{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:35:00Z","timestamp":1777905300658,"version":"3.51.4"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","award":["2018-2023"],"award-info":[{"award-number":["2018-2023"]}],"id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["2021-2024 KB1 11220200102210CO"],"award-info":[{"award-number":["2021-2024 KB1 11220200102210CO"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT 2016-0042"],"award-info":[{"award-number":["PICT 2016-0042"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT 2020-2179"],"award-info":[{"award-number":["PICT 2020-2179"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT 2021-I-INVI 00657"],"award-info":[{"award-number":["PICT 2021-I-INVI 00657"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.chemosphere.2025.144145","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T15:35:27Z","timestamp":1737732927000},"page":"144145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Exposure to environmentally relevant levels of DEHP during development modifies the distribution and expression patterns of androgen receptors in the anterior pituitary in a sex-specific manner"],"prefix":"10.1016","volume":"372","author":[{"given":"Pablo A.","family":"Perez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3405-1432","authenticated-orcid":false,"given":"Tamara Y.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-5751","authenticated-orcid":false,"given":"Jonathan","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Gom\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L.","family":"De Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-8219","authenticated-orcid":false,"given":"Amado A.","family":"Quintar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.chemosphere.2025.144145_bib1","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1095\/biolreprod65.4.1252","article-title":"Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate","volume":"65","author":"Akingbemi","year":"2001","journal-title":"Biol. Reprod."},{"issue":"Pt 1","key":"10.1016\/j.chemosphere.2025.144145_bib2","article-title":"The relationship between urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization: nested case-control study","volume":"286","author":"Al-Saleh","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2025.144145_bib3","series-title":"Toxicological Profile for Di(2-Ethylhexyl)Phthalate (DEHP)","year":"2022"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib4","first-page":"96","article-title":"Prenatal exposure to DEHP induces premature reproductive senescence in male mice","volume":"156","author":"Barakat","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.chemosphere.2025.144145_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/toxics8040115","article-title":"Endocrine disruption: structural interactions of androgen receptor against di(2-ethylhexyl) phthalate and its metabolites","volume":"8","author":"Beg","year":"2020","journal-title":"Toxics"},{"issue":"11","key":"10.1016\/j.chemosphere.2025.144145_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103227","article-title":"Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-alpha","volume":"24","author":"Bolt","year":"2021","journal-title":"iScience"},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2025.144145_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tox.2006.03.015","article-title":"Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis","volume":"223","author":"Borch","year":"2006","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1289\/ehp.1408163","article-title":"Prenatal phthalate exposures and anogenital distance in Swedish boys","volume":"123","author":"Bornehag","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1210\/en.2017-03004","article-title":"Prenatal exposure to di(2-ethylhexyl) phthalate causes long-term transgenerational effects on female reproduction in mice","volume":"159","author":"Brehm","year":"2018","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.chemosphere.2025.144145_bib10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.envres.2009.07.015","article-title":"Influence of litter size on the postnatal growth of rat pups: is there a rationale for litter-size standardization in toxicity studies?","volume":"109","author":"Chahoud","year":"2009","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.chemosphere.2025.144145_bib11","doi-asserted-by":"crossref","first-page":"11452","DOI":"10.3390\/molecules180911452","article-title":"Determination and pharmacokinetics of di-(2-ethylhexyl) phthalate in rats by ultra performance liquid chromatography with tandem mass spectrometry","volume":"18","author":"Chang-Liao","year":"2013","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.reprotox.2010.04.005","article-title":"Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats","volume":"30","author":"Christiansen","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.112009","article-title":"Androgen receptor nucleocytoplasmic trafficking - a one-way journey","volume":"576","author":"Cole","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.envres.2019.03.037","article-title":"Di(2-ethylhexyl) phthalate (DEHP) increases proliferation of epithelial breast cancer cells through progesterone receptor dysregulation","volume":"173","author":"Crobeddu","year":"2019","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.chemosphere.2025.144145_bib15","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1095\/biolreprod.107.065649","article-title":"In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat","volume":"78","author":"Culty","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.chemosphere.2025.144145_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.etap.2017.05.010","article-title":"Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES\/YAS in vitro assay","volume":"53","author":"Czernych","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib17","first-page":"3","article-title":"Androgen receptor structure, function and biology: from bench to bedside","volume":"37","author":"Davey","year":"2016","journal-title":"Clin. Biochem. Rev."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0065-1281(97)80022-0","article-title":"Heterogeneity of pituitary lactotrophs: immunocytochemical identification of functional subtypes","volume":"99","author":"De Paul","year":"1997","journal-title":"Acta Histochem."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/toxsci\/kfq394","article-title":"Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor","volume":"120","author":"DeKeyser","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2025.144145_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.toxlet.2017.05.028","article-title":"Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERalpha, ERbeta, and AR","volume":"277","author":"Engel","year":"2017","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.taap.2010.07.016","article-title":"Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium","volume":"248","author":"Erkekoglu","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.reprotox.2016.07.004","article-title":"Maternal exposure to a mixture of di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) causes reproductive dysfunction in adult male mouse offspring","volume":"65","author":"Fiandanese","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.chemosphere.2025.144145_bib23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mnfr.200600243","article-title":"Metabolism of phthalates in humans","volume":"51","author":"Frederiksen","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4161\/epi.5.2.10778","article-title":"Epigenetic regulation of androgen receptor signaling in prostate cancer","volume":"5","author":"Gao","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.chemosphere.2025.144145_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.reprotox.2021.12.008","article-title":"Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary","volume":"108","author":"Ge","year":"2022","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1677\/joe.0.1640265","article-title":"Effect of neonatal and adult testosterone treatment on the cellular composition of the adult female rat anterior pituitary","volume":"164","author":"Gonzalez-Parra","year":"2000","journal-title":"J. Endocrinol."},{"issue":"9","key":"10.1016\/j.chemosphere.2025.144145_bib27","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1289\/ehp.5946","article-title":"Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol","volume":"111","author":"Guvenius","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2025.144145_bib28","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.scitotenv.2016.04.145","article-title":"Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5alpha-Reductase 2","volume":"563\u2013564","author":"Ha","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2025.144145_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.publhealth.012809.103714","article-title":"Plastics and health risks","volume":"31","author":"Halden","year":"2010","journal-title":"Annu Rev Public Health"},{"issue":"11","key":"10.1016\/j.chemosphere.2025.144145_bib30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/oem.2004.017590","article-title":"Phthalates and human health","volume":"62","author":"Hauser","year":"2005","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.chemosphere.2025.144145_bib31","article-title":"Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: the protective role of hesperidin","volume":"433\u2013434","author":"Helmy","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.chemosphere.2025.144145_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2023.109951","article-title":"Micropipette-guided Drug Administration (MDA) as a non-invasive chronic oral administration method in male rats","volume":"398","author":"Heraudeau","year":"2023","journal-title":"J. Neurosci. Methods"},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib33","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1210\/endo-123-3-1405","article-title":"Effects of gonadal steroids on somatotroph function in the rat: analysis by the reverse hemolytic plaque assay","volume":"123","author":"Ho","year":"1988","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib34","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/toxsci\/kfm069","article-title":"Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes","volume":"99","author":"Howdeshell","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tem.2008.12.001","article-title":"Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence","volume":"20","author":"Hu","year":"2009","journal-title":"Trends Endocrinol Metab"},{"issue":"15","key":"10.1016\/j.chemosphere.2025.144145_bib36","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/pros.21382","article-title":"A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities","volume":"71","author":"Hu","year":"2011","journal-title":"Prostate"},{"key":"10.1016\/j.chemosphere.2025.144145_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113119","article-title":"Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR\/SREBP-1c\/PPARalpha\/gamma and NF-kappaB signaling pathway","volume":"165","author":"Huang","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.chemosphere.2025.144145_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-3806(96)83481-X","article-title":"Androgen receptor-like immunoreactivity in the Brazilian opossum brain and pituitary: distribution and effects of castration and testosterone replacement in the adult male","volume":"703","author":"Iqbal","year":"1995","journal-title":"Brain Res."},{"issue":"Pt B","key":"10.1016\/j.chemosphere.2025.144145_bib39","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.envpol.2018.07.067","article-title":"Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China","volume":"242","author":"Junaid","year":"2018","journal-title":"Environ Pollut"},{"issue":"7","key":"10.1016\/j.chemosphere.2025.144145_bib40","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jat.3792","article-title":"In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites","volume":"39","author":"Kambia","year":"2019","journal-title":"J. Appl. Toxicol."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.reprotox.2006.04.007","article-title":"NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate","volume":"22","author":"Kavlock","year":"2006","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/taap.2001.9318","article-title":"Effects of maternal exposure to a reconstituted mixture of polychlorinated biphenyls on sex-dependent behaviors and steroid hormone concentrations in rats: dose-response relationship","volume":"178","author":"Kaya","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"8","key":"10.1016\/j.chemosphere.2025.144145_bib43","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1210\/endo.136.8.7628354","article-title":"Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus","volume":"136","author":"Kerr","year":"1995","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.chemosphere.2025.144145_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24081558","article-title":"The effects of mono-(2-ethylhexyl) phthalate (MEHP) on human estrogen receptor (hER) and androgen receptor (hAR) by YES\/YAS in vitro assay","volume":"24","author":"Kim","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.12717\/DR.2019.23.3.263","article-title":"Chronic and low dose exposure to nonlyphenol or di(2-ethylhexyl) phthalate alters cell proliferation and the localization of steroid hormone receptors in uterine endometria in mice","volume":"23","author":"Kim","year":"2019","journal-title":"Dev Reprod"},{"issue":"6","key":"10.1016\/j.chemosphere.2025.144145_bib46","first-page":"4972","article-title":"Analysis of the in vitro effects of di-(2-ethylhexyl) phthalate exposure on human uterine leiomyoma cells","volume":"15","author":"Kim","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-003-0522-3","article-title":"Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP","volume":"78","author":"Koch","year":"2004","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.chemosphere.2025.144145_bib48","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ijheh.2005.07.001","article-title":"Di(2-ethylhexyl)phthalate (DEHP) exposure of voluntary plasma and platelet donors","volume":"208","author":"Koch","year":"2005","journal-title":"Int. J. Hyg Environ. Health"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2605.2005.00607.x","article-title":"Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure-- an update and latest results","volume":"29","author":"Koch","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.chemosphere.2025.144145_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2022.902218","article-title":"Organizational effects of estrogens and androgens on estrogen and androgen receptor expression in pituitary and adrenal glands in adult male and female rats","volume":"16","author":"Lagunas","year":"2022","journal-title":"Front. Neuroanat."},{"issue":"14","key":"10.1016\/j.chemosphere.2025.144145_bib51","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1289\/ehp.6202","article-title":"In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy","volume":"111","author":"Latini","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.chemosphere.2025.144145_bib52","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2003-030261","article-title":"Endocrine mechanisms of disease: expression and degradation of androgen receptor: mechanism and clinical implication","volume":"88","author":"Lee","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib53","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1210\/jcem-62-1-159","article-title":"The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males","volume":"62","author":"Link","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib54","first-page":"178","article-title":"Decoding the androgen receptor splice variants","volume":"2","author":"Lu","year":"2013","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106101","article-title":"The internal exposure of phthalate metabolites and bisphenols in waste incineration plant workers and the associated health risks","volume":"145","author":"Lu","year":"2020","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.chemosphere.2025.144145_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084063","article-title":"Perinatal exposure to phthalates: from endocrine to neurodevelopment effects","volume":"22","author":"Lucaccioni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.chemosphere.2025.144145_bib57","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141335","article-title":"Regulation and targeting of androgen receptor nuclear localization in castration-resistant prostate cancer","volume":"131","author":"Lv","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.chemosphere.2025.144145_bib58","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10937400903094091","article-title":"Reproductive and developmental toxicity of phthalates","volume":"12","author":"Lyche","year":"2009","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.chemosphere.2025.144145_bib59","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jenvman.2013.04.013","article-title":"Di 2-ethylhexylphtalate in the aquatic and terrestrial environment: a critical review","volume":"127","author":"Magdouli","year":"2013","journal-title":"J Environ Manage"},{"issue":"12","key":"10.1016\/j.chemosphere.2025.144145_bib60","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/jp.2014.157","article-title":"Phthalates and critically ill neonates: device-related exposures and non-endocrine toxic risks","volume":"34","author":"Mallow","year":"2014","journal-title":"J. Perinatol."},{"issue":"6","key":"10.1016\/j.chemosphere.2025.144145_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/35078596","article-title":"Passage through the nuclear pore","volume":"3","author":"Marte","year":"2001","journal-title":"Nat. Cell Biol."},{"issue":"12","key":"10.1016\/j.chemosphere.2025.144145_bib62","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1210\/en.2009-0847","article-title":"In utero exposure to di-(2-ethylhexyl) phthalate decreases mineralocorticoid receptor expression in the adult testis","volume":"150","author":"Martinez-Arguelles","year":"2009","journal-title":"Endocrinology"},{"issue":"13","key":"10.1016\/j.chemosphere.2025.144145_bib63","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1128\/MCB.02039-06","article-title":"The pituitary function of androgen receptor constitutes a glucocorticoid production circuit","volume":"27","author":"Miyamoto","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"9\u201310","key":"10.1016\/j.chemosphere.2025.144145_bib64","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.crvi.2017.07.004","article-title":"What is an endocrine disruptor?","volume":"340","author":"Monneret","year":"2017","journal-title":"C R Biol"},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib65","article-title":"Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse","volume":"10","author":"O'Hara","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.chemosphere.2025.144145_bib66","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/andr.13040","article-title":"Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female-like lactotroph development","volume":"9","author":"O'Hara","year":"2021","journal-title":"Andrology"},{"key":"10.1016\/j.chemosphere.2025.144145_bib67","series-title":"Puberty in the Rat","first-page":"2061","author":"Ojeda","year":"2006"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib68","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1210\/en.2002-220770","article-title":"Androgen receptors in gonadotrophs in pituitary cultures from adult male monkeys and rats","volume":"144","author":"Okada","year":"2003","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib69","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1091\/mbc.01-06-0308","article-title":"Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm","volume":"13","author":"Pante","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib70","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/58.2.339","article-title":"The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat","volume":"58","author":"Parks","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.chemosphere.2025.144145_bib71","first-page":"1261","article-title":"Localization of androgen and estrogen receptors in rat and primate tissues","volume":"15","author":"Pelletier","year":"2000","journal-title":"Histol. Histopathol."},{"issue":"5","key":"10.1016\/j.chemosphere.2025.144145_bib72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10735-023-10144-7","article-title":"Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression","volume":"54","author":"Perez","year":"2023","journal-title":"J. Mol. Histol."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib73","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1210\/en.2011-1450","article-title":"Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring","volume":"153","author":"Pocar","year":"2012","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.chemosphere.2025.144145_bib74","article-title":"Prenatal exposure to DEHP affects spermatogenesis and sperm DNA methylation in a strain-dependent manner","volume":"10","author":"Prados","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1210\/mend-4-1-22","article-title":"Autologous down-regulation of androgen receptor messenger ribonucleic acid","volume":"4","author":"Quarmby","year":"1990","journal-title":"Mol. Endocrinol."},{"issue":"Pt 1","key":"10.1016\/j.chemosphere.2025.144145_bib76","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.envint.2018.07.029","article-title":"Phthalate exposure and male reproductive outcomes: a systematic review of the human epidemiological evidence","volume":"121","author":"Radke","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.chemosphere.2025.144145_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.02.003","article-title":"Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence","volume":"130","author":"Radke","year":"2019","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib78","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/biolre\/iox154","article-title":"Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice","volume":"98","author":"Rattan","year":"2018","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib79","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"issue":"5","key":"10.1016\/j.chemosphere.2025.144145_bib80","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10408440600779065","article-title":"Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver","volume":"36","author":"Rusyn","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"issue":"11","key":"10.1016\/j.chemosphere.2025.144145_bib81","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0022-4731(77)90063-2","article-title":"Distribution of androgen target cells in rat forebrain and pituitary after [3H]-dihydrotestosterone administration","volume":"8","author":"Sar","year":"1977","journal-title":"J. Steroid Biochem."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12022-007-9012-0","article-title":"Immunoexpression of androgen receptor in the nontumorous pituitary and in adenomas","volume":"19","author":"Scheithauer","year":"2008","journal-title":"Endocr. Pathol."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib83","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00204-018-2350-5","article-title":"Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders","volume":"93","author":"Schwartz","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"7","key":"10.1016\/j.chemosphere.2025.144145_bib84","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/jcb.25108","article-title":"In utero exposure to phthalate downregulates critical genes in Leydig cells of F1 male progeny","volume":"116","author":"Sekaran","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.chemosphere.2025.144145_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133537","article-title":"Genistein prevents the production of hypospadias induced by Di-(2-ethylhexyl) phthalate through androgen signaling and antioxidant response in rats","volume":"466","author":"Shi","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"12","key":"10.1016\/j.chemosphere.2025.144145_bib86","volume":"17","author":"Silano","year":"2019","journal-title":"EFSA J."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib87","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02739938","article-title":"Pituitary sex steroid receptors: localization and function","volume":"8","author":"Stefaneanu","year":"1997","journal-title":"Endocr. Pathol."},{"issue":"7","key":"10.1016\/j.chemosphere.2025.144145_bib88","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrm2928","article-title":"The nuclear pore complex: bridging nuclear transport and gene regulation","volume":"11","author":"Strambio-De-Castillia","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib89","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/JOE-06-0004","article-title":"Stimulation of the pituitary-adrenal axis and of adrenocortical steroidogenesis ex vivo by administration of di-2-ethylhexyl phthalate to prepubertal male rats","volume":"192","author":"Supornsilchai","year":"2007","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib90","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1677\/JOE-07-0238","article-title":"The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats","volume":"194","author":"Svechnikova","year":"2007","journal-title":"J. Endocrinol."},{"issue":"8","key":"10.1016\/j.chemosphere.2025.144145_bib91","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib92","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.envres.2008.08.007","article-title":"Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans","volume":"108","author":"Swan","year":"2008","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib93","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1677\/joe.0.1260017","article-title":"Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor","volume":"126","author":"Takeda","year":"1990","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib94","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0006-291X(91)92010-H","article-title":"Autoregulation of androgen receptor expression in rodent prostate: immunohistochemical and in situ hybridization analysis","volume":"177","author":"Takeda","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2\u20133","key":"10.1016\/j.chemosphere.2025.144145_bib95","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tox.2005.02.002","article-title":"Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor","volume":"210","author":"Takeuchi","year":"2005","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib96","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/15287398209530149","article-title":"Toxicity and metabolism of monoethylhexyl phthalate and diethylhexyl phthalate: a survey of recent literature","volume":"9","author":"Thomas","year":"1982","journal-title":"J. Toxicol. Environ. Health"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib97","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-23-0209","article-title":"FLNA expression modulates pathological markers of pituitary neuroendocrine tumours","volume":"260","author":"Toledo","year":"2024","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.chemosphere.2025.144145_bib98","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1210\/jcem-71-4-846","article-title":"Testosterone and oxandrolone, a nonaromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life","volume":"71","author":"Ulloa-Aguirre","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"17","key":"10.1016\/j.chemosphere.2025.144145_bib99","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127817","article-title":"Gonadotrope androgen receptor mediates pituitary responsiveness to hormones and androgen-induced subfertility","volume":"5","author":"Wang","year":"2019","journal-title":"JCI Insight"},{"issue":"39","key":"10.1016\/j.chemosphere.2025.144145_bib100","doi-asserted-by":"crossref","first-page":"16759","DOI":"10.1073\/pnas.1012443107","article-title":"Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor","volume":"107","author":"Watson","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib101","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.toxlet.2003.09.012","article-title":"Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis","volume":"146","author":"Wilson","year":"2004","journal-title":"Toxicol. Lett."},{"issue":"6","key":"10.1016\/j.chemosphere.2025.144145_bib102","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/endo.138.6.5163","article-title":"Transcriptional up-regulation of the human androgen receptor by androgen in bone cells","volume":"138","author":"Wiren","year":"1997","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.chemosphere.2025.144145_bib103","first-page":"924","article-title":"Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen","volume":"7","author":"Wolf","year":"1993","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.chemosphere.2025.144145_bib104","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1210\/me.2014-1154","article-title":"Conditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice","volume":"28","author":"Wu","year":"2014","journal-title":"Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.chemosphere.2025.144145_bib105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.21037\/tau-23-503","article-title":"Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression","volume":"13","author":"Xie","year":"2024","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2024.105943","article-title":"Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells","volume":"101","author":"Yasuda","year":"2024","journal-title":"Toxicol. Vitro"},{"issue":"1","key":"10.1016\/j.chemosphere.2025.144145_bib107","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13148-021-01119-0","article-title":"A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer","volume":"13","author":"Ylitalo","year":"2021","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.chemosphere.2025.144145_bib108","doi-asserted-by":"crossref","DOI":"10.1177\/09603271221139444","article-title":"Transcriptomic and proteomic characteristics of the di(2-ethylhexyl) phthalate-induced sperm dna damage mouse model","volume":"41","author":"Zhang","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104233","article-title":"Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: results from the TREE cohort","volume":"102","author":"Zhang","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2025.144145_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114005","article-title":"Investigation of phthalate metabolites in urine and daily phthalate intakes among three age groups in Beijing, China","volume":"260","author":"Zhang","year":"2020","journal-title":"Environ Pollut"},{"issue":"6","key":"10.1016\/j.chemosphere.2025.144145_bib111","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1210\/en.2017-00100","article-title":"Exposure to an environmentally relevant phthalate mixture causes transgenerational effects on female reproduction in mice","volume":"158","author":"Zhou","year":"2017","journal-title":"Endocrinology"},{"issue":"18","key":"10.1016\/j.chemosphere.2025.144145_bib112","doi-asserted-by":"crossref","first-page":"13115","DOI":"10.1016\/S0021-9258(17)36806-0","article-title":"A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences","volume":"269","author":"Zhou","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chemosphere.2025.144145_bib113","first-page":"249","article-title":"The androgen receptor: an overview","volume":"49","author":"Zhou","year":"1994","journal-title":"Recent Prog. Horm. Res."},{"issue":"2","key":"10.1016\/j.chemosphere.2025.144145_bib114","first-page":"208","article-title":"Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability","volume":"9","author":"Zhou","year":"1995","journal-title":"Mol. Endocrinol."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653525000864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653525000864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:26:23Z","timestamp":1777465583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653525000864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":114,"alternative-id":["S0045653525000864"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144145","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to environmentally relevant levels of DEHP during development modifies the distribution and expression patterns of androgen receptors in the anterior pituitary in a sex-specific manner","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"144145"}}