{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:06:13Z","timestamp":1781042773042,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.chemosphere.2024.143766","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T21:26:54Z","timestamp":1732310814000},"page":"143766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Mutational landscape induced by chronic exposure to environmental PM10 and PM2.5 in A549 lung epithelial cell"],"prefix":"10.1016","volume":"368","author":[{"given":"Ericka Marel","family":"Quezada-Maldonado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-1998","authenticated-orcid":false,"given":"Dennis","family":"Cerrato-Izaguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-4021","authenticated-orcid":false,"given":"Roc\u00edo","family":"Morales-B\u00e1rcenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0786-847X","authenticated-orcid":false,"given":"Yanueh","family":"Bautista-Ocampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-6342","authenticated-orcid":false,"given":"Miguel","family":"Santib\u00e1\u00f1ez-Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-4093","authenticated-orcid":false,"given":"Ra\u00fal","family":"Quintana-Belmares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda I.","family":"Chirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Basurto-Lozada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Daniela","family":"Robles-Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0103-9188","authenticated-orcid":false,"given":"Yesennia","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-5797","authenticated-orcid":false,"given":"Claudia M.","family":"Garc\u00eda-Cuellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2024.143766_bib1","article-title":"Tumor cell SYK expression modulates the tumor immune microenvironment composition in human cancer via TNF-\u03b1 dependent signaling","volume":"10","author":"Adam","year":"2022","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"10.1016\/j.chemosphere.2024.143766_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1126\/science.aag0299","article-title":"Mutational signatures associated with tobacco smoking in human cancer","volume":"354","author":"Alexandrov","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2024.143766_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","article-title":"The repertoire of mutational signatures in human cancer","volume":"578","author":"Alexandrov","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2024.143766_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13073-023-01162-x","article-title":"Influence network model uncovers relations between biological processes and mutational signatures","volume":"15","author":"Amgalan","year":"2023","journal-title":"Genome Med."},{"key":"10.1016\/j.chemosphere.2024.143766_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006881","article-title":"Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations","volume":"15","author":"Anandakrishnan","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1155\/2002\/371680","article-title":"Genetic alterations in presumptive precursor lesions of breast carcinomas","volume":"24","author":"Aubele","year":"2002","journal-title":"Anal. Cell Pathol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.4081\/jphia.2018.813","article-title":"Global burden of diseases attributable to air pollution","volume":"9","author":"Babatola","year":"2018","journal-title":"J Public Health Afr"},{"key":"10.1016\/j.chemosphere.2024.143766_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/5584_2016_55","article-title":"Ambient PM2.5 exposure and mortality due to lung cancer and cardiopulmonary diseases in polish cities","volume":"944","author":"Badyda","year":"2016","journal-title":"Advances in experimental medicine and biology"},{"key":"10.1016\/j.chemosphere.2024.143766_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108248","article-title":"Oxidative stress and inflammation induced by air pollution-derived PM(2.5) persist in the lungs of mice after cessation of their sub-chronic exposure","volume":"181","author":"Barbier","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2024.143766_bib10","article-title":"Calling somatic SNVs and indels with Mutect2","author":"Benjamin","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.chemosphere.2024.143766_bib11","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1158\/0008-5472.CAN-08-4252","article-title":"Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia","volume":"69","author":"Buchner","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.chemosphere.2024.143766_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41467-021-27872-7","article-title":"BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chemosphere.2024.143766_bib13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/em.21867","article-title":"Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer patients","volume":"55","author":"Chiou","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.chemosphere.2024.143766_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.toxlet.2010.01.009","article-title":"PM(10) impairs the antioxidant defense system and exacerbates oxidative stress driven cell death","volume":"193","author":"Chirino","year":"2010","journal-title":"Toxicology letters"},{"key":"10.1016\/j.chemosphere.2024.143766_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10653-016-9901-6","article-title":"Combined toxic effect of airborne heavy metals on human lung cell line A549","volume":"40","author":"Choi","year":"2018","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.chemosphere.2024.143766_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16224335","article-title":"Genomics of particulate matter exposure associated cardiopulmonary disease: a narrative review","volume":"16","author":"Citron","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.chemosphere.2024.143766_bib17","series-title":"Human Cancer Signatures","year":"2023"},{"key":"10.1016\/j.chemosphere.2024.143766_bib18","series-title":"Assigning Mutational Signatures to Individual Samples and Individual Somatic Mutations with SigProfilerAssignment","author":"Diaz-Gay","year":"2023"},{"key":"10.1016\/j.chemosphere.2024.143766_bib19","article-title":"Short-term exposure to fine particulate matter and genome-wide DNA methylation in chronic obstructive pulmonary disease: a panel study conducted in Beijing, China","volume":"10","author":"Duan","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.chemosphere.2024.143766_bib20","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/thoraxjnl-2015-207927","article-title":"Air pollution affects lung cancer survival","volume":"71","author":"Eckel","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.chemosphere.2024.143766_bib21","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1021\/acs.est.2c08092","article-title":"Genomic characterization revealed pm2.5-associated mutational signatures in lung cancer including activation of APOBEC3B","volume":"57","author":"Fan","year":"2023","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.chemosphere.2024.143766_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13148-019-0726-x","article-title":"Particulate matter exposure shapes DNA methylation through the lifespan","volume":"11","author":"Ferrari","year":"2019","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.chemosphere.2024.143766_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/excr.1998.4172","article-title":"Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism","volume":"243","author":"Foster","year":"1998","journal-title":"Experimental cell research"},{"key":"10.1016\/j.chemosphere.2024.143766_bib24","doi-asserted-by":"crossref","first-page":"12632","DOI":"10.3390\/ijms222312632","article-title":"Particulate matter (PM10) promotes cell invasion through epithelial\u2013mesenchymal transition (EMT) by TGF-\u03b2 activation in A549 lung cells","volume":"22","author":"Garc\u00eda-Cuellar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2024.143766_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115752","article-title":"Inter-annual variability of source contributions to PM(10), PM(2.5), and oxidative potential in an urban background site in the central mediterranean","volume":"319","author":"Giannossa","year":"2022","journal-title":"J Environ Manage"},{"key":"10.1016\/j.chemosphere.2024.143766_bib26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cell.2006.06.032","article-title":"p53 and metabolism: inside the TIGAR","volume":"126","author":"Green","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143766_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.130872","article-title":"Characterisation of the correlations between oxidative potential and in vitro biological effects of PM(10) at three sites in the central Mediterranean","volume":"448","author":"Guascito","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2024.143766_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105640","article-title":"Long-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: a cohort study","volume":"138","author":"Guo","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2024.143766_bib29","article-title":"Daily exposure to PM(2.5) and 1.5 million deaths: a time-stratified case-crossover analysis in the Mexico City Metropolitan Area","volume":"17","author":"Gutierrez-Avila","year":"2023","journal-title":"medRxiv.Preprint.Jan"},{"key":"10.1016\/j.chemosphere.2024.143766_bib30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.chemosphere.2024.143766_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05874-3","article-title":"Lung adenocarcinoma promotion by air pollutants","volume":"616","author":"Hill","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2024.143766_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcaa017","article-title":"Defining the mutation signatures of DNA polymerase theta in cancer genomes","volume":"2","author":"Hwang","year":"2020","journal-title":"NAR Cancer"},{"key":"10.1016\/j.chemosphere.2024.143766_bib33","first-page":"1","article-title":"Outdoor air pollution","volume":"109","year":"2015","journal-title":"IARC (Int. Agency Res. Cancer) Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.chemosphere.2024.143766_bib34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/08958378.2020.1850936","article-title":"Particulate matter less than 10 \u03bcm (PM10) activates cancer related genes in lung epithelial cells","volume":"32","author":"Kang","year":"2020","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2022.100004","article-title":"Whole-genome sequencing reveals mutational signatures related to radiation-induced sarcomas and DNA-damage-repair pathways","volume":"36","author":"Kim","year":"2023","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib36","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ng.3557","article-title":"Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors","volume":"48","author":"Kim","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chemosphere.2024.143766_bib37","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1038\/s41467-022-30582-3","article-title":"Mutational signatures are markers of drug sensitivity of cancer cells","volume":"13","author":"Levatic","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chemosphere.2024.143766_bib38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chemosphere.2024.143766_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/2042018819897046","article-title":"Association between air pollution and type 2 diabetes: an updated review of the literature","volume":"10","author":"Li","year":"2019","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.chemosphere.2024.143766_bib40","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/ijc.34402","article-title":"Clinical and genomic characterization of mutational signatures across human cancers","volume":"152","author":"Liao","year":"2023","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.chemosphere.2024.143766_bib41","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/cbin.10973","article-title":"Role of NCoR1 in mitochondrial function and energy metabolism","volume":"42","author":"Lima","year":"2018","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.chemosphere.2024.143766_bib42","article-title":"Effect of NCOR1 mutations on immune microenvironment and efficacy of immune checkpoint inhibitors in patient with bladder cancer","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/acs.chemrestox.2c00216","article-title":"Ambient fine particulate matter and cancer: current evidence and future perspectives","volume":"36","author":"Liu","year":"2023","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib44","doi-asserted-by":"crossref","first-page":"31663","DOI":"10.1074\/jbc.274.44.31663","article-title":"Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells","volume":"274","author":"Meplan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2024.143766_bib45","doi-asserted-by":"crossref","first-page":"D394","DOI":"10.1093\/nar\/gkaa1106","article-title":"PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API","volume":"49","author":"Mi","year":"2021","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.chemosphere.2024.143766_bib46","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-021-03822-7","article-title":"The mutational landscape of human somatic and germline cells","volume":"597","author":"Moore","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chemosphere.2024.143766_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13060592","article-title":"Health outcomes of exposure to biological and chemical components of inhalable and respirable particulate matter","volume":"13","author":"Morakinyo","year":"2016","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.chemosphere.2024.143766_bib48","first-page":"5","article-title":"A global perspective of fine particulate matter pollution and its health effects","volume":"244","author":"Mukherjee","year":"2018","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib49","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/JLB.1RI0418-168R","article-title":"NCOR1-a new player on the field of T cell development","volume":"104","author":"Muller","year":"2018","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.chemosphere.2024.143766_bib50","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/ijerph18031046","article-title":"Analysis of single nucleotide variants (SNVs) induced by exposure to PM10 in lung epithelial cells using whole genome sequencing","volume":"18","author":"Park","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health."},{"key":"10.1016\/j.chemosphere.2024.143766_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12864-016-3420-9","article-title":"Identification of coding and non-coding mutational hotspots in cancer genomes","volume":"18","author":"Piraino","year":"2017","journal-title":"BMC Genom."},{"key":"10.1016\/j.chemosphere.2024.143766_bib52","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.287.9.1132","article-title":"Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution","volume":"287","author":"Pope","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.chemosphere.2024.143766_bib53","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nsmb.2040","article-title":"Alternative splicing of SYK regulates mitosis and cell survival","volume":"18","author":"Prinos","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042224","article-title":"Nucleotide excision repair pathway activity is inhibited by airborne particulate matter (PM10) through XPA deregulation in lung epithelial cells","volume":"23","author":"Quezada-Maldonado","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chemosphere.2024.143766_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117313","article-title":"Airborne particulate matter induces oxidative damage, DNA adduct formation and alterations in DNA repair pathways","volume":"287","author":"Quezada-Maldonado","year":"2021","journal-title":"Environ Pollut"},{"key":"10.1016\/j.chemosphere.2024.143766_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007902","article-title":"Intronic CNVs and gene expression variation in human populations","volume":"15","author":"Rigau","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.chemosphere.2024.143766_bib57","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/1947601911408889","article-title":"Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis","volume":"2","author":"Rivlin","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.chemosphere.2024.143766_bib58","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.canlet.2009.01.010","article-title":"DNA damage response of A549 cells treated with particulate matter (PM10) of urban air pollutants","volume":"278","author":"Sanchez-Perez","year":"2009","journal-title":"Cancer letters"},{"key":"10.1016\/j.chemosphere.2024.143766_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171933","article-title":"Sampling, composition, and biological effects of Mexico City airborne particulate matter from multiple periods","author":"Santibanez-Andrade","year":"2024","journal-title":"The Science of the total environment"},{"key":"10.1016\/j.chemosphere.2024.143766_bib60","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/bioinformatics\/bts271","article-title":"Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs","volume":"28","author":"Saunders","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chemosphere.2024.143766_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/biology12091243","article-title":"A549 as an in vitro model to evaluate the impact of microplastics in the air","volume":"12","author":"Shahzadi","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.chemosphere.2024.143766_bib62","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00204-016-1907-4","article-title":"Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repair","volume":"91","author":"Shi","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib63","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/15230860260196335","article-title":"Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells","volume":"4","author":"Takano","year":"2002","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.chemosphere.2024.143766_bib64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13073-018-0531-8","article-title":"Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations","volume":"10","author":"Tamborero","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.chemosphere.2024.143766_bib65","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192362","article-title":"Abnormally localized DLK1 interacts with NCOR1 in non-small cell lung cancer cell nuclear","volume":"39","author":"Tan","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.chemosphere.2024.143766_bib66","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/ijpo.12188","article-title":"Effects of air pollution exposure on glucose metabolism in Los Angeles minority children","volume":"13","author":"Toledo-Corral","year":"2018","journal-title":"Pediatr Obes"},{"issue":"Suppl. 5","key":"10.1016\/j.chemosphere.2024.143766_bib67","article-title":"Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer","volume":"7","author":"Udyavar","year":"2013","journal-title":"BMC Syst. Biol."},{"issue":"11.10","key":"10.1016\/j.chemosphere.2024.143766_bib68","first-page":"11","article-title":"From FastQ data to high-confidence variant calls: the genome analysis toolkit best practices pipeline","volume":"43","author":"Van der Auwera","year":"2013","journal-title":"Current Protocols in Bioinformatics"},{"key":"10.1016\/j.chemosphere.2024.143766_bib69","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chemosphere.2024.143766_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139511","article-title":"Synergistic and antagonistic interactions among organic and metallic components of the ambient particulate matter (PM) for the cytotoxicity measured by Chinese hamster ovary cells","volume":"736","author":"Wang","year":"2020","journal-title":"The Science of the total environment"},{"key":"10.1016\/j.chemosphere.2024.143766_bib71","series-title":"World Health Organization","year":"2022"},{"key":"10.1016\/j.chemosphere.2024.143766_bib72","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1158\/2767-9764.CRC-24-0352","article-title":"Poor prognosis among radiation-associated bladder cancer is defined by clinicogenomic features","volume":"4","author":"Wijetunga","year":"2024","journal-title":"Cancer Res Commun"},{"key":"10.1016\/j.chemosphere.2024.143766_bib73","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S2542-5196(18)30001-9","article-title":"Ambient air pollution in relation to diabetes and glucose-homoeostasis markers in China: a cross-sectional study with findings from the 33 Communities Chinese Health Study","volume":"2","author":"Yang","year":"2018","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.chemosphere.2024.143766_bib74","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1021\/acs.est.7b04261","article-title":"Synergistic and antagonistic interactions among the particulate matter components in generating reactive oxygen species based on the dithiothreitol assay","volume":"52","author":"Yu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2024.143766_bib75","article-title":"Cohort studies of long-term exposure to outdoor particulate matter and risks of cancer: a systematic review and meta-analysis","volume":"2","author":"Yu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.chemosphere.2024.143766_bib76","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ebiom.2015.04.003","article-title":"Characterization of somatic mutations in air pollution-related lung cancer","volume":"2","author":"Yu","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.chemosphere.2024.143766_bib77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.scitotenv.2019.04.431","article-title":"In vitro toxicity evaluation of heavy metals in urban air particulate matter on human lung epithelial cells","volume":"678","author":"Yuan","year":"2019","journal-title":"The Science of the total environment"},{"key":"10.1016\/j.chemosphere.2024.143766_bib78","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41588-021-00920-0","article-title":"Genomic and evolutionary classification of lung cancer in never smokers","volume":"53","author":"Zhang","year":"2021","journal-title":"Nat. Genet."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524026675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653524026675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:34:55Z","timestamp":1751384095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653524026675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":78,"alternative-id":["S0045653524026675"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143766","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutational landscape induced by chronic exposure to environmental PM10 and PM2.5 in A549 lung epithelial cell","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"143766"}}