{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:23:35Z","timestamp":1775841815206,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"publisher","award":["SVV 260664"],"award-info":[{"award-number":["SVV 260664"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministry of Education Youth and Sports of the Czech Republic","doi-asserted-by":"publisher","award":["CZ.02.01.01\/00\/22_008\/0004607"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/0004607"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.chemosphere.2025.144281","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T17:20:38Z","timestamp":1741454438000},"page":"144281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Environment-like exposure of free-living stages of Haemonchus contortus to albendazole: The intra- and intergeneration stability of altered expression of UDP-glycosyl transferases and ABC-transporters"],"prefix":"10.1016","volume":"376","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-5947","authenticated-orcid":false,"given":"Karol\u00edna","family":"\u0160t\u011brbov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-6971","authenticated-orcid":false,"given":"Linh Nguyen","family":"Thuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"\u017dofka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-5744","authenticated-orcid":false,"given":"Petra","family":"Matou\u0161kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-5008","authenticated-orcid":false,"given":"Josef","family":"Kr\u00e1tk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-3871","authenticated-orcid":false,"given":"Lenka","family":"Sk\u00e1lov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2025.144281_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2021.108169","article-title":"Anthelmintic resistance: is a solution possible?","volume":"230","author":"Ahuir-Baraja","year":"2021","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ani11020363","article-title":"Haemonchosis: a challenging parasitic infection of sheep and goats","volume":"11","author":"Arsenopoulos","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.chemosphere.2025.144281_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpara.2018.10.005","article-title":"Deep amplicon sequencing as a powerful new tool to screen for sequence polymorphisms associated with anthelmintic resistance in parasitic nematode populations","volume":"49","author":"Avramenko","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vetpar.2011.11.068","article-title":"Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the beta-tubulin isotype 1 encoding gene in Haemonchus contortus","volume":"186","author":"Barrere","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116106","article-title":"Environmental risk assessment of the anthelmintic albendazole in Eastern Africa, based on a systematic review","volume":"269","author":"Belew","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2025.144281_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/bs.apar.2016.02.022","article-title":"The pathophysiology, ecology and epidemiology of Haemonchus contortus infection in small ruminants","volume":"93","author":"Besier","year":"2016","journal-title":"Haemonchus Contortus and Haemonchosis - Past, Present and Future Trends"},{"key":"10.1016\/j.chemosphere.2025.144281_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijpddr.2018.02.001","article-title":"Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13","volume":"8","author":"David","year":"2018","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpddr.2020.08.003","article-title":"Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles","volume":"14","author":"Dilks","year":"2020","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153527","article-title":"Environmental circulation of the anthelmintic drug albendazole affects expression and activity of resistance-related genes in the parasitic nematode Haemonchus contortus","volume":"822","author":"Dimunova","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2025.144281_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/03602532.2022.2083632","article-title":"The role of UDP-glycosyltransferases in xenobioticresistance","volume":"54","author":"Dimunova","year":"2022","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.chemosphere.2025.144281_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpddr.2022.06.001","article-title":"The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole","volume":"19","author":"Dimunov\u00e1","year":"2022","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib12","article-title":"Advances in the development of anti-Haemonchus contortus vaccines: challenges","volume":"8","author":"Ehsan","year":"2020","journal-title":"Opportunities, and Perspectives"},{"key":"10.1016\/j.chemosphere.2025.144281_bib13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ijpara.2016.07.001","article-title":"Haemonchus contortus: the then and now, and where to from here?","volume":"46","author":"Emery","year":"2016","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijpddr.2019.05.001","article-title":"Refugia and anthelmintic resistance: concepts and challenges","volume":"10","author":"Hodgkinson","year":"2019","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.594116","article-title":"UDP-glycosyltransferases and albendazole metabolism in the juvenile stages of Haemonchus contortus","volume":"11","author":"Kellerov\u00e1","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13567-020-00820-x","article-title":"Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults","volume":"51","author":"Kellerov\u00e1","year":"2020","journal-title":"Vet Res"},{"key":"10.1016\/j.chemosphere.2025.144281_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijpddr.2012.02.003","article-title":"Relative level of thiabendazole resistance associated with the E198A and F200Y SNPs in larvae of a multi-drug resistant isolate of Haemonchus contortus","volume":"2","author":"Kotze","year":"2012","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126439","article-title":"Bioaugmentation of animal feces as a mean to mitigate environmental contamination with anthelmintic benzimidazoles","volume":"419","author":"Lagos","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.chemosphere.2025.144281_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102357","article-title":"The diversity of ABC transporter genes across the Phylum Nematoda","volume":"83","author":"Langeland","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.chemosphere.2025.144281_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molbiopara.2015.08.001","article-title":"Reliable reference gene selection for quantitative real time PCR in Haemonchus contortus","volume":"201","author":"Lecov\u00e1","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.chemosphere.2025.144281_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2022.109647","article-title":"ABC-transporter gene expression in ivermectin-susceptible and resistant Haemonchus contortus isolates","volume":"302","author":"Mate","year":"2022","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ijpddr.2018.09.005","article-title":"UDP-glycosyltransferase family in Haemonchus contortus: phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences","volume":"8","author":"Matouskova","year":"2018","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.pt.2016.02.004","article-title":"The role of xenobiotic-metabolizing enzymes in anthelmintic deactivation and resistance in helminths","volume":"32","author":"Matou\u0161kov\u00e1","year":"2016","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.chemosphere.2025.144281_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144804","article-title":"An analysis of the spatio-temporal occurrence of anthelmintic veterinary drug residues in groundwater","volume":"769","author":"Mooney","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2025.144281_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-019-2050-2","article-title":"Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep","volume":"15","author":"Mravcakova","year":"2019","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.chemosphere.2025.144281_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117590","article-title":"Proof of the environmental circulation of veterinary drug albendazole in real farm conditions","volume":"286","author":"Navratilova","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.chemosphere.2025.144281_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138343","article-title":"Albendazole from ovine excrements in soil and plants under real agricultural conditions: distribution, persistence, and effects","volume":"324","author":"Navr\u00e1tilov\u00e1","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2025.144281_bib28","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1007\/s11356-016-6472-0","article-title":"Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination","volume":"23","author":"Prchal","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.chemosphere.2025.144281_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-016-1806-9","article-title":"Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro","volume":"9","author":"Raza","year":"2016","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.chemosphere.2025.144281_bib30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.vetpar.2015.04.025","article-title":"Effects of third generation P-glycoprotein inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro","volume":"211","author":"Raza","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpara.2003.10.002","article-title":"Genetic analysis of inbreeding of two strains of the parasitic nematode Haemonchus contortus","volume":"34","author":"Roos","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.pt.2018.05.001","article-title":"Ten events that defined anthelmintic resistance Research","volume":"34","author":"Sangster","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetpar.2015.05.002","article-title":"In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only","volume":"211","author":"Sarai","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2021.109345","article-title":"Combination of synthetic anthelmintics and monoterpenes: assessment of efficacy, and ultrastructural and biophysical properties of Haemonchus contortus using atomic force microscopy","volume":"290","author":"Silva","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.chemosphere.2025.144281_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijpddr.2018.01.005","article-title":"Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: sex differences, resistance-related differences and the identification of new metabolites","volume":"8","author":"Stuchl\u00edkov\u00e1","year":"2018","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib36","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s00436-019-06367-x","article-title":"Strategic vaccination of hair sheep against Haemonchus contortus","volume":"118","author":"Teixeira","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.chemosphere.2025.144281_bib37","first-page":"147","article-title":"A technique for the recovery of nematodes from ruminants by migration from gastro-intestinal ingesta gelled in agar: large-scale application","volume":"47","author":"van Wyk","year":"1980","journal-title":"Onderstepoort J. Vet. Res."},{"key":"10.1016\/j.chemosphere.2025.144281_bib38","article-title":"Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database","volume":"27","author":"Vineer","year":"2020","journal-title":"Parasite"},{"key":"10.1016\/j.chemosphere.2025.144281_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140446","article-title":"Anthelmintics in the environment: their occurrence, fate, and toxicity to non-target organisms","volume":"345","author":"Vok\u0159\u00e1l","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.chemosphere.2025.144281_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141653","article-title":"Identification of indicator PPCPs in landfill leachates and livestock wastewaters using multi-residue analysis of 70 PPCPs: analytical method development and application in Yangtze River Delta, China","volume":"753","author":"Wu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.chemosphere.2025.144281_bib41","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijpddr.2017.10.001","volume":"7","author":"Yilmaz","year":"2017","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.chemosphere.2025.144281_bib42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.drudis.2019.12.007","article-title":"Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes","volume":"25","author":"Zaj\u00edckov\u00e1","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.chemosphere.2025.144281_bib43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chemosphere.2013.10.091","article-title":"Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry","volume":"99","author":"Zrn\u010di\u0107","year":"2014","journal-title":"Chemosphere"}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653525002231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0045653525002231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:55:10Z","timestamp":1762224910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0045653525002231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":44,"alternative-id":["S0045653525002231"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144281","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environment-like exposure of free-living stages of Haemonchus contortus to albendazole: The intra- and intergeneration stability of altered expression of UDP-glycosyl transferases and ABC-transporters","name":"articletitle","label":"Article Title"},{"value":"Chemosphere","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144281","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"144281"}}