{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:42:10Z","timestamp":1792813330163,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.chemosphere.2024.143004","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T09:17:50Z","timestamp":1722676670000},"page":"143004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro"],"prefix":"10.1016","volume":"364","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3358-8718","authenticated-orcid":false,"given":"Chunyan","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongwang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":",","given":"Quanjiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengzhe","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houhui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2024.143004_bib1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.sjbs.2021.09.046","article-title":"Antioxidant and antimicrobial activities of Spirulina platensis extracts and biogenic selenium nanoparticles against selected pathogenic bacteria and fungi","volume":"29","author":"Abdel-Moneim","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.chemosphere.2024.143004_bib2","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s00204-022-03317-y","article-title":"Ferroptosis as a mechanism of non-ferrous metal toxicity","volume":"96","author":"Aschner","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib3","doi-asserted-by":"crossref","first-page":"12476","DOI":"10.1007\/s11356-020-07751-2","article-title":"Selenium mitigates cadmium toxicity by preventing oxidative stress and enhancing photosynthesis and micronutrient availability on radish (Raphanus sativus L.) cv. Cherry Belle","volume":"27","author":"Auobi Amirabad","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.chemosphere.2024.143004_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109851","article-title":"Isoorientin plays an important role in alleviating Cadmium-induced DNA damage and G0\/G1 cell cycle arrest","volume":"187","author":"Chen","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.143004_bib5","article-title":"Characteristics and biomarkers of ferroptosis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib6","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.3390\/ijms23136879","article-title":"Ferroptosis modulation: potential therapeutic target for glioblastoma treatment","volume":"23","author":"de Souza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2024.143004_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104810","article-title":"Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying beta-amyloid pathology","volume":"139","author":"Diouf","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.chemosphere.2024.143004_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143004_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167165","article-title":"Association of cadmium environmental exposure with chronic kidney disease: a systematic review and meta-analysis","volume":"906","author":"Doccioli","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143004_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.942189","article-title":"Nano-selenium alleviates cadmium-induced acute hepatic toxicity by decreasing oxidative stress and activating the Nrf2 pathway in male kunming mice","volume":"9","author":"Du","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.chemosphere.2024.143004_bib11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s12020-014-0477-6","article-title":"Selenium: an element for life","volume":"48","author":"Duntas","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.chemosphere.2024.143004_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100598","article-title":"Selenium nanoparticles for biomedical applications: from development and characterization to therapeutics","volume":"10","author":"Ferro","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.chemosphere.2024.143004_bib13","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3390\/ijms23031768","article-title":"Is cadmium toxicity tissue-specific? Toxicogenomics studies reveal common and specific pathways in pulmonary, hepatic, and neuronal cell models","volume":"23","author":"Forcella","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2024.143004_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112135","article-title":"Comparative study on protective effect of different selenium sources against cadmium-induced nephrotoxicity via regulating the transcriptions of selenoproteome","volume":"215","author":"Ge","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.143004_bib15","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2020.04.039","article-title":"SnapShot: ferroptosis","volume":"181","author":"Hadian","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143004_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fphar.2020.00239","article-title":"Ferroptosis and its potential role in human diseases","volume":"11","author":"Han","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12011-020-02139-2","article-title":"Nano-selenium supplementation increases selenoprotein (sel) gene expression profiles and milk selenium concentration in lactating dairy cows","volume":"199","author":"Han","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.chemosphere.2024.143004_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114123","article-title":"Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis","volume":"245","author":"He","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.chemosphere.2024.143004_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157819","article-title":"Cadmium induces ferroptosis mediated inflammation by activating Gpx4\/Ager\/p65 axis in pancreatic beta-cells","volume":"849","author":"Hong","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143004_bib20","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2147\/IJN.S157541","article-title":"Nano-selenium and its nanomedicine applications: a critical review","volume":"13","author":"Hosnedlova","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.chemosphere.2024.143004_bib21","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.2147\/IJN.S372485","article-title":"Silica nanoparticles cause activation of NLRP3 inflammasome in-vitro model-using microglia","volume":"17","author":"Hou","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.chemosphere.2024.143004_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161183","article-title":"Cadmium chloride exposure impairs the growth and behavior of Drosophila via ferroptosis","volume":"865","author":"Hu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143004_bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143004_bib24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.chemosphere.2024.143004_bib26","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.3390\/nu15245065","article-title":"Causal effect of selenium levels on osteoporosis: a mendelian randomization study","volume":"15","author":"Li","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.chemosphere.2024.143004_bib27","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.cell.2023.05.003","article-title":"Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones","volume":"86","author":"Liang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143004_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9919466","article-title":"Leonurine ameliorates oxidative stress and insufficient angiogenesis by regulating the PI3K\/Akt-eNOS signaling pathway in H(2)O(2)-induced HUVECs","volume":"2021","author":"Liao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.chemosphere.2024.143004_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5021983","article-title":"Beta-phenethyl isothiocyanate induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the MAPK signaling pathway","volume":"2020","author":"Lv","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.chemosphere.2024.143004_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113023","article-title":"MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis","volume":"42","author":"Phadnis","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.chemosphere.2024.143004_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.846747","article-title":"Antiviral effect of selenomethionine on porcine deltacoronavirus in pig kidney epithelial cells","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib32","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.2147\/IJN.S370585","article-title":"Chitosan-coated selenium nanoparticles attenuate PRRSV replication and ROS\/JNK-Mediated apoptosis in vitro","volume":"17","author":"Shao","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.chemosphere.2024.143004_bib33","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143004_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cmet.2019.06.012","article-title":"A physiological function for ferroptosis in tumor suppression by the immune system","volume":"30","author":"Stockwell","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib35","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1021\/acs.jafc.2c06562","article-title":"Nano-selenium antagonized cadmium-induced liver fibrosis in chicken","volume":"71","author":"Sun","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chemosphere.2024.143004_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.chemosphere.2024.143004_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2024.143004_bib38","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/tox.23740","article-title":"GPX4 utilization by selenium is required to alleviate cadmium-induced ferroptosis and pyroptosis in sheep kidney","volume":"38","author":"Wang","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib39","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.7150\/thno.70830","article-title":"Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1\/NLRP3\/Caspase-1 pathway","volume":"12","author":"Wang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.chemosphere.2024.143004_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132243","article-title":"VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes","volume":"459","author":"Wang","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.143004_bib41","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41556-023-01133-9","article-title":"Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function","volume":"25","author":"Wu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chemosphere.2024.143004_bib42","doi-asserted-by":"crossref","first-page":"14053","DOI":"10.1021\/acsnano.3c04344","article-title":"Translational selenium nanoparticles to attenuate allergic dermatitis through nrf2-keap1-driven activation of selenoproteins","volume":"17","author":"Xie","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.chemosphere.2024.143004_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.chemosphere.2024.143004_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.159626","article-title":"Honokiol reduces cadmium-induced oxidative injury and endosomal\/lysosomal vacuolation via protecting mitochondrial function in quail (Coturnix japonica) liver tissues","volume":"857","author":"Yuan","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2024.143004_bib45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.freeradbiomed.2021.09.028","article-title":"Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion","volume":"176","author":"Zeng","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chemosphere.2024.143004_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122207","article-title":"Role of Caveolin-1 on the molybdenum and cadmium exposure induces pulmonary ferroptosis and fibrosis in the sheep","volume":"334","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2024.143004_bib47","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3390\/biom12070917","article-title":"Selenium metabolism and selenoproteins in prokaryotes: a bioinformatics perspective","volume":"12","author":"Zhang","year":"2022","journal-title":"Biomolecules"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524018988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524018988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:26:09Z","timestamp":1741865169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524018988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"alternative-id":["S0045653524018988"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143004","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"143004"}}