cid","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib60","first-page":"1355","article-title":"Histopathological and biochemical changes in rat thyroid following acute exposure to hexavalent chromium","author":"Mahmood","year":"2010","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib61","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1177\/0748233713485887","article-title":"Effects of phytate on thyroid gland of rats intoxicated with cadmium","volume":"31","author":"Mohamed","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.chemosphere.2024.142441_bib62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chemosphere.2024.142441_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.133664","article-title":"Association of As, Pb, Cr, and Zn urinary heavy metals levels with predictive indicators of cardiovascular disease and obesity in children and adolescents","volume":"294","author":"Nasab","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2024.142441_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0246748","article-title":"Mercury in the human thyroid gland: potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism","volume":"16","author":"Pamphlett","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.chemosphere.2024.142441_bib65","first-page":"113","article-title":"Thyroid and parathyroid function and structure in male rats chronically exposed to cadmium","volume":"17","author":"Pi\u0142at-Marcinkiewicz","year":"2008","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.chemosphere.2024.142441_bib66","doi-asserted-by":"crossref","DOI":"10.2478\/10004-1254-63-2012-2151","article-title":"Reproductive toxicity of metals in men","volume":"63","author":"Pizent","year":"2012","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib67","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10661-019-7528-7","article-title":"The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview","volume":"191","author":"Rahman","year":"2019","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.chemosphere.2024.142441_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-014-0023-7","article-title":"Perspectives in endocrine toxicity of heavy metals\u2014a review","volume":"160","author":"Rana","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib69","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fct.2009.06.038","article-title":"Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid","volume":"48","author":"Rao","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib70","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3803\/EnM.2021.1198","article-title":"Deiodinases and the three types of thyroid hormone deiodination reactions","volume":"36","author":"Sabatino","year":"2021","journal-title":"Endocrinol Metab"},{"key":"10.1016\/j.chemosphere.2024.142441_bib71","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s12011-021-02815-x","article-title":"Protective effects of selenium and zinc against nickel chloride\u2013induced hormonal changes and oxidative damage in thyroid of pregnant rats","volume":"200","author":"Salah","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/875125","article-title":"Role of estrogen in thyroid function and growth regulation","author":"Santin","year":"2011","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.chemosphere.2024.142441_bib73","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12403-019-00309-9","article-title":"Risk assessment of toxic and essential trace metals on the thyroid health at the tissue level: the significance of lead and selenium for colloid goiter disease","volume":"12","author":"Stojsavljevi\u0107","year":"2020","journal-title":"Expo Health"},{"key":"10.1016\/j.chemosphere.2024.142441_bib74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.envpol.2015.05.037","article-title":"Short-term exposure of arsenite disrupted thyroid endocrine system and altered gene transcription in the HPT axis in zebrafish","volume":"205","author":"Sun","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.142441_bib75","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jhazmat.2015.10.032","article-title":"Arsenic impacted the development, thyroid hormone and gene transcription of thyroid hormone receptors in bighead carp larvae (Hypophthalmichthys nobilis)","volume":"303","author":"Sun","year":"2016","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.142441_bib76","doi-asserted-by":"crossref","DOI":"10.12703\/r\/10-32","article-title":"Adipotropic effects of heavy metals and their potential role in obesity","volume":"10","author":"Tinkov","year":"2021","journal-title":"Fac Rev"},{"key":"10.1016\/j.chemosphere.2024.142441_bib77","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00204-019-02641-0","article-title":"Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials","volume":"94","author":"Tung","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib78","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s00204-014-1351-2","article-title":"Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis","volume":"89","author":"Van Breda","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib79","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.chemosphere.2024.142441_bib80","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldr030","article-title":"The epidemiology of thyroid disease","volume":"99","author":"Vanderpump","year":"2011","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.chemosphere.2024.142441_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2019.111197","article-title":"A review on heavy metal pollution, toxicity and remedial measures: current trends and future perspectives","volume":"290","author":"Vardhan","year":"2019","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.chemosphere.2024.142441_bib82","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/1471-2105-10-326","article-title":"Text mining and manual curation of chemical-gene-disease networks for the Comparative Toxicogenomics Database (CTD)","volume":"10","author":"Wiegers","year":"2009","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.chemosphere.2024.142441_bib83","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s12276-021-00597-9","article-title":"Neuroendocrine control of appetite and metabolism","volume":"53","author":"Yoo","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.chemosphere.2024.142441_bib84","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-4800(91)90021-O","article-title":"Cadmium toxicity in the thyroid gland of pregnant rats","volume":"55","author":"Yoshizuka","year":"1991","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib85","doi-asserted-by":"crossref","first-page":"10652","DOI":"10.1021\/es2026592","article-title":"Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish","volume":"45","author":"Yu","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.142441_bib86","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1476-069X-13-118","article-title":"A path forward in the debate over health impacts of endocrine disrupting chemicals","volume":"13","author":"Zoeller","year":"2014","journal-title":"Environ. Health"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524013341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524013341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T20:51:17Z","timestamp":1727988677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524013341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":86,"alternative-id":["S0045653524013341"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.142441","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thyroid under siege: Unravelling the toxic impact of real-life metal mixture exposures in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.142441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"142441"}}